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AU3225289A - Novel alkanophenones - Google Patents

Novel alkanophenones

Info

Publication number
AU3225289A
AU3225289A AU32252/89A AU3225289A AU3225289A AU 3225289 A AU3225289 A AU 3225289A AU 32252/89 A AU32252/89 A AU 32252/89A AU 3225289 A AU3225289 A AU 3225289A AU 3225289 A AU3225289 A AU 3225289A
Authority
AU
Australia
Prior art keywords
optionally
lower alkyl
salt
denotes
obtainable according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU32252/89A
Other versions
AU623383B2 (en
Inventor
Andreas Beck
Andreas Von Sprecher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU3225289A publication Critical patent/AU3225289A/en
Application granted granted Critical
Publication of AU623383B2 publication Critical patent/AU623383B2/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request to Amend Deed and Register Assignors: CIBA-GEIGY AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Substituted alkanophenones of the general formula <IMAGE> in which R1 denotes optionally fluorinated lower alkyl, R2 represents hydrogen, optionally fluorinated lower alkyl or lower alkenyl, X denotes lower alkylene, oxy, thio or a direct bond, alk represents lower alkylene, n stands for 1 or 2, R3 denotes phenyl which is unsubstituted or substituted by optionally fluorinated lower alkyl, etherified or esterified hydroxyl, optionally lower alkylated amino and/or optionally esterified or amidated carboxyl or denotes lower alkyl which is optionally fluorinated or substituted by optionally esterified or amidated carboxyl, R4 represents optionally esterified or amidated carboxyl or 5-tetrazolyl and R5 stands for hydrogen or lower alkyl, have leukotriene-antagonist properties and can be used as antiallergic pharmaceutical active compounds. The process for their preparation is characterised in that an epoxide of the formula <IMAGE> in which R1, R2, X, alk, n and R3 have the above meanings, is reacted with a thiol of the formula <IMAGE> in which R4 and R5 have the above meanings, or a salt thereof and, if desired, a compound obtainable according to the process is converted into another compound of the formula I, a stereoisomer mixture obtainable according to the process is resolved into the components and/or a free compound obtainable according to the process is converted into a salt or a salt obtainable according to the process is converted into the free compound or into another salt.
AU32252/89A 1988-03-29 1989-03-29 Novel alkanophenones Ceased AU623383B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH118688 1988-03-29
CH1186/88 1988-03-29
CH385788 1988-10-14
CH3857/88 1988-10-14

Publications (2)

Publication Number Publication Date
AU3225289A true AU3225289A (en) 1989-10-12
AU623383B2 AU623383B2 (en) 1992-05-14

Family

ID=25686932

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32252/89A Ceased AU623383B2 (en) 1988-03-29 1989-03-29 Novel alkanophenones

Country Status (19)

Country Link
EP (1) EP0335315B1 (en)
JP (1) JP2777183B2 (en)
KR (1) KR0125933B1 (en)
AT (1) ATE107639T1 (en)
AU (1) AU623383B2 (en)
CA (1) CA1340463C (en)
CY (1) CY1967A (en)
DE (1) DE58907920D1 (en)
DK (1) DK148989A (en)
ES (1) ES2056137T3 (en)
FI (1) FI94342C (en)
HK (1) HK192696A (en)
HU (2) HU202852B (en)
IE (1) IE66248B1 (en)
IL (1) IL89713A0 (en)
NO (1) NO171555C (en)
NZ (1) NZ228477A (en)
PT (1) PT90125B (en)
YU (1) YU63089A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU634286B2 (en) * 1989-09-19 1993-02-18 Ciba-Geigy Ag Additional further novel alkanophenones

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0419410A3 (en) * 1989-09-19 1991-08-14 Ciba-Geigy Ag Alkanophenones
US6596260B1 (en) * 1993-08-27 2003-07-22 Novartis Corporation Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol
ATE258813T1 (en) 1995-04-14 2004-02-15 Smithkline Beecham Corp DEVICE FOR THE DOSED INHALATION OF BECLOMETHASONE DIPROPRIONATE
DK0820322T3 (en) 1995-04-14 2002-10-07 Smithkline Beecham Corp Dose-measuring inhaler for Fluticasone Propionate
DK0820323T3 (en) 1995-04-14 2003-11-24 Smithkline Beecham Corp Inhalator for metered doses of salmeterol
SK281746B6 (en) 1995-04-14 2001-07-10 Glaxo Wellcome Inc. MEASURING DOSING INHALATOR, FULL MEASURING MEASURING INHALATOR AND MEASURING DOSING INHALATION SYSTEM
IT1320162B1 (en) 2000-02-09 2003-11-18 Rotta Research Lab DERIVATIVES OF THYROSIN WITH ANTI LEUKOTRIENIC ACTIVITY, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE.
ATE358672T1 (en) 2000-10-23 2007-04-15 Arizona Biomedical Res Commiss ANTITUMOR COMPOUNDS BASED ON REGULATION OF PROTEIN PRENYLATION
EP2565178A1 (en) 2002-10-03 2013-03-06 Ono Pharmaceutical Co., Ltd. LPA Receptor Antagonists
JP4766384B2 (en) * 2003-12-19 2011-09-07 小野薬品工業株式会社 Compound having lysophosphatidic acid receptor antagonistic activity and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3070912D1 (en) * 1979-03-20 1985-09-05 Fisons Plc Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them
ATE25251T1 (en) * 1981-11-12 1987-02-15 Fisons Plc ANTI SRS-A CARBONIC ACID DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM.
AU548450B2 (en) * 1983-08-08 1985-12-12 G.D. Searle & Co. Substituted dihydrobenzopyrans
CA1288107C (en) * 1983-12-27 1991-08-27 Yves Girard Leukotriene antagonists
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
US4546194A (en) * 1984-05-29 1985-10-08 G. D. Searle & Co. Substituted chromanon-2-yl alkanols and derivatives thereof
US4785004A (en) * 1985-12-23 1988-11-15 Ciba-Geigy Corporation Aromatic thioethers
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
EP0419411A3 (en) * 1989-09-19 1991-09-04 Ciba-Geigy Ag Additional alkanophenones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU634286B2 (en) * 1989-09-19 1993-02-18 Ciba-Geigy Ag Additional further novel alkanophenones

Also Published As

Publication number Publication date
DE58907920D1 (en) 1994-07-28
IL89713A0 (en) 1989-09-28
KR890014511A (en) 1989-10-24
HUT49599A (en) 1989-10-30
NO891286D0 (en) 1989-03-28
KR0125933B1 (en) 1997-12-26
IE66248B1 (en) 1995-12-27
FI94342C (en) 1995-08-25
JPH01299283A (en) 1989-12-04
DK148989A (en) 1989-09-30
NO171555C (en) 1993-03-31
HU210531A9 (en) 1995-04-28
AU623383B2 (en) 1992-05-14
ATE107639T1 (en) 1994-07-15
IE890935L (en) 1989-09-29
DK148989D0 (en) 1989-03-28
HU202852B (en) 1991-04-29
ES2056137T3 (en) 1994-10-01
HK192696A (en) 1996-10-25
EP0335315B1 (en) 1994-06-22
FI891362A0 (en) 1989-03-22
FI94342B (en) 1995-05-15
NO891286L (en) 1989-10-02
JP2777183B2 (en) 1998-07-16
NZ228477A (en) 1990-11-27
NO171555B (en) 1992-12-21
PT90125A (en) 1989-11-10
PT90125B (en) 1994-10-31
CA1340463C (en) 1999-03-23
CY1967A (en) 1997-07-04
EP0335315A1 (en) 1989-10-04
YU63089A (en) 1990-12-31
FI891362A (en) 1989-09-30

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired