AU2005239698B2

AU2005239698B2 - Use of macrolides in pest control

Info

Publication number: AU2005239698B2
Application number: AU2005239698A
Authority: AU
Inventors: Max Angst; Franz Brandl; Roger Graham Hall; Dieter Hofer; Bruce Lee; Marius Sutter
Original assignee: Syngenta Participations AG
Current assignee: Syngenta Participations AG
Priority date: 1997-12-23
Filing date: 2005-11-29
Publication date: 2009-01-08
Anticipated expiration: 2018-12-21
Also published as: AU2005239698A1; AU2004212571A1

Description

I 1 P/00/011 Regulation 3.2

AUSTRALIA

Patents Act 1990 COMPLETE SPECIFICATION STANDARD PATENT

(ORIGINAL)

Name of Applicant: Actual Inventors: Address for Service: Invention Title:.

Syngenta Participations AG, of Schwarzwaldallee 215, CH-4058 Basel, Switzerland Dieter HOFER Marius SUTTER Franz BRANDL Bruce LEE Roger Graham HALL Max ANGST DAVIES COLLISON CAVE, Patent Trademark Attorneys, of 1 Nicholson Street, Melbourne, 3000, Victoria, Australia Ph: 03 9254 2777 Fax: 03 9254 2770 Attorney Code: DM "Use of macrolides in pest control" The following statement is a full description of this invention, including the best method of performing it known to us:-

I

r -1-

O

N Use of macrolides in pest control SThis is a divisional of Australian Patent Application No. 2004212571, the entire contents of Swhich are incorporated herein by reference.

SThe present invention relates to a method of controlling pests with macrolide compounds; more specifically to 00 a novel method of controlling pests in and on transgenic crops of useful plants with a IN macrolide compound; N method of protecting plant propagation material and plant organs formed at a later point 0 in time from attack by pests with such a macrolide compound; and l a method of controlling wood pests and molluscs with a macrolide compound.

Certain pest control methods are proposed in the literature. However, these methods are not fully satisfactory in the field of pest control, which is why there is a demand for providing further methods for controlling and combating pests, in particular insects and representatives of the order Acarina, or for protecting plants, especially crop plants. This object is achieved according to the invention by providing the present method.

A first aspect of the present invention therefore relates to a method of controlling pests in crops of transgenic useful plants, such as, for example, in crops of maize, cereals, soya beans, tomatoes, cotton, potatoes, rice and mustard, characterized in that a pesticidal composition comprising a macrolide compound, in particular abamectin, in free form or in agrochemically useful salt form and at least one auxiliary is applied to the .pstseor their environment, in particular to the crop plant itself; to the use of the coi,Psition in question "andto propagation material of transgenic plants which has been tre~btd'with it.

Surprisingly, it has now emerged that the use of a macrolide compound for controlling pests on transgenic useful plants which contain for instance one ormore genes expressing a pesticidally, particularly insecticidally, acaricidally, nematocidally or fugicidally active ingredient, or which are tolerant against herbicides, has a synergistic effect. It is highly surprising that the use of a macrolide compound in combination with a transgenic plant exceeds the additive effect, to be expected in principle, on the pests to be controlled and thus extends the range of action of the macrolide compound and of the active principle expressed by the transgenic plant in particular in two respects: In particular, it has been found, surprisingly, that within the scope of invention the pesticidal activity of a macrolide compound in combination with the effect expressed by the -2transgenic useful plant, is not only additive in comparison with the pesticidal activities of the Smacrolide compound alone and of the transgenic crop plant alone, as can generally be C, expected, but that a synergistic effect is present. The term "synergistic", however, is in no way to be understood in this connection as being restricted to the pesticidal activity, but the term also refers to other advantageous properties of the method according to the invention compared with the macrolide compound alone and the transgenic useful plant alone.

a Examples of such advantageous properties which may be mentioned are: extension of the

C

N I pesticidal spectrum of action to other pests, for example to resistant strains; reduction in the Sapplication rate of the macrolide compound, or sufficient control of the pests with the aid of cN the compositions according to the invention even at an application rate of the macrolide compound alone and the transgenic useful plant alone are entirely ineffective; enhanced crop safety; improved quality of produce such as higher content of nutrient or oil, better fiber quality, enhanced shelf life, reduced content of toxic products such as mycotoxins, reduced content of residues or unfavorable constituents of any kind or better digestability; improved tolerance to unfavorable temperatures, draughts or salt content of water; enhanced assimilation rates such as nutrient uptake, water uptake and photosynthesis; favorable crop properties such as altered leaf aerea, reduced vegetative growth, increased yields, favorable seed shape/seed thickness or germination properties, altered colonialisation by saprophytes or epiphytes, reduction of senescense, improved phytoalexin production, improved of accelerated ripening, flower set increase, reduced boll fall and shattering, better attraction to beneficials and predators, increased pollination, reduced attraction to birds; or other advantages known to those skilled in the art.

The macrolide compounds used according to the inventions part and are known to those skilled in the art. They are the classes of substances which are disclosed as milbemycins and avermectins, for example in US-P-4 310 519, US-P-5 077 298, German Offenlegungsschrift 2 717 040 or US-P-4 427 663. These macrolides are also to be understood as meaning, in accordance with the invention, the derivatives of these substances, that is, for example, milbemycin oxime, moxidectin, ivermectin, abamectin, emamectin and doramectin, and also spinosyns of the formula -3- ORs in which R 1

R

2

R

3

R

4 R 3 and Re independently of one another are hydrogen or a sub- 0 o R0

O

In in which Ri, R2, R3, R4, Rs and R6 independently of one another are hydrogen or a sub- 0 stituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclyl group and the substructures A.and B independently of one another denote that the two carbon atoms, to which each of these substructures is bonded, are linked by a single bond, by a double bond or by a single bond and an epoxy bridge, in free form or, if appropriate, in agrochemically utilizable salt form.

Within the scope of invention abamectin is preferred. Abamectin is a mixture of avermectin Bla and avermectin Bib and is described, for example, in The Pesticide Manual, t Ed. (1994), The British Crop Protection Council, London, page 3.

Also preferred within the scope of invention is emamectin, which is 4"-Deoxy-4"-epi-N-methylamino avermectin BidB 1 known from US-P-4,874,749 and as MK-244 described in Journal of Organic Chemistry, Vol. 59 (1994), pages 7704-7708. Agrochemically especially useful salts of emamectin are described in US-P-5,288,710.

Also preferred within the scope of invention is the group of compounds consisting of the spinosyns and their derivatives; the group of compounds consisting of the naturally occurring spinosyns; or the group of compounds consisting of the derivatives of the naturally occurring spinosyns. Preferably, the active ingredient may comprise, within the scope of the subject-matter of the invention spinosyn A; spinosyn D; or a mixture composed of spinosyn A and spinosyn D; especially preferred is spinosad. spinosad is known from the "The Pesticide Manual", 11 Ed. (1997), The British Crop Protection Council, London, United Kingdom, pages 1272-1273.

The agrochemically compatible salts of the macrolide compounds are, for example, acid addition salts of inorganic and organic acids, in particular of hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, perchloric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, malonic acid, toluenesulfonic acid or benzoic acid. Preferred -4- Swithin the scope of the present invention is a composition known per se which comprises, as active ingredient, abamectin or spinosad in the free form, and emamectin as the 0" benzoate salt.

The transgenic plants used according to the invention are plants, or propagation 00 material thereof, which are transformed by means of recombinant DNA technology in such a 0 way that they are for instance capable of synthesizing selectively acting toxins as are m known, for example, from toxin-producinginvertebrates, especially of the phylum iC Arthropoda, as can be obtained from Bacillus thuringiensis strains; or as are known from 0 plants, such as lectins; or in the alternative capable of expressing a herbicidal or fungicidal resistance. Examples of such toxins, or transgenic plants which are capable of synthesizing such toxins, have been disclosed, for example, in EP-A-0 374 753, WO 93/07278, WO 95/34656, EP-A-0 427 529 and EP-A-451 878 and are incorporated by reference in the present application.

The methods for generating such transgenic plants are widely known to those skilled in the art and described, for example, in the publications mentioned above.

The toxins which can be expressed by such transgenic plants include, for example, toxins, such as proteins which have insecticidal properties and which are expressed by transgenic plants, for example Bacillus cereus proteins or Bacillus popliae proteins; or Bacillus thuringiensis endotoxins such as CrylA(a), CrylA(b), CrylA(c), CryllA, CrylllA, CrylllB2 orCytA; VIP1; VIP2; VIP3; or insecticidal proteins of bacteria colonising nematodes like Photorhabdus spp or Xenorhabdus spp such as Photorhabdus luminescens, Xenorhabdus nematophilus etc.; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin, papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize RIP, abrin, luffin, saporin or bryodin; plant lectins such as pea lectins, barley lectins or snowdrop lectins; or agglutinins; toxins produced by animals, such as scorpion toxins, spider venoms, wasp venoms and other insect-specific neurotoxins; steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid UDP-glycosyl transferase, cholesterol oxidases, ecdysone inhibitors, HMG-COAreductase, ion channel blockers such as sodium and calcium, juvenile hormone esterase, diuretic hormone receptors, stilbene synthase, bibenzyl synthase, chitinases and glucanases.

Examples of known transgenic plants which comprise one or more genes which encode insecticidal resistance and express one or more toxins are the following: KnockOut( 1 0 z 00

NO

C In (maize), YieldGard® (maize); NuCOTN 33B (cotton), Bollgard@ (cotton), NewLeaf@ (potatoes), NatureGard@ and Protecta@.

The following table comprises further examples of targets and principles and crop phenotypes of transgenic crops which show tolerance against pests mainly insects, mites, nematodes, virus, bacteria and diseases or are tolerant to specific herbicides or classes of herbicides.

Table Al: Crop: Maize Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

I

-6- Effected target or expressed principle(s) I Crop phenotype Tolerance to Cytochrome P450 eg. P450 SUl Dimboa biosynthesis (Bxl gene) CMIII (small basic maize seed peptide Corn- SAFP (zeamatin) Hml gene Chitinases Glucanases Coat proteins Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Xenobiotics and herbicides such as Sulfonylureas Helminthosporium turcicum, Rhopalosiphum maydis, Diplodia maydis, Ostrinia nubilalis, lepidoptera sp.

plant pathogenes eg. tusarium, altemaria, scierotina plant pathogenes eg. fusarium, alternaria, scierotina, rhizoctonia, chaetomium,phycomyces Cochliobulus plant pathogenes plant pathogenes viruses such as maize dwarf mosaic virus, maize chiorotic dwarf virus lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.

spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer,weevils lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.

spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer, weevils lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.

spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn -7- Effected target or expressed principle(s) Crop phenotype Tolerance to Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor (LAPI) Limonene synthase Lectines Protease Inhibitors eg. cystatin, patatin, virgiferin, OPTI ribosome inactivating protein maize 5C9 polypeptide HMG-CoA reductase borer, weevils lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, arryworrs eg.

spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer, weevils corn rootworms lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.

spodoptera frugiperda, corn rootworms, sesamia sp., black cutworm, asian corn borer, weevils weevils, corn rootworm lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.

spodoptera frugiperda, corn rootworms, -8- Effected target or expressed principle(s) Crop phenotype Tolerance to sesamia sp., black cutworm, asian corn borer, weevils Table A2: Crop Wheat Effected target or expressed principle(s) I Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glutosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas plant pathogenes eg septoria and Antifungal polypeptide AIyAFP -9- Effected target or expressed principle(s) Crop phenotype Tolerance to 1i glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Glucanases double stranded ribonuclease Coat proteins Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg. cystatin, patatin, virgiferin, CPTI ribosome inactivating protein HMG-CoA reductase fusarioum plant pathogenes eg. fusarium, septoria plant pathogenes eg. fusarium, septoria plant pathogenes eg. fusarium, septoria and other diseases plant pathogenes eg. fusarium, septoria and other diseases viral, bacterial, fungal, nematodal pathogens plant pathogenes plant pathogenes viruses such as BYDV and MSMV viruses such as BYDV and MSMV lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, eg. ostrinia nubilalis, heliothis zea, armyworms eg.

spodoptera frugiperda, corn rootworms,

I

Effected target or expressed principle(s) Crop phenotype Tolerance to sesamia sp., black cutworm, asian corn borer, weevils Table A3: Crop Barley Effected target or expressed principle(s) I Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas plant pathogenes eg septoria and Antifungal polypeptide AIyAFP -11- Effected target or expressed principle(s) Crop phenotype Tolerance to glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Glucanases double stranded ribonuclease Coat proteins Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg. cystatin, patatin, virgiferin, CPTI ribosome inactivating protein HMG-CoA reductase fusarioum plant pathogenes eg. fusarium, septoria plant pathogenes eg. fusarium, septoria plant pathogenes eg. fusarium, septoria and other diseases plant pathogenes eg. fusarium, septoria and other diseases viral, bacterial, fungal, nematodal pathogens plant pathogenes plant pathogenes viruses such as BYDV and MSMV viruses such as BYDV and MSMV lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids lepidoptera, coleoptera, diptera, nematodes, aphids Table A4: Crop Rice *12- Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl Antifungal polypeptide AIyAFP glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Phenylalanine ammonia lyase (PAL) Sulfonylureas, Imidazolinones, Thazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas plant pathogenes plant pathogenes plant pathogenes plant pathogenes plant pathogenes eg bacterial leaf blight and rice blast, inducible -13- Effected target or expressed principle(s) Crop phenotype Tolerance to phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Glucanases double stranded ribonuclease Coat proteins Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines plant pathogenes eg and rice blast plant pathogenes eg and rice blast plant pathogenes eg and rice blast plant pathogenes bacterial leaf blight bacterial leaf blight bacterial leaf blight viral, bacterial, fungal, nematodal pathogens plant pathogenes eg bacterial leaf blight and rice blast plant pathogenes viruses such as BYDV and MSMV viruses such as BYDV and MSMV lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg Protease Inhibitors, -14- Effected target or expressed principle(s) Crop phenotype I Tolerance to ribosome inactivating protein HMG-CoA reductase rice water weevil, diptera, ricb hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper lepidoptera eg. stemborer, coleoptera eg rice water weevil, diptera, rice hoppers eg brown rice hopper Table A5: Crop Soya Effected target or expressed principle(s) Crop phenotype Tolerance to

P

Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Effected target or expressed principle(s) Crop phenotype Tolerance to Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Phenylalanine ammonia lyase (PAL) phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Glucanases Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot plant pathogenes eg bacterial leaf blight and rice blast plant pathogenes eg bacterial leaf blight and rice blast bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot plant pathogenes viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot bacterial and fungal pathogens such as fusarium, sclerotinia, stemrot -16- Effected target or expressed principle(s) Crop phenotype Tolerance to i double stranded ribonuclease Coat proteins Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg virgiferin ribosome inactivating protein HMG-CoA reductase Barnase Cyst nematode hatching stimulus Antifeeding principles viruses such as BPMV and SbMV viruses such as BYDV and MSMV lepidoptera, coleoptera, aphids lepidoptera, coleoptera, aphids lepidoptera, coleoptera, aphids lepidoptera, coleoptera, aphids lepidoptera, coleoptera, aphids lepidoptera, coleoptera, aphids lepidoptera, coleoptera, aphids lepidoptera, coleoptera, aphids nematodes eg root knot nematodes and cyst nematodes cyst nematodes nematodes eg root knot nematodes and cyst nematodes Table A6: Crop Potatoes Effected target or expressed principle(s) Crop phenotype Tolerance to i Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or -17- Effected target or expressed principle(s) Crop phenotype Tolerance to

I

(HPPD)

Phosphinothricin acetyl transf erase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshiki mate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AIyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes Isoxachiortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyraZoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas blackspot bruise bacterial and fungal pathogens such as phytophtora Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as phytophtora bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia -18- Effected target or expressed principle(s) Crop phenotype Tolerance to serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Barnase Disease resistance response gene 49 trans aldolase antisense Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacteria such as corynebacterium sepedonicum, Erwinia carotovora bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia blackspots bacterial and fungal pathogens such as Phytophtora, Verticillium, Rhizoctonia viruses such as PLRV, PVY and TRV viruses such as PLRV, PVY and TRV viruses such as PLRV, PVY and TRV viruses such as PLRV, PVY and TRV

I

-19- Effected target or expressed principle(s) Crop phenotype Tolerance to Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor stilbene synthase Lectines Protease Inhibitors eg cystatin, patatin ribosome inactivating protein HMG-CoA reductase Cyst nematode hatching stimulus Barnase Antifeeding principles viruses such as PLRV, PVY and TRV viruses such as PLRV, PVY and TRV coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids coleoptera eg colorado potato beetle, aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes nematodes eg root knot nematodes and cyst nematodes Table A7: Crop Tomatoes Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) SSulfonylureas, Imiclazlinones,

I

Effected target or expressed principle(s) I Crop phenotype Tolerance to AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AIyAFP Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachiortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas blackspot bruise bacterial and fungal pathogens such as phytophtora Phytophtora, Verticillium, Rhizoctonia bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould -21 Effected target or expressed principle(s) Crop phenotype Tolerance to oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin etc.

bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.

leaf mould alternaria solani bacteria bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould -22- Effected target or expressed principle(s) Crop phenotype Tolerance to Polygalacturonase inhibitors Prf regulatory gene 12 Fusarium resistance locus phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases etc.

fusarium bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.

viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.

-23- Effected target or expressed principle(s) Crop phenotype Tolerance to Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin ribosome inactivating protein bacterial and fungal pathogens such as bacterial speck, fusarium, soft rot, powdery mildew, crown rot, leaf mould etc.

viruses such as PLRV, PVY and ToMoV viruses such as PLRV, PVY and ToMoV viruses such as PLRV, PVY and ToMoV viruses such as PLRV, PVY and ToMoV

TRV

viruses such as PLRV, PVY and ToMoV viruses such as PLRV, PVY and ToMoV lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies aphids lepidoptera eg heliothis, whiteflies stilbene synthase -24- Effected target or expressed principle(s) Crop phenotype Tolerance to HMG-CoA reductase Cyst nematode hatching stimulus Barnase Antifeeding principles aphids lepidoptera eg heliothis, whiteflies aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes nematodes eg root knot nematodes and cyst nematodes Table A8: Crop Peppers Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Effected target or expressed principle(s) Crop phenotype Tolerance to Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene 12 Fusarium resistance locus phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens rot, leaf mould etc.

bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens fusarium bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens viral, bacterial, fungal, nematodal pathogens genes -26- Effected target or expressed principle(s) Crop phenotype /Tolerance to i Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase Antifeeding principles bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens viruses such as CMV, TEV viruses such as CMV, TEV viruses such as CMV, TEV viruses such as CMV, TEV viruses such as CMV, TEV viruses such as CMV, TEV lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids lepidoptera, whiteflies aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes nematodes eg root knot nematodes and cyst nematodes Table A9: Crop Grapes Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) SSulfonylureas, Imidazolinones, -27- Effected target or expressed principle(s) I Crop phenotype Tolerance to AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AIyAFP Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew -28- Effected target or expressed principle(s) oxalate oxidase glucose oxidase 00 \0 pyrrolnitrin synthesis genes tI serine/threonine kinases

O

Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Crop phenotype Tolerance to bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Hypersensitive response eliciting

I

-29- Effected target or expressed principle(s) Crop phenotype Tolerance to polypeptide Systemic acquires resistance (SAR) genes Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase Botrytis and powdery mildew viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew bacterial and fungal pathogens like Botrytis and powdery mildew viruses viruses viruses viruses viruses viruses lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids, diseases lepidoptera, aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes or general diseases root knot nematodes

CBI

Effected target or expressed principle(s) I Crop phenotype Tolerance to Antifeeding principles nematodes eg root knot nematodes or root cyst nematodes Table Al0: crop Oil Seed rape Effected target or expressed principle(s) Crop phenotype Tolerance to i Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshiki mate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU or selection Polyphenol oxidase or Polyphenol Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyoxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens like -31- Effected target or expressed principle(s) Crop phenotype Tolerance to oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Scierotinia bacterial and fungal pathogens like phytoalexins -32- Effected target or expressed principle(s) Crop phenotype Tolerance to SB-1,3-glucanase antisense 00 receptor kinase M Hypersensitive response eliciting in polypeptide

O

0 Systemic acquires resistance (SAR) genes Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia, nematodes bacterial and fungal pathogens like Cylindrosporium, Phoma, Sclerotinia viruses viruses viruses viruses viruses viruses lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, lepidoptera, aphids aphids 1 -33- Effected target or expressed principle(s) Crop phenotype Tolerance to

CPTI

ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase

CBI

Antifeeding principles induced at a nematode feeding site lepidoptera, aphids lepidoptera, aphids, diseases lepidoptera, aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table Al11: Crop Brassica vegetable (cabbage, brussel sprouts, broccoli etc.) Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate -34- Effected target or expressed principle(s) Crop phenotype Tolerance to Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Chitinases Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens bacterial and fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens Effected target or expressed principle(s) Crop phenotype Tolerance to i Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin,

CPTI

CBI

Antifeeding principles induced at a nematode feeding site bacterial and fungal pathogens bacterial and fungal pathogens viruses viruses viruses viruses viruses viruses lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids lepidoptera, aphids, diseases lepidoptera, aphids cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes

I

-36- Table A12 Crop Pome fruits eg apples, pears Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase 0-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachiortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like Ribonuclease -37- Effected target or expressed principle(s) Crop phenotype Tolerance to Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Pr regulatory gene phytoalexins B-1,3-glucanase antisense apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like receptor kinase -38- Effected target or expressed principle(s) Crop phenotype Tolerance to Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight viral, bacterial, fungal, nematodal pathogens bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight bacterial and fungal pathogens like apple scab or fireblight viruses viruses viruses viruses viruses viruses lepidoptera, aphids, mites lepidoptera, aphids, mites lepidoptera, aphids, mites lepidoptera, aphids, mites lepidoptera, aphids, mites lepidoptera, aphids, mites -39- Effected target or expressed principle(s) Crop phenotype Tolerance to

CPTI

CBI

Antifeeding principles induced at a nematode feeding site lepidoptera, aphids, mites lepidoptera, aphids, diseases, mites lepidoptera, aphids, mites cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A13: Crop Melons Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Effected target or expressed principle(s) Crop phenotype Tolerance to Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora -41 Effected target or expressed principle(s) Crop phenotype Tolerance to Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora bacterial or fungal pathogens like phytophtora viruses as CMV,, PRSV, WMV2, SMV,

ZYMV

viruses as CMV,, PRSV, WMV2, SMV, Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins -42- Effected target or expressed principle(s) Crop phenotype Tolerance to

ZYMV

17kDa or 60 kDa protein viruses as CMV,, PRSV, WMV2, SMV,

ZYMV

Nuclear inclusion proteins eg. a or b or viruses as CMV,, PRSV, WMV2, SMV, Nucleoprotein

ZYMV

Pseudoubiquitin viruses as CMV,, PRSV, WMV2, SMV,

ZYMV

Replicase viruses as CMV,, PRSV, WMV2, SMV,

ZYMV

Racillis thuringiensis toxins, VIP 3, lepidoptera, aphids, mites Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase

CBI

Antifeeding principles induced at a nematode feeding site lepidoptera, aphids, lepidoptera, aphids, lepidoptera, aphids, lepidoptera, aphids, lepidoptera, aphids, mites, whitefly mites, whitefly mites, whitefly mites, whitefly mites, whitefly lepidoptera, aphids, mites, whitefly lepidoptera, aphids, mites, whitefly lepidoptera, aphids, mites, whitefly cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A14: Crop Banana Effected target or expressed principle(s) Crop phenotype Tolerance to .43 Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxypheflylpyruvate dioxygenase (HP PD) Phosphinothricin acetyl transf erase 0-Methyl transf erase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyriflogen oxidase (PROTOX) Cytochrome P450 eg. P450 SUl or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase Sulfonylureas, Imidazolinones, THazolopyrimidlires, Pyrimidyloxyberizoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glut osinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo.4-hydroxy-benzornitriles such as Bromoxynil and loxinyl Glyphosate or sult osate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or tungal pathogens bacterial or fungal pathogens bacterial or fungal pAthogens bacterial or fungal pathogens -44- Effected target or expressed principle(s) Crop phenotype Tolerance to pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as Banana bunchy top virus

(BBTV)

viruses as Banana bunchy top virus

(BBTV)

viruses as Banana bunchy top virus

(BBTV)

viruses as Banana bunchy top virus

(BBTV)

viruses as Banana bunchy top virus

(BBTV)

Effected target or expressed principle(s) Crop phenotype Tolerance to Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase

CBI

Antifeeding principles induced at a nematode feeding site viruses as Banana bunchy top virus

(BBTV)

lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes lepidoptera, aphids, mites, nematodes cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A15: Crop Cotton Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as 46- Effected target or expressed principle(s) Crop phenotype Tolerance to Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens -47- Effected target or expressed principle(s) Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus an Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Crop phenotype Tolerance to bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as wound tumor virus (WTV) viruses as wound tumor virus (WTV) viruses as wound tumor virus (WTV) viruses as wound tumor virus (WTV) viruses as wound tumor virus (WTV) viruses as wound tumor virus (WTV) lepidoptera, aphids, mites, nematodes, d whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, -48- Effected target or expressed principle(s) Crop phenotype Tolerance to Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase

CBI

Antifeeding principles induced at a nematode feeding site whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly lepidoptera, aphids, mites, nematodes, whitefly cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A16: Crop Sugarcane Effected target or expressed principle(s) Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Crop phenotype Tolerance to Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis -49- Effected target or expressed principle(s) Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Crop phenotype Tolerance to Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens Effected target or expressed principle(s) Crop phenotype Tolerance to Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin bacterial or fungal pathogens viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens bacterial or fungal pathogens eg clavibacter bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as SCMV, SrMV viruses as SCMV, SrMV viruses as SCMV, SrMV viruses as SCMV, SrMV viruses as SCMV, SrMV viruses as SCMV, SrMV lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer -51- Effected target or expressed principle(s) I Crop phenotype Tolerance to ribosome inactivating protein stilbene synthase HMG-CoA reductase Cyst nematode hatching stimulus Barnase

CBI

Antifeeding principles induced at a nematode feeding site lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer lepidoptera, aphids, mites, nematodes, whitefly, beetles eg mexican rice borer cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Table A1 7: Crop Sunflower Effected target or expressed principle(s) Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphihothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such Nitrilase -52- Effected target or expressed principle(s) 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense receptor kinase Hypersensitive response eliciting polypeptide Crop phenotype Tolerance to as Bromoxynil and loxinyl Glyphosate or sulfosate Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens eg sclerotinia bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens -53- Effected target or expressed principle(s) Crop phenotype Tolerance to Systemic acquires resistance (SAR) genes Lytic protein Lysozym Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein viral, bacterial, fungal, nematodal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as CMV, TMV viruses as CMV, TMV viruses as CMV, TMV viruses as CMV, TMV viruses as CMV, TMV viruses as CMV, TMV lepidoptera, aphids, mites, nematodes, whitefly, beetles lepidoptera, aphids, mites, nematodes, whitefly, beetles lepidoptera, aphids, mites, nematodes, whitefly, beetles lepidoptera, aphids, mites, nematodes, whitefly, beetles lepidoptera, aphids, mites, nematodes, whitefly, beetles lepidoptera, aphids, mites, nematodes, whitefly, beetles lepidoptera, aphids, mites, nematodes, whitefly, beetles lepidoptera, aphids, mites, nematodes, stilbene synthase -54- Effected target or expressed principle(s) Crop phenotype Tolerance to i.

HMG-CoA reductase Cyst nematode hatching stimulus Barnase

CBI

Antifeeding principles induced at a nematode feeding site Table A18: Crop Sugarbeet, Beet root Effected target or expressed principle(s) whitefly, beetles lepidoptera, aphids, mites, nematodes, whitefly, beetles cyst nematodes nematodes eg root knot nematodes and cyst nematodes root knot nematodes nematodes eg root knot nematodes, root cyst nematodes Crop phenotype Tolerance to Acetolactate synthase (ALS) AcetylCoA Carboxylase (ACCase) Hydroxyphenylpyruvate dioxygenase

(HPPD)

Phosphinothricin acetyl transferase O-Methyl transferase Glutamine synthetase Adenylosuccinate Lyase (ADSL) Adenylosuccinate Synthase Anthranilate Synthase Nitrilase 5-Enolpyruvyl-3phosphoshikimate Synthase (EPSPS) Sulfonylureas, Imidazolinones, Triazolopyrimidines, Pyrimidyloxybenzoates, Phtalides Aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones Isoxazoles such as Isoxaflutol or Isoxachlortol, Triones such as mesotrione or sulcotrione Phosphinothricin altered lignin levels Glufosinate, Bialaphos Inhibitors of IMP and AMP synthesis Inhibitors of adenylosuccinate synthesis Inhibitors of tryptophan synthesis and catabolism 3,5-dihalo-4-hydroxy-benzonitriles such as Bromoxynil and loxinyl Glyphosate or sulfosate

I

Effected target or expressed principle(s) Crop phenotype Tolerance to Glyphosate oxidoreductase Protoporphyrinogen oxidase (PROTOX) Cytochrome P450 eg. P450 SU1 or selection Polyphenol oxidase or Polyphenol oxidase antisense Metallothionein Ribonuclease Antifungal polypeptide AlyAFP oxalate oxidase glucose oxidase pyrrolnitrin synthesis genes serine/threonine kinases Cecropin B Phenylalanine ammonia lyase (PAL) Cf genes eg. Cf 9 Cf5 Cf4 Cf2 Osmotin Alpha Hordothionin Systemin Polygalacturonase inhibitors Prf regulatory gene phytoalexins B-1,3-glucanase antisense AX WIN proteins receptor kinase Hypersensitive response eliciting polypeptide Systemic acquires resistance (SAR) Glyphosate or sulfosate Diphenylethers, cyclic imides, phenylpyrazoles, pyridin derivatives, phenopylate, oxadiazoles etc.

Xenobiotics and herbicides such as Sulfonylureas bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens eg sclerotinia bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens like Cercospora beticola bacterial or fungal pathogens bacterial or fungal pathogens viral, bacterial, fungal, nematodal -56- Effected target or expressed principle(s) Crop phenotype Tolerance to genes Lytic protein Lysozym Chitinases Barnase Glucanases double stranded ribonuclease Coat proteins 17kDa or 60 kDa protein Nuclear inclusion proteins eg. a or b or Nucleoprotein Pseudoubiquitin Replicase Bacillus thuringiensis toxins, VIP 3, Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3- Hydroxysteroid oxidase Peroxidase Aminopeptidase inhibitors eg. Leucine aminopeptidase inhibitor Lectines Protease Inhibitors eg cystatin, patatin, CPTI, virgiferin ribosome inactivating protein stilbene synthase HMG-CoA reductase pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens bacterial or fungal pathogens viruses as BNYV viruses as BNYVV viruses as BNYVV viruses as BNYVV viruses as BNYVV viruses as BNYVV lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies lepidoptera, aphids, mites, nematodes, whitefly, beetles, rootflies -57- >-Effected target or expressed principle(s) Crop phenotype Tolerance to 0 Z Cyst nematode hatching stimulus cyst nematodes Barnase nematodes eg root knot nematodes and cyst nematodes 00 Beet cyst nematode resistance locus cyst nematodes ,0 CBI root knot nematodes M Antifeeding principles induced at a nematodes eg root knot nematodes, root In nematode feeding site cyst nematodes The abovementiofed animal pests which can be controlled by the method according to the invention include, for example, insects, representatives of the order acarina and representatives of the class nematoda; especially from the order Lepidoptera Acleris spp., Adoxophyes spp., especially Adoxophyes reticulana; Aegeria spp., Agrotis spp., especially Agrotis spinifera; Alabama argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp., Argyrotaenia spp., Autographa spp., Busseola fusca, Gadra cautella, Carposina nipponensis, Chilo spp., Choristoneura spp., Clysia ambiguella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp., Coleophora spp., Crocidolomia binotalis, Cryptophlebia leucotreta, Cydia spp., especially Cydia pomonella; Diatraea spp., Diparopsis castanea, Earias spp., Ephestia spp., especially E. Khoniella; Eucosma spp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Grapholita spp., Hedya nubiferana, Heliothis spp., especially H. virescens and H. zea; Hellula undalis, Hyphantria cunea, Keiferia lycopersicella, Leucoptera scitella, Lithocollethis spp., Lobesiaspp., Lymantria spp., Lyonetia spp., Malacosoma spp., Mamestra brassicae, Manduca sexta, Operophtera spp., Ostrinia nubilalis, Pammene spp., Pandemis spp., Panolis flammea, Pectinophora spp., Phthorimaea operculella, Pieris rapae, Pieris spp., Plutella xylostella, Prays spp., Scirpophaga spp., Sesamia spp., Sparganothis spp., Spodopteralittoralis, Synanthedon spp., Thaumetopoea spp., Tortrix spp., Trichoplusia ni and Yponomeuta spp.; from the order Coleoptera, for example Agriotes spp., Anthonomus spp., Atomaria linearis, Chaetocnema tibialis, Cosmopolites spp., Curculio spp., Dermestes spp., Diabrotica spp., Epilachna spp., Eremnus spp., Leptinotarsa decemlineata, Lissorhoptrus spp., Melolontha spp., Oryzaephilus spp., Otiorhynchus spp., Phlyctinus spp., Popillia spp., Psylliodes spp., Rhizopertha spp., Scarabeidae, Sitophilus spp., Sitotroga spp., Tenebrio spp., Tribolium spp. and Trogoderma spp.; 58- >-from the order Orthoptera, for example Blatta spp., Blattella spp., Gryllotalpa spp., 0 ZLeucophaea maderae, Locusta spp., Periplaneta spp. and Schistocerca spp.; C rmteodrIopea o xml Rtcltre\p.

N from the order soptera, for example eipcelims spp.; 00 a'from the order Anoplura, for example Haematopinus spp., Linognathus spp., Pediculus Sspp., Pemiphigus spp. and Phylloxera spp.; V)l from the order Mallophaga, for example Damalinea spp. and Trichodectes spp.; N from the order Thysanoptera, for example Frankliniella spp., Hercinothrips spp., Taeniothrips spp., Thrips palmi, Thrips tabaci and Scirtothrips aurantil; from the order Heteroptera, for example Cimex spp., Distantiella theobroma, Dysdercus spp., Euchistus spp. Eurygaster spp. Leptocorisa spp., Nezara spp., Piesma spp., Rhodnius spp., Sahibergella singularis, Scotinophara spp. and Triatoma spp.; from the order Homoptera, for example Aleurothrixus floccosus, Aleyrodes brassicae, Aonidiella auranti, Aphididae, Aphiscraccivora, A. fabae, A. gosypil; Aspidiotus spp., Bemisia tabaci, Ceroplaster spp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Coccus hesperidum, Empoasca spp., Eriosoma lanigerum, Erythroneura spp., Gascardia spp., Laodelphax spp., Lecanium corni, Lepidosaphes spp., Macrosiphus spp., Myzus spp., especially M.persicae; Nephotettix spp., especially N. cincticeps; Nilaparvata spp., especially N. lugens; Paratoria spp., Pemphigus spp., Planococcus spp., Pseudaulacaspis spp., Pseudococcus spp., especially P. Fragilis, P. citriculus and P. comstocki; Psylla spp., especially P. pyri; Pulvinaria aethiopica, Quadraspidiotus spp., Rh opalosiphum spp., Saissetia spp., Scaphoideus spp., Schizaphis spp., Sitobion spp., Trialeurodes vaporariorum, Trioza erytreae and Unaspis citri; from the order Hymenoptera, for example Acromyrmex, Atta spp., Cephus spp., Diprion spp., Diprionidae, Gilpinia polytoma, Hoplocampa spp., Lasius spp., Monomorium pharaonis, Neodiprion spp., Solenopsis spp. and Vespa spp.; from the order Diptera, for example Aedes spp., Antherigona soccata, Bibio hortulanus, Calliphora erythrocephala, Ceratitis spp., Chrysomyia spp., Culex spp., Cuterebra spp., Dacus spp., Drosophila melanogaster, Fannia spp., Gastrophilus spp., Glossina spp., Hypoderma spp., Hyppobosca spp., Liriomyza spp., Lucilia spp., Melanagromyza spp., Musca spp., Oestrus spp., Orseolia spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., -59- Rhagoletis pomonella, Sciara spp., Stomoxys spp., Tabanus spp., Tannia spp. and Tipula 0 Sspp.; Sfrom the order Siphonaptera, for example Ceratophyllus spp. and Xenopsylla cheopis; from the order Thysanura, for example Lepisma saccharina and 00 from the order Acarina, for example Acarus siro, Aceria sheldoni; Aculus spp., especially A.

a schlechtendali; Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., especially B. californicus and B. phoenicis; Bryobia praetiosa, Calipitrimerus spp., Chorioptes spp., SDermanyssus gallinae, Eotetranychus spp., especially E.carpini and E. orientalis; Eriophyes S spp., especially E. vitis; Hyalomma spp., Ixodes spp., Olygonychus pratensis, Ornithodoros spp., Panonychus spp., especially P. ulmi and P. citri; Phyllocoptruta spp., especially P.

oleivora; Polyphagotarsonemus spp., especially P. latus; Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Tarsonemus spp. and Tetranychus spp., in particular T. urticae, T. cinnabarinus and T. Kanzawai; representatives of the class Nematoda; nematodes selected from the group consisting of root knot nematodes, cyst-forming nematodes, stem eelworms and foliar nematodes; nematodes selected from the group consisting of Anguina spp.; Aphelenchoides spp.; Ditylenchus spp.; Globodera spp., for example Globodera rostochiensis; Heterodera spp., for example Heterodera avenae, Heterodera glycines, Heterodera schachtii or Heterodera trifolii; Longidorus spp.; Meloidogyne spp., for example Meloidogyne incognita or Meloidogyne javanica; Pratylenchus, for example Pratylenchus neglectans or Pratylenchus penetrans; Radopholus spp., for example Radopholus similis; Trichodorus spp.; Tylenchulus, for example Tylenchulus semipenetrans; and Xiphinema spp.; or nematodes selected from the group consisting of Heterodera spp., for example Heterodera glycines; and Meloidogyne spp., for example Meloidogyne incognita.

The method according to the invention allows pests of the abovementioned type to be controlled, i.e. contained or destroyed, which occur, in particular, on transgenic plants, mainly useful plants and ornamentals in agriculture, in horticulture and in forests, or on parts, such as fruits, flowers, foliage, stalks, tubers or roots, of such plants, the protection against these pests in some cases even extending to plant parts which form at a later point in time.

SThe method according to the invention can be employed advantageously for controlling pests in rice, cereals such as maize or sorghum; in fruit, for example stone fruit, pome fruit and soft fruit such as apples, pears, plums, peaches, almonds, cherries or berries, for example strawberries, raspberries and blackberries; in legumes such as beans, lentils, peas 0 or soya beans; in oil crops such as oilseed rape, mustard, poppies, olives, sunflowers, Scoconuts, castor-oil plants, cacao or peanuts; in the marrow family such as pumpkins, Scucumbers or melons; in fibreplants such as cotton, flax, hemp or jute; in citrus fruit such as oranges, lemons, grapefruit or tangerines; in vegetables such as spinach, lettuce, asparagus, cabbage species, carrots, onions, tomatoes, potatoes, beet or capsicum; in the laurel family such as avocado, Cinnamonium or camphor; or in tobacco, nuts, coffee, egg plants, sugar cane, tea, pepper, grapevines, hops, the banana family, latex plants or ornamentals, mainly in maize, rice, cereals, soya beans, tomatoes, cotton, potatoes, sugar beet, rice and mustard; in particular in cotton, rice, soya beans, potatoes and maize.

It has emerged that the method according to the invention is valuable preventatively and/or curatively in the field of pest control even at low use concentrations of the pesticidal composition and that a very favourable biocidal spectrum is achieved thereby. Combined with a favourable compatibility of the composition employed with warm-blooded species, fish and plants, the method according to the invention can be employed against all or individual developmental stages of normally-sensitive, but also of normally-resistant, animal pests such as insects and representatives of the order Acarina, depending on the species of the transgenic crop plant to be protected from attack by pests. The insecticidal arind/or acaricidal effect of the method according to the invention may become apparent directly, i.e.

in a destruction of the pests which occurs immediately or only after some time has elapsed, for example, during ecdysis, or indirectly, for example as a reduced oviposition and/or hatching rate, the good action corresponding to a destruction rate (mortality) of at least to Depending on the intended aims and the prevailing circumstances, the pesticides within the scope of invention which are known per se, are emulsifiable concentrates, suspension concentrates, directly sprayable or dilutable solutions, spreadable pastes, dilute emulsions, wettable powders, soluble powders, dispersible powders, wettable powders, dusts, granules or encapsulations in polymeric substances which comprise a macrolide compound.

I

-61 SThe active ingredients are employed in these compositions together with at least one of the

O

Sauxiliaries conventionally used in art of formulation, such as extenders, for example solvents or solid carriers, or such as surface-active compounds (surfactants).

Formulation auxiliaries which are used are, for example, solid carriers, solvents, stabilizers, "slow release" auxiliaries, colourants and, if appropriate, surface-active substances 0 (surfactants). Suitable carriers and auxiliaries are all those substances which are cont ventionally used for crop protection products. Suitable auxiliaries such as solvents, solid n carriers, surface-active compounds, non-ionic surfactants, cationic surfactants, anionic surfactants and other auxiliaries in the compositions employed according to the invention are, for example, those which have been described in EP-A-736 252.

These compositions for controlling pests can be formulated, for example, as wettable powders, dusts, granules, solutions, emulsifiable concentrates, emulsions, suspension concentrates or aerosols. For example, the compositions are of the type described in EP- A-736 252.

The action of the compositions within the scope of invention which comprise a macrolide compound can be extended substantially and adapted to prevailing circumstances by adding other insecticidally, acaricidally and/or fungicidally active ingredients. Suitable examples of added active ingredients are representatives of the following classes of active ingredients: organophosphorous compounds, nitrophenols and derivatives, formamidines, ureas, carbamates, pyrethroids, chlorinated hydrocarbons; especially preferred components in mixtures are, for example, thiamethoxam, pymetrozine, fenoxycarb, imidacloprid, Ti-435, fipronil, pyriproxyfen, emamectin, diazinon or diafenthiuron.

As a rule, the compositions within the scope of invention comprise 0.1 to 99%, in particular 0.1 to 95 of a macrolide compound and 1 to 99.9 in particular 5 to 99.9 of at least one solid or liquid auxiliary, it being possible, as a rule, for 0 to 25 in particular 0.1 to 20 of the compositions to be surfactants in each case meaning per cent by weight). While concentrated compositions are more preferred as commercial products, the end user will, as a rule, use dilute compositions which have considerably lower concentrations of active ingredient.

The compositions according to the invention may also comprise other solid or liquid auxiliaries, such as stabilisers, for example epoxidized or unepoxidized vegetable oils (for example epoxidized coconut oil, rapeseed oil or soya bean oil), antifoams, for example

I

62silicone oil, preservatives, viscosity regulators, binders and/or tackifiers, and also fertilizers 0 Z or other active ingredients for achieving specific effects, for example, bactericides, fungicides, nematicides, molluscicides or herbicides.

The compositions according to the invention are produced in a known manner, for 00 C example prior to mixing with the auxiliary/auxiliaries by grinding, screening and/or compressing the active ingredient, for example to give a particular particle size, and by t' intimately mixing and/or grinding the active ingredient with the auxiliary/auxiliaries.

SThe method according to the invention for controlling pests of the abovementioned type is N carried out in a manner known per se to those skilled in the art, depending on the intended aims and prevailing circumstances, that is to say by spraying, wetting, atomizing, dusting, brushing on, seed dressing, scattering or pouring of the composition. Typical use concentrations are between 0.1 and 1000 ppm, preferably between 0.1 and 500 ppm of active ingredient. The application rate may vary within wide ranges and depends on the soil constitution, the type of application (foliar application; seed dressing; application in the seed furrow), the transgenic crop plant, the pest to be controlled, the climatic circumstances prevailing in each case, and other factors determined by the type of application, timing of application and target crop. The application rates per hectare are generally 1 to 2000 g of macrolide compound per hectare, in particular 10 to 1000 g/ha, preferably 10 to 500 g/ha, especially preferably 10 to 200 g/ha.

A preferred type of application in the field of crop protection within the scope of invention is application to the foliage of the plants (foliar application), it being possible to adapt frequency and rate of application to the risk of infestation with the pest in question.

However, the active ingredient may also enter into the plants via the root system (systemic action), by drenching the site of the plants with a liquid composition or by incorporating the active ingredient in solid form into the site of the plants, for example into the soil, for example in the form of granules (soil application). In the case of paddy rice crops, such granules may be metered into the flooded paddy field.

The compositions according to invention are also suitable for protecting propagation material of transgenic plants, for example seed, such as fruits, tubers or kemels, or plant cuttings, from animal pests, in particular insects and representatives of the order Acarina.

The propagation material can be treated with the composition prior to application, for example, seed being dressed prior to sowing. The active ingredient may also be applied to -63seed kernels (coating), either by soaking the kernels in a liquid composition or by coating Sthem with a solid composition. The composition may also be applied to the site of Sapplication when applying the propagation material, for example into the seed furrow during Ssowing. These treatment methods for plant propagation material and the plant propagation material treated thus are a further subject of the invention.

CO Examples of formulations of macrolide compounds which can be used in the method M according to the invention for instance solutions, granules, dusts, sprayable powders, Semulsion concentrates, coated granules and suspension concentrates, are of the type as 0 has been described in, for example, EP-A-580 553, Examples F1 to Table B The following abreviations are used in the table: Active Principle of transgenic plant: AP Photorhabdus luminescens:

PL

Xenorhabdus nematophilus:

XN

Proteinase Inhibitors: PInh.

Plant lectins Plec Agglutinins: Aggl.

3-Hydroxysteroid oxidase: HO Cholesteroloxidase:

CO

Chitinase: CH Glucanase:

GL

Stilbensynthase

SS

Table B: AP Control of AP Control of B.1 CrylA(a) Adoxophyes spp. B.5 CrylA(a) Chilo spp.

B.2 CrylA(a) Agrotis spp. B.6 CrylA(a) Clysia ambiguella B.3 CrylA(a) Alabama B.7 CrylA(a) Crocidolomia argillaceae binotalis B.4 CrylA(a) Anticarsia B.8 CrylA(a) Cydia spp.

gemmatalis B.9 CrylA(a) Diparopsis 64

IAP

Control of AP jControl of B.1 I B.12 B.13 B. 14 B. 16 B.17 B. 18 B. 19 B .21 B.22 B.23 B .24 B .25 B.26 B .27 B.28 B.29 B .30 B.31 B .32 B.33 B .34 B.36 B.37 castanea CrylA(a) Earias spp.

CrylA(a) Ephestia spp.

CrylA(a) Heliothis spp.

CrylA(a) Hellula undalis CrylA(a) Keiferia lycopersicella CrylA(a) Leucoptera scitella CrylA~a) Lithocollethis spp.

CrytA(a) Lobesia botrana CrylA(a) Ostrinia nubilalis CrylA(a) Pandemis spp.

CrylA(a) Pectinophora gossyp.

CrylA(a) Phyllocnistis citrella CrylA(a) Pieris spp.

CrylA(a) Plutella xylostella CrylA(a) Scirpophaga spp.

CryIA(a) Sesamia spp.

CryIA(a) Sparganothis spp..

CrylA(a) Spodloptera spp.

CrylA(a) Toririx spp.

CrylA(a) Trichoplusia ni CrylA(a) Agriotes spp.

CrylA(a) Anthonomus grandis CrylA(a) Curcuio spp.

CrylA(a) Diabrotica balteata GrylA(a) Leptinotarsa spp.

CrylA(a) Lissorhoptrus spp.

CrylA(a) Otiorhynchus spp.

CrylA(a) Aleurothrixus spp.

B.38 B.39 B.40 B.41 B.42 B.43 B.44 B .45 B.46 B.47 B.48 B.49 B.50 B.5 1 B.52 B.53 B.54 B.55 B.56 B.57 B.58 B.59 B.60 B.61 B.62 B.63 B.64 B.65 B.66 B .67 B.68 CrylA(a) Aleyrodes spp.

CrylA(a) Aonidliella spp.

CryIA(a) Aphididae spp.

CrylA(a) Aphis spp.

CrytA(a) Bemisia tabaci CryIA(a) Empoasca spp.

CrylA(a) Mycus spp.

CryIA(a) Nephotettix spp.

CrylA(a) Nilaparvata spp.

CrylA(a) Pseudlococcus spp.

CrylA(a) Psylla spp.

CryIA(a) Quadraspidiotus sppD.

CryIA(a) Schizaphis spp.

CryIA(a) Trialeurodes spp.

CrylA(a) Lyriomyza spp.

CrylA(a) Oscinella spp.

CrylA(a) Phorbia spp.

CrylA(a) Frankliniella spp.

CrylA(a) Thrips spp.

CrylA(a) Scirtothrips aurantii CrylA(a) Aceria spp.

CrylA(a) Aculus spp.

CryIA(a) Brevipalpus spp.

CrylA(a) Panonychus spp.

CryIA(a) Phyllocoptruta spp.

CryIA(a) Tetranychus spp.

CryIA(a) Heterodera spp.

CrylA(a) Meloidlogyne spp.

CrylA(b) Adoxophyes spp.

CrylA(b) Agrotis spp.

CrylA(b) Alabama 65 LAP Control of IAP IControl of B.69 B .70 B .71 B.72 B.73 B.74 B .75 B .76 B .77 B.78 B.79 B. 81 B.82 B.83 B.84 B.86 B .87 B.88 B.89 B .91 B.92 B.93 B.94 CrylA(b) CrylA(b) CrylA(b) CryIA(b) CrylA(b) CryIA~b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CryIA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CryiA(b) CryIA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) arg illaceae Anticarsia gemnmatalis Chilo spp.

Clysia ambiguella Crocidolom ja binotalis Cydlia spp.

Dipa ropsis castanea Earias spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Ke if era lycope rsicell a Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodloptera spp.

Tortrix spp.

Trichoplusia ni B.915 B.96 B.97 B.98 B.99 B.100 B.101 B. 102 B. 103 B. 104 B. 105 B. 106 B. 107 B. 108 B. 109 B.I10 BA I1I B. 112 BA113 B.1 114 B. 115 B. 116 B. 117 B. 118 B.1 119 B. 120 B. 121 B. 122 B. 123 B. 124 CrylA(b) CrylA(b) CryIA(b) CrylA(b) CryIA(b) CrylA(b) CrylA(b) CryIA(b) CryIA(b) CrylA(b) CrylA(b) C rylA(b) CryIA(b) CrylA(b) CrylA(b) CryIA(b) CrylA(b) CrylA(b) CrylA(b) CryIA(b) C ryIA(b) CryIA(b) CrylA(b) CrylA(b) CrylA(b) CryIA(b) CrylA(b) CryIA(b) CrylA(b) CryIA(b) Agriotes spp.

Anthonomus grandis Curculio spp.

Diabrotica balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidiella spp.

Aphididae spp.

Aphis spp.

Bemisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudlococcus spp.

Psylla spp.

Quadraspidiotus sppD.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Thnips spp.

Scirtothrips aurantli Aceria spp.

Aculus spp.

66 AP Control of

IAP

I Control of B. 125 B. 126 B. 127 B. 128 B. 129 B. 130 B. 131 B. 132 B. 133 B. 134 B. 135 B. 136 B. 137 B. 138 B. 139 B. 140 B. 141 B. 142 B. 143.

B. 144 B. 145 B. 146 B. 147 B. 14& B. 149 B. 150 CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CrylA(b) CryIA(c) CryIA(c) CrylA~c) CryIA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CrylA(c) CryIA(c) CrylA(c) CrylA(c) CrylA(c) CryIA(c) CryIA(c) CryIA(c) CrylA(c) CrylA(c) CrylA(c) CryIA(c) Brevipalpus spp.

Panonychus spp.

Phyllocoptruta spp.

Tet ranychus spp.

Heterodera spp.

Meloidlogyne spp.

Adoxophyes spp.

Agrotis app.

Alabama argillaceae Antica rsaa gemnmatalis Chilo spp.

Clysia ambiguella C rocidolomi a binotalis Cydlia app.

Diparopsis castanea Earias spp.

Epheatia spp.

Heliothis app.

Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandem'is spp.

Pectinopho ra gossypiella.

B. 151 B. 152 B. 153 B. 154 B. 155 B. 156 B. 157 B. 158 B. 159 B. 160 B. 161 B.162 B. 163 B. 164 B. 165 B. 166 B. 167 B. 168 B.169 B. 170 B. 171 B. 172 B. 173 B. 174 B. 175 B. 176 B. 177 B.178 B. 179 B.180 CrylA(c) Phyllocnistis citrella CrylA(c) Piens spp.

CrylA(c) Plutella xylostella CrylA(c) Scirpophaga spp.

CrylA(c) Sesamia spp.

CrylA(c) Sparganothis app.

CrylA(c) Spodloptera app.

CryIA(c) Tortrix spp.

CryIA(c) Trichoplusia ni CrylA(c) Agriotes app.

CrylA(c) Anthonomus g randis CrylA(c) Curcuio app.

CrylA(c) Diabrotica balteata CrylA(c) Leptinotarsa app.

CrylA(c) Lissorhoptrus app.

CrylA~c) Otiorhynchus spp.

CrylA(c) Aleurothrixus app.

CrylA(c) Aleyrodes app.

CrylA(c) Aonidiella app.

CryIA(c) Aphididae app.

CryIA(c) Aphis spp.

CrylA(c) Bemnisia tabaci CrylA(c) Empoasca spp.

CrylA(c) Mycus spp.

CryIA(c) Nephotettix spp.

CrylA(c) Nilaparvata spp.

CryIA(c) Pseudococcus spp.

CrylA(c) Psylla app.

CryIA(c) Quadraspidiotus app.

CrylA(c) Schizaphis app.

67

~AP

B. 181 CrylA(c) ciB

B

00 B

\QB

SB

I

.182 .183 CrylA(c) CryIA(c) 15 CS ryIAkkc) .185 CrylA(c) .186 CrylA(c) .187 CrylA(c) 3.189 CrylA(c) 3.189 CrylA(c 3.190 CrylA(c 3.192 CrylA(c B. 192 CrylA(c B. 193 CrylA(c B. 194 CrylA(c B. 195 CryllAc B. 196 CryllA B. 197 CryllA B. 198 CryllA B .200 CryllA Control of Trialeurodles spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Thrips spp.

Scirtothrips aurantli Aceria. spp.

Aculus spp.

Brevipalpus spp.

Panonychus spp.

Phyllocoptruta spp.

Tetranychus spp.

Heterodera spp.

Meloidogyfle spp.

Adoxophyes spp.

Agrotis spp.

Alabama a rgillace ae Anticarsia.

gemnmatalis Chilo spp.

Clysia ambiguelia Crocidolomia binotalis Cydlia spp.

Diparopsis castanea, Earias spp.

Ephestia, spp.

Heliothis spp.

I AP

I

B.209 B .210 B.211 B.212 B.213 B.214 B.215 B.216 B.217 B.218 B.219 B.220 B.221 B.222 B.223 B.224 B.225 B.226 B. .227 B.228 B.229 B.230 B.231 B.232 B.233 B.234 B.235 B.236 CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemnis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodoptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grandis Curculio spp.

Diabrotica. balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidliella spp.

Aphididae spp.

Aphis spp.

Bemnisia tabaci Control of B .201 B.202 B.203 B.20.4 B.205 B.206 B.207 B.208 CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA Hellula undalis B.237 68 AP Control of I_ AP IControl of B.238 B .239 B.240 B .241 B.242 B.243 B. 244 B. 245 B.246 B.247 B.248 B.249 B.250 B.251 B.252 3 B.254 B.255 B.256 B.257 B.259 B. 259 B.260 B.261 B.262 B.263 B.264 B.265 B.266 CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CrylIA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CryllA CrylilA CryillIA CrylliA CrylliA CryillIA CryllIA Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudlococcus spp.

Psylla spp.

Quadraspidiotus sppD.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Tb rips spp.

Scirtothrips aurantli Aceria spp.

Aculus spp.

Brevipalpus spp.

Panonychus spp.

Phyllocoptruta spp.

Tetranychus spp.

Heterodera spp.

Meloidlogyne spp.

Adoxophyes spp.

Agrotis spp.

Alabama argi llaceae Anticarsia gemmatalis Chilo spp.

Clysia ambiguella B .267 B.268 B.269 B.270 B.271I B.272 B.273 B.274 B.275 B.276 B.277 B.278 B.279 B.280 B.281 B.282 B.283 B.284 B.285 B.286 B.287 B.288 B.289 B.290 B.291 B.292 B.293 CrylliA CryillIA CryillIA CrylilA CrylliA CrylilA CrylliA CrylilA CrylliA CrylilA CryillIA CryillIA CryillIA CryillIA CryllIA CrylilA CryillIA CrylilA CrylilA CryllIA CryillIA CrylilA CrylilA CrylilA CryllIA CryllIA CrylilA Crocidolomia binotalis Cydlia spp.

Diparopsis castanea Earias spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Keiferia lycopersicella, Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella* Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodloptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grandis Curcullo spp.

Diabrotica balteata 69 I AP Control of AP IControl of B.294 B.295 B.296 B.297 B.298 B.299 B.300 B .301 B.302 B .303 B.304 B.305 B.306 B.307 B.308 B.309 B.310 B.31 1 B.312 B.3 13 B .314 B.3 15 B.3 16 B.317 B.318 B .319 B .320 B.321 B.322 B.323 B .324 CrylliA CryillIA CrylilA CrylliA CrylliA CryllIA CryillA CrylilA CrylllA CryillIA CrylliA CrylIlA CrylIlA CrylliA CrylliA CryllIA CryillIA CryIIlA CrylilA CrylilA CrylilA CryillIA CryllA CrylilA CrylliA CrylliA CrylilA CrylliA CrylliA CryilliA CrylilA Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidliella spp.

Aphididae spp.

Aphis spp.

Bemnisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudococcus spp.

Psylla spp.

Quadraspidiotus spp.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Thrips spp.

Scirtothrips aurantil Aceria spp.

Aculus spp.

Brevipalpus spp.

Panonychus spp.

Phyllocoptruta spp.

Tetranychus spp.

Heterodera spp.

B.325 B.326 B.327 B.328 B.329 B.330 B.331 B.332 B.333 B .334 B.335 B.336 B.337 B.338 B.339 B.340 B.341 B.342 B.343 B.344 B.345 B.346 B.347 B.348 B.349 B.350 CryllIA CrylllB2 CrylllB2 CrylllB2 CrylllB2 CrylllB2 CryllIB2 CrylllB2 CrylllB2 CryllIB2 CrylllB2 CrylllB32 CrylllB2 CrylllB2 CrylIllB2 CrylIlB12 CrylIlB2 CrylllB2 CrylllB2 CrylllB2 CryIllB32 CryIllB32 CryIllB2 CrylIB12 CrylllB2 CrylllB2 Meloidlogyne spp.

Adoxophyes spp.

Agrotis spp.

Alabama argillaceae Anticarsia gem matalis Chilo spp.

Clysia ambiguella Crocidolomia binotalis Cydlia spp.

Diparopsis castanea Earias spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemnis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

70 IAP I Control of

IAP

IControl of B.351 B.352 B.353 B.354 B.355 B.356 B.357 B.358 B.359 B.360 B.361 B.362 B.363 B.364 B. 365 B.366 B.367 B.368 B.369 B.370 B.371 B .372 B.373 B.374 B.375 B.376 B.377 B .378 B.379 B.380 CryIllB32 CrylllB2 CrylllB2 CrylIIB12 CryIIl1B2 CryllB2 CryIllB2 CryIIlB32 CryIIlB32 CrylllB2 CrylIIB2 CrylllB2 CryllIB2 CryllIB2 CrylIlB2 CrylIlB2 CryllIB2 CryIIlB2 CryIll1B2 CryII11B2 CryllB2 CrylllB2 CrylllB32 CryII1lB2 CryllIB2 CrylllB2 CrylIlB2 CrylIIB2 CryllIB2 CrylIIB2 Sparganothis spp.

Spodloptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grandis Curcuio spp.

Diabrotica balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidliella spp.

Aphididae spp.

Aphis spp.

Bemisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudlococcus spp.

Psylla spp.

Quadraspidiotus spp.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

B.381 B.382 B.383 B.384 B.385 B.386 B.387 B.388 B.389 B.390 B.391 B.392 B.393 B .394 B.395 B.396 B.397 B.398 B .399 B .400 B.401 B.402 B.403 B .404 B.405 B.406 B.407 CrylllB2 CrylllB2 CrylltB2 CrylIlB32 CryllIB2 CrylIIB2 CrylIlB2 CryIIllB2 CrylllB2 CrylllB2 CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA Thrips spp.

Scirtothrips aurantii Aceria spp.

Aculus spp.

Brevipalpus spp.

Panonychus spp.

Phyllocoptruta spp.

Tetranychus sp p.

Heterodera spp.

Meloidlogyne spp.

Adoxophyes spp.

Agrotis spp.

Alabama argillaceae Anticarsia gemmatalis Chilo spp.

Clysia ambiguella C rocidolomia binotalis Cydlia spp.

Dipa ro p sis castanea Earias spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Keiferia lycopersicel Ia Leucoptera scitella.

Lithocollethis spp.

Lobesia botrana, -71

IAID

B.408 CYtA B.409 CytA 15.41 u B.'41 1 B .412 B .413 B .414 B.415 B.416 B.417 B.418 B.419 B.420 B.421 Y um B.422 B.423 B.424 B.425 B.426 B.427 B.428 B.429 B.430 B.431 B.432 B.433 B.434 B.435 B.436 B.437 CytA CytA CytA CytA CytA, CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA Control of Ostrinia nubilalis Pandemnis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodloptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grand is Curcullo spp.

Diabrotica balteata Leptinotarsa spp.

Lisgorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidiella spp.

Aphididae spp.

Aphis spp.

Bemnisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudlococcus spp.

B.438 B.439 B.440 B.441 B.442 B.443 B .444 B.445 B.446 B.447 B.448 B.449 B.450 B.451 B.452 B.453 B.454 B.455 B.456 B.457 B.458 B.459 B.460 B.461 B.462 B.463 B .46.4 IAP IControl of CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA CytA VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 Psylla spp.

Quad raspidliotus spp.

Schizaphis spp.

Trialeurodes spp.

Lyniomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Thrips spp.

Scirtothrips aurantil Aceria spp.

Aculus spp.

Brevipaipus spp.

Panonychus spp.

Phyllocoptruta spp.

Tetranychus spp.

Heterodera spp.

Meloidlogyne spp.

Adoxophyes spp.

Agrotis spp.

Alabama argillaceae Anticarsia gemnmatalis Chilo spp.

Clysia ambiguella C rocidolomia binotalis Cydlia spp.

Dipa ropsis castanea 72-

AP

B.465 VIP3 B.466 B.467 B.468 B.469 B.470 B.471 B.472 B.473 B.474 B .475 B.476 B.477 B.478 B.479 B.480 B.481 B.482 B.483 B.484 B.485 B.486 B.487 B.488 B.489 B.490 B.491 B.492 B.493 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 Control Of Earias spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemis spp.

Pectinopho ra gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodloptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus g randis Curcullo spp.

Diabrotica balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

B.494 B.495 B.496 B.497 B.498 B.499 B.500 B.501 B.502 B.503 B .504 B.505 B.506 B.507 B.508 B.509 B.5 10 B.511 B.512 B.513 B.514 B.515 B.516 B.517 B.5 18 B.519 B .520 B.521 B.522 B.523 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 ViP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3 VIP3

GL

Aonidliella spp.

Aphididae spp.

Aphis spp.

Bemnisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudococcus spp.

Psylla spp.

Quadraspidiotus spp.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Thrips spp.

Scirtothrips aurantil Aceria spp.

Aculus spp.

Brevipalpus spp.

Panonychus spp.

Phyllocoptruta spp.

Tetranychus spp.

Heterodera spp.

Meloidlogyne spp.

Adoxophyes spp.

Agrotis spp.

Alabama argillaceae IAP IControl of -73 I AP IControl of AP Control of B.524 B.525 B.526 B.527 B.528 B.'529 B.530 B.531 B.532 B.533 B.534 B.535 B.536 B.537 B.538 B.539 B.540 B.541 B .542 B.543 B .544 B.545 B.546 B.547 B.548 B.549 B.550

GL

Anticarsia gemnmatalis Chilo spp.

Clysia ambiguella Crocidolomnia binotalis Cydlia spp.

Diparopsis castanea Eariag spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Ke if era lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodloptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

B.551 B.552 B.553 B.554 B.555 B.556 B.557 B .558 B.559 B.560 B.561 B.562 B.563 B.564 B.565 B.566 B.567 B.568 B.569 B.570 B.571 B.572 B.573 B.574 B.575 B.576 B.577 B.578 B.579 B.580

GL

An th on o m u grandis Curcuio app.

Diabrotica balteata Leptinotarsa app.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidliella app.

Aphididae app.

Aphis app.

Bemnisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudlococcus spp.

Psylla app.

Quadraspidliotus spp.

Schizaphis app.

Trialeurodes spp.

Lyriomyza app.

Oscinella app.

Phorbia spp.

Franklinielia spp.

Thrips spp.

Scirtothrips aurantii Aceria spp.

Aculus spp.

Brevipalpus spp.

74 AP Control of ZB.581 GL Panonychus spp.

B.582 GL Phylloicoptruta spp.

B.583 GL Tetranychus spp.

00 B.584 GL Heterodera spp.

,OC B.585 GL Meloidlogyfle spp.

M~f B.586 PL Adoxophyes spp.

knt B.587 PL Agrotis spp.

C) B.588 PL Alabama argillaceae B.589 PL Anticarsia gemmatalis B.590 PL Chilo spp.

B.591 PL Clysia ambiguella B.592 PL Crocidolomia binotalis B. 59 3 PL Cydia spp.

B.594 PL DiparopSiS castanea MR ~1I i c AP IControl of B.607 B.608 B.609 B.610 B.611 B.612 B.613 B.614 B.615 B.616 B .617 B.618 B .619 B.620 B .621 B.622 B.623 B.624 B.625 B.626 B.627 B .628 B.629 B.630 B.631 B.632 B.633 B.634 B.635 B.636

PL

FL

PL

FL

PL

FL

PL

FL

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodoptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus g randis Curcullo spp.

Diabrotica balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidiella spp.

Aphididae spp.

Aphis spp.

Bemisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Fseudococcus spp.

Psylla spp.

Quadraspidiotus spp.

Schizaphis spp.

Trialeurodes spp.

b. D. B.596 B.597 B.598 B.599 B. 600 B.601 B.602 B.603 B.604 B.605 B.606 Ephestia spp.

Heliothis spp.

Hellula undalis Keiferia lycopersicella Leucopte ra scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Fandemis spp.

Fectinophora gossyp.

Fhyllocnistis citrethI IlAP Control of IAP IControl of B.637 B.638 B.639 B.640 B. 641 B. 642 B. 643 B. 644 B.645 B.646 B.647 B.648 B.649 B.650 B.651 B.652 B.653 B.654 B.655 B.656 B.657 B.658 B.659 B.660 B.661 B.662 B.663 B .664

PL

PIL

PL

FL

XN

Lyniomyza spp.

Oscinella spp.

Fhorbia spp.

Frankliniella spp.

Thnips spp.

Scirtothrips aurantli Aceria spp.

Aculus spp.

Brevipalpus spp.

Fanonychus spp.

Phyllocoptruta spp.

Tetranychus spp.

Heterodera spp.

Meloidogyne spp.

Adoxophyes spp.

Agrotis spp.

Alabama arg iilaceae Anticarsia gemnmatalis Chilo spp.

Clysia ambiguella Crocidolo mia binotalis Cydlia spp.

Diparopsis castanea Earias spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Ke iferia B.665 B.666 B.667 B.668 B.669 B.670 B.671 B.672 B.673 B .674 B.675 B.676 B.677 B.678 B.679 B.680 B.681 B.682 B.683 B.684 B .685 B.686 B.687 B .688 B.689 B.690 B.691 B.692 B.693

XN

lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Fandemnis spp.

Pectinophora gossyp.

Fhyllocnistis citrella Fieris spp.

Flutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodoptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grand is Curcullo spp.

Diabrotica balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidiella spp.

Aphididlae spp.

Aphis spp.

Bemnisia tabaci Empoasca spp.

76 AP Control of B.694 XN Mycus spp.

B.695 XN Nephotettix spp.

B.696 XN Nilaparvata spp.

B.697 XN Pseudlococcus spp.

B.698 XN Psylla spp.

B.699 XN Quadraspidiotus sppD.

B.700 XN Schizaphis spp.

B.701 XN Trialeurodes spp.

B.702 XN Lyriomyza spp.

B.703 XN Oscinella spp.

B.704 XN Phorbia spp.

B.705 XN Frankliniella spp.

B.706 XN Thrips spp.

B.707 XN Scirtothrips aurantli B.708 XN Aceria spp.

B.709 XN Aculus spp.

B.710 XN Brevipalpus spp.

B.711 XN Panonychus spp.

B.712 XN Phyllocoptruta sppD.

B.713 XN Tetranychus spp.

B.714 XN Heterodera spp.

B.715 XN Meloidlogyne spp.

B.716 Plnh. Adoxophyes spp.

B.717 Plnh. Agrotis spp.

B.718 Plnh. Alabama I AP IControl of binotalis B.723 B.724 B.725 B.726 B.727 B.728 B.729 B.730 B.731 B.732 B.733 B.734 B.735 B.736 B.737 B.738 B.739 B.740 B.741 B.742 B.743 B.744 B.745 B.746 B.747 B.748 B.749 Plnh.

Plnh.

Pinh.

Plnh.

Pinh.

Plnh.

Ptnh.

Plnh.

Pinh.

Cydlia spp.

Diparopsis castanea Earias spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemis spp.

Pectinophora, gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga. spp.

Sesamia spp.

Sparganothis spp.

Spodoptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grandis Curcullo spp.

Diabrotica balteata Leptinotarsa spp.

B.719 B.720 B.721 B.722 Plnh.

Plnh.

argillaceae Anticarsia gemnmatalis Chilo spp.

Clysia ambiguella Crocidolomia 77

AP

B.750 Plnh.

B.751 Plnh.

B.752 Plnh.

B.753 Pinh.

B.754 Plnh.

B.755 Plnh.

B.756 Plnh.

B.757 Plnh.

B.758 Plnh.

B.759 Pinh.

B.760 Plnh.

B.761 Plnh.

B.762 Plnh.

B.763 Plnh.

B.764 Plnh.

B.765 Plnh.

B.766 Plnh.

B.767 Plnh.

B.768 Plnh.

B.769 Plnh.

B.770 Plnh.

B.771 Plnh.

B.772 Plnh.

Control of Lissorhoptwus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidiella spp.

Aphididae spp.

Aphis spp.

Bemisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudococcus spp.

Psylla spp.

QuadraspidiotuS spp.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Thrips spp.

Scirtothrips aurantil Aceria spp.

Aculus spp.

Brevipalpus spp.

Panonychus spp.

Phyllocoptruta spp.

Tetranychus spp.

Heterodera spp.

Meloidlogyfle spp.

AP

B.781 Plec B.782 Plec B.783 Plec B.784 Plec B.785 B.786 B.787 B .788 B.789 B.790 B.791 B.792 B.793.

B.794 B.795 B.796 B.797 B.798 B.799 B. 800 B.801 B.802 B.803 B. 804 B.805 B .806 Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Plec Control of Adoxophyes spp.

Agrotis spp.

Alabama argillaceae Antica rsia gemmatalis Chilo spp.

Clysia ambiguella Crocidolomia binotalis Cydlia spp.

Diparopsis castanea Earias spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostninia nub ilalis Pandemnis spp.

Pectinophora gossyp.

Phyllocnistis ci trella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

B.773 B.774 B.775 B.776 B.777 B.778 B.779 B .780 Plnh.

Pinh.

Plnh.

Pinh.

Plnh.

-78 AP Control of B.807 Plec Spodoptera spp.

B.808 Plec Tortrix spp.

B.809 Plec Trichoplusia ni B.810 Plec Agriotes spp.

B.81 I Plec Anthoflomus grandis B.812 Plec Curcuio spp.

B.813 Plec Diabrotica balteata B. 814 Plec Leptinotarsa spp.

B.815 Plec Lissorhoptrus spp.

B. 816 Plec Otiorhynchus spp.

B.817 Plec Aleurothrixus spp.

B.818 Plec Aleyrodes spp.

B.819 Plec Aonidiella spp.

B.820 Plec Aphididae spp.

B.821 Plec Aphis spp.

B.822 Plec Bemnisia tabaci B.823 Plec Empoasca spp.

B.824 Piec Mycus spp.

B.825 Plec Nephotettix spp.

B.826 Plec Nilaparvata spp.

B.827 Plec Pseudococcus spp.

B.828 Plec Psylla spp.

B.829 Plec QuadraspidiotuS spp).

B.830 Plec Schizaphis spp.

B.831 Plec Trialeurodes spp.

B.832 Plec Lyriomyza spp.

B.833 Plec Oscinella spp.

B.834 Plec Phorbia spp.

B.835 Plec Frankliniella spp.

B.836 Plec Thrips spp.

AP Control of B.837 Plec Scirtothrips aurantii B.838 Plec Aceria spp.

B.839 Plec Aculus spp.

B.840 Plec Brevipaiptis spp.

B.841 Plec Panonychus spp.

B.842 Plec Phyllocoptruta spp.

B.843 Plec Tetranychus spp.

B.844 Plec Heterodera spp.

B.845 Plec Meloidogyne spp.

B.846 Aggi. Adoxophyes spp.

B. 847 Aggi. Agrotis spp.

B.848 Aggl. Alabama argillaceae B.849 Aggi. Anticarsia gemmatalis B.850 Aggl. Chilo spp.

B.851 Aggi. Clysia ambiguella B.852 Aggi. Crocidolomia binotalis B.853 Aggi. Cydia spp.

B.854 Aggi. Diparopsis castanea B.855 'Aggl. Earias spp.

B.856 Aggl. Ephestia spp.

B.857 Aggl. Heliothis spp.

B.858 B.859 B.860 B .861 B.862 B.863 Aggi.

AggI.

Aggi.

AggI.

Keiferia lycopersicell a Leucoptera scitella Lithocotlethis spp.

Lobesia botrana Ostrinia nubilalis 79 I AP Control of IControl of B.864 B.865 B.866 B. 867 B.868 B.869 8.870 B. 871 B.872 B.873 B.874 B.875 B.876 B.877 B.878 B.879 B.880 B.881 B.882 B.883 B.884 B.885 B.886 B.887 B.888 B.889 B.890 B.891 B.892 B.893 A991.

Aggi.

Agg91.

Aggi.

A9g1.

Aggl.

Aggi., Aggi.

Aggi.

Agg1.

Aggi.

Agg1.

Aggi.

Agg1.

Aggl.

Aggi.

Pandemis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodloptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grandis Curcullo spp.

Diabrotica balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothnxus spp.

Aleyrodes spp.

Aonidliella spp.

Aphididae spp.

Aphis spp.

Bemnisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudlococcus spp.

Psylla spp.

B.894 B.895 B.896 B .897 B.898 B.899 B.900 B.901 B.902 B.903 B.904 B.905 B.906 B.907 B.908 B.909 B.910 B.911 8.9 12 8.913 B.914 8.915 B.9 16 B.917 B.918 B.919 B.920 Aggl.

Aggi.

Aggl.

Aggi.

Aggl.

Aggi.

Go Co Co Co Co Co Co Co Co

CO

Quadraspidiotus spp.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Thrips spp.

Scirtothrips aurantil Acenia spp.

Aculus spp.

Brevipalpus spp.

Panonychus spp.

Phyllocoptruta spp.

Tetranychus spp.

Heterodera spp.

Meloidlogyne spp.

Adoxophyes spp.

Agrotis spp.

Alabama a rgillaceae Anticarsia gemmatalis Chito spp.

Clysia ambiguella C rocidolomi a binotalis Cydlia spp.

Dipa ropsis castanea Earias spp.

80

IAP

Control of AP Coontrol of B.921 B.922 B.923 B.924 B.925 B.926 B .927 B.928 B .929 B.930 B.931 B .932 B.933 B.934 B.935 B.936 B.937 B.938 B.939 B.940 B .941 B.942 B .943 B. 94-4 B.945 B.946 B.947 B.948 B.949 Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Ephestia spp.

Heliothis spp.

Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemnis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodoptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grandis Curcuio s.pp.

Diabrotica balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidliella spp.

B.950 B.951 B.952 B.953 B.954 B.955 B.956 B.957 B.958 B.959 B.960 B.961 B.962 B.963 B.964 B.965 B.966 B.967 B.968 B.969 B.970 B.971 B.972 B.973 B.974 B.975 B.976 B.977 B.978 B.979 co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co Co

CH

OH

Aphididae spp.

Aphis spp.

Bemisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudococcus spp.

Psylla spp.

Quadraspidiotus spIp.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Thrips spp.

Scirtothrips aurantii Aceria spp.

Aculus spp.

Brevipalpus spp.

Panonychus spp.

Phyllocoptruta spp.

Tetranychus spp.

Heterodera spp.

Meloidlogyne spp.

Adoxophyes spp.

Agrotis spp.

Alabama argillaceae Anticarsia 81

AP

B.980 CH B.981 OH B.982 OH B.983 OH B.984 OH B.985 OH B.986 OH B.987 OH B.988 OH B.989 OH B.990 OH B.991 OH B.992 CH B.993 OH B.994 OH B.995 OH B.996 OH B.997 OH B.998 OH B.999 OH B. 1000 O H B.1001 O H B. 1002 OH B. 1003 OH B. 1004 OH B. 1005 OH B. 1006 OH Control of gemmatalis Ohito spp.

Olysia ambiguella Orocidolomia binotalis Oydlia spp.

Diparopsis castanea Earias spp.

Ephestia spp.

Heliothis spp.

Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodloptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus IAP IOontrol of B. 1007 B. 1008 B. 1009 B. 1010 B. 10 11 B. 1012 B. 1013 B. 1014 B. 1015 B. 1016 B. 1017 B. 1018 B. 1019 B. 1020 B. 102 1 B. 1022 B. 1023 B. 1024 B. 1025 B. 1026 B. 1027 B. 1028 B. 1029 B. 1030 B. 1031 B. 1032 B.1033 B. 1034 B. 1035 B. 1036

CH

OH

CH

OH

CH

OH

CH

OH

CH

OH

CH

OH

CH

OH

CH

OH

CH

g randis Ourcullo spp.

Diabrotica balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidiella spp.

Aphididae spp.

Aphis spp.

Bemisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudococcus spp.

Psytla spp.

Quadraspidiotus spp.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

Oscinella spp.

Phorbia spp.

Frankliniella spp.

Thrips spp.

Scirtothrips aurantil Aceria spp.

Aculus spp.

Brevipalpus spp.

Panonychus spp.

82 IAP Control of B. 1037 OH Phyllocoptruta spp.

B.1038 CH Tetranychus spp.

B. 1039 OH Heterodera spp.

B. 1040 OH Meloidogyne spp.

B. 1041 SS Adoxophyes spp.

B. 1042 SS Agrotis spp.

B.1043 SS Alabama argillaceae B. 1044 SS Anticarsia gemmatalis B. 1045 SS Chilo spp.

B. 1046 SS Clysia ambiguella B. 1047 SS Crocidolomia binotalis' B. 104 8 SS Cydia spp.

B. 1049 SS Diparopsis castanea B. 1050 SS Earias spp.

I AP Control of 1 B. 1063 SS B. 1064 SS B. 1065 SS B. 1066 SS B. 1067 SS B. 1068 SS B. 1069 SS B. 107 0 SS B. 1071 SS B. 1072 SS B. 1073 SS B. 1074 SS B. 107 5 SS B. 1076 SS B. 1077 SS B.1078 SS B.1079 SS B.1080 SS B. 108 SS B. 1082 SS B. 1083 SS B. 1084 SS B. 1085 SS B. 1086 SS B. 1087 SS B.1088 SS B. 1089 SS B. 1090 SS B. 109 1. SS B. 1092 SS Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodoptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grandis Curculio spp.

Diabrotica balteata Leptinotarsa spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidiella spp.

Aphididae spp.

Aphis spp.

Bemnisia tabaci Empoasca spp.

Mycus spp.

Nephotettix spp.

Nilaparvata spp.

Pseudlococcus spp.

Psylla spp.

Quadraspidiotus spp.

Schizaphis spp.

Trialeurodes spp.

Lyriomyza spp.

D IU B. 1052 B. 1053 B. 1054 B. 1055 B. 1056 B. 1057 B. 1058 B. 1059 B. 1060 Heliothis spp.

Hellula undalis Keiferia lycopersicella Leucoptera scitella Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemnis spp.

Pectinophora gossyp.

Phyllocnistis citrella Pieris spp.

B. 1061 SS B. 1062 SS 83 AP Control of B. 1093 SS Oscinella spp.

B. 1094 SS Phorbia spp.

B. 1095 SS Franklifliella spp.

B. 1096 SS Thrips spp.

B. 1097 SS Scirtothrips aurantii B. 1098 SS Aceria spp.

B. 1099 SS Aculus spp.

B. 1100 SS Brevipalpus spp.

101 SS Panonychiis spp.

B. 1102 SS Phyllocoptruta spp.

B. 1103 SS Tetranychus spp.

B. 1104 SS Heteroderaspp.

B. 1105 SS Meloidlogyfle spp.

B. 1106 HO Adoxophyes spp.

B. 1107 HO Agrotis spp.

B. 1108 HO Alabama argillaceae B.1 109 HO Anticarsia gemmatalis B.IlIl1 HO Chilo spp.

B.1 I1I1 HO Clysia ambiguella B.1 112 HO Crocidolomia binotalis B.1 113 HO Cydlia spp.

B. 1114 HO Diparopsis castanea B. 1115 HO Earias spp.

B.1 116 HO Ephestia spp.

B.1 117 HO Heliothis spp.

B. 1118 HO Hellula undalis B. 1119 HO Keiferia lycopersicella AP Control of B.1 120 1HO B.1121 HO B. 1122 HO B. 1123 HO B. 1124 HO B. 1125 HO B. 1126 HO B. 1127 HO B. 1128 HO B. 1129 HO B. 1130 HO0 B. 1131 HO0 B. 1132 HO B. 1133 HO B. 1134 HO B. 1135 HO B. 1136 HO B. 1137 HO B.1 138 HO B. 1139 HO B. 1140 HO B.1141 HO B. 1142 HO B. 1143 HO B. 1144 HO0 B. 1145 HO B. 1146 HO B. 1147 HO B. 1148 HO B. 1149 HO Lithocollethis spp.

Lobesia botrana Ostrinia nubilalis Pandemis spp.

Pectinop hora.

gossypiella Phyllocnistis citrella Pieris spp.

Plutella xylostella Scirpophaga spp.

Sesamia spp.

Sparganothis spp.

Spodloptera spp.

Tortrix spp.

Trichoplusia ni Agriotes spp.

Anthonomus grandis Curculio spp.

Diabrotica balteata Leptinotarsa. spp.

Lissorhoptrus spp.

Otiorhynchus spp.

Aleurothrixus spp.

Aleyrodes spp.

Aonidliella spp.

Aphididae spp.

Aphis spp.

Bemisia tabaci Empoasca spp.

Mycus spp.

-84- SAP Control of AP Control of Z B.1150 HO Nephotettix spp. B.1160 HO Frankliniella spp.

SB. 1151 HO Nilaparvata spp. B.1161 HO Thrips spp.

B.1152 HO Pseudococcus spp. B.1162 HO Scirtothrips aurantii 00 B.1153 HO Psylla spp. B.1163 HO Aceria spp.

C B.1154 HO Quadraspidiotus B.1164 HO Aculus spp.

spp. B.1165 HO Brevipalpus spp.

t B.1155 HO Schizaphis spp. B.1166 HO Panonychus spp.

O B.1156 HO Trialeurodes spp. B.1167 HO Phyllocoptruta spp.

B.1157 HO Lyriomyza spp. B.1168 HO Tetranychus spp.

B.1158 HO Oscinella spp. B.1169 HO Heterodera spp.

B.1159 HO Phorbia spp. B.1170 HO Meloidogyne spp.

Biological Examples Table 1: A method of controlling pests comprising the application of Abamectin to transgenic cotton, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 2: A method of controlling pests comprising the application of Abamectin to transgenic rice, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 3: A method of controlling pests comprising the application of Abamectin to transgenic potatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 4: A method of controlling pests comprising the application of Abamectin to transgenic brassica, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 5: A method of controlling pests comprising the application of Abamectin to transgenic tomatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

IT-

O

Table 6: A method of controlling pests comprising the application of Abamectin to Stransgenic cucurbits, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 7: A method of controlling pests comprising the application of Abamectin to 00 transgenic soybeans, wherein the combination of the active principle expressed by the \0 transgenic plant and the pest to be controlled correspond to a line of the table B.

N Table 8: A method of controlling pests comprising the application of Abamectin to C transgenic maize, wherein the combination of the active principle expressed by the N transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 9: A method of controlling pests comprising the application of Abamectin to transgenic wheat, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 10: A method of controlling pests comprising the application of Abamectin to transgenic bananas, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 11: A method of controlling pests comprising the application of Abamectin to transgenic citrus trees, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 12: A method of controlling pests comprising the application of Abamectin to transgenic pome fruit trees, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 13: A method of controlling pests comprising the application of Emamectin-Benzoate to transgenic cotton, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 14: A method of controlling pests comprising the application of Emamectin-Benzoate to transgenic rice, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 15: A method of controlling pests comprising the application of Emamectin-Benzoate to transgenic potatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

-86- Table 16: A method of controlling pests comprising the application of Emamectin-Benzoate Z to transgenic tomatoes, wherein the combination of the active principle expressed by the 0 transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 17: A method of controlling pests comprising the application of Emamectin-Benzoate 00 to transgenic cucurbits, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

N Table 18: A method of controlling pests comprising the application of Emamectin-Benzoate 0 to transgenic soybeans, wherein the combination of the active principle expressed by the c transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 19: A method of controlling pests comprising the application of Emamectin-Benzoate to transgenic maize, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 20: A method of controlling pests comprising the application of Emamectin-Benzoate to transgenic wheat, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 21: A method of controlling pests comprising the application of Emamectin-Benzoate to transgenic bananas, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 22: A method of controlling pests comprising the application of Emamectin-Benzoate to transgenic orange trees, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 23: A method of controlling pests comprising the application of Emamectin-Benzoate to transgenic pome fruit, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 24: A method of controlling pests comprising the application of Emamectin-Benzoate to transgenic cucurbits, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 25: A method of controlling pests comprising the application of Spinosad to transgenic cotton, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

-87- Table 26: A method of controlling pests comprising the application of Spinosad to

O

Z transgenic rice, wherein the combination of the active principle expressed by the transgenic Splant and the pest to be controlled correspond to a line of the table B.

Table 27: A method of controlling pests comprising the application of Spinosad to 00 transgenic potatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

N Table 28: A method of controlling pests comprising the application of Spinosad to C transgenic brassica, wherein the combination of the active principle expressed by the Stransgenic plant and the pest to be controlled correspond to a line of the table B.

Table 29: A method of controlling pests comprising the application of Spinosad to transgenic tomatoes, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 30: A method of controlling pests comprising the application of Spinosad to transgenic cucurbits, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 31: A method of controlling pests comprising the application of Spinosad to transgenic soybeans, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 32: A method of controlling pests comprising the application of Spinosad to transgenic maize, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 33: A method of controlling pests comprising the application of Spinosad to transgenic wheat, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 34: A method of controlling pests comprising the application of Spinosad to transgenic bananas, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table 35: A method of controlling pests comprising the application of Spinosad to transgenic citrus trees, wherein the combination of the active principle expressed by the transgenic plant and the pest to be controlled correspond to a line of the table B.

-88 ~abe 6-'A method of controlling pests comprising the application of Spinosad to 0 Z ransgenic pome fruit trees, wherein the combination of the active principle expressed by a'the transgenic plant and the pest to be controlled correspond to a line of the table B.

Table C: 00 Abbreviations: SAcetyl-COA Carboxylase: ACCase SAcetolactate Synthase:

ALS

'nHydroxyphenylpyruvat dioxygenase:

HPPD

SInhibition of protein synthesis:

IPS

Hormone mimic: HO Glutamine* Synthetase:

GS

Protoporphyrinogen oxidase:

PROTOX

-Enolpyruvyl-3-Phosphoshikimate Synthase:

EPSPS

P rinci ple Tolerant to C. I ALS SulfonylureaS etc.*** C.2 ALS Suit onylureas etc.

C.3 ALS Sult onylureas etc.

CA4 ALS Sulfonylureas etc.

ALS Sult onylureas etc.

C.6 ALS Suit onylureas etc.

C.7 ALS SulfonylureaS etc.

C.8 ALS Sulfonylureas etc.

C.9 ALS Sultonylureas etc.

ALS Sulfonylureas etc.

CA I ALS Sulfonylureas etc.

C. 12 ALS SulfonylureaS etc.

C. 13 ACCase C. 14 ACCase C. 15 ACCase C. 16 ACCase C. 17 ACCase Crop Cotton Rice Brassica Potatoes Tomatoes C ucu rbits Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes 89 P rincipleLole rant to. Crop C. 18 C. 19 C .20 C.21 C .22 C.23 C.24 C.26 C.27 C.28 C.29 C.31 C.32 C.33 C.34 C.36 C.37 C.38 C.39 C.41 C.42 C.43 C.44 C .46 C.47 C.48 C.49 ACCase ACCase ACCase ACCase ACCase ACCase ACCase

HPPD

Nitrilase Nitrilase Nitrilase N itrilase Nitrilase Nitrilase Nitnilase N it rila se Nitrilase Nitril ase Nitrilase Nitrilase

IPS

Isoxaf lutol, Isoxachlotol, Sulcotrion, Mesotrion Isoxaflutol, Isoxachlotol, Isoxaf lutol, Isoxachlotol, Isoxaflutol, Isoxachlotol, Isoxaf lutol, Isoxachiotol, Isoxaflutol, Isoxachlotol, Isoxaf lutol, Isoxachlotol, Isoxaflutol, Isoxachlotol, Isoxaflutol, Isoxachlotol, Isoxaf lutol, Isoxachlotol, Sulcotrion, Mesotrion Sulcotrion, Mesotrion Sulcotrion, Mesotrion Sulcotrion, Mesotrion Sulcotrion, Mesotrion Sulcotrion, Mesotrion Sulcot rion, Mesotrion Sulcotrion, Mesotrion Sulcotrion, Mesotrion Cucurbits Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Isoxaflutol, Isoxachlotol, Sulcotrion, Isoxaflutol, Isoxachiotol, Sulcotrion, Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Bromoxynil, loxynil Chloroactanilides Mesotrion Mesotrion 90 Principle Tolerant to Crop C.51 C.52 C.53 C.54 C.56.

C.57 C.58 C.59 C .60 C.61 C.62 C.63 C.64 C.66 C.67 C.68 C.69 C.71 C.72 C.73 C.74 C.76 C.77 C.78 C.79 C.81

IPS

'PS

IFS

IPS

'PS.

IPS

HOM

PROTOX

P ROTOX P ROTOX

PROTOX

P ROTO> Chloroactanilides Chloroactanilide ChloroactanilideS Chloroactanilides ChloroactanilideS Chloroactanilides ChloroactanilideS ChioroactanilideS Chloroactanilides Chioroactanilides ChloroactanilideS 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P 2,4-D, Mecoprop-P Protox inhibitorsI/ Protox inhibitorsI/ Protox inhibitorsI/ Protox inhibitorsI/ Protox inhibitorsII Protox inhibitorsI/ Protox inhibitorsII Protox inhibitorsI/ Protox inhibitorsI/ Rice Brassica Potatoes Tomatoes Cucurbits Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucu rb its Soybeans Maize Wheat pome fruit stone fruit citrus Cotton Rice Brassica Potatoes Tomatoes Cucurbits Soybeans Maize Wheat -91- Crop "-83 PROTOX Protox inhibitors stI ome fruit 8 2 PRO TO X Protox inhibitors I sone f ruit :.84 PROTOX Protox inhibitors ffcitrus C' Z.85 EPSPS, Glyphosate and for Sulphosate Cotton 1- .6 ESP lpost n frSlhoaeRc C.87 EPSPS Glyphosate and /or Sulphosate Raic N C.88 EPSPS Glyphosate and /or Sulphosate Basc C-i C.898 PP lyhst and for Sulphosate Toatoes NC.89 EPSPS Glyphosate and for Sulphosate Cuomrats EPSPS Glyphosate and /or Sulphosate Soyubans C.91 EPSPS Glyphosate and /or Sulphosate Moaize C.93 EPSPS Glyphosate and for Sulphosate Whie C.93 EPSPS Glyphosate and for Sulphosate pomeaft C.94 EPSPS Glyphosate and for Sulphosate stone fruit C.96 EPSPS Glyphosate and for Sulphosate ctonru t C.96 GPSS Gluphosiate and for Blphos ctton C.97 GS Gluphosinate and for Bialaphos Ceto C.98 GS Gluphosiflate and for Bialaphos Raic C.990 GS Gluphosinate and for Bialaphos Poatoes C.100 GS Gluphosinate and for Bialaphos Toatoes C.101 GS Gluphosinate and for Bialaphos Cucurats C. 102 G S Gluphosinate and /or Bialaphos Soyubans C. 103 GS Gluphosinate and for Bialaphos Moaize C. 104 GS Gluphosinate and for Bialaphos Whie C. 105 GS Gluphosiflate and for Bialaphos pomeaft C. 106 G S Gluphosinate and /or Bialaphos stone fruit C. 107 GS Gluphosinate and for Bialaphos cstonru t Included are Sulfonylureas, Imidazolinofles, Triazolopyrimidines, Dirnethoxypyriflidines and N-Acylsulfoflarides: Sulfonylureas such as ChlorsulfuroIn, Chlorimuron, Ethamethsulfuron, Metsulfuron, Primisulfuron, Prosulfuror', Triasulfuron, Cinosulfuron, Trifusulfuron, Oxasulfuron, -92- SBensulfuron, Tribenuron, ACC 322140, Fluzasulfuron, Ethoxysulfuron, Fluzasdulfuron, 0 SNicosulfuron, Rimsulfuron, Thifensulfuron, Pyrazosulfuron, Clopyrasulfuron, NC 330, 0 Azimsulfuron, Imazosulfuron, Sulfosulfuron, Amidosulfuron, Flupyrsulfuron, CGA 362622 Imidazolinones such as imazamethabenz, Imazaquin, Imazamethypyr, Imazethapyr, 0 Imazapyr and Imazamox; O Triazolopyrimidines such as DE 511, Flumetsulam and Chloransulam; SDimethoxypyrimidines such as Pyrithiobac, Pyriminobac, Bispyribac and Pyribenzoxim.

Tolerant to Diclofop-methyl, Fluazifop-P-butyl, Haloxyfop-P-methyl, Haloxyfop-P-ethyl, Quizalafop-P-ethyl clodinafop propargyl, fenoxaprop -ethyl, Tepraloxydim, Alloxydim, Sethoxydim, Cycloxydim, Cloproxydim, Tralkoxydim, Butoxydim, Caloxydim, Clefoxydim, Clethodim.

Chloroacetanilides such as Alachlor Acetochlor, Dimethenamid Protox inhibitors: For instance diphenyethers such as Acifluorfen, Aclonifen, Bifenox, Chlornitrofen, Ethoxyfen, Fluoroglycofen, Fomesafen, Lactofen, Oxyfluorfen; Imides such as Azafenidin, Carfentrazone-ethyl, Cinidon-ethyl, Flumiclorac-pentyl, Flumioxazin, Fluthiacet-methyl, Oxadiargyl, Oxadiazon, Pentoxazone, Sulfentrazone, Imides and others,such as Flumipropyn, Flupropacil, Nipyraclofen and Thidiazimin; and further Fluazolate and Pyraflufen-ethyl Biological Examples Table 39: A method of controlling representatives of the genus Adoxophyes comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 40: A method of controlling representatives of the genus Agrotis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 41: A method of controlling Alabama argillaceae comprising the application of Abamrnectin to a herbicidally resistant transgenic crop, wherein the combination of the active -93-

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principle expressed by the transgenic plant and the crop to be protected against the pest z correspond to a line of the table C.

Table 42: A method of controlling Anticarsia gemmatalis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active OO principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 43: A method of controlling representatives of the genus Chilo comprising the Sapplication of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 44: A method of controlling Clysia ambiguella comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 45: A method of controlling representatives of the genus Cnephalocrocis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 46: A method of controlling Crocidolomia binotalis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 47: A method of controlling representatives of the genus Cydia comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 48: A method of controlling Diparopsis castanea comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-94- Table 49: A method of controlling representatives of the genus Earias comprising the 0 Sapplication of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

00 Table 50: A method of controlling representatives of the genus Ephestia comprising the 0 application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination t of the active principle expressed by the transgenic plant and the crop to be protected 'C against the pest correspond to a line of the table C.

o Table 51: A method of controlling representatives of the genus Heliothis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 52: A method of controlling Hellula undalis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 53: A method of controlling Keiferia lycopersicella comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 54: A method of controlling Leucoptera scitella comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 55: A method of controlling representatives of the genus Lithocollethis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 56: A method of controlling Lobesia botrana comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond

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z to a line of the table C.

Table 57: A method of controlling Ostrinia nubilalis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle 00 expressed by the transgenic plant and the crop to be protected against the pest correspond CO to a line of the table C.

Table 58: A method of controlling representatives of the genus Pandemis comprising the Sapplication of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 59: A method of controlling Pectinophora gossypiella comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 60: A method of controlling Phyllocnistis citrella comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 61: A method of controlling representatives of the genus Pieris comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 62: A method of controlling Plutella xylostella comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 63: A method of controlling representatives of the genus Scirpophaga comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-96- Sable 64: A method of controlling representatives of the genus Sesamia comprising the Z Lpplication of Abamectin to a herbicidally resistant transgenic crop, wherein the combination )f the active principle expressed by the transgenic plant and the crop to be protected igainst the pest correspond to a line of the table C.

0 able 65: A method of controlling representatives of the genus Sparganothis comprising the I application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination Sf the active principle expressed by the transgenic plant and the crop to be protected Sagainst the pest correspond to a line of the table C.

N Table 66: A method of controlling representatives of the genus Spodoptera comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 67: A method of controlling representatives of the genus Tortrix comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 68: A method of controlling Trichoplusia ni comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 69: A method of controlling representatives of the genus Agriotes comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 70: A method of controlling Anthonomus grandis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 71: A method of controlling representatives of the genus Curculio comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination -97 f the active principle expressed by the transgenic plant and the crop to be protected Z against the pest correspond to a line of the table C.

N Table 72: A method of controlling Diabrotica balteata comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active C principle expressed by the transgenic plant and the crop to be protected against the pest Scorrespond to a line of the table C.

S Table 73: A method of controlling representatives of the genus Leptinotarsa comprising the O application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination N of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 74: A method of controlling representatives of the genus Lissorhoptrus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 75: A method of controlling representatives of the genus Otiorhynchus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 76: A method of controlling representatives of the genus Aleurothrixus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 77: A method of controlling representatives of the genus Aleyrodes comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 78: A method of controlling representatives of the genus Aonidiella comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-98- Table 79: A method of controlling representatives of the family Aphididae comprising the 0 z application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination O\ of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

00 Table 80: A method of controlling representatives of the genus Aphis comprising the C application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination M of the active principle expressed by the transgenic plant and the crop to be protected in against the pest correspond to a line of the table C.

2 Table 81: A method of controlling Bemisia tabaci comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 82: A method of controlling representatives of the genus Empoasca comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 83: A method of controlling representatives of the genus Mycus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 84: A method of controlling representatives of the genus Nephotettix comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 85: A method of controlling representatives of the genus Nilaparvata comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 86: A method of controlling representatives of the genus Pseudococcus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the -99combination of the active principle expressed by the transgenic plant and the crop to be z protected against the pest correspond to a line of the table C.

Table 87: A method of controlling representatives of the genus Psylla comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination oO of the active principle expressed by the transgenic plant and the crop to be protected O against the pest correspond to a line of the table C.

Table 88: A method of controlling representatives of the genus Quadraspidiotus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the 0 combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 89: A method of controlling representatives of the genus Schizaphis comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 90: A method of controlling representatives of the genus Trialeurodes comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 91: A method of controlling representatives of the genus Lyriomyza comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 92: A method of controlling representatives of the genus Oscinella comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 93: A method of controlling representatives of the genus Phorbia comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

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-100- Table 94: A method of controlling representatives of the genus Frankliniella comprising the 0 Sapplication of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

0 o Table 95: A method of controlling representatives of the genus Thrips comprising the .C application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination tn of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

o Table 96: A method of controlling Scirtothrips aurantii comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 97: A method of controlling representatives of the genus Aceria comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 98: A method of controlling representatives of the genus Aculus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 99: A method of controlling representatives of the genus Brevipalpus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 100: A method of controlling representatives of the genus Panonychus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 101: A method of controlling representatives of the genus Phyllocoptruta comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the -101 combination of the active principle expressed by the transgenic plant and the crop to be

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z protected against the pest correspond to a line of the table C.

STable 102: A method of controlling representatives of the genus Tetranychus comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the 00 combination of the active principle expressed by the transgenic plant and the crop to be \0 protected against the pest correspond to a line of the table C.

STable 103: A method of controlling representatives of the genus Heterodera comprising the S application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 104: A method of controlling representatives of the genus Meloidogyne comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 105: A method of controlling Mamestra brassica comprising the application of Abamectin to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 106: A method of controlling representatives of the genus Adoxophyes comprising the application of Emamectin-Benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 107: A method of controlling representatives of the genus Agrotis comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 108: A method of controlling Alabama argillaceae comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-102- STable 109: A method of controlling Anticarsia gemmatalis comprising the application of 0 Z Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of Sthe active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

0 0 Table 110: A method of controlling representatives of the genus Chilo comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the Scombination of the active principle expressed by the transgenic plant and the crop to be Sprotected against the pest correspond to a line of the table C.

r Table 111: A method of controlling Clysia ambiguella comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 112: A method of controlling representatives of the genus Cnephalocrocis comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 113: A method of controlling Crocidolomia binotalis comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 114: A method of controlling representatives of the genus Cydia comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 115: A method of controlling Diparopsis castanea comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 116: A method of controlling representatives of the genus Earias comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the

I

-103combination of the active principle expressed by the transgenic plant and the crop to be Z protected against the pest correspond to a line of the table C.

N Table 117: A method of controlling representatives of the genus Ephestia comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the 00 combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

0 Table 118: A method of controlling representatives of the genus Heliothis of Emamectin- 3 benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active N principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 119: A method of controlling Hellula undalis comprising the application of Emamectinbenzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 120: A method of controlling Keiferia lycopersicella comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 121: A method of controlling Leucoptera scitella comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 122: A method of controlling representatives of the genus Lithocollethis comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 123: A method of controlling Lobesia botrana comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-104- Table 124: A method of controlling Ostrinia nubilalis comprising the application of 0 Z Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of 0 the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

oO Table 125: A method of controlling representatives of the genus Pandemis comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the t combination of the active principle expressed by the transgenic plant and the crop to be t protected against the pest correspond to a line of the table C.

Table 126: A method of controlling Pectinophora gossypiella comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 127: A method of controlling Phyllocnistis citrella comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 128: A method of controlling representatives of the genus Pieris comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 129: A method of controlling Plutella xylostella comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 130: A method of controlling representatives of the genus Scirpophaga comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 131: A method of controlling representatives of the genus Sesamia comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the -105combination of the active principle expressed by the transgenic plant and the crop to be Z protected against the pest correspond to a line of the table C.

N Table 132: A method of controlling representatives of the genus Sparganothis comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein oO the combination of the active principle expressed by the transgenic plant and the crop to be Sprotected against the pest correspond to a line of the table C.

S Table 133: A method of controlling representatives of the genus Spodoptera comprising the 0 application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the r combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 134: A method of controlling representatives of the genus Tortrix comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 135: A method of controlling Trichoplusia ni comprising the application of Emamectinbenzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 136: A method of controlling representatives of the genus Agriotes comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 137: A method of controlling Anthonomus grandis comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 138: A method of controlling representatives of the genus Curculio comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-106- Table 139: A method of controlling Diabrotica balteata comprising the application of 0 SEmamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

0 0 Table 140: A method of controlling representatives of the genus Leptinotarsa comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein t c the combination of the active principle expressed by the transgenic plant and the crop to be Sprotected against the pest correspond to a line of the table C.

c Table 141: A method of controlling representatives of the genus Lissorhoptrus comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 142: A method of controlling representatives of the genus Otiorhynchus comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 143: A method of controlling representatives of the genus Aleurothrixus comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 144: A method of controlling representatives of the genus Aleyrodes comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 145: A method of controlling representatives of the genus Aonidiella comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 146: A method of controlling representatives of the family Aphididae comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the -n -107-

O

0 combination of the active principle expressed by the transgenic plant and the crop to be Sprotected against the pest correspond to a line of the table C.

Table 147: A method of controlling representatives of the genus Aphis comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the 00 combination of the active principle expressed by the transgenic plant and the crop to be 'sO protected against the pest correspond to a line of the table C.

Table 148: A method of controlling Bemisia tabaci comprising the application of Emamectinbenzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 149: A method of controlling representatives of the genus Empoasca comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 150: A method of controlling representatives of the genus Mycus comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 151: A method of controlling representatives of the genus Nephotettix comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 152: A method of controlling representatives of the genus Nilaparvata comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 153: A method of controlling representatives of the genus Pseudococcus comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-108- Table 154: A method of controlling representatives of the genus Psylla comprising the 0 z application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

oO Table 155: A method of controlling representatives of the genus Quadraspidiotus CO comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic M crop, wherein the combination of the active principle expressed by the transgenic plant and I) the crop to be protected against the pest correspond to a line of the table C.

O

Table 156: A method of controlling representatives of the genus Schizaphis comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 157: A method of controlling representatives of the genus Trialeurodes comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 158: A method of controlling representatives of the genus Lyriomyza comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 159: A method of controlling representatives of the genus Oscinella comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 160: A method of controlling representatives of the genus Phorbia comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 161: A method of controlling representatives of the genus Frankliniella comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the tn- 109-

O

combination of the active principle expressed by the transgenic plant and the crop to be Sprotected against the pest correspond to a line of the table C.

Table 162: A method of controlling representatives of the genus Thrips comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the 00 combination of the active principle expressed by the transgenic plant and the crop to be O protected against the pest correspond to a line of the table C.

t C Table 163: A method of controlling Scirtothrips aurantii comprising the application of n Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of O the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 164: A method of controlling representatives of the genus Aceria comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 165: A method of controlling representatives of the genus Aculus comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 166: A method of controlling representatives of the genus Brevipalpus comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 167: A method of controlling representatives of the genus Panonychus comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 168: A method of controlling representatives of the genus Phyllocoptruta comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-110- STable 169: A method of controlling representatives of the genus Tetranychus comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein 0 the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

00 Table 170: A method of controlling representatives of the genus Heterodera comprising the 'O application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the tM combination of the active principle expressed by the transgenic plant and the crop to be Vi) protected against the pest correspond to a line of the table C.

O Table 171: A method of controlling representatives of the genus Meloidogyne comprising the application of Emamectin-benzoate to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 172: A method of controlling representatives of the genus Adoxophyes comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 173: A method of controlling representatives of the genus Agrotis comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 174: A method of controlling Alabama argillaceae comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 175: A method of controlling Anticarsia gemmatalis comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 176: A method of controlling representatives of the genus Chilo comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination -111of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 177: A method of controlling Clysia ambiguella comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active 00 principle expressed by the transgenic plant and the crop to be protected against the pest 0 correspond to a line of the table C.

Table 178: A method of controlling Crocidolomia binotalis comprising the application of SSpinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 179: A method of controlling representatives of the genus Cydia comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 180: A method of controlling Diparopsis castanea comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 181: A method of controlling representatives of the genus Earias comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 182: A method of controlling representatives of the genus Ephestia comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 183: A method of controlling representatives of the genus Heliothis of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-112- Table 184: A method of controlling Hellula undalis comprising the application of Spinosad to 0 Sa herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

0 0 Table 185: A method of controlling Keiferia lycopersicella comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active

C

c principle expressed by the transgenic plant and the crop to be protected against the pest k correspond to a line of the table C.

Table 186: A method of controlling Leucoptera scitella comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 187: A method of controlling representatives of the genus Lithocollethis comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 188: A method of controlling Lobesia botrana comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 189: A method of controlling Ostrinia nubilalis comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 190: A method of controlling representatives of the genus Pandemis comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 191: A method of controlling Pectinophora gossypiella comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active -113- Sprinciple expressed by the transgenic plant and the crop to be protected against the pest Z correspond to a line of the table C.

Table 192: A method of controlling Phyllocnistis citrella comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active oO principle expressed by the transgenic plant and the crop to be protected against the pest O correspond to a line of the table C.

r n Table 193: A method of controlling representatives of the genus Pieris comprising the Sapplication of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 194: A method of controlling Plutella xylostella comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 195: A method of controlling representatives of the genus Scirpophaga comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 196: A method of controlling representatives of the genus Sesamia comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 197: A method of controlling representatives of the genus Sparganothis comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 198: A method of controlling representatives of the genus Spodoptera comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-114- Table 199: A method of controlling representatives of the genus Tortrix comprising the 0 Z application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

00 Table 200: A method of controlling Trichoplusia ni comprising the application of Spinosad to C a herbicidally resistant transgenic crop, wherein the combination of the active principle CfM expressed by the transgenic plant and the crop to be protected against the pest correspond I) to a line of the table C.

O Table 201: A method of controlling representatives of the genus Agriotes comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 202: A method of controlling Anthonomus grandis comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 203: A method of controlling representatives of the genus Curculio comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 204: A method of controlling Diabrotica balteata comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 205: A method of controlling representatives of the genus Leptinotarsa comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 206: A method of controlling representatives of the genus Lissorhoptrus comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the -115-

O

combination of the active principle expressed by the transgenic plant and the crop to be z protected against the pest correspond to a line of the table C.

a' Table 207: A method of controlling representatives of the genus Otiorhynchus comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the oO combination of the active principle expressed by the transgenic plant and the crop to be O protected against the pest correspond to a line of the table C.

C Table 208: A method of controlling representatives of the genus Aleurothrixus comprising n the application of Spinosad to a herbicidally resistant transgenic crop, wherein the 0 combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 209: A method of controlling representatives of the genus Aleyrodes comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 210: A method of controlling representatives of the genus Aonidiella comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 211: A method of controlling representatives of the family Aphididae comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 212: A method of controlling representatives of the genus Aphis comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 213: A method of controlling Bemisia tabaci comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

1 -116- Table 214: A method of controlling representatives of the genus Empoasca comprising the 0 Sapplication of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

oO Table 215: A method of controlling representatives of the genus Mycus comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 216: A method of controlling representatives of the genus Nephotettix comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 217: A method of controlling representatives of the genus Nilaparvata comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 218: A method of controlling representatives of the genus Pseudococcus comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 219: A method of controlling representatives of the genus Psylla comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 220: A method of controlling representatives of the genus Quadraspidiotus comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 221: A method of controlling representatives of the genus Schizaphis comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination -117of the active principle expressed by the transgenic plant and the crop to be protected 0 Z against the pest correspond to a line of the table C.

STable 222: A method of controlling representatives of the genus Trialeurodes comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the 0 0 combination of the active principle expressed by the transgenic plant and the crop to be

C\

NO protected against the pest correspond to a line of the table C.

N Table 223: A method of controlling representatives of the genus Lyriomyza comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination i of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 224: A method of controlling representatives of the genus Oscinella comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 225: A method of controlling representatives of the genus Phorbia comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 226: A method of controlling representatives of the genus Frankliniella comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 227: A method of controlling representatives of the genus Thrips comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 228: A method of controlling Scirtothrips aurantii comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

-118- Table 229: A method of controlling representatives of the genus Aceria comprising the 0 z application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

00 Table 230: A method of controlling representatives of the genus Aculus comprising the C application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination M of the active principle expressed by the transgenic plant and the crop to be protected n against the pest correspond to a line of the table C.

0 Table 231: A method of controlling representatives of the genus Brevipalpus comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 232: A method of controlling representatives of the genus Panonychus comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 233: A method of controlling representatives of the genus Phyllocoptruta comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 234: A method of controlling representatives of the genus Tetranychus comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 235: A method of controlling representatives of the genus Heterodera comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active principle expressed by the transgenic plant and the crop to be protected against the pest correspond to a line of the table C.

Table 236: A method of controlling representatives of the genus Meloidogyne comprising the application of Spinosad to a herbicidally.resistant transgenic crop, wherein the -119- :ombination of the active principle expressed by the transgenic plant and the crop to be 0 z protected against the pest correspond to a line of the table C.

N Table 237: A method of controlling Mamestra brassica comprising the application of Spinosad to a herbicidally resistant transgenic crop, wherein the combination of the active 00 principle expressed by the transgenic plant and the crop to be protected against the pest .0 correspond to a line of the table C.

t Examlep B1: Action against Anthonomus orandis adults. Spodoptera littoralis or Heliothis i virescens 8 Young transgenic cotton plants which express the 8-endotoxin CrylllA are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of emamectin-benzoate respectively. After the spray coating has dried on, the cotton plants are populated with adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants which have been treated with an emulsion spray mixture comprising emamectin-benzoate and conventional CryllIA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively..

In this test, the control of the tested insects in the transgenic plant is superior, while it is insufficient in the non-transgenic plant.

Example B2: Action against Anthonomus grandis adults. Spodoptera littoralis or Heliothis virescens Young transgenic cotton plants which express the 5-endotoxin CrylllA are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of abamectin respectively. After the spray coating has dried on, the cotton plants are populated with adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants n -120-

O

which have been treated with an emulsion spray mixture comprising abamectin and conven- Stional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.

SIn this test, the control of the tested insects in the transgenic plant is superior, while it is insufficient in the non-transgenic plant.

00 Example B3: Action against Anthonomus grandis adults, Spodoptera littoralis or Heliothis

\D

virescens Young transgenic cotton plants which express the 8-endotoxin CrylllA are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of spinosad respectively.

After the spray coating has dried on, the cotton plants are populated with 10 adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants which have been treated with an emulsion spray mixture comprising spinosad and conventional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.

Example 84: Action against Anthonomus grandis adults. Spodoptera littoralis or Heliothis virescens Young transgenic cotton plants which express the 5-endotoxin Cryla(c) are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of spinosad respectively.

-121 Example B5: Action against Anthonomus grandis adults, Spodoptera littoralis or Heliothis O0 Z virescens Young transgenic cotton plants which express the 8-endotoxin Cryla(c) are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of abamectin oo respectively. After the spray coating has dried on, the cotton plants are populated with adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae m respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the Sfeeding damage on the transgenic cotton plants with that of non-transgenic cotton plants which have been treated with an emulsion spray mixture comprising abamectin and conventional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.

Example B6: Action against Anthonomus arandis adults, Spodoptera littoralis or Heliothis virescens Young transgenic cotton plants which express the 8-endotoxin Cryla(c) are sprayed with an aqueous emulsion spray mixture comprising 100, 50, 10, 5, 1 ppm of emamectin benzoate respectively. After the spray coating has dried on, the cotton plants are populated with adult Anthonomus grandis, 10 Spodoptera littoralis larvae or 10 Heliothis virescens larvae respectively and introduced into a plastic container. Evaluation takes place 3 to 10 days later. The percentage reduction in population, or the percentage reduction in feeding damage action), is determined by comparing the number of dead beetles and the feeding damage on the transgenic cotton plants with that of non-transgenic cotton plants which have been treated with an emulsion spray mixture comprising emamectin benzoate and conventional CrylllA-toxin at a concentration of in each case 100, 50, 10, 5, 1 ppm respectively.

Example B7: Action against Ostrinia nubilalis. Spodoptera spp. or Heliothis spp.

A plot planted with maize cv. KnockOut® and an adjacent plot of the same size which is planted with conventional maize, both showing natural infestation with Ostrinia

I

-122- Subilalis. Sodootera s or Heliothis, are sprayed with an aqueous emulsion spray mixture S:omprising 200, 100, 50, 10, 5, 1ppm of spinosad. Immediately afterwards, plot is a reated with an emulsion spray mixture comprising 200, 100, 50, 10, 5, 1 ppm of the endotoxin expressed by KnockOut®. Evaluation takes place 6 days later. The percentage 00 reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot N Improved control of strinia nubilalis Sodtera or Heliothis is observed on the plants O of plot while plot shows a control level of not over SExamle Action aqainst Ostrinia nubilalis, Sodoptera or Heiothis sp A plot planted with maize cv. KnockOut® and an adjacent plot of the same size which is planted with conventional maize, both showing natural infestation with Ostrinia nubilali Sodotera s or Heliothis, are sprayed with an aqueous emulsion spray mixture comprising 200, 100, 50, 10, 5, 1ppm of abamectin. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 200, 100, 50, 10, 5, 1 ppm of the endotoxin expressed by KnockOut®. Evaluation takes place 6 days later. The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Ostrinia nubilalis, SDodootera sp or Heliothis is observed on the plants of plot while plot shows a control level of not over Examle 9: Action against Ostrinia nubilalis. Sodoptera so or Heliothis sp A plot planted with maize cv. KnockOut® and an adjacent plot of the same size which is planted with conventional maize, both showing natural infestation with Ostrinia nubilalis Sodoptera s or Heliothis, are sprayed with an aqueous emulsion spray mixture comprising 200, 100, 50, 10, 5, 1ppm of emamectin benzoate. Immediately afterwards, plot is treated with an emulsion spray mixture comprising 200, 100, 50, 10, 5, 1 ppm of the endotoxin expressed by KnockOut®. Evaluation takes place 6 days later. The percentage reduction in population action) is determined by comparing the number of dead pests on the plants of plot with that on the plants of plot Improved control of Ostrinia nubilalis. Spodoptera sp or Heliothis is observed on the plants of plot while plot shows a control level of not over -123-

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SThe invention further relates to oO A method of protecting plant propagation material and plant organs formed at a later a\ point in time from attack by pests, characterized in that

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Mq a pesticide comprising, as pesticidally active compound, at least one macrolide compound, I especially abamectin, emamectin or spinosad in free form or in agrochemically utilizable salt S form as active ingredient and at least one auxiliary in close spatial proximity to, or spatially together with, planting or applying the propagation material is employed to the site of planting or sowing; the corresponding use of these compounds, corresponding pesticides whose active ingredient is selected from amongst these compounds, a method of producing and using these compositions, and plant propagation material thus protected against attack by pests.

The macrolides used according to the invention are known to those skilled in the art. They are the classes of substances as mentioned under invention part Abamectin and emamectin are preferred.

Agrochemically utilizable salts of the macrolides according to the invention are, for example, the same as under invention part In the case of abamectin, the free form is preferred in the frame of invention part Especially preferred within the scope of the invention part is a method in which emamectin is employed in free form or as agrochemically acceptable salt; especially as salt; in particular as the benzoate, substituted benzoate, benzenesulphonate, citrate, phosphate, tartrate or maleate; preferably as the benzoate or benzenesulphonate, especially preferably as the benzoate.

The scope of the subject-matter of the invention extends in particular to representatives of the classes Insecta, Arachnida and Nematoda.

These are mainly insects of the order Lepidoptera, for example Acleris spp., Adoxophyes spp., Aegeria spp., Agrotis spp., Alabama argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp., Argyrotaenia spp., Astylus atromaculatus, Autographa spp., Busseola fusca, Cadra cautella, Carposina nipponensis, Chilo spp., Choristoneura spp., Clysia ambiguella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp., -124- >-Coleophora spp., Crocidolomia binotalis, Cryptophiebia leucotreta, Cydia spp., Diatraea.

0 Zspp., Diparopsis castanea, Eanias spp., Ephestia spp., Eucosma spp., Eupoecilia a'ambiguella, Euproctis spp., Euxoa spp., Grapholita spp., Hedya nubiferana, Heliothis spp., Hellula undalis, Heteronychus arator, Hyphantria cunea, Keiferia, lycopersicella, Leucoptera 00 scitella, Lithocollethis spp., Lobesia botrana, Lymantria spp., Lyonetia spp., Malacosoma Sspp., Mamestra brassicae, Manduca sexta, Operophtera spp., Ostrinia nubilalis, Pammene Sspp., Pandemnis spp., Panolis 'IaTmmea, Pectinophora gossypiella, Phthorimaea operculella, SPieris rapae, Pieris spp., Plutella xylostella, Prays spp., Scirpophaga spp., Sesamia spp., SSparganothis spp., Spodloptera spp., Synanthedon spp., Thaumetopoea spp., Toririx spp., Trichoplusia ni and Yponomeuta spp.; of the order Coleoptera, for example Agriotes spp., Anthonomus spp., Atomaria linearis, Chaetocnema tibialis, Cosmopolites spp., Curculio spp., Dermestes spp., Diabrotica spp., Epilachna spp., Eremnus spp., Leptinotarsa decemlineata, Lissorhoptrus spp., Melolontha spp., Orycaephilus spp., Otiorhync hus spp., Phlyctinus spp., Popillia spp., Psylliodes spp., Rhizopertha spp., Scarabeidae, Sitophilus spp., Sitotroga spp., Tenebrio spp., Triboliumn spp. and Trogoderma spp.; of the order Orthoptera, for example Blatta spp., Blattella spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Periplaneta spp. and Schistocerca spp.; of the order Psocoptera, for example Liposcelis spp.; of the order Anoplura, for example Haemnatopinus spp., Linognathus spp., Pediculus spp., Pemphigus spp. und Phylloxera spp.; of the order Mallophaga, for example Damalinea spp. and Trichodectes spp.; of the order Thysanoptera, for example Frankliniella spp., Hercinothrips spp., Taeniothrips spp., Thrips palmi, Thrips tabaci and Scirtothrips aurantil; of the order Heteroptera, for example Cimex spp., Distantiella theobroma, Dysdlercus spp., Euchistus spp. Eurygaster spp. Leptoconisa spp., Nezara spp., Piesma spp., Rhodnius spp., Sahlbergella singularis, Scotinophara spp. and Triatoma spp.; of the order Homoptera, for example Aleurothrixus floccosus, Aleyrodes brassicae, Aonidliella spp., Aphididae, Aphis spp., Aspidiotus spp., Bemisia tabaci, Ceroplaster spp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Coccus hesperidlum, Empoasca spp., Eriosoma larigerum, Erythroneura spp., Gascardia spp., Laodelphax spp., Lecaniumn 125- >-corni, Lepidosaphes spp., Macrosiphus spp., Myzus spp., Nephotettix spp., Nilaparvata 0 Zspp., Paratoria spp., Pemphigus spp., Planococcus spp., Pseudaulacaspis spp., a'Pseudococcus spp., Psylla spp., Pulvinaria aethiopica, Quadraspidiotus spp., Rhopalosiphum spp., Saissetia spp., Scaphoideus spp., Schizaphis spp., Sitobion spp., 00 Trialeurodes vaporariorum, Trioza erytreae, and Unaspis citri;.

Sof the order Hymenoptera, for example Acromyrmex, Atta spp., Cephus spp., Diprion spp., SDiprionidae, Gilpinia polytoma, Hoplocampa spp., Lasius spp., Ivonomorium pharaonis, SNeodiprion spp., Solenopsis spp. and Vespa spp.; of the order Diptera, for example Aedes spp., Antherigona soccata, Bibio hortulanus, Calliphora erythrocephala, Ceratitis spp., Chrysomyia spp., Culex spp., Cutereb ra spp., Dacus spp., Drosophila melanogaster, Fannia spp., Gastrophilus spp., Glossina spp., Hypoderma spp., Hyppobosca spp., Liriomyza spp., Lucilia spp., Melanagromyza spp., Musca spp., Oestrus spp., Orseolia spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Rhagoletis pomonella, Sciara spp., Stomoxys spp., Tabanus spp., Tannia spp. and Tipula spp.; of the order Siphonaptera, for example Ceratophyllus spp. and Xenopsylla cheopis; or of the order Thysanura, for example Lepisma saccharina.

Amongst the class Arachnida, they are preferably representatives of the order Acarina, for example Acarus siro, Aceria sheldoni, Acutus schlechtendali, Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae, Eotetranychus carpini, Eriophyes spp., Hyalomma spp., Ixodes spp., Olygonychus pratensis, Ornithodoros spp., Panonychus spp., Phyllocoptruta oleivora, PolyphagotarSonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Tarsonemus spp. and Tetranychus spp..

Especially preferred is the control of insects of the orders Coleoptera and Lepidoptera; in the order Colepotera especially the genera and species Agriotes spp., Anthonomnus spp., Atomaria linearis, Chaetocnema tibialis, Diabrotica spp. and Leptinotarsa decemlineata; in the order Lepidoptera the genera and species Adoxophyes spp., Agrotis spp., Alabama argillaceae, Anticarsia gemnmatalis, Chilo spp., Cydia spp., Ephestia spp., Heliothis spp., Keiferia lycopersicella, Mamnestra. brassicae, Pectinophora gossypiella, Plutella xylostella, Sesamia spp., Spodoptera spp., Tortrix spp., and Trichoplusia.

-126- A further preferred subject according to the invention part is the control of repre- Z sentatives of the class Nematoda, such as root knot nematodes, stem eelworms and foliar Snematodes; especially Heterodera spp., for example Heterodera schachtii, Heterodora avenae and oO Heterodora trifolii; Globodera spp., for example Globodera rostochiensis; Meloidogyne spp., O for example Meloidogyne incoginita and Meloidogyne javanica; Radopholus spp., for Sexample Radopholus similis; Pratylenchus, for example Pratylenchus neglectans and SPratylenchus penetrans; Tylenchulus, for example Tylenchulus semipenetrans; Longidorus, Trichodorus, Xiphinema, Ditylenchus, Aphelenchoides and Anguina, in particular Meloidogyne, for example Meloidogyne incognita, and Heterodera, for example Heterodera glycines.

The macrolides used according to the invention are preventatively and/or curatively valuable active ingredients in the fields of insect control, even at low application rates, while being well tolerated by warm-blooded species, fish, beneficials and plants. The active ingredients used according to the invention are effective against all or individual development stages of normally sensitive, but also resistant, pests. The action of the active ingredients used according to the invention may become apparent directly, i.e. in the form of destruction of the pests, which occurs immediately or only after some time has elapsed, for example during ecdysis, or indirectly, for example as a reduced oviposition and/or hatching rate, the good action corresponding to a destruction rate (mortality) of at least to With the aid of the active ingredients used in accordance with the invention part it is possible to control, i.e. contain or destroy, pests which occur on plant propagation material, mainly on propagation material of useful plants and ornamentals in agriculture, in horticulture and in forests, and even plant organs which grow at a later point in time are still protected from these pests, that is to say the protection lasts, for example, until resistant mature plants have developed, and where the propagation material, or the plants developing therefrom, are protected not only from pests which attack the aerial plant organs, but also from soil-dwelling pests.

Suitable plant propagation material in the invention part that is, for example, seedlings, rhizomes, nursery plants, cuttings or, in particular seed (seeds), such as fruit, tubers, kerels or bulbs, are, in particular, propagation material of cereals, such as wheat, barley, rye, oats, rice, maize or sorghum; beet, such as sugar or fodder beet; fruit, for example -127me fruit, stone fruit and soft fruit, for example apples, pears, plums, peaches, almonds, Z ,erries or berries, for example strawberries, raspberries and blackberries; legumes, such s beans, lentils, peas or soya beans, oil crops, such as oilseed rape, mustard, poppies, lives, sunflowers, coconut, castor-oil plants, cacao or peanuts; cucurbits, such as 00 umpkins, cucumbers or melons; fibre plants, such as cotton, flax, hemp or jute; citrus fruit, ;O uch as oranges, lemons, grapefruit or mandarins; vegetables, such as spinach, lettuce, i sparagus, cabbage species, carrots, onions, tomatoes, potatoes or capsicums; Lauraceae, V ;uch as avocado, Cinnamonium or camphor; or tobacco, nuts, coffee, egg plants, sugar S:;ane, tea, pepper, grapevines, hops, Musaceae, latex plants or ornamentals; especially of cereals, rice, cotton, maize, soya beans, oilseed rape, vegetables, potatoes, sunflowers, sugar beet and sorghum.

The genetically modified propagation material is preferably propagation material, in particular seed, which contains one or more genes expressing a pesticidal resistance, in particular an insecticidal or acaricidal, but also a fungicidal or nematocidal, resistance, which make the plant resistant to herbicides, which lead to increased resistance to plant diseases or which introduce other agronomically advantageous properties into the plant.

Such plants, or their propagation material, are in particular those which contain a gene derived from a Bacillus thuringiensis and which encode an insecticidally active protein or contain a gene. These are, especially, genetically modified plant propagation materials of potatoes, alfalfa, cereals, such as wheat, barley, rye, oats, rice, maize or sorghum; legumes, such as beans, lentils, peas or soya beans; beet such as sugar or fodder beet; oil crops, such as oilseed rape, mustard, poppies, olives, sunflowers, coconut, castor-oil plant, cacao or peanuts; cucurbits, such as pumpkins, cucumbers or melons; fibre plants, such as cotton, flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruit or mandarins; vegetables, such as spinach, lettuce, asparagus, cabbage species, carrots, onions or tomatoes.

Examples of the genetically modified plant propagation material mentioned are, for example, the commercially available products Maximizer" (KnockOute), Yieldgard*, Roundup Ready Soybeans', TC Blend" or NuCOTN 33B all of which are known to those skilled in the art.

-128- Other fields of application for the active ingredients used in accordance with the invention

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Z part are, for example, the protection of stored products or stores or in the hygiene sector; in particular the protection of domestic animals or productive livestock from pests.

The invention of subject-matter therefore also relates to corresponding pesticides for Suse, to be selected depending on the intended aims and the prevailing circumstances, such Sas emulsifiable concentrates, suspension concentrates, directly sprayable or dilutable Ssolutions, spreadable pastes, dilute emulsions, sprayable powders, soluble powders, dispersible powders, wettable powders, dusts, granules or encapsulations in polymeric substances which comprise at least one of the active ingredients used in accordance with the invention, and to the use of these insecticidal compositions for use in a method.

Preferred is a composition which comprises only one macrolide compound, especially emamectin or a salt thereof.

In these compositions, the active ingredient is employed in pure form, for example a solid active ingredient in a particular particle size or, preferably, together with at least one of the auxiliaries conventionally used in the art of formulation, such as extenders, for example solvents or solid carriers, or such as surface-active compounds (surfactants).

Suitable auxiliaries such as solvents, solid carriers, surface-active compounds, non-ionic surfactants, cationic surfactants and anionic surfactants in the compositions employed in accordance with the invention are, for example, those which have been described in EP-A-736 252.

Liquid formulations for the treatment of plant propagation material according to invention part especially of seed, comprise, for example, surface-active substances (1 15% by weight), such as ethoxylated tristyrenephenols and their salts, alkyl polyglycol ether ethoxylates, polyoxypropylene/polyoxyethylene copolymers, the sodium salt of lignosulphonic acid, salts of polynaphthalenesulphonic acid and alkylbenzenesulphonic acid triethanolamine salt; antifreeze agents (5 such as, for example, DL-propane-1,2-diol or propane-1,2,3triol; colourants (1 such as pigments or water-soluble dyes; antifoams (0.05 such as polydimethylsiloxane; coatings (1 such as polyethylene glycol, polyvinyl acetate, polyvinylpyrrolidone, polyacrylate; -129preservatives 0.1 such as 1,2-benzoisothiazol-3-one;

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Z thickeners (0.1 such as heteropolysaccharide; and Ssolvents, such as water.

Solid formulations for the treatment of plant propagation material, especially of seed, 00 comprise, for example: I surface-active substances 1- such as alkyl polyglycol ether ethoxylate, c polyoxypropylene/polyoxyethylene copolymers, the sodium salt of lignosulphonic acid, salts n of polynaphthalenesulphonic acid; O colourants (1 such as pigments or water-soluble dyes; antifoams such as polydimethylsiloxane; coatings 1 such as polyethylene glycol or cellulose; and carriers (to 100% such as silica powder, talc powder, clays and the like.

As a rule, the compositions comprise 0.1 to 99%, in particular 0.1 to 95%, of active ingredient and 1 to 99.9%, in particular 5 to 99.9%, of at least one solid or liquid auxiliary, it being possible, as a rule, for 0 to 25%, in particular 0.1 to 20%, of the compositions to be surfactants is in each case per cent by weight). While concentrated compositions are more preferred as commercially available goods, the end consumer will use, as a rule, dilute compositions having much lower concentrations of active ingredient.

Preferred compositions, such as emulsifiable concentrations, dusts, suspension concentrates, wettable powders and granules have, for example, those compositions which are mentioned in EP-A-736 252.

The compositions according to the invention part can also comprise other solid or liquid auxiliaries, such as stabilizers, for example unepoxidized or epoxidized vegetable oils (for example epoxidized coconut oil, rapeseed oil or soya oil), antifoams, for example silicone oil, preservatives, viscosity regulators, binders and/or tackifiers, and also fertilizers or other active ingredients for achieving specific effects, for example bactericides, nematicides, molluscides or selective herbicides.

The action of the compositions according to the invention part can be broadened considerably by adding other, for example insecticidally, acaricidally and/or fungicidally active, ingredients and adapted to prevailing circumstances. Suitable additions of insecticidally and acaricidally active ingredients are, for example, representatives of the following classes of active ingredients: organophosphorus compounds, nitrophenols and

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130- Sderivatives, formamidines, triazine derivatives, nitroenamine derivatives, nitro- and Z cyanoguanidine derivatives, ureas, benzoylureas, carbamates, pyrethroids, chlorinated N hydrocarbons and Bacillus thuringiensis products. Especially preferred components in mixtures are NI-25, TI-304, TI-435, MTI-446, fipronil, lufenuron, pyripfoxyfen, thiacloprid, 00 fluxofenime; imidacloprid, thiamethoxam, fenoxycarb, diafenthiuron, pymetrozine, diazinon, '0 disulphoton; profenofos, furathiocarb, cyromazin, cypermethrin, tau-fluvalinate, tefluthrin or M Bacillus thuringiensis products, very especially Ni-25, TI-304, TI-435, MTI-446, fipronil, in thiacloprid, imidacloprid, thiamethoxam and tefluthrin.

o Examples of suitable additions of fungicidally active ingredients are the following compounds: azoxystrobin; bitertanol; carboxin; Cu 2 0; cymoxanil; cyproconazole; cyprodinil; dichlofluamid; difenoconazole; diniconazole; epoxiconazole; fenpiclonil; fludioxonil; fluquiconazole; flusilazole; flutriafol; furalaxyl; guazatin; hexaconazole; hymexazol; imazalil; imibenconazole; ipconazole; kresoxim-methyl; mancozeb; metalaxyl; R-metalaxyl; metconazole; oxadixyl, pefurazoate; penconazole; pencycuron; prochloraz; propiconazole; pyroquilone; SSF-109; spiroxamin; tebuconazole; teflutrin; thiabendazole; tolifluamide; triazoxide; triadimefon; triadimenol; triflumizole; triticonazole and uniconazole.

The compositions to be used according to the invention part are prepared in a known manner, for example in the absence of auxiliaries by grinding and/or screening, for example to a particular particle size, or by compressing a solid active ingredient, and in the presence of at least one auxiliary, for example by intimately mixing and/or grinding the active ingredient with the auxiliary/auxiliaries. These methods for preparing the compositions according to the invention and the use of macrolides for preparing these compositions are also subjects of the invention.

The application methods according to the invention part for the protection of plant propagation material, which, in accordance with the invention, is any plant material capable of developing complete plants after planting or sowing to the site of planting or sowing, for example seedlings, rhizomes, nursery plants, cuttings or, in particular, seed (seeds), such as fruits, tubers, kernels or bulbs, against attack by pests are characterized in that, for example, suitable compositions are applied in such a manner that they are applied in close spatial proximity to, or spatially together with, planting or sowing the propagation material to the site of planting or sowing. Application of these compositions in close spatial proximity to planting or sowing the propagation material to the site of planting or sowing takes place in accordance with the invention, preferably prior to planting or sowing the propagation 1 -131 o material, by applying the compositions by soil application directly to the site where the Z propagation material has been planted or sown, for example preferably prior to sowing into Sthe seed furrow or to a closely delimited area around the site of planting or sowing the propagation material. Application of such compositions, which takes place spatially together 00 with planting or applying the propagation material to the site of planting or sowing is to be understood as meaning that propagation material which has been pretreated with these Scompositions is planted or sown at the site of planting or sowing, it being possible, depending on the intended aims and prevailing circumstances, for the pretreatment of the propagation material to be effected for example by spraying, atomizing, dusting or scattering the compositions over the propagation material or brushing or pouring the compositions over the propagation material or, in the event of seed, in particular also by dressing the seed. When carrying out seed dressing, which is preferred according to the invention, i.e. dry seed, wet seed-dressing, liquid seed-dressing or slurry dressing, a suitable pesticide is added to the seed prior to sowing in a seed-dressing apparatus and the composition is distributed uniformly over the seed, for example by stirring the contents of the seed-dressing apparatus and/or by rotating and/or shaking the entire seed-dressing apparatus. Particular embodiments of such a seed-dressing treatment comprise, for example, immersing the seed in a liquid composition, coating the seed with a solid composition (seed coating) or by achieving penetration of the active ingredient into the seed by adding the composition to the water used for pre-soaking the seed (seed soaking).

Typical application rates for the compositions used in the seed-dressing treatment according to the invention are, for example, between 0.1 and 100 g of active ingredient per 100 kg of seed, in particular between 1 and 60 g 100 kg of seed, preferably between 4 and 40g 100 kg of seed.

The seed-dressing treatment according to invention part comprises, in particular, that due to the low toxicity of the active ingredient used, good tolerance by birds of the dressed seed is observed, for example, in the case of birds which, being seed-eaters in the open countryside, tend to take seed from freshly seeded fields, such as buntings, blackbirds, thrushes, ducks, pheasants, finches, geese, linnets, chickens, crows, skylarks, tits, seagulls, ravens, partridges, wood pigeons, goldfinches, pigeons or siskins. The seeddressing treatment according to the invention also extends to the dressing of stored seed.

The commercial plant propagation material which has been pretreated according to invention part is another subject of the invention.

-132- O _xamples of formulations of macrolide compounds which can be used in the method Z iccording to the invention that is to say solutions, granules, dusts, sprayable powders, mulsion concentrates, coated granules and suspension concentrates, are of the type as ias been described in, for example, EP-A-580 553, Examples F1 to 00 Example Fl: General procedure for liquid seed dressing C The required amount of liquid formulation is placed into an Erlenmeyer flask. The flask is N shaken to distribute the liquid on the entire bottom of the vessel. The required amount of O seed is introduced into the flask immediately thereafter. The flask is shaken vigorously by N hand for approximately one minute so that all the seed is covered with liquid. The contents of the flask are turned out onto a drying rack and dried in an oven.

Example F2: General procedure for dry seed dressing Various wide-necked flasks are each filled with the same number of seed kernels, and each flask is charged with such an amount of wettable powder that the desired amount of active ingredient per seed kernel (for example 0.03, 0.1 or 0.3 mg per kernel) is obtained. The flasks are placed on a roller and rotated for three minutes at 80 rotations/minute. The seed kernels which are attached to the walls of the flasks are then disengaged by shaking by hand, and the flasks are rotated in the opposite direction for three minutes.

Biological examples per cent by weight, unless otherwise specified) Example B4: Seed-dressing action against first-instar larvae of Spodoptera littoralis on maize leaves Maize seeds which have been dressed as described in procedure F1 are sown. 12, 19, 26, 33, 40 and 47 days after sowing, sections 5 to 8 cm in length of the top-most leaves of the plants are placed in glass beakers and infested with a predetermined quantity of a suspension of freshly hatched L1 larvae of Spodoptera littoralis. The beakers are closed with a lid and kept at 25 0 C, a relative atmospheric humidity of 60% and a day-light cycle of 16 hours. Evaluation takes place three to five days after infestation. The percentage reduction in population action) is determined by comparing the number of surviving larvae on the plants grown from dressed seeds and from untreated seeds.

Example B5: Seed-dressing action against adult Diabrotica balteata on sugar beet leaves Seeds of sugar beet which have been dressed as described in procedure F1 are sown. 33, 47, 54 and 61 days after sowing, the leaves of in each case three to 5 plants are placed -133in a glass beaker and infested with a predetermined number of young adult Diabrotica 0 Z balteata. The beakers are closed with a lid and kept at 25°C, a relative atmospheric humidity of 60% and 16 hours of daylight. Evaluation takes place three to five days after infestation. The percentage reduction in population action) is determined by comparing 00 the number of surviving Diabrotica adults on the plants grown from dressed seeds and from \O untreated seeds.

n Example B6: Seed-dressing action against third-instar larvae of Diabrotica balteata on Smaize roots O Maize seeds which have been treated as described in procedure F1 are sown. 14, 21 and 28 days after sowing, in each case five third-instar larvae of Diabrotica balteata are placed on the bottom of each plant pot. Evaluation takes place 6 days after infestation. The data registered are the number of surviving instars (larvae and pupae) in the stem of the plants, on the soil surface and in the soil. The percentage reduction in population action) is determined by comparing the number of surviving larvae and pupae on the plants grown from dressed seeds and from untreated seeds and their environment.

Example B7: Seed-dressing action against Aphis fabae A glass flask or a plastic container is filled with 100 g of bean seeds and such an amount of a formulation of the active ingredient that a ratio of 0.1, 1 or 10 g of active ingredient per kg of seed is achieved. The active ingredient is distributed uniformly on the seed surface by rotating and/or shaking the container. The seeds which have been dressed in this way are sown in flowerpots (3 seeds per pot). The plantlets are grown in a greenhouse at 25 to until they have reached the 2-leaf stage and then populated with Aphis fabae. 6 days after population, the test is evaluated. The percentage reduction in population action) is determined by comparing the number of surviving individuals on the plants grown from dressed seeds and from untreated seeds.

In this test, a good action is shown by abamectin, emamectin and spinosad.

Example B8: Seed-dressing action against Mzus persicae A glass flask or a plastic container is filled with 100 g of sugar beet seeds and such an amount of a pasty formulation of the active ingredient, prepared with a sprayable powder and a little water, that a ratio of 0.1, 1 or 10 g of active ingredient per kg of seed is achieved. The closed seed-dressing container is agitated on a roller until the paste is distributed uniformly on the seed surface. The seeds which have been dressed (coated) in -134is way are dried and sown into loess soil in plastic pots. The seedlings are grown in a 0 Z reenhouse at 24 to 260C, a relative atmospheric humidity of 50 to 60% and a daily lumination time of 14 hours. 4 weeks after germination, the plants, which are 10 cm high, ire populated with a mixed population of Myzus persicae. Evaluation takes place 2 and 7 00 lays after the plants have been populated. The percentage reduction in population C iction) is determined by comparing the number of surviving individuals on the plants grown M rom dressed seeds and from untreated seeds.

In this test, a good action is shown by abamectin, emamectin and spinosad.

The invention further relates to A method of controlling wood pests and molluscs, characterized in that a pesticidally active amount of a pesticide comprising, as pesticidally active compound, at least one macrolide, preferably abamectin, emamectin or spinosad, in free form or agrochemically utilizable salt form, as active ingredient and at least one auxiliary is applied to the pests or their environment; to the corresponding use of these compounds, to corresponding pesticides whose active ingredient is selected from amongst these compounds, to a process for the preparation of and to the use of these compositions, and to plant propagation material thus protected from attack by pests.

The macrolides used in accordance with the invention are the same as mentioned under the aspect of the invention. Also the salt are as mentioned under invention part In the case of abamectin, the free form is preferred in accordance with the invention. Especially preferred for the purposes of the present invention is a composition which comprises emamectin in free form or as an agrochemically tolerated salt as the only pesticidally active component; especially as the salt; more especially as the benzoate, substituted benzoate, benzenesulphonate, citrate, phosphate, tartrate or maleate; preferably as the benzoate or benzenesulphonate, especially preferably as the benzoate.

A larger number of different classes of active ingredient are mentioned in the literature as arthropodecidally acting active ingredients for controlling gastropods and termites.

Surprisingly, it has now been found that the compounds known under the collective term -135macrolides, too, exhibit an important molluscicidal and termiticidal activity, specifically

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Sagainst gastropods, such as slugs and snails, and against wood pests, in particular representatives of the order of Isoptera.

The molluscs include, for example, 00 SAmpullariidae; Arion ater, A. circumscriptus, A. hortensis, A. rufus); Bradybaenidae 0 (Bradybaena fruticum); Cepaea hortensis, C. Nemoralis); Cochlodina; Deroceras (D.

agrestis, D. empiricorum, D. laeve, D. reticulatum); Discus rotundatus); Euomphalia; Galba trunculata); Helicella itala, H. obvia); Helicidae (Helicigona arbustorum); Helicodiscus; Helix aperta); Limax cinereoniger, L. flavus, L. marginatus, L. maximus, L. tenellus); Lymnaea; Milax gagates, M. marginatus, M. sowerbyi); Opeas; Pomacea canaticulata); Vallonia and Zanitoides.

The termites include, in particular, the families Hodotermitidae, Kalotermitidae, Rhinotermitidae and Termitidae. Other pests which damage wood by feeding on wood, using it as a substrate or reproducing on wood, are to be understood as meaning, for example, woodboring insects such as representatives of the family Lyctidae, the family Apidae, for example Xylocopa virginica, and of the family Anobiidae, such as Anobium punctatum.

Slugs and snails as pests in horticulture and agriculture are a massively increasing problem.

They can cause severe plant damage by feeding, and can also bring about undesirable soiling by slug and snail mucus and faeces. Novel changes in the management of crops have led to an increased number in varieties of plant species which are sensitive to slugs and snails, and the obligation to dispense with burning stubble fields which is based on an ecological approach and to plough in the straw instead suggests that the existing mollusc problems, especially slug problems, will be made worse.

Termites are capable of inflicting substantial damage to buildings in particular at geographical latitudes of between 420 N and 42 In principle, two types of termites can be distinguished: Termites which live in the subsoil the most widely distributed type require warm air and a moist environment. In order always to have available the necessary moisture, these termites must have direct access to the moist soil. Damage caused by subterranean termites is virtually always associated with damage to wood.

Termites which use dry wood as their substrate represent even though less frequently a large problem since they do not require contact with the moist soil. They penetrate into -136o buildings underneath roof shingles, through gaps and through ventilation holes. Others are Sbrought into households with items of furniture which are already infested. Pretreatment of Sthe wood is considered the most efficient method of controlling such termites. The damages of termites living on dry wood are caused more slowly than damages of termites living in a 00 moist environment, therefore, damage caused by termites of the first-mentioned type is found predominantly in old buildings.

C Damage caused by termites living subterraneously in a humid environment can be C prevented by the application of insecticidally active substances to the termites or their environment. Such compounds are conventionally employed mainly for application to the soil around the buildings.

Gastropodicides which are currently commercially available comprise metaldehyde and carbamates such as, for example, methiocarb. Carbamates are highly effective as molluscicides, but exhibit the serious disadvantage of being highly toxic to mammals such as, for example, cats, dogs and hedgehogs, and other organisms such as, for example, earthworms, which should be left unharmed. While the metaldehyde molluscicides exhibit a lower toxicity, they are not lethal to molluscs but have an anaestheticizing or dehydrating effect, thus immobilizing the pests. There is therefore a demand for a useful molluscicide which is highly effective against, for example, slugs and snails, but has no, or a very low, toxic effect on beneficials such as, for example, earthworms, and mammals. This object is achieved with the macrolides of the present invention.

Also, the currently available compositions for controlling termites are not satisfactory in all respects since generally relatively large zones around building constructions, or these buildings themselves, must be treated with large amounts of insecticide. This can lead to secondary problems, in particular in the case of persistent pesticides, especially in houses.

Here too, there is therefore a further demand for improved solutions, in particular by applying active ingredients which can be employed in particularly low quantities and which have low volatility.

The invention part therefore also relates to pesticides such as emulsifiable concentrates, suspension concentrates, directly sprayable or dilutable solutions, spreadable pastes, dilute emulsions, sprayable powders, soluble powders, dispersible powders, wettable powders, dusts, granules, pellets or encapsulations in polymeric substances, all of -137- /hich are to be chosen to suit the intended aims and the prevailing circumstances and Z jhich comprise at least one of the active ingredients according to the invention.

he active ingredient is employed in these compositions in pure form, for example a solid ictive ingredient in a particular particle size, or, preferably, together with at least one of 0 he auxiliaries or carriers conventionally used in formulation technology.

0C Examples of formulation auxiliaries are solid carriers, solvents, stabilizers, slow-release N auxiliaries, colorants and, if appropriate, surface-active substances (surfactants). Suitable O carriers and auxiliaries are all substances conventionally used in crop protection products, N in particular in gastropodicides. Suitable auxiliaries such as solvents, solid carriers, surfaceactive compounds, non-ionic surfactants, cationic surfactants, anionic surfactants and other auxiliaries in the compositions employed in accordance with the invention are, for example, those which have been described in EP-A-736'252.

Other suitable substances which can be used as carriers for molluscicides are phagostimulants, that is to say the attractants and/or food (that is to say substances which can be utilized physiologically by slugs and snails) usually contained in slug and snail bait formulations. Mixtures of phagostimulants with other suitable organic and/or inorganic carriers may also be used.

Suitable phagostimulants for molluscicides are preferably: ground cereals, such as, for example, wheat flour, barley flour, rye flour, and also rice starch, crushed soya beans, fish meal, molasses, crushed rapeseed and the like. It is possible to employ either only one phagostimulant or else a mixture of phagostimulants.

To make the bait more palatable for the molluscs, one or more of the following substances can be used as additive for slug and snail baits: a) a vitamin B, in particular B1, B2, nicotinic acid or nicotinamide; b) vitamin E; c) animal or vegetable proteinaceous material, for example albumins and their hydrolytic degradation products, in particular those obtained by enzymatic hydrolysis by, for example, pepsin, such as metaproteins, proteoses, peptones, polypeptides, peptides, diketopiperazines and amino acids; d) one or more amino acids or salts or amides thereof, which may also be synthetic products; -138- O e) a nucleic acid or a hydrolytic degradation product thereof, such as a nucleotide, a Snucleoside, adenine, guanine, cytosine, uracile or thymine; C f) urea, carbamic acid; oO g) an ammonium salt, for example ammonium acetate; 'O h) an amino sugar, for example, glucosamine or galactosamine; t i) compounds of sodium, potassium, calcium or magnesium, or traces of compounds of Smanganese, copper, iron, cobalt, zinc, aluminium, boron or molybdenum, in particular chelates of these, such as Versene*; j) phosphoric acid, or glyceryl or sugar phosphates; k) water.

Stabilizers may be all known food stabilizers which have a fungistatic, fungicidal, bacteriostatic and/or bactericidal action, such as sodium benzoate, methyl p-hydroxybenzoate, cetyltrimethylammonium bromide, citric acid, tartaric acid, sorbic acid, phenols, alkylphenols or chlorinated phenols.

Slow-release auxiliaries which may be employed include, in addition to the substances mentioned as solid carriers, resins such as urea/formaldehyde resins, soya-bean meal, waxes, stearates and oils such as castor oil.

Substances which can be employed as auxiliaries for molluscicides according to part of the invention are, for example, binders such as methylcellosolve, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylates, polymethacrylates, natural waxes, chemically modified waxes and synthetic waxes, sugars, starch, alginates, agar, lignosulphonates and gum arabic, humectants such as polyalcohols, for example sugars or glycerol, preservatives, colorants, snail and slug attractants, repellents for warm-blooded species and/or other formulation auxiliaries. Combinations with known molluscicidally active ingredients, for example metaldehyde or mercaptodimethur, are also possible.

The formulation steps can be complemented by kneading, granulating (granules) and, if appropriate, compressing (pills, tablets, pellets).

The molluscicidal compositions which preferably comprise, other carriers and/or auxiliaries in addition to the active ingredient are preferably present in the ready-to-use form as sprayable powders, tracking powders, as granules (the active ingredient being present as a -139nixture with the carrier material), or as pellets. Especially preferred formulations are Z racking powders, granules or pellets.

N :ormulations which are specifically suitable for controlling molluscs according to part of :he invention are granules or pellets which comprise, as a rule, 0 to 90%, preferably 0 to 00 C 70%, of carrier material, 0.1 to 10%, preferably 1 to of active ingredient, 10 to preferably 25 to 90%, of phagostimulant, 0.5 to 25%, preferably 5 to 20%, of binder and, if N appropriate, 0 to 15% of other auxiliaries is in each case per cent by weight).

SThe amount to be applied in each case as gastropodicide is not critical, due to the lack of, or low, toxicity to warm-blooded species and depends on the prevailing circumstances, such as severity of infestation, climatic conditions and the plants to be protected. The application rate of bait types according to the invention can be varied within a substantial range. In general, between 3 and 15 kg of snail and slug bait are used per hectare, preferably between 5 and 10 kg per hectare. Expediently, the gastropodicides are distributed as uniformly as possible between the crop plants by spraying an aqueous suspension or by spreading the powders, granules or pellets on the soil. If the plant canopy is not dense, it may also be expedient to establish "trapping strips" around the plants to be protected.

Since the gastropodicides according to the invention are outstandingly well tolerated by plants, no limitations apply to the plants to be protected. Thus, all ornamentals and crop plants in agriculture, forests and horticulture (also in greenhouses) in all growth stages can be protected from slug and snail damage.

The formulation and the use of the slug and snail baits according to the invention and of the compositions for controlling wood pests can be seen from the examples which follow.

The compositions to be used according to the invention part for controlling gastropods and wood pests are prepared in the known manner, in the absence of auxiliaries for example by grinding and/or straining, for example to obtain a particular particle size, or by compressing a solid active ingredient, and in the presence of at least one auxiliary for example by intimately mixing and/or grinding the active ingredient with the auxiliary auxiliaries. These processes for the preparation of the compositions according to the invention and the use of the macrolides for the preparation of these compositions are also the subject of the invention.

As a rule, the compositions in the frame of part of the invention comprise 0.1 to 99%, in particular 0.1 to 95%, of active ingredient and 1 to 99.9%, in particular 5 to 99.9%, of -at

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-140- Seast one solid or liquid auxiliary, it being possible, as a rule, for surfactants to account for Z 0 to 25%, in particular 0.1 to 20%, of the compositions is in each case per cent by N weight). While concentrated compositions are more preferred as commercially available goods, the consumer uses, as a rule, dilute compositions which have much lower concen- 00 trations of active ingredient.

The activity of the compositions according to the invention can be widened considerably by Sadding other, for example insecticidally, acaricidally and/or fungicidally active ingredients Sand adapted to the prevailing circumstances. Examples of suitable added active ingredients are the same as mentioned under part of the invention.

In an especially preferred embodiment of the invention, the macrolide compound is used for controlling the termites and other wood-destroying pests in the soil, thus achieving an indirect protection of timber constructions. An amount of the macrolide sufficient to control the pests is applied to the soil, preferably at an application rate of 1 g to 2000 g per hectare, especially 2 to 200 g, in particular 5 to 100 g.

Worker termites must work on the pesticide-treated soil to gain access to the wood. Inevitably, they will take up some of the pesticide and carry it back to the termite colony and thus spread the active ingredient in the termite colony.

The active ingredient(s) can also be applied in the form of baits, for example in the form of tablets which comprise the active ingredient, such as are described in U.S. Patent No.

5,096,710. Especially preferably, the macrolide is applied to materials which are used by the termites as food and building materials for the termite colony. Examples of such materials are board, paper, wood dust, cellulose powder or cotton. Useful concentrations on these materials are 0.01 to 10,000 ppm. Such baits are especially efficient even when pheromones are additionally employed and wood is used which has already been attacked by fungi. Such uses are discussed, for example, in in U.S. Patent No. 5,151,443.

The macrolides according to the invention part are preventatively and/or curatively valuable active ingredients with a very favourable biocidal spectrum in the field of mollusc and wood-pest control, even at low use concentrations, and are well tolerated by warmblooded species, fish and plants. The active ingredients according to the invention are active against all or individual developmental stages of normally sensitive, but also resistant, molluscs and wood pests, especially termites. The molluscicidal action of the active ingredients according to the invention may manifest itself directly, i.e. in destruction -141 o )f the pests, either immediately or only after some time has elapsed, or indirectly, for Z xample in a reduced oviposition and/or hatching rate, the good action corresponding to a N Jestruction rate (mortality) of at least 50 to Jsing the active ingredients according to the invention part it is possible to control, i.e.

a" contain or destroy, mollusc damage in particular on plants, mainly on useful plants and C* ornamentals in agriculture, in horticulture and in forests, or pests of the abovementioned N type which occur on organs of such plants, such as fruits, flowers, foliage, stalks, tubers or C roots and in some cases even plant organs which grow at a later point in time are still N protected from these pests.

Suitable target crops for mollusc control are, in particular, cereals, such as wheat, barley, rye, oats, rice, maize or sorghum; beet, such as sugar or fodder beet; fruit, for example pome fruit, stone fruit and soft fruit, such as apples, pears, plums, peaches, almonds, cherries or berries, for example strawberries, raspberries or blackberries; legumes such as beans, lentils, peas or soya beans; oil crops such as oil seed rape, mustard, poppies, olives, sunflowers, coconuts, castor, cacao or peanuts; the marrow family, such as pumpkins, cucumbers or melons; fibre plants such as cotton, flax, hemp or jute; citrus fruits such as oranges, lemons, grapefruits or tangerines; vegetables such as spinach, lettuce, asparagus, cabbage species, carrots, onions, tomatoes, potatoes, or capsicums; the laurel family such as avocado, Cinnamonium or camphor; and tobacco, nuts, coffee, egg plants, sugar cane, tea, pepper, grapevines, hops, the banana family, latex plants and ornamentals.

Other fields of application for the active ingredients according to the invention part are the protection of stored products and stores and of materials from molluscs and wood pests.

The compositions according to the invention part are also suitable for the protection of plant propagation material, for example seed, such as fruits, tubers or kernels, or plant propagules, from gastropods and termites, especially gastropods. The propagation material can be treated with the composition prior to planting, for example seed prior to sowing.

Alternatively, the active ingredients according to the invention can be applied to seed kernels (coating) either by soaking the kemels in a liquid composition or by coating them with a solid composition. Alternatively, the composition can be applied to the site of planting when the propagation material is being planted, for example into the seed furrow during -142- O .wing. These treatment methods for plant propagation material and the plant propagation Z iaterial treated thus are further subjects of the invention.

he examples which follow are intended to illustrate part of the invention. They do not npose any limitation thereto.

00 :ormulation examples M Example F3: Preparation of slug pellets kg of crushed rapeseed (ratio of extracted/non-extracted crushed rapeseed 65:35), S2.6 kg of a finely ground premix comprising 2.1 kg of macrolide and 500 g of highly-disperse silica, 4.7 kg of cold crosslinked comstarch, 540 g of urea/formaldehyde resin, 100 g of isopropanol, 3 kg of sugar beet molasses and 140 g of blue colorant (1,4di(isobutylamino)anthraquinone) are introduced in succession into a mixer and mixed intimately. This is followed by compression moulding. The product is left to cool and dry, and fines are removed using a 0.5 mm screen. This gives a ready-to-use slug and snail bait formulation.

Instead of the abovementioned compression moulding method, another, customary compacting method may also be used for preparing the slug and snail bait formulation.

Use examples Example Al: Test for determining the efficacy of slug and snail pellets against Deroceras reticulatum The efficacy of slug and snail pellets against small slug species, for example Deroceras species, is tested in polycarbonate boxes with a 17 cm x 22 cm base. The bottom of the box is covered with several layers of cellulose paper which is moistened sufficiently. The slug and snail pellets are scattered uniformly over one half of the test area at an application rate of 20 particles; the other half remains untreated. To avoid forced behaviour, the slugs are additionally given untreated supplementary feed: two potato halves arranged in diagonally opposite corners of the box. 10 adult reticulated field slugs (Derocers reticulatum) are introduced to the untreated area of each box. Each test is replicated three times.

Temperature and atmospheric humidity are kept virtually constant during the entire test period: 19" and 90 to 95% relative atmospheric humidity. The state of the slugs is checked and scored daily on seven consecutive days. When assessing the efficacy, the mortality -143- Srate and the number of animals which show symptoms of damage are taken into 0 Z consideration.

N In this test, the macrolides according to the invention are very effective.

Example A2: Test for determining the efficacy of slug and snail pellets against Arion rufus 00 O The efficacy of slug and snail pellets against larger slug species is tested in plastic test t boxes equipped with a wire mesh. Each box has a base of 0.25 m 2 The bottom of the box tis covered by a 2 to 3 cm deep layer of potting compost. The potting compost is moistened sufficiently before the beginning of the experiment. Slug and snail pellets are scattered uniformly over the left half of the experimental area at an application rate of 3.1 g; the right half remains unireated. To avoid forced behaviour, the slugs are additionally given untreated supplementary feed: two potato halves arranged in diagonally opposite corners of the box. 10 adult red slugs (Arion rugus) are introduced to the untreated area of each box.

Each test is replicated four times. Temperature and atmospheric humidity are kept virtually constant during the entire test period: 190 and 90 to 95% relative atmospheric humidity. The state of the slugs is checked and scored daily on seven consecutive days. When assessing the efficacy, the mortality rate and the number of animals which show symptoms of damage are taken into consideration.

In this test, the macrolides according to the invention are very effective.

Example A3: Test for determining systemic efficacy against Deroceras reticulatum a) Lettuce plants A test solution is prepared by dissolving a macrolide sample in 1 ml of acetone and making up the solution with water to 50 ml. The roots, previously cleaned with fresh water, of young lettuce plants 6 cm in height are immersed for at least two days in this solution. For each test, individual leaves are excised from these lettuce plants and placed on a paper filter in a 9 cm Petri dish. 1 ml of water is pipetted onto each paper filter to keep the leaves moist during the experiment. Then, two medium-sized slugs are introduced into each Petri dish and the amount of consumed leaves and the mortality is determined over a period of two days.

In this test, the macrolides according to the invention show a good action.

b) Seed -144- Batches of 10 slugs are introduced into 5 sealed boxes containing compost and having a 0 Z base of 35 cm x 20 cm. In each case 100 treated winter wheat kernels are scattered uniformly into four boxes. In the fifth box, 50 treated winter wheat kernels are distributed over one side of the box and 50 untreated winter wheat kemrnels over the other side of the oo box to test the repellent action.

ID In this test, the macrolides according to the invention are very effective.

Example A4: Action against termites Wood baits are treated with different amounts of macrolide, and their effect on hatching rate and survival of termites is tested. Solutions with concentrations of 0 ppm, 0.1 ppm, 100 ppm and 1000 ppm of the test substance in acetone are used. Water is used in the control study. The baits consist of pine wood which have been kept in a natural environment for four months.

The termites are collected from infested pieces of wood in the open. To carry out the wood bait study, the wood is kept for 48 hours in an oven at 80°C. The dried wood is then weighed, and the pieces are placed for 18 hours in solutions of the active ingredient at the desired concentration. The pieces of wood are then removed from the solutions, dried in the air and reweighed. To determine the action of the baits against termites, the pieces of wood thus treated are placed on a thin layer of untreated soil in Petri dishes.

The termites (50 workers and 2 soldiers) are introduced into each Petri dish. The dishes are inspected three times per week, over a period of 8 weeks. Insect development, abnormalities and mortalities are recorded. After 8 weeks, the logs are rinsed with water and dried again in an oven for 48 hours at 800C. Again, the weight of each piece of wood is subsequently determined. The weight differential corresponds to the amount of the wood consumed by the termites.

In this test, the macrolides according to the invention are very effective.

P:\OPER\MALU\OI2693900 Irp.doc.25I /11200 00

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0 -145z Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will c be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.

00 SThe reference in this specification to any prior publication (or information derived from it), or to any matter which is known, is not, and should not be taken as an acknowledgment or admission or any form of suggestion that that prior publication (or information derived from it) or known matter forms part of the common general knowledge in the field of endeavour to which this specification relates.

Claims

1. Method of synergistically controlling pests in and on transgenic crops of useful plants, wherein a pesticidal composition comprising abamectin or spinosad, in free form or 00 in agrochemically useful salt form as active ingredient and at least one auxiliary, is applied to the pests or their environment, wherein the transgenic crop in genetically modified to Scontain one or more genes that confer resistance against insects, acaricides, nematodes or fungi or tolerance to herbicides.

2. Method according to claim 1, wherein abamectin or spinosad is employed in free form.

3. Method according to claim 1 or claim 2, wherein the pests are selected from insects, representatives of the order Acarina and representatives of the class nematoda.

4. Method according to claim 3, wherein the pests are selected from insects and representatives of the order Acarina.

Method according to any one of claims 1 to 4, wherein the foliage of the transgenic useful plant is treated.

6. Method according to any one of claims 1 to 4, wherein the propagation material of the transgenic useful plant is treated.

7. Method according to any one of claims 1 to 6, wherein the transgenic crops of useful plants are selected from cotton, rice, potatoes, brassica, tomatoes, cucurbits, soybeans, maize, wheat, bananas, citrus trees, and pome fruit trees.

8. A method according to any one claims 1 to 7 substantially as hereinbefore described with references to the examples.