AU2003285498A1 - Benzoxazole, benzthiazole and benzimidazole derivatives useful as heparanase inhibitors - Google Patents
Benzoxazole, benzthiazole and benzimidazole derivatives useful as heparanase inhibitorsInfo
- Publication number
- AU2003285498A1 AU2003285498A1 AU2003285498A AU2003285498A AU2003285498A1 AU 2003285498 A1 AU2003285498 A1 AU 2003285498A1 AU 2003285498 A AU2003285498 A AU 2003285498A AU 2003285498 A AU2003285498 A AU 2003285498A AU 2003285498 A1 AU2003285498 A1 AU 2003285498A1
- Authority
- AU
- Australia
- Prior art keywords
- benzthiazole
- benzoxazole
- benzimidazole derivatives
- derivatives useful
- heparanase inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 2
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
- 102100024025 Heparanase Human genes 0.000 title 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- 108010037536 heparanase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0226822.5 | 2002-11-16 | ||
| GB0226822A GB0226822D0 (en) | 2002-11-16 | 2002-11-16 | Novel compounds |
| PCT/GB2003/004980 WO2004046123A1 (en) | 2002-11-16 | 2003-11-17 | Benzoxazole, benzthiazole and benzimidazole derivatives useful as heparanase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003285498A1 true AU2003285498A1 (en) | 2004-06-15 |
Family
ID=9948008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003285498A Abandoned AU2003285498A1 (en) | 2002-11-16 | 2003-11-17 | Benzoxazole, benzthiazole and benzimidazole derivatives useful as heparanase inhibitors |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2003285498A1 (en) |
| GB (1) | GB0226822D0 (en) |
| WO (1) | WO2004046123A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214695B2 (en) | 2002-12-19 | 2007-05-08 | The Scripps Research Institute | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
| BRPI0510033A (en) | 2004-05-20 | 2007-10-02 | Scripps Res Insittute | transthyretin stabilization |
| KR20140054231A (en) | 2011-09-16 | 2014-05-08 | 화이자 인코포레이티드 | Solid forms of a transthyretin dissociation inhibitor |
| SG11201608342VA (en) * | 2014-05-22 | 2016-11-29 | Univ Sydney | Omega-3 analogues |
| EP3381907A1 (en) | 2017-03-27 | 2018-10-03 | Leadiant Biosciences SA | Symmetrical 2-aminophenyl-benzazolyl-5-acetate compounds and their use as anti-heparanase |
| EP3381906A1 (en) | 2017-03-27 | 2018-10-03 | Leadiant Biosciences SA | Compounds for use as heparanase inhibitors |
| CN108299413A (en) * | 2018-01-22 | 2018-07-20 | 复旦大学 | A method of no metal catalytic prepares 2- (aminocarbonyl phenyl) benzoxazoles and its derivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002060374A2 (en) * | 2001-01-29 | 2002-08-08 | Insight Strategy And Marketing Ltd | Benz-1,3-azole derivatives and their uses as heparanase inhibitors |
| GB0205256D0 (en) * | 2002-03-06 | 2002-04-17 | Oxford Glycosciences Uk Ltd | Novel compounds |
-
2002
- 2002-11-16 GB GB0226822A patent/GB0226822D0/en not_active Ceased
-
2003
- 2003-11-17 WO PCT/GB2003/004980 patent/WO2004046123A1/en not_active Application Discontinuation
- 2003-11-17 AU AU2003285498A patent/AU2003285498A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GB0226822D0 (en) | 2002-12-24 |
| WO2004046123A1 (en) | 2004-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |