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AU3734699A - Fumagillol derivatives and processes for preparing the same - Google Patents

Fumagillol derivatives and processes for preparing the same

Info

Publication number
AU3734699A
AU3734699A AU37346/99A AU3734699A AU3734699A AU 3734699 A AU3734699 A AU 3734699A AU 37346/99 A AU37346/99 A AU 37346/99A AU 3734699 A AU3734699 A AU 3734699A AU 3734699 A AU3734699 A AU 3734699A
Authority
AU
Australia
Prior art keywords
preparing
processes
same
fumagillol derivatives
fumagillol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU37346/99A
Inventor
Soon Kil Ahn
Nam Song Choi
Hyoung Sik Chun
Cheol Kyu Han
Chung Il Hong
Ryung Kee Hong
Jung Woo Kim
Sang Joon Lee
Seung Kee Moon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chong Kun Dang Corp
Original Assignee
Chong Kun Dang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Corp filed Critical Chong Kun Dang Corp
Publication of AU3734699A publication Critical patent/AU3734699A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU37346/99A 1998-05-15 1999-05-11 Fumagillol derivatives and processes for preparing the same Abandoned AU3734699A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19980017636 1998-05-15
KR9817636 1998-05-15
PCT/KR1999/000229 WO1999059986A1 (en) 1998-05-15 1999-05-11 Fumagillol derivatives and processes for preparing the same

Publications (1)

Publication Number Publication Date
AU3734699A true AU3734699A (en) 1999-12-06

Family

ID=19537397

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37346/99A Abandoned AU3734699A (en) 1998-05-15 1999-05-11 Fumagillol derivatives and processes for preparing the same

Country Status (10)

Country Link
US (1) US6063812A (en)
EP (1) EP1077964B1 (en)
JP (1) JP3370985B2 (en)
KR (1) KR100357542B1 (en)
CN (1) CN100352810C (en)
AU (1) AU3734699A (en)
CA (1) CA2331873C (en)
DE (1) DE69903279T2 (en)
ES (1) ES2185338T3 (en)
WO (1) WO1999059986A1 (en)

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US7105482B2 (en) 2000-11-01 2006-09-12 Praecis Pharmaceuticals, Inc. Methionine aminopeptidase-2 inhibitors and methods of use thereof
MXPA03003775A (en) 2000-11-01 2003-07-28 Praecis Pharm Inc Therapeutic agents and methods of use thereof for the modulation of angiogenesis.
US6548477B1 (en) 2000-11-01 2003-04-15 Praecis Pharmaceuticals Inc. Therapeutic agents and methods of use thereof for the modulation of angiogenesis
KR100455900B1 (en) * 2001-09-27 2004-11-12 주식회사 아이디알 Novel fumagillol derivatives and preparing method thereof
KR100451485B1 (en) * 2002-03-28 2004-10-06 주식회사종근당 Inclusion compounds of fumagillol derivative or its salt, and pharmaceutical compositions comprising the same
KR100552043B1 (en) * 2004-02-28 2006-02-20 주식회사종근당 Composition for the treatment of obesity comprising fumarylol derivative
CN101142210A (en) * 2005-01-26 2008-03-12 株式会社钟根堂 Fumagillol derivatives or method for preparation of fumagillol derivatives, and pharmaceutical compositions comprising the same
EP1967175A1 (en) 2007-03-06 2008-09-10 Cognis IP Management GmbH Use of derivatives of sinapinic acid and compositions comprising such derivatives
JP5557746B2 (en) * 2007-11-28 2014-07-23 メルサナ セラピューティックス，インク． Biocompatible biodegradable fumagillin analog complex
WO2010009374A1 (en) 2008-07-18 2010-01-21 Zafgen, Inc. Methods of treating an overweight or obese subject
US20120004162A1 (en) 2008-12-04 2012-01-05 Vath James E Methods of Treating an Overweight or Obese Subject
WO2010065883A2 (en) 2008-12-04 2010-06-10 Zafgen Corporation Method of treating an overweight or obese subject
MX337575B (en) 2009-10-09 2016-03-10 Zafgen Corp Sulphone compounds for use in the treatment of obesity.
WO2011085198A1 (en) 2010-01-08 2011-07-14 Zafgen Corporation Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph)
EP2521719B1 (en) 2010-01-08 2015-07-29 Zafgen, Inc. Fumagillol type compounds and methods of making and using same
WO2011088055A2 (en) 2010-01-12 2011-07-21 Zafgen Corporation Methods and compositions for treating cardiovascular disorders
WO2011127304A2 (en) 2010-04-07 2011-10-13 Zafgen Corporation Methods of treating an overweight subject
ES2853204T3 (en) 2010-05-25 2021-09-15 Syndevrx Inc Polymer-Conjugated MetAP2 Inhibitors, and Therapeutic Methods of Using The Same
US9895449B2 (en) 2010-05-25 2018-02-20 Syndevrx, Inc. Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof
KR20130043207A (en) 2010-07-22 2013-04-29 자프겐 인크. Tricyclic compounds and methods of making and using same
PH12013500934A1 (en) * 2010-11-09 2022-10-24 Zafgen Inc Crystalline solids of a metap-2 inhibitor and methods of making and using same
WO2012064928A1 (en) 2010-11-10 2012-05-18 Zafgen Corporation Methods and compositions for treating thyroid hormone related disorders
WO2012074968A1 (en) 2010-11-29 2012-06-07 Zafgen Corporation Methods of reducing risk of hepatobiliary dysfunction during rapid weight loss with metap-2 inhibitors
WO2012075020A1 (en) 2010-11-29 2012-06-07 Zafgen Corporation Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
US9189078B2 (en) 2010-12-20 2015-11-17 Apple Inc. Enhancing keycap legend visibility with optical components
MX344238B (en) 2011-01-26 2016-12-07 Zafgen Inc Tetrazole compounds and methods of making and using same.
AU2012225531B2 (en) 2011-03-08 2017-03-30 Zafgen, Inc Oxaspiro (2.5) octane derivatives and analogs
MX343688B (en) 2011-05-06 2016-11-16 Zafgen Inc Tricyclic pyrazole sulfonamide compounds and methods of making and using same.
EP2705030B1 (en) 2011-05-06 2016-07-27 Zafgen, Inc. Partially saturated tricyclic compounds and methods of making and using same
US9187494B2 (en) 2011-05-06 2015-11-17 Zafgen, Inc. Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
EP2763671A2 (en) 2011-10-03 2014-08-13 Zafgen, Inc. Methods of treating age related disorders
KR20140112566A (en) 2012-01-18 2014-09-23 자프겐 인크. Tricyclic sulfone compounds and methods of making and using same
EP2804866B1 (en) 2012-01-18 2016-11-16 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
AU2013259760A1 (en) 2012-05-07 2014-11-20 Zafgen, Inc. Polymorphic salt of the oxalate salt of 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol and methods of making and using same
WO2013169857A1 (en) 2012-05-08 2013-11-14 Zafgen, Inc. Treating hypothalamic obesity with metap2 inhibitors
CN104364251B (en) 2012-05-09 2017-02-22 扎夫根股份有限公司 Fumigillol type compounds and methods of making and using same
US9561209B2 (en) 2012-11-05 2017-02-07 Zafgen, Inc. Methods of treating liver diseases
AU2013337282A1 (en) 2012-11-05 2015-05-21 Zafgen, Inc. Tricyclic compounds and methods of making and using same
CA2890344A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
CA2904353A1 (en) 2013-03-14 2014-09-25 Zafgen, Inc. Methods of treating renal disease and other disorders
EA033912B1 (en) 2013-04-10 2019-12-09 Синдевркс, Инк. MetAP2 INHIBITORS AND METHODS OF TREATING OBESITY
TW201636342A (en) * 2014-12-19 2016-10-16 武田藥品工業有限公司 Fumagillol derivatives
CN106432255A (en) 2015-08-11 2017-02-22 扎夫根公司 Fumigillol spiro-compound, preparation and use method thereof
AR105671A1 (en) 2015-08-11 2017-10-25 Zafgen Inc HUMEROCYCLIC COMPOUNDS OF FUMAGILLOL AND ITS METHODS OF ELABORATION AND USE
KR20180093995A (en) 2015-12-10 2018-08-22 신데브알엑스, 인크. A fumagillol derivative and its polymorph
WO2017123603A1 (en) 2016-01-11 2017-07-20 Syndevrx, Inc. Treatment for tumors driven by metabolic dysfunction
CN113453721A (en) 2018-10-26 2021-09-28 辛德弗雷克斯公司 Biomarkers of METAP2 inhibitor and uses thereof

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* Cited by examiner, † Cited by third party
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PH26256A (en) * 1988-08-12 1992-04-01 Fujisawa Pharmaceutical Co Oxaspiro [2,5] octane derivative
ATE106726T1 (en) * 1988-09-01 1994-06-15 Takeda Chemical Industries Ltd ANGIOGENESIS INHIBITING AGENT.
EP0386667B1 (en) * 1989-03-06 1993-11-18 Takeda Chemical Industries, Ltd. 6-Amino-6-desoxyfumagillols, production and use thereof
US5290807A (en) * 1989-08-10 1994-03-01 Children's Medical Center Corporation Method for regressing angiogenesis using o-substituted fumagillol derivatives
EP0415294A3 (en) * 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
ATE205092T1 (en) * 1992-01-30 2001-09-15 Takeda Chemical Industries Ltd METHOD FOR PRODUCING HIGHLY WATER SOLUBLE CYCLODEXTRIN COMPLEXES
EP0799616A1 (en) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative

Also Published As

Publication number Publication date
DE69903279T2 (en) 2003-08-07
JP3370985B2 (en) 2003-01-27
CA2331873A1 (en) 1999-11-25
JP2002515497A (en) 2002-05-28
KR19990088113A (en) 1999-12-27
KR100357542B1 (en) 2002-10-18
EP1077964A1 (en) 2001-02-28
CA2331873C (en) 2005-12-06
DE69903279D1 (en) 2002-11-07
CN1301260A (en) 2001-06-27
EP1077964B1 (en) 2002-10-02
WO1999059986A1 (en) 1999-11-25
CN100352810C (en) 2007-12-05
US6063812A (en) 2000-05-16
ES2185338T3 (en) 2003-04-16

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase