[go: up one dir, main page]

AU4959193A - High affinity, strongly neutralizing monoclonal antibodies against the CD-4 binding site of GP120 of human immunodeficiency virus - Google Patents

High affinity, strongly neutralizing monoclonal antibodies against the CD-4 binding site of GP120 of human immunodeficiency virus

Info

Publication number
AU4959193A
AU4959193A AU49591/93A AU4959193A AU4959193A AU 4959193 A AU4959193 A AU 4959193A AU 49591/93 A AU49591/93 A AU 49591/93A AU 4959193 A AU4959193 A AU 4959193A AU 4959193 A AU4959193 A AU 4959193A
Authority
AU
Australia
Prior art keywords
monoclonal antibodies
binding site
high affinity
antibodies against
immunodeficiency virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU49591/93A
Inventor
Abraham Pinter
Shermaine Tilley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Public Health Research Institute of City of New York Inc
Original Assignee
Public Health Research Institute of City of New York Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Public Health Research Institute of City of New York Inc filed Critical Public Health Research Institute of City of New York Inc
Publication of AU4959193A publication Critical patent/AU4959193A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • AIDS & HIV (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU49591/93A 1992-03-31 1993-03-31 High affinity, strongly neutralizing monoclonal antibodies against the CD-4 binding site of GP120 of human immunodeficiency virus Abandoned AU4959193A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86110892A 1992-03-31 1992-03-31
US861108 1992-03-31
PCT/US1993/003010 WO1993019786A1 (en) 1992-03-31 1993-03-31 High affinity, strongly neutralizing monoclonal antibodies against the cd-4 binding site of gp120 of human immunodeficiency virus

Publications (1)

Publication Number Publication Date
AU4959193A true AU4959193A (en) 1993-11-08

Family

ID=25334900

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49591/93A Abandoned AU4959193A (en) 1992-03-31 1993-03-31 High affinity, strongly neutralizing monoclonal antibodies against the CD-4 binding site of GP120 of human immunodeficiency virus

Country Status (2)

Country Link
AU (1) AU4959193A (en)
WO (1) WO1993019786A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474894A (en) * 1994-01-21 1995-12-12 Quality Biological, Inc. Immunodeficiency virus neutralization assay
US8722861B2 (en) 2007-11-19 2014-05-13 Kumamoto University Monoclonal antibodies that bind to the V3 loop of HIV-1 gp120
US9493549B2 (en) 2011-07-25 2016-11-15 The Rockefeller University Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth
US9890207B2 (en) 2011-07-25 2018-02-13 California Institute Of Technology Highly active agonistic CD4 binding site anti-HIV antibodies (HAADS) comprising modified CDRH2 regions that improve contact with GP120
WO2013090644A2 (en) * 2011-12-13 2013-06-20 California Institute Of Technology Anti-hiv antibodies having increased potency and breadth
US9879068B2 (en) 2012-06-21 2018-01-30 California Institute Of Technology Antibodies targeting HIV escape mutants

Also Published As

Publication number Publication date
WO1993019786A1 (en) 1993-10-14

Similar Documents

Publication Publication Date Title
AU8083594A (en) Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus
FI951488L (en) Human neutralizing monoclonal antibodies against human immunodeficiency virus
CA2082948A1 (en) Immunogenic peptides, antibodies and uses thereof relating to cd4 receptor binding
EP0554401A4 (en) Neutralizing human monoclonal antibodies specific for the v3 loop and cd-4 binding site of hiv-1 gp120
NO970221D0 (en) Human neutralizing monoclonal antibodies against human immunodeficiency virus
AU6916296A (en) Recombinant anti-cd4 antibodies for human therapy
CA2109815A1 (en) Antibody preparation
EP1266965A3 (en) Recombinant antibodies for human therapy
AU1866895A (en) Human monoclonal antibodies to herpes simplex virus and methods therefor
CA2144043A1 (en) Human neutralizing monoclonal antibodies to respiratory syncytial virus
AU1332099A (en) Costimulating t-cell polypeptide, monoclonal antibodies, their preparation and use
AU5726694A (en) Human immunodeficiency virus decoy
AU7450094A (en) Monoclonal iga antibody against respiratory syncytial virus
WO2002024149A3 (en) Immunogen comprising ligand bound hiv envelpe protein
AU3727695A (en) Compositions and methods for the abrogation of cellular proliferation utilizing the human immunodeficiency virus vpr protein
AU7198291A (en) Human monoclonal antibodies against rabies viruses, the production and the use thereof
CA2192512A1 (en) Nm03 antibody materials and methods
AU7203194A (en) Bispecific human monoclonal antibodies specific for human immunodeficiency virus
AU2784792A (en) Human monoclonal antibodies to the cd4-binding domain of hiv, uses thereof and synergistic neutralization of hiv
AU3505397A (en) Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same
AU7160691A (en) Monoclonal antibodies which neutralize hiv-1 infection and their anti-idiotypes
AU4959193A (en) High affinity, strongly neutralizing monoclonal antibodies against the CD-4 binding site of GP120 of human immunodeficiency virus
IL94624A0 (en) Human monoclonal antibodies to hiv-1 mn qq120
AU2370592A (en) Epitopes of the env protein of the hepatitis c virus
AU641736B2 (en) Delivery of agents