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AU4289193A - Mutant cytokines having increased receptor affinity - Google Patents

Mutant cytokines having increased receptor affinity

Info

Publication number
AU4289193A
AU4289193A AU42891/93A AU4289193A AU4289193A AU 4289193 A AU4289193 A AU 4289193A AU 42891/93 A AU42891/93 A AU 42891/93A AU 4289193 A AU4289193 A AU 4289193A AU 4289193 A AU4289193 A AU 4289193A
Authority
AU
Australia
Prior art keywords
receptor affinity
increased receptor
mutant cytokines
cytokines
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU42891/93A
Inventor
Fadi Lakkis
John R. Murphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Hospital
Original Assignee
University Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Hospital filed Critical University Hospital
Publication of AU4289193A publication Critical patent/AU4289193A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU42891/93A 1992-04-17 1993-04-16 Mutant cytokines having increased receptor affinity Abandoned AU4289193A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US870500 1978-01-18
US87050092A 1992-04-17 1992-04-17

Publications (1)

Publication Number Publication Date
AU4289193A true AU4289193A (en) 1993-11-18

Family

ID=25355515

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42891/93A Abandoned AU4289193A (en) 1992-04-17 1993-04-16 Mutant cytokines having increased receptor affinity

Country Status (2)

Country Link
AU (1) AU4289193A (en)
WO (1) WO1993021308A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1044720C (en) * 1993-07-07 1999-08-18 株式会社乐喜 Modified human granulocyte macrophagecolony stimulating factor gene and expression thereof in yeast
US5986059A (en) * 1996-06-14 1999-11-16 Bayer Corporation T-cell selective interleukin-4 agonists
HUP9902824A3 (en) * 1996-06-14 2001-11-28 Bayer Corp Pittsburgh T-cell selective interleukin-4 agonists
US6335426B1 (en) 1996-06-14 2002-01-01 Bayer Corporation T-cell selective interleukin-4 agonists
US6028176A (en) * 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
MY124565A (en) * 1996-07-19 2006-06-30 Bayer Corp High-affinity interleukin-4-muteins
AU2728200A (en) * 1999-01-15 2000-08-01 Zymogenetics Inc. Mammalian alpha-helical protein - 12

Also Published As

Publication number Publication date
WO1993021308A1 (en) 1993-10-28

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