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AU2975092A - Benzimidazole derivatives - Google Patents

Benzimidazole derivatives

Info

Publication number
AU2975092A
AU2975092A AU29750/92A AU2975092A AU2975092A AU 2975092 A AU2975092 A AU 2975092A AU 29750/92 A AU29750/92 A AU 29750/92A AU 2975092 A AU2975092 A AU 2975092A AU 2975092 A AU2975092 A AU 2975092A
Authority
AU
Australia
Prior art keywords
benzimidazole derivatives
benzimidazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU29750/92A
Other versions
AU647978B2 (en
Inventor
Masatoshi Hayashi
Yutaka Nomura
Susumu Okabe
Masaru Satoh
Tomio Yamakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59182400A external-priority patent/JPS6160660A/en
Priority claimed from JP60061194A external-priority patent/JPH068283B2/en
Priority claimed from JP60061195A external-priority patent/JPH0764826B2/en
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Publication of AU2975092A publication Critical patent/AU2975092A/en
Application granted granted Critical
Publication of AU647978B2 publication Critical patent/AU647978B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU29750/92A 1984-08-31 1992-11-27 Benzimidazole derivatives Ceased AU647978B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP59182400A JPS6160660A (en) 1984-08-31 1984-08-31 Benzimidazole derivative, its preparation, and antitumor agent containing it
JP59-182400 1984-08-31
JP60-61195 1985-03-26
JP60061194A JPH068283B2 (en) 1985-03-26 1985-03-26 Benzimidazole derivative, method for producing the same, and antiulcer agent containing the same
JP60-61194 1985-03-26
JP60061195A JPH0764826B2 (en) 1985-03-26 1985-03-26 Benzimidazole derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU41271/89A Division AU4127189A (en) 1984-08-31 1989-09-11 Benzimidazole derivatives, process for preparing the same and antiulcer agents containing the same

Publications (2)

Publication Number Publication Date
AU2975092A true AU2975092A (en) 1993-01-28
AU647978B2 AU647978B2 (en) 1994-03-31

Family

ID=27297422

Family Applications (3)

Application Number Title Priority Date Filing Date
AU46409/85A Abandoned AU4640985A (en) 1984-08-31 1985-08-19 Benzimidazole derivatives
AU41271/89A Abandoned AU4127189A (en) 1984-08-31 1989-09-11 Benzimidazole derivatives, process for preparing the same and antiulcer agents containing the same
AU29750/92A Ceased AU647978B2 (en) 1984-08-31 1992-11-27 Benzimidazole derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AU46409/85A Abandoned AU4640985A (en) 1984-08-31 1985-08-19 Benzimidazole derivatives
AU41271/89A Abandoned AU4127189A (en) 1984-08-31 1989-09-11 Benzimidazole derivatives, process for preparing the same and antiulcer agents containing the same

Country Status (14)

Country Link
KR (1) KR920004936B1 (en)
AR (1) AR242195A1 (en)
AU (3) AU4640985A (en)
BE (1) BE903128A (en)
BR (1) BR8504252A (en)
CH (1) CH665417A5 (en)
DE (1) DE3531487C2 (en)
ES (1) ES8703142A1 (en)
FR (1) FR2569691B1 (en)
GB (1) GB2163747B (en)
IT (1) IT1189601B (en)
MX (1) MX159807A (en)
NL (1) NL8502384A (en)
SE (1) SE500669C2 (en)

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AU5768886A (en) * 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
US4824856A (en) * 1985-08-14 1989-04-25 Nippon Chemiphar Co., Ltd. Method of protecting gastrointestinal tract
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AR243167A1 (en) 1985-08-24 1993-07-30 Hoechst Ag Substituted toluidines, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors
AU619444B2 (en) * 1986-06-02 1992-01-30 Nippon Chemiphar Co. Ltd. 2-(2-aminobenzylsulfinyl)- benzimidazole derivatives
EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
DE3639926A1 (en) * 1986-11-22 1988-06-01 Hoechst Ag SUBSTITUTED THIENOIMIDAZOLTOLUIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING IT AND THEIR USE AS AN INGESTIC ACID INHIBITOR
IT1222412B (en) * 1987-07-31 1990-09-05 Chiesi Farma Spa THYOMETHYL AND SULFINYL METHYL DERIVED WITH ANTI-SECRET ACID GASTRIC ACTION, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP2614756B2 (en) * 1988-08-10 1997-05-28 日本ケミファ株式会社 Imidazole derivative, method for producing the same, and anti-ulcer agent containing the same
JPH06298611A (en) * 1993-04-16 1994-10-25 Nippon Chemiphar Co Ltd Antibacterial agent
SE9301489D0 (en) 1993-04-30 1993-04-30 Ab Astra VETERINARY COMPOSITION
SE9402431D0 (en) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE9500422D0 (en) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (en) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
DK1092434T3 (en) * 1995-09-21 2004-07-26 Pharma Pass Ii Llc New composition containing lansoprazole and process for its preparation
SE9600070D0 (en) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
US6599927B2 (en) 1996-10-11 2003-07-29 Astrazeneca Ab Use of an H+, K+-ATPase inhibitor in the treatment of Widal's Syndrome
SI1003554T1 (en) 1997-07-25 2005-04-30 Altana Pharma Ag Proton pump inhibitor in therapeutic combination with antibacterial substances
SE9704869D0 (en) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
SE9704870D0 (en) 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
US7041313B1 (en) 1998-08-12 2006-05-09 Altana Pharma Ag Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles
AU1054899A (en) * 1998-11-06 2000-05-29 Dong-A Pharmaceutical Co., Ltd. Method of preparing sulfide derivatives
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
CA2376202C (en) 1999-06-07 2008-11-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel preparation and administration form comprising an acid-labile active compound
SE9903831D0 (en) 1999-10-22 1999-10-22 Astra Ab Formulation of substituted benzimidazoles
SE0000774D0 (en) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
SE0101379D0 (en) 2001-04-18 2001-04-18 Diabact Ab Composition that inhibits gastric acid secretion
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (en) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
PT1492531E (en) 2002-04-09 2008-12-10 Flamel Tech Sa Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillin
DE60325709D1 (en) 2002-04-09 2009-02-26 Flamel Tech Sa ORAL AQUEOUS SUSPENSION CONTAINING MICRO CAPSULES FOR THE CONTROLLED RELEASE OF ACTIVE SUBSTANCES
SE0203065D0 (en) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
EP2112920B1 (en) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
US8246986B2 (en) 2003-09-26 2012-08-21 Alza Corporation Drug coating providing high drug loading
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
EP2007360B1 (en) 2006-04-03 2014-11-26 Isa Odidi Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
JP5474541B2 (en) 2006-07-25 2014-04-16 ベクタ・リミテッド Compositions and methods for inhibiting gastric acid secretion using PPI in combination with small dicarboxylic acid derivatives
EP2478894A3 (en) 2006-12-22 2012-12-19 Ironwood Pharmaceuticals, Inc. Compositions for treating esophageal disorders
CN102209529A (en) 2008-09-09 2011-10-05 阿斯利康(瑞典)有限公司 Method for delivering a pharmaceutical composition to patient in need thereof
JP2012531409A (en) 2009-06-25 2012-12-10 アストラゼネカ・アクチエボラーグ Methods for treating patients at risk of developing NSAID-related ulcers
WO2011080501A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
EA028049B1 (en) 2011-12-28 2017-10-31 Поузен Инк. Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid
EA201591338A1 (en) 2013-01-15 2016-01-29 Айронвуд Фармасьютикалз, Инк. GASTRORETENTIVE MEDICAL FORM OF SECRESTRANATE OF BILIC ACIDS, SLOWLY RELEASED FOR ORAL APPLICATION
EP2801565B1 (en) 2013-05-06 2015-07-22 King Saud University Compounds for use as anti-ulcer agent and/or anti-Helicobacter pylori agent and pharmaceutical compositions thereof
US20180015118A1 (en) 2015-02-03 2018-01-18 Ironwood Pharmaceuticals, Inc. Methods of treating upper gastrointestinal disorders in ppi refractory gerd

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* Cited by examiner, † Cited by third party
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US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
EP0174717B1 (en) * 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors

Also Published As

Publication number Publication date
CH665417A5 (en) 1988-05-13
FR2569691B1 (en) 1989-08-04
ES8703142A1 (en) 1986-11-16
GB2163747A (en) 1986-03-05
DE3531487A1 (en) 1986-03-13
AU647978B2 (en) 1994-03-31
KR920004936B1 (en) 1992-06-22
IT1189601B (en) 1988-02-04
GB2163747B (en) 1989-02-08
AR242195A1 (en) 1993-03-31
SE8504048D0 (en) 1985-08-30
BE903128A (en) 1985-12-16
KR860001793A (en) 1986-03-22
MX159807A (en) 1989-08-31
GB8521493D0 (en) 1985-10-02
AU4127189A (en) 1989-12-21
BR8504252A (en) 1986-06-17
SE8504048L (en) 1986-03-01
DE3531487C2 (en) 1995-08-17
AU4640985A (en) 1986-03-06
FR2569691A1 (en) 1986-03-07
SE500669C2 (en) 1994-08-08
NL8502384A (en) 1986-03-17
ES546445A0 (en) 1986-11-16
IT8567743A0 (en) 1985-08-30

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired