AU3817197A - Troponyl piperazines as selective dopamine d4 receptor ligands - Google Patents
Troponyl piperazines as selective dopamine d4 receptor ligandsInfo
- Publication number
- AU3817197A AU3817197A AU38171/97A AU3817197A AU3817197A AU 3817197 A AU3817197 A AU 3817197A AU 38171/97 A AU38171/97 A AU 38171/97A AU 3817197 A AU3817197 A AU 3817197A AU 3817197 A AU3817197 A AU 3817197A
- Authority
- AU
- Australia
- Prior art keywords
- troponyl
- piperazines
- receptor ligands
- selective dopamine
- dopamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000003962 Dopamine D4 receptors Human genes 0.000 title 1
- 108090000357 Dopamine D4 receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70137096A | 1996-08-22 | 1996-08-22 | |
| US08701370 | 1996-08-22 | ||
| PCT/US1997/013264 WO1998007711A1 (en) | 1996-08-22 | 1997-07-30 | Troponyl piperazines as selective dopamine d4 receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU3817197A true AU3817197A (en) | 1998-03-06 |
Family
ID=24817086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU38171/97A Abandoned AU3817197A (en) | 1996-08-22 | 1997-07-30 | Troponyl piperazines as selective dopamine d4 receptor ligands |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0929537A1 (en) |
| JP (1) | JP2000516629A (en) |
| KR (1) | KR20000068255A (en) |
| CN (1) | CN1227550A (en) |
| AR (1) | AR009274A1 (en) |
| AU (1) | AU3817197A (en) |
| BR (1) | BR9711965A (en) |
| CA (1) | CA2259515A1 (en) |
| HU (1) | HUP9903913A3 (en) |
| IL (1) | IL128629A0 (en) |
| NO (1) | NO990796D0 (en) |
| NZ (1) | NZ333519A (en) |
| WO (1) | WO1998007711A1 (en) |
| ZA (1) | ZA977445B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100394083B1 (en) * | 2000-12-04 | 2003-08-06 | 학교법인 성신학원 | Novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors, and preparation thereof |
| KR100394086B1 (en) * | 2000-12-04 | 2003-08-06 | 한국과학기술연구원 | Novel isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors, and preparation thereof |
| US6890919B2 (en) | 2001-06-26 | 2005-05-10 | Shitij Kapur | Atypical antipsychotic agents having low affinity for the D2 receptor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1153764A (en) * | 1980-02-25 | 1983-09-13 | Jehan F. Bagli | 2-(1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives |
| DK0546102T3 (en) * | 1990-08-29 | 1998-06-02 | Upjohn Co | Tropolone derivatives and their pharmaceutical composition for the prevention and treatment of ischemic diseases |
| SG65570A1 (en) * | 1992-02-25 | 1999-06-22 | Recordati Chem Pharm | Heterobicyclic compounds |
| US5541179A (en) * | 1995-05-02 | 1996-07-30 | American Home Products Corporation | Tropon-2-one piperazine carboxamides as serotonergic agents |
-
1997
- 1997-07-30 WO PCT/US1997/013264 patent/WO1998007711A1/en not_active Application Discontinuation
- 1997-07-30 KR KR1019997001390A patent/KR20000068255A/en not_active Application Discontinuation
- 1997-07-30 CN CN97197238A patent/CN1227550A/en active Pending
- 1997-07-30 NZ NZ333519A patent/NZ333519A/en unknown
- 1997-07-30 IL IL12862997A patent/IL128629A0/en unknown
- 1997-07-30 AU AU38171/97A patent/AU3817197A/en not_active Abandoned
- 1997-07-30 BR BR9711965A patent/BR9711965A/en not_active Application Discontinuation
- 1997-07-30 JP JP10510754A patent/JP2000516629A/en active Pending
- 1997-07-30 CA CA002259515A patent/CA2259515A1/en not_active Abandoned
- 1997-07-30 HU HU9903913A patent/HUP9903913A3/en unknown
- 1997-07-30 EP EP97935166A patent/EP0929537A1/en not_active Withdrawn
- 1997-08-19 ZA ZA9707445A patent/ZA977445B/en unknown
- 1997-08-20 AR ARP970103771A patent/AR009274A1/en unknown
-
1999
- 1999-02-19 NO NO990796A patent/NO990796D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO990796L (en) | 1999-02-19 |
| BR9711965A (en) | 1999-08-24 |
| WO1998007711A1 (en) | 1998-02-26 |
| JP2000516629A (en) | 2000-12-12 |
| HUP9903913A2 (en) | 2000-09-28 |
| NO990796D0 (en) | 1999-02-19 |
| NZ333519A (en) | 1999-10-28 |
| ZA977445B (en) | 1998-02-23 |
| AR009274A1 (en) | 2000-04-12 |
| CN1227550A (en) | 1999-09-01 |
| IL128629A0 (en) | 2000-01-31 |
| EP0929537A1 (en) | 1999-07-21 |
| HUP9903913A3 (en) | 2000-11-28 |
| CA2259515A1 (en) | 1998-02-26 |
| KR20000068255A (en) | 2000-11-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU8096798A (en) | Dopamine d4 receptor ligands | |
| AU2900499A (en) | Substituted aminomethylphosphines as ligands for catalysts | |
| AU8697998A (en) | Proning bed | |
| AUPO919997A0 (en) | Hold down bracket | |
| AU4057097A (en) | Fused indolecarboxamides: dopamine receptor subtype specific ligands | |
| AU3934895A (en) | 5-ht2 receptor ligands | |
| AU4595997A (en) | Self-configuring telephone interface unit | |
| AU3072797A (en) | Benzoxazinone dopamine d4 receptor antagonists | |
| AU2403195A (en) | Tryptamine derivatives as 5-ht-1d receptor ligands | |
| AU2248195A (en) | Opiate receptor ligands | |
| AU6230698A (en) | Dopamine d4 receptor antagonist | |
| AU8919098A (en) | Fumonosin resistance | |
| AU1286399A (en) | 3-aminoalkylamino- 2h-1,4-benzoxazines and 3-aminoalkylamino- 2h-1,4-benzothiazines: dopamine receptor subtype specific ligands | |
| AU3817197A (en) | Troponyl piperazines as selective dopamine d4 receptor ligands | |
| AU2459597A (en) | N-aminoalkyl-2-anthraquinonecarboxamides; new dopamine receptor subtype specific ligands | |
| AU2335797A (en) | Novel n-aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands | |
| AU8296998A (en) | 2-aminoalkylaminoquinolines as dopamine d4 ligands | |
| AU1767797A (en) | Heterocyclyl-ergoline derivatives as 5-ht1a receptor ligands | |
| AU7669394A (en) | Adrenergic receptor | |
| AU4600296A (en) | Opiate receptor ligands | |
| AU3384697A (en) | Diphenyl-cyclopropenes as selective k-agonists | |
| AU6256198A (en) | Benzamides having dopamine d4 receptor affinity | |
| AU3250997A (en) | Tricyclic radiolabeled d4 receptor ligands | |
| AU4479297A (en) | Mine-disposal machine | |
| AU7124098A (en) | Adjustable bed |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |