AU2011501A - Benzimidazoles, production thereof and the use thereof as antithrombotic - Google Patents

Benzimidazoles, production thereof and the use thereof as antithrombotic

Info

Publication number: AU2011501A
Authority: AU; Australia
Prior art keywords: benzimidazoles; antithrombotic; production
Prior art date: 1999-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU20115/01A

Inventor

Norbert Hauel

Iris Kauffmann-Hefner

Herbert Nar

Henning Priepke

Uwe Dr Ries

Jean-Marie Stassen

Wolfgang Wienen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Boehringer Ingelheim Pharma GmbH and Co KG

Boehringer Ingelheim Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-23

Filing date

2000-12-16

Publication date

2001-07-09

2000-12-16 Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG

2001-07-09 Publication of AU2011501A publication Critical patent/AU2011501A/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AU20115/01A 1999-12-23 2000-12-16 Benzimidazoles, production thereof and the use thereof as antithrombotic Abandoned AU2011501A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19962329		1999-12-23
DE19962329A DE19962329A1 (en)	1999-12-23	1999-12-23	New substituted 2-(phenylaminomethyl)-benzimidazoles, used as thrombin inhibitors, serine protease inhibitors, antithrombotic agents and intermediates
PCT/EP2000/012841 WO2001047896A1 (en)	1999-12-23	2000-12-16	Benzimidazoles, production thereof and the use thereof as antithrombotic

Publications (1)

Publication Number	Publication Date
AU2011501A true AU2011501A (en)	2001-07-09

Family

ID=7934028

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU20115/01A Abandoned AU2011501A (en)	1999-12-23	2000-12-16	Benzimidazoles, production thereof and the use thereof as antithrombotic

Country Status (10)

Country	Link
EP (1)	EP1244636A1 (en)
JP (1)	JP2003519129A (en)
AR (1)	AR027050A1 (en)
AU (1)	AU2011501A (en)
CA (1)	CA2393916A1 (en)
DE (1)	DE19962329A1 (en)
MX (1)	MXPA02006299A (en)
PE (1)	PE20010954A1 (en)
UY (1)	UY26492A1 (en)
WO (1)	WO2001047896A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10125478A1 (en) *	2001-05-25	2002-11-28	Boehringer Ingelheim Pharma	Treatment or prophylaxis of arterial thrombosis, using 5-quinolinesulfonylamino-benzimidazole derivatives having combined thrombin inhibiting and fibrinogen receptor inhibiting action
US7169934B2 (en)	2002-06-20	2007-01-30	Boehringer Ingelheim International Gmbh	(R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
DE10227666A1 (en) *	2002-06-20	2004-01-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	(R) -2- (4-amidinophenylaminomethyl) -1-methyl-5- [1- (carboxymethylamino) -1- (pyrrolidinocarbonyl) ethyl] benzimidazole, its monohydrochloride, process for its preparation and use as a medicament
PE20040804A1 (en)	2002-12-19	2004-12-31	Boehringer Ingelheim Pharma	CARBOXAMID DERIVATIVES AS INHIBITORS OF THE Xa FACTOR
US7371743B2 (en)	2004-02-28	2008-05-13	Boehringer Ingelheim International Gmbh	Carboxylic acid amides, the preparation thereof and their use as medicaments
EP1609784A1 (en) *	2004-06-25	2005-12-28	Boehringer Ingelheim Pharma GmbH & Co.KG	Process for the preparation of 4-(benzimidazolylmethylamino)-benzamidines
DE102005061623A1 (en) *	2005-12-21	2007-06-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Improved process for the preparation of 4- (benzimidazolylmethylamino) -benzamidines and their salts
DE102005061624A1 (en) *	2005-12-21	2007-06-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Improved process for the preparation of salts of 4- (benzimidazolylmethylamino) -benzamidines
WO2014068587A2 (en) *	2012-10-29	2014-05-08	Biophore India Pharmaceuticals Pvt. Ltd.	An improved process for the synthesis of dabigatran and its intermediates
US10077251B2 (en)	2012-10-29	2018-09-18	Biophore India Pharmaceuticals Pvt. Ltd.	Process for the synthesis of Dabigatran Etexilate and its intermediates
RU2623439C1 (en) *	2016-10-14	2017-06-26	федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет"	1-substituted-3-{[2-(3,5-di-tret-4-hydroxyphenyl)-2-oxoethyl]}-2aminobenzimidazolium bromides with antiplatelet and antioxidant properties

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4129603A1 (en) *	1991-09-06	1993-03-11	Thomae Gmbh Dr K	CONDENSED 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THESE COMPOUNDS
EP1060166A1 (en) *	1998-02-03	2000-12-20	Boehringer Ingelheim Pharma KG	Five-membered, benzo-condensed heterocycles used as antithrombotic agents
TWI248435B (en) *	1998-07-04	2006-02-01	Boehringer Ingelheim Pharma	Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19829964A1 (en) *	1998-07-04	2000-01-05	Boehringer Ingelheim Pharma	New benzimidazolyl amidine or nitrile compounds, used as thrombin inhibitors, antithrombotic agents or intermediates

1999
- 1999-12-23 DE DE19962329A patent/DE19962329A1/en not_active Withdrawn
2000
- 2000-12-16 AU AU20115/01A patent/AU2011501A/en not_active Abandoned
- 2000-12-16 CA CA002393916A patent/CA2393916A1/en not_active Abandoned
- 2000-12-16 WO PCT/EP2000/012841 patent/WO2001047896A1/en not_active Application Discontinuation
- 2000-12-16 JP JP2001549368A patent/JP2003519129A/en active Pending
- 2000-12-16 EP EP00983342A patent/EP1244636A1/en not_active Withdrawn
- 2000-12-16 MX MXPA02006299A patent/MXPA02006299A/en unknown
- 2000-12-19 PE PE2000001365A patent/PE20010954A1/en not_active Application Discontinuation
- 2000-12-20 UY UY26492A patent/UY26492A1/en not_active Application Discontinuation
- 2000-12-21 AR ARP000106819A patent/AR027050A1/en not_active Suspension/Interruption

Also Published As

Publication number	Publication date
UY26492A1 (en)	2001-07-31
PE20010954A1 (en)	2001-10-09
MXPA02006299A (en)	2002-12-09
JP2003519129A (en)	2003-06-17
EP1244636A1 (en)	2002-10-02
AR027050A1 (en)	2003-03-12
WO2001047896A1 (en)	2001-07-05
DE19962329A1 (en)	2001-06-28
CA2393916A1 (en)	2001-07-05

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Legal Events

Date	Code	Title	Description
2002-01-17	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase