AU3421493A - Use of spiperone or spiperone derivatives as immunosuppressant agents - Google Patents

Use of spiperone or spiperone derivatives as immunosuppressant agents

Info

Publication number: AU3421493A
Authority: AU; Australia
Prior art keywords: spiperone; derivatives; immunosuppressant agents; immunosuppressant; agents
Prior art date: 1991-12-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU34214/93A

Inventor

Kenneth A. Arndt

Stephen J. Galli

Peter C. Meltzer

Raj K Razdan

Howard P Sard

Richard J Sharpe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beth Israel Deaconess Medical Center Inc

Original Assignee

Beth Israel Deaconess Medical Center Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-27

Filing date

1992-12-23

Publication date

1993-07-28

1991-12-27 Priority claimed from US07/815,283 external-priority patent/US5290783A/en

1992-02-05 Priority claimed from US07/831,429 external-priority patent/US5244902A/en

1992-06-04 Priority claimed from US07/893,534 external-priority patent/US5574041A/en

1992-06-04 Priority claimed from US07/893,536 external-priority patent/US5703088A/en

1992-12-23 Application filed by Beth Israel Deaconess Medical Center Inc filed Critical Beth Israel Deaconess Medical Center Inc

1993-07-28 Publication of AU3421493A publication Critical patent/AU3421493A/en

Status Abandoned legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AU34214/93A 1991-12-27 1992-12-23 Use of spiperone or spiperone derivatives as immunosuppressant agents Abandoned AU3421493A (en)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US07/815,283 US5290783A (en)	1990-03-16	1991-12-27	Use of spiperone derivatives as immunosuppressant agents
US815283		1991-12-27
US831429		1992-02-05
US07/831,429 US5244902A (en)	1989-08-21	1992-02-05	Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US893536		1992-06-04
US893534		1992-06-04
US07/893,534 US5574041A (en)	1990-03-16	1992-06-04	Use of spiperone derivatives as immunosuppressant agents
US07/893,536 US5703088A (en)	1989-08-21	1992-06-04	Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses

Publications (1)

Publication Number	Publication Date
AU3421493A true AU3421493A (en)	1993-07-28

Family

ID=27505847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU34214/93A Abandoned AU3421493A (en)	1991-12-27	1992-12-23	Use of spiperone or spiperone derivatives as immunosuppressant agents

Country Status (5)

Country	Link
EP (1)	EP0661972A1 (en)
JP (1)	JPH08500326A (en)
AU (1)	AU3421493A (en)
CA (1)	CA2126678A1 (en)
WO (1)	WO1993012789A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5703088A (en) *	1989-08-21	1997-12-30	Beth Israel Deaconess Medical Center, Inc.	Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5693645A (en) *	1992-12-23	1997-12-02	Beth Israel Deaconess Medical Center, Inc.	Use of spiperone or spiperone derivatives as immunosuppressant agents
US5484788A (en) *	1993-03-26	1996-01-16	Beth Israel Hospital Association	Buspirone as a systemic immunosuppressant
US5631017A (en) *	1993-03-26	1997-05-20	Beth Israel Deaconess Medical Center, Inc.	Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5637314A (en) *	1995-06-07	1997-06-10	Beth Israel Deaconess Medical Center, Inc.	Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
AU1335397A (en) *	1995-12-21	1997-07-17	Eli Lilly And Company	Method for treating dermatitis
AU3809999A (en) *	1998-05-18	1999-12-06	Novo Nordisk A/S	Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6277991B1 (en)	1998-05-18	2001-08-21	Novo Nordisk A/S	1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
WO2004019921A2 (en) *	2002-08-29	2004-03-11	University Of Southampton	Use of apoptosis inducing agents in the preparation of a medicament for the treatment of liver diseases
NZ538307A (en)	2002-09-09	2008-04-30	Janssen Pharmaceutica Nv	Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
JP5727139B2 (en)	2006-11-28	2015-06-03	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎＰｈａｒｍａｃｅｕｔｉｃａＮａａｍｌｏｚｅＶｅｎｎｏｏｔｓｃｈａｐ	3- (3-Amino-2- (R) -hydroxy-propyl) -1- (4-fluoro-phenyl) -8- (8-methyl-naphthalen-1-ylmethyl) -1,3,8-triaza- Spiro [4.5] decan-4-one salt
WO2008124209A1 (en)	2007-04-09	2008-10-16	Janssen Pharmaceutica, N.V.	1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
JP2020519639A (en) *	2017-05-12	2020-07-02	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	Treatment of gastroparesis with triazaspiro[4.5]decanone

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3155669A (en) *	1962-06-22	1964-11-03	Res Lab Dr C Janssen N V	2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US4839342A (en) *	1987-09-03	1989-06-13	University Of Georgia Research Foundation, Inc.	Method of increasing tear production by topical administration of cyclosporin
CA2065375A1 (en) *	1989-08-21	1991-02-22	Richard J. Sharpe	Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists
EP0520032B1 (en) *	1990-03-16	1998-09-16	Beth Israel Hospital Association	Use of spiperone as an immunosuppressant and anti-inflammatory agent

1992
- 1992-12-23 AU AU34214/93A patent/AU3421493A/en not_active Abandoned
- 1992-12-23 WO PCT/US1992/011205 patent/WO1993012789A1/en not_active Application Discontinuation
- 1992-12-23 EP EP93902752A patent/EP0661972A1/en not_active Withdrawn
- 1992-12-23 JP JP5511900A patent/JPH08500326A/en active Pending
- 1992-12-23 CA CA002126678A patent/CA2126678A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0661972A4 (en)	1994-10-27
WO1993012789A1 (en)	1993-07-08
CA2126678A1 (en)	1993-07-08
JPH08500326A (en)	1996-01-16
EP0661972A1 (en)	1995-07-12

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