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AU3661500A - Method for the production of 4'-demethyl - 4'-phosphate-2",3" - bis pentafluorophenoxyacetyl 4",6"-ethylidene - beta-d- glucoside epipodophyllotoxin and the salts thereof - Google Patents

Method for the production of 4'-demethyl - 4'-phosphate-2",3" - bis pentafluorophenoxyacetyl 4",6"-ethylidene - beta-d- glucoside epipodophyllotoxin and the salts thereof

Info

Publication number
AU3661500A
AU3661500A AU36615/00A AU3661500A AU3661500A AU 3661500 A AU3661500 A AU 3661500A AU 36615/00 A AU36615/00 A AU 36615/00A AU 3661500 A AU3661500 A AU 3661500A AU 3661500 A AU3661500 A AU 3661500A
Authority
AU
Australia
Prior art keywords
epipodophyllotoxin
demethyl
beta
glucoside
ethylidene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU36615/00A
Inventor
Yves Guminski
Thierry Imbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of AU3661500A publication Critical patent/AU3661500A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a method for the production of 4'-demethyl -4'- phosphate-2",3" -bispentafluorophenoxyacetyl - 4",6"-ethylidene - beta -D-glucoside epipodophyllotoxin, characterized in that 2,3-bis pentafluorophenoxyacetyl-1-O-triethylsilyl- beta -D-glucopyranoside is condensed with 4'-demethyl-4'-aryloxyacetyl-epipodophyllotoxin.
AU36615/00A 1999-03-29 2000-03-29 Method for the production of 4'-demethyl - 4'-phosphate-2",3" - bis pentafluorophenoxyacetyl 4",6"-ethylidene - beta-d- glucoside epipodophyllotoxin and the salts thereof Abandoned AU3661500A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9903877 1999-03-29
FR9903877A FR2791682B1 (en) 1999-03-29 1999-03-29 PROCESS FOR THE PREPARATION OF 4'-DEMETHYL-4'-PHOSPHATE-2 ", 3" -BIS PENTAFLUOROPHENOXYACETYL-4 ", 6" -ETHYLDIDENE-BETA-D- EPIPODOPHYLLOTOXIN GLUCOSIDE, AND ITS SALTS
PCT/FR2000/000776 WO2000058324A1 (en) 1999-03-29 2000-03-29 METHOD FOR THE PRODUCTION OF 4'-DEMETHYL - 4'-PHOSPHATE-2',3' - BIS PENTAFLUOROPHENOXYACETYL - 4',6'-ETHYLIDENE - β-D- GLUCOSIDE EPIPODOPHYLLOTOXIN AND THE SALTS THEREOF

Publications (1)

Publication Number Publication Date
AU3661500A true AU3661500A (en) 2000-10-16

Family

ID=9543738

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36615/00A Abandoned AU3661500A (en) 1999-03-29 2000-03-29 Method for the production of 4'-demethyl - 4'-phosphate-2",3" - bis pentafluorophenoxyacetyl 4",6"-ethylidene - beta-d- glucoside epipodophyllotoxin and the salts thereof

Country Status (7)

Country Link
EP (1) EP1165581B1 (en)
AT (1) ATE231157T1 (en)
AU (1) AU3661500A (en)
CA (1) CA2367442A1 (en)
DE (1) DE60001225D1 (en)
FR (1) FR2791682B1 (en)
WO (1) WO2000058324A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2859724B1 (en) * 2003-09-16 2005-12-30 Pf Medicament FREE-FORM CRYSTALLINE COMPOUND OR HEMIETHANOLATE OF EPPODOPHYLLOTOXIN 4'-DEMETHYL-4'-PHOSPHATE-2 ", 3" -BISPENTAFLUOROPHENOXYACETYL-4 ", 6" -ETHYLIDENE-BETA-D-GLUCOSIDE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658824B1 (en) * 1990-02-27 1992-07-03 Pf Medicament TRIS ACETYL-2 ", 3", 4 'ETHYLIDENE-4 ", 6" BETA-D-GLUCOPYRANOSIDES, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF DEMETHYL-4' EPIPODOPHYLLOTOXIN ETHYLIDENE BETA-D-GLUCOPYRANOSIDE.
FR2725990B1 (en) * 1994-10-21 1997-01-10 Pf Medicament WATER-SOLUBLE DERIVATIVES OF EPIPODOPHYLLOTOXIN, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, AND THEIR USE FOR CANCER TREATMENTS

Also Published As

Publication number Publication date
DE60001225D1 (en) 2003-02-20
WO2000058324A1 (en) 2000-10-05
FR2791682B1 (en) 2001-06-22
CA2367442A1 (en) 2000-10-05
EP1165581A1 (en) 2002-01-02
EP1165581B1 (en) 2003-01-15
FR2791682A1 (en) 2000-10-06
ATE231157T1 (en) 2003-02-15

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase