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AU2007312557A8 - Substituted tetrahydropyrrolopyrazine compounds having affinity with the KCNQ 2/3 K+ channel and use thereof in medicaments - Google Patents

Substituted tetrahydropyrrolopyrazine compounds having affinity with the KCNQ 2/3 K+ channel and use thereof in medicaments

Info

Publication number
AU2007312557A8
AU2007312557A8 AU2007312557A AU2007312557A AU2007312557A8 AU 2007312557 A8 AU2007312557 A8 AU 2007312557A8 AU 2007312557 A AU2007312557 A AU 2007312557A AU 2007312557 A AU2007312557 A AU 2007312557A AU 2007312557 A8 AU2007312557 A8 AU 2007312557A8
Authority
AU
Australia
Prior art keywords
kcnq
medicaments
affinity
channel
substituted tetrahydropyrrolopyrazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2007312557A
Other versions
AU2007312557B2 (en
AU2007312557A1 (en
Inventor
Gregor Bahrenberg
Thomas Christoph
Robert Frank
Sven Kuhnert
Beatrix Merla
Stefan Oberborsch
Klaus Schiene
Wolfgang Schroder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Chemie Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH, Chemie Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of AU2007312557A1 publication Critical patent/AU2007312557A1/en
Publication of AU2007312557A8 publication Critical patent/AU2007312557A8/en
Application granted granted Critical
Publication of AU2007312557B2 publication Critical patent/AU2007312557B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2007312557A 2006-10-17 2007-10-16 Substituted tetrahydropyrrolopyrazine compounds having affinity with the KCNQ 2/3 K+ channel and use thereof in medicaments Expired - Fee Related AU2007312557B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006049452.0 2006-10-17
DE102006049452A DE102006049452A1 (en) 2006-10-17 2006-10-17 Substituted tetrahydropyrolopiperazine compounds and their use in medicaments
PCT/EP2007/008957 WO2008046582A1 (en) 2006-10-17 2007-10-16 Substituted tetrahydropyrrolopyrazine compounds having affinity with the kcnq2/3 k+ channel and use thereof in medicaments

Publications (3)

Publication Number Publication Date
AU2007312557A1 AU2007312557A1 (en) 2008-04-24
AU2007312557A8 true AU2007312557A8 (en) 2009-06-25
AU2007312557B2 AU2007312557B2 (en) 2013-06-13

Family

ID=39125609

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007312557A Expired - Fee Related AU2007312557B2 (en) 2006-10-17 2007-10-16 Substituted tetrahydropyrrolopyrazine compounds having affinity with the KCNQ 2/3 K+ channel and use thereof in medicaments

Country Status (17)

Country Link
US (3) US7625900B2 (en)
EP (2) EP2144913A2 (en)
JP (1) JP5256203B2 (en)
KR (1) KR20090084873A (en)
CN (1) CN101547925A (en)
AU (1) AU2007312557B2 (en)
BR (1) BRPI0715298A2 (en)
CA (1) CA2666647A1 (en)
CO (1) CO6160331A2 (en)
DE (1) DE102006049452A1 (en)
EC (1) ECSP099320A (en)
IL (1) IL198073A (en)
MX (1) MX2009004108A (en)
NO (1) NO20091509L (en)
NZ (1) NZ576021A (en)
RU (1) RU2469037C2 (en)
WO (2) WO2008046582A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2350093T1 (en) * 2008-10-24 2012-11-30 Gruenenthal Chemie Substituted 4,5,6,7-tetrahydrothienopyridines as kcnq2/3 modulators for treating pain, epilepsy and urinary incontinence
US8367700B2 (en) 2008-12-17 2013-02-05 Gruenenthal Gmbh Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators
EP2398796A4 (en) * 2009-02-23 2012-10-10 Merck Canada Inc Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
TWI504395B (en) 2009-03-10 2015-10-21 Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier
TW201038565A (en) 2009-03-12 2010-11-01 Gruenenthal Gmbh Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators
TWI461197B (en) 2009-03-12 2014-11-21 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier
PE20140214A1 (en) 2010-08-27 2014-02-19 Gruenenthal Chemie 2-OXO- AND 2-THIOXO-DIHYDROQUINOLINE-3-CARBOXAMIDES SUBSTITUTED AS KCNQ2 / 3 MODULATORS
MX2013002121A (en) 2010-08-27 2013-04-03 Gruenenthal Gmbh Substituted quinoline-3-carboxamides as kcnq2/3 modulators.
JP5837933B2 (en) 2010-08-27 2015-12-24 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Substituted 2-oxy-quinoline-3-carboxamides as KCNQ2 / 3 modulators
MX2013000748A (en) 2010-08-27 2013-03-05 Gruenenthal Gmbh Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators.
CA2807886A1 (en) 2010-09-01 2012-03-08 Gruenenthal Gmbh Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators
US9168259B2 (en) 2010-10-20 2015-10-27 Grünenthal GmbH Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
CN103209962B (en) 2010-10-20 2016-03-02 格吕伦塔尔有限公司 As the 6-amino-nicotinamide of the replacement of KCNQ2/3 conditioning agent
MY165612A (en) 2010-11-05 2018-04-18 Senomyx Inc Compounds useful as modulators of trpm8
CN102229610B (en) * 2011-04-22 2014-10-29 中山大学 Method for synthesizing optical pure chiral 1,2,3,4-tetrahydropyrrole[1,2-a] pyrazine compound
EP2844645A1 (en) 2012-04-18 2015-03-11 Grünenthal GmbH Substituted 4-aminobenzamides as kcnq2/3 modulators
AU2013248637A1 (en) 2012-04-18 2014-12-04 Grünenthal GmbH Substituted 6-amino-nicotinamides bearing an OH-containing group as KCNQ2/3 modulators
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
WO2014082738A1 (en) 2012-11-28 2014-06-05 Grünenthal GmbH Heteroquinoline-3-carboxamides as kcnq2/3 modulators
JP2016508960A (en) 2012-11-28 2016-03-24 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Specific carboxamides as KCNQ2 / 3 modulators
US9688684B2 (en) * 2013-12-19 2017-06-27 Merck Patent Gmbh Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors
US10392371B2 (en) 2015-10-01 2019-08-27 Senomyx, Inc. Compounds useful as modulators of TRPM8
WO2018189214A1 (en) * 2017-04-12 2018-10-18 F. Hoffmann-La Roche Ag A method for labeling of aldehyde containing target molecules

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188389A (en) * 1978-11-03 1980-02-12 Ayerst Mckenna & Harrison, Inc. 1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines
TW224974B (en) 1991-07-02 1994-06-11 Hoffmann La Roche
EP0572863A1 (en) * 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag CNS pyrazinoindoles
US5378846A (en) * 1993-06-11 1995-01-03 Russian-American Institute For New Drug Development 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives
IL157313A0 (en) * 2001-02-20 2004-02-19 Bristol Myers Squibb Co Modulators of kcnq potassium channels and uses thereof
CN100391958C (en) * 2001-09-19 2008-06-04 安万特医药股份有限公司 Chemical compounds
UA77515C2 (en) * 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
SE524324C2 (en) * 2002-04-20 2004-07-27 Sqs Ab Method and apparatus at a value space
JP2006511479A (en) * 2002-09-27 2006-04-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 3,4-disubstituted pyrroles and their use in the treatment of inflammatory diseases
US7247628B2 (en) * 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
CA2535265C (en) * 2003-08-22 2014-01-28 Dendreon Corporation Compositions and methods for the treatment of disease associated with trp-p8 expression
WO2006048750A2 (en) * 2004-11-02 2006-05-11 Pfizer Inc. Novel compounds of substituted and unsubstituted adamantyl amides

Also Published As

Publication number Publication date
NO20091509L (en) 2009-05-28
US20080167315A1 (en) 2008-07-10
WO2008046581A2 (en) 2008-04-24
DE102006049452A1 (en) 2008-05-08
WO2008046582A1 (en) 2008-04-24
US7879858B2 (en) 2011-02-01
EP2112993A1 (en) 2009-11-04
CA2666647A1 (en) 2008-04-24
NZ576021A (en) 2011-03-31
WO2008046581A3 (en) 2008-06-12
ECSP099320A (en) 2009-06-30
BRPI0715298A2 (en) 2014-10-29
AU2007312557B2 (en) 2013-06-13
CN101547925A (en) 2009-09-30
JP2010506869A (en) 2010-03-04
US7625900B2 (en) 2009-12-01
RU2469037C2 (en) 2012-12-10
CO6160331A2 (en) 2010-05-20
EP2144913A2 (en) 2010-01-20
US20090258880A1 (en) 2009-10-15
AU2007312557A1 (en) 2008-04-24
IL198073A0 (en) 2009-12-24
US8017772B2 (en) 2011-09-13
KR20090084873A (en) 2009-08-05
MX2009004108A (en) 2009-04-28
RU2009118491A (en) 2010-11-27
IL198073A (en) 2013-03-24
US20100004252A1 (en) 2010-01-07
JP5256203B2 (en) 2013-08-07

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Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 23, NO 22, PAGE(S) 8534 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME GRUNENTHAL GMBH, APPLICATION 2007312557, UNDER INID (54) CORRECT THE TITLE TO READ SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE COMPOUNDS HAVING AFFINITY WITH THE KCNQ 2/3 K+ CHANNEL AND USE THEREOF IN MEDICAMENTS

MK25 Application lapsed reg. 22.2i(2) - failure to pay acceptance fee