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AU3008595A - N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels - Google Patents

N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels

Info

Publication number
AU3008595A
AU3008595A AU30085/95A AU3008595A AU3008595A AU 3008595 A AU3008595 A AU 3008595A AU 30085/95 A AU30085/95 A AU 30085/95A AU 3008595 A AU3008595 A AU 3008595A AU 3008595 A AU3008595 A AU 3008595A
Authority
AU
Australia
Prior art keywords
ion
cyanine dyes
heteroaromatic
fluorescence labels
iminium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU30085/95A
Inventor
Linda G. Lee
Sam L Woo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biometric Imaging Inc
Original Assignee
Biometric Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/268,852 external-priority patent/US5453505A/en
Application filed by Biometric Imaging Inc filed Critical Biometric Imaging Inc
Publication of AU3008595A publication Critical patent/AU3008595A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0041—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through a nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AU30085/95A 1994-06-30 1995-06-29 N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels Abandoned AU3008595A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US268852 1988-11-09
US08/268,852 US5453505A (en) 1994-06-30 1994-06-30 N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
US38860795A 1995-02-14 1995-02-14
US388607 1995-02-14
PCT/US1995/008778 WO1996000902A1 (en) 1994-06-30 1995-06-29 N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels

Publications (1)

Publication Number Publication Date
AU3008595A true AU3008595A (en) 1996-01-25

Family

ID=26953369

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30085/95A Abandoned AU3008595A (en) 1994-06-30 1995-06-29 N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels

Country Status (4)

Country Link
EP (1) EP0769145A1 (en)
AU (1) AU3008595A (en)
CA (1) CA2194150A1 (en)
WO (1) WO1996000902A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360523A (en) * 1984-03-29 1994-11-01 Li-Cor, Inc. DNA sequencing
US6207421B1 (en) 1984-03-29 2001-03-27 Li-Cor, Inc. DNA sequencing and DNA terminators
US6086737A (en) * 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US4729947A (en) * 1984-03-29 1988-03-08 The Board Of Regents Of The University Of Nebraska DNA sequencing
US5863403A (en) * 1984-03-29 1999-01-26 The Board Of Regents Of The University Of Nebraska Digital DNA typing
US5571388A (en) * 1984-03-29 1996-11-05 Li-Cor, Inc. Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
US6004446A (en) * 1984-03-29 1999-12-21 Li-Cor, Inc. DNA Sequencing
AU4565697A (en) * 1996-10-07 1998-05-05 Amersham International Plc Analysis of carbohydrates
US6348599B1 (en) * 1997-07-28 2002-02-19 Nycomed Amersham Plc Cyanine dyes
EP1163372A4 (en) * 1999-03-24 2002-10-02 Princeton Separations Chemically reactive plane-rigidized cyanine dyes and their derivatives
AU4245500A (en) * 1999-04-15 2000-11-02 Regents Of The University Of California, The Protein transport assays
DE19937024A1 (en) 1999-08-05 2001-02-08 Bayer Ag Use of acylsulfonamido substituted polymethine dyes as fluorescent dyes and / or markers
JP2003529632A (en) * 2000-01-18 2003-10-07 マリンクロッド・インコーポレイテッド Hydrophilic cyanine dye
US7790144B2 (en) 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US6733744B1 (en) * 2000-10-16 2004-05-11 Mallinckrodt Inc. Indole compounds as minimally invasive physiological function monitoring agents
US6673334B1 (en) 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US20030105299A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
US7172907B2 (en) * 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
GB2425315B (en) * 2005-04-22 2009-10-07 Ge Healthcare Uk Ltd Water-soluble fluoro-substituted cyanine dyes as reactive fluorescence labelling reagents
WO2009121055A1 (en) 2008-03-28 2009-10-01 Georgia Tech Research Corporation Reduced dye probes for the detection of radical oxygen species
WO2011119114A1 (en) 2010-03-24 2011-09-29 National University Of Singapore Development of photostable near-ir cyanine dyes for in vivo imaging
JP7032969B2 (en) * 2018-03-28 2022-03-09 日本化薬株式会社 Cyanine compound
WO2023235452A1 (en) * 2022-06-01 2023-12-07 Georgia State University Research Foundation, Inc. Quaternary ammonium cyanine dyes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3482978A (en) * 1966-08-25 1969-12-09 Eastman Kodak Co Carbocyanine filter dyes and sensitizers for silver halide emulsions
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
DE3912046B4 (en) * 1988-09-02 2004-03-25 Carnegie Mellon University Method of labeling a component of an aqueous liquid and luminescent photostable reaction product

Also Published As

Publication number Publication date
CA2194150A1 (en) 1996-01-11
EP0769145A1 (en) 1997-04-23
WO1996000902A1 (en) 1996-01-11

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