AU2003241338A1 - Warming and nonirritating anhydrous lubricant compositions - Google Patents

Description

WO 03/092652 PCT/USO3/13554 - 1 WARMING AND NONIRRITATING ANHYDROUS LUBRICANT COMPOSITIONS 5 This application is a continuation-in-part of patent application United States Serial No. 10/137,509 and of copending patent application United States Serial No. (Attorney Docket No. PPC 834 CIP 1) which are hereby incorporated herein by reference. 10 FIELD OF THE INVENTION This invention relates to substantially anhydrous, personal lubricant gel and jelly compositions that are warming and nonirritating when applied to the skin or mucous membranes, 15 especially the vaginal or oral mucosa. In some embodiments, the compositions of this invention are substantially anhydrous and contain one or more polyhydric alcohol. This invention also relates to the method that can be used to test and compare the irritation of the compositions of this invention and other personal lubricants 20 known to the art. Unlike previously-known compositions that use exothermic reactions to generate warmth or use irritants to convey a perception of warmth, the compositions of this invention use "heat of solution" to generate warmth. The feeling of warmth generated by the compositions of this invention is very pleasant 25 and mild in comparison with previously-known compositions. The compositions of this invention are also more lubricating to tissue than previously-known warming compositions. Furthermore, the WO 03/092652 PCT/USO3/13554 2 lubricity of the compositions of this invention increases upon dilution with water; the lubricity of previously-known aqueous compositions tends to decrease upon dilution with water. In actual use, therefore, the compositions of this invention will be 5 considerably more lubricating than those previously known to the art. BACKGROUND OF THE INVENTION Humans are warm-blooded animals that maintain a constant body 10 temperature of 98.6 0 F (370C). Human skin and external organs have a very efficient circulatory and nervous system with the result that the human body can very quickly perceive changes in temperature. Personal lubricants and medicaments are usually applied to humans' mucous membranes at room temperature, i.e., 15 between at 60 0 F and 80aF. Because there is an appreciable difference in temperature between room temperature and human body temperature, users of such lubricants and medicaments perceive them to be quite cold. This feeling of cold can be quite uncomfortable for the user. From time to time, attempts have been made to 20 develop products that overcome this perception of cold. An appreciable number of personal lubricant compositions are known to the art. These compositions range from jellies to liquids to vaginal suppositories and vary from being aqueous to oils to silicone based. The majority of the compositions actually used 25 today are aqueous jellies or aqueous liquids. Almost all personal WO 03/092652 PCT/USO3/13554 - 3 lubricants known and available for use today are cold to touch, a feeling that can be uncomfortable. A number of compositions are known to the trade or described in the literature that claim to impart a warming sensation upon 5 application to the skin or mucosa. These compositions generally fall into a few main categories based upon mechanism of action. Some of these compositions use plant extracts which are irritating to the skin and mucous membranes and give a feeling or perception of warmth by virtue of their irritant action. Others 10 claim to enhance blood flow in order to cause tissue warming. Still others are alleged to work on the principle of freezing point depression and are well suited for heating in a microwave or cooling in a refrigerator. There is one cosmetic composition rendered self-heating by inclusion of compound containing a boron 15 to-boron linkage, which reacts exothermally with water. One category of warming compositions use plant extracts or agents, such as methyl salicylate, that are irritating to the skin or mucous membranes. For example, WO 97/02273A describes phosphate derivatives useful in oral and topical compositions to provide a 20 perceived sensation of warmth. The compositions contain warming components such as vanillyl derivatives. The compositions also incorporate an additional warming agent, including ethanol, niacin, jambu, nicotinic acid, zingerone, vanillyl alcohol isopropyl ether, gingerol, methyl salicylate, shogaol, paradol, zingerone, 25 capsaicin, dihydrocapsaicin, nordihydrocapsaicin homocapsaicin, tincture capsicum, eucalyptus oil.

WO 03/092652 PCT/USO3/13554 - 4 Another category of warming products utilize the mechanism of increased blood circulation. U.S. Patent No. 5,895,658, entitled "Delivery of L-Arginine to Cause Tissue Warming, Sustained Release of Nitric Oxide to treat effects of Diabetes, Stimulate Hair Growth 5 and Heal Wounds," describes a preparation for producing enhanced blood flow in tissues thus causing beneficial effects, such as warming cold tissues of hands and feet. Yet another category of warming products uses inorganic compounds to create exothermic reactions resulting in the evolution 10 of heat. WO 200260408 Al, for example, relates to anhydrous cosmetic hair care compositions containing inorganic salts such as sodium sulfate, calcium sulfate, aluminum sulfate, calcium chloride, magnesium chloride or calcium oxide, or magnesium sulfate. Upon mixing with water, these compositions generate heat. 15 KR20010227018 describes exothermic cosmetic containing active zeolite compositions that promote blood circulation and metabolism by giving warm-sense to the skin. Active zeolite contains ethoxylated alcohol. JP63159490A relates to exothermic cosmetic compositions especially for softening hair containing reducing 20 agents such as sodium sulphite, sodium thiosulphate, sodium pyrosulphite or sodium hydrogen sulphite and an oxidizing agent such as sodium bromate, potassium bromate or sodium perbromate. EP2001306347 refers to compositions for use in preparing hair for shaving. The compositions contain at least one substance that 25 undergoes a discernible chemical change when mixed during shaving. The substance changes temperature, emits a scent or undergoes WO 03/092652 PCT/USO3/13554 - 5 oxidation, hydration, an acid-base reaction or an exothermic reaction. Another category of heat-producing products uses mechanisms other than the three aforementioned categories. US 20020142015 Al 5 and JP 2002179517 A describe warming compositions for cosmetics, toiletries, bath additives and pharmaceuticals that contain a cooling agent and a specific p-hydroxybenzaldehyde derivative. The use of this p-hydroxybenzaldehyde cooling agent is intended to product a warming effect for a longer duration. FR2810240 Al 10 describes cosmetic compositions containing a component that can absorb or release heat thereby providing a cooling and refreshing effect during exposure to heat or a warming effect during exposure to cold, such as a combination of long chain hydrocarbon compounds that can absorb thermal energy and store or exchange heat. 15 US3632516A describes a self-heating lather that is rapidly heated by hydrogen peroxide via a thiosulphredox reaction. Another category of heat-producing products uses mechanisms other than the three aforementioned categories. US 20020142015 Al and JP 2002179517 A describe warming compositions for cosmetics, 20 toiletries, bath additives and pharmaceuticals that contain a cooling agent and a specific p-hydroxybenzaldehyde derivative. The use of this p-hydroxybenzaldehyde cooling agent is intended to product a warming effect for a longer duration. FR2810240 Al describes cosmetic compositions containing a component that can 25 absorb or release heat thereby providing a cooling and refreshing effect during exposure to heat or a warming effect during exposure WO 03/092652 PCT/USO3/13554 6 to cold, such as a combination of long chain hydrocarbon compounds that can absorb thermal energy and store or exchange heat. US3632516A describes a self-heating lather that is rapidly heated by hydrogen peroxide via a thiosulphredox reaction. 5 JP2001335429 describes gel-like cosmetics that contain 40-75% by weight of polyethylene glycol, 20-55% by weight of glycerol and carboxyvinyl polymer. These compositions are used for generating heat for promoting blood circulation and metabolism in fatigue conditions and to provide warm feeling during shaving. One example 10 of a composition known to the trade, Prosensual T M , distributed by Lexie Trading, Inc., Fairlaw, New Jersey, contains plant extracts such as Cinnamon cassia (Cinnamon), Zingiber officinalis (Ginger), Mint, Sandalwood, Orange and Clove, which are all known to be skin irritants. Such a composition has the disadvantage of causing 15 irritation to the mucosa, which can be problematic in relation to the vaginal or oral mucosa as irritation may promote the growth of unwanted bacteria and cause infection. Another current composition, WETTM Heating Massage Oil, distributed by International, Valencia, California, uses Retinyl 20 Palmitate (Vitamin A Palmitate), Prunus amygdalis (Prunes), Amara (Almond), Persica gratissima (Avacado Oil), Macdamia ternifulia Seed Oil, Kakeri Nut Oil, Helianthus annus (hybrid Sunflower), Cannabis sativa (Hemp) Seed Oil and Aloe vera. Most of these ingredients are known irritants that are not suitable for use on 25 mucous membranes.

WO 03/092652 PCT/USO3/13554 - 7 U.S. Patent No. 5,513,629 entitled "Microwavable Heat Releasing and Absorbing Compositions and Container, Pliable Gel Comprising Humectant, Freezing Point Depressant, Gel Sealer, Polyacrylamide Absorbent, Corn Starch Binder, Mineral Oil and 5 Plasticizers, Durability, Efficacy" describes compositions that have a high vapor points and are, therefore, suited for heating in a microwave oven or cooling in a freezer and placement in a suitable container or vinyl package, such as a hot-and-cold pack, but not for human consumption or use. 10 However, none of the foregoing compositions are actually "warm", or at a relatively higher temperature than the ambient temperature of the product or the surrounding environment. U.S. Patent No. 4,110,426, entitled "Method of Treating Skin and Hair with a Self Heated Cosmetic, Organic Boron-Oxygen-Boron 15 Compounds" describes non-aqueous compositions such as shaving creams, that are rendered self-heating by including therein a compound containing at least one boron-oxygen-boron linkage, such as triethoxyboroxine. The boron-containing compound reacts exothermally with water or other protic material to increase 20 temperature. Such compositions are not suitable for vaginal or oral use due to the potential toxicity of boron-containing compounds to the human reproductive system (Fail PA, et al., general, reproductive, developmental, and endocrine toxicity of boronated compounds., Reprod toxicol 12: 1, 1-18, Jan-Feb, 1998). 25 Physical energy forms have been utilized to enhance material transport across a membrane for therapeutic purposes. Such energy WO 03/092652 PCT/USO3/13554 - 8 forms include electricity, ultrasound and thermal energy (e.g., heat-assisted drug delivery), (reviewed by Sun, in "Skin Absorption Enhancement by Physical Means: Heat, Ultrasound, and Electricity", Transdermal and Topical Drug Delivery Systems, Interpharm Press, 5 Inc., 1997, pages 327-355). Local heating of a drug delivery system or formulation, as well as the skin or mucosal tissues, not only increases thermodynamic energy of drug molecules and membrane permeability to facilitate drug movement across a barrier membrane, it improves blood circulation in the tissue to expedite drug 10 removal from the local tissue into the systemic circulation. Both processes leads to an enhanced absorption of the drug. Experimental evidence demonstrates that low-level heating (i.e., a tissue temperature of less than about 42 0 C) significantly enhances percutaneous drug absorption. 15 U.S. Patent No. 5,658,583 describes a heat-generating apparatus for improved dermal permeation of pharmaceuticals. The apparatus includes a thin drug formulation reservoir and a heat generating chamber of oxidation reaction separated by a non permeable wall. The drug formulation reservoir houses a 20 predetermined amount of a formulation containing pharmaceutical agents. The heat-generating/temperature-regulating chamber includes a heat-generating medium consisting of carbon, iron, water and/or salt which is activated upon contact with oxygen in the air. However, a complicated heating device such as this is not suitable 25 for use in the vaginal or oral cavity for obvious safety concerns. Locally applied heat (such as an abdominal heating patch) has WO 03/092652 PCT/USO3/13554 - 9 also been used to treat dysmenorrhea, or menstrual cramps, with demonstrated efficacy (Akin MD et al., Continuous low-level topical heat in the treatment of dysmenorrhea., Obstet Gynecol 97: 3, 343 9, Mar, 2001). 5 U.S. Patent No. 6,019,782 describes disposable thermal body pads with heat generation via an oxidation reaction intended for relieving menstrual pain when applied onto the abdominal skin. There is currently a commercial product in the U.S. market for dysmenorrhea treatment based on abdominal heating, ThermaCare® Air 10 Activated Heatwraps, Menstrual Cramp Relief patches manufactured by Procter & Gamble (Cincinnati, OH). However, there are no products or description of internal localized heating to treat dysmenorrhea. SUMMARY OF THE INVENTION 15 The compositions and methods of this invention relate to substantially anhydrous non-irritating gel and jelly compositions. The compositions and methods of this invention contain cellulose gelling derivatives and polyhydric alcohols. Preferably, the cellulose gelling derivatives are hydrocolloids. The compositions 20 of this invention may be used as warming lubricant compositions that are non-toxic and non-irritating and that can be used as personal lubricants designed to come into contact with the skin or mucosa. When mixed with water, the gel and jelly compositions of this invention increase in temperature or generate warmth. This has 25 a soothing effect on the tissues to which these compositions are WO 03/092652 PCT/USO3/13554 - 10 applied. This substantially eliminates the feeling or perception of cold that conventional personal lubricants convey upon use. The compositions of this invention have excellent lubrication characteristics. The gels and jelly compositions of this invention 5 are more lubricating than even aqueous lubricant products currently available on the market. The compositions of this invention, in particular, the jelly compositions of this invention, are novel in that their lubricity increases upon dilution with water. Known, commercially available aqueous compositions decrease in lubricity 10 upon dilution with water. This is a particular advantage in that the compositions of this invention may be used in connection with moist vaginal or oral mucosa and will become increasingly lubricious upon exposure to the moisture therein. Although anhydrous compositions are ordinarily perceived to 15 be irritating to the skin and mucous membranes, the gel and jelly compositions of this invention are surprisingly non-irritating. The compositions of this invention may be applied to the skin or mucous membranes, preferably the vaginal or oral mucosa. The compositions of this invention are preferably substantially 20 anhydrous and preferably contain at least one polyhydric alcohol. We theorize that, when the polyhydric alcohols contained in the compositions of this invention come into contact with water or body moisture in humans, they react with the ambient water molecules to cause an increase in temperature or generate warmth, 25 thus having a soothing effect on the tissues to which these compositions are applied.

WO 03/092652 PCT/USO3/13554 - 11 Surprisingly, and contrary to the general belief that polyhydric alcohols in compositions are irritating to the mucosa, compositions of this invention containing such polyhydric alcohols have been found to be non-irritating. We theorize that the 5 hydrocolloids useful in the compositions and methods of this invention swell when they come into contact with water, yielding a lubrication coating gel. This coating physically blocks the irritant action of other anhydrous elements of the compositions of this invention. Furthermore, as the polyhydric alcohols useful in 10 the compositions of this invention are humectants and moisturizers, when the hydrocolloids swell and form thin films over mucosal tissues, the films retain the moisturizers on the surface of the tissues. Thus, the compositions of this invention overcome dry conditions such as vaginal dryness and mouth dryness caused by 15 various factors including menopause and aging, as well as various disease conditions. Thus, the compositions of this invention are very mild to the skin and mucous membranes. The compositions of this invention are soothing when applied to oral mucous membranes and may function to 20 relieve minor irritation of the mouth and throat. The combination of polyhydric alcohols in the compositions of this invention may also be used as a vehicle to solubilize otherwise insoluble drugs, including, but not limited to, antifungals, antibacterials, antivirals, analgesics, anti 25 inflammatory steroids, contraceptives, local anaesthetics, hormones and the like.

WO 03/092652 PCT/USO3/13554 - 12 Preferably, the compositions of this invention are maintained at an acidic pH. An acidic pH is very helpful for the maintenance of healthy vaginal and oral flora, particularly for the maintenance of Lactobacilli in the vaginal area. Conventional acids or buffers 5 are known to be insoluble in anhydrous compositions. Preferably, the compositions of this invention contain an organic acid that is soluble therein to maintain an acidic pH. More preferably, the organic acid is lactic acid. Lactic acid is not only soluble in the anhydrous compositions of this invention, it is a natural acid 10 generated in human tissue and is very safe for use in the compositions of this invention. Such an organic acid is particularly useful as an acidifying agent that may assist in lowering the pH of the tissues where the compositions of this invention are applied. This will help maintain the natural acidic 15 environment of the mucosa and encourage the growth of appropriate flora. The compositions of this invention may also preferably contain an insulating agent which functions to preserve the temperature increase by maintaining the heat within the composition 20 after it has been applied to the skin or mucosa. More preferably, honey may be utilized as an insulating agent. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a graph depicting the % viable Epiderm cells vs 25 Exposure Time using the composition of Example 1.

WO 03/092652 PCT/USO3/13554 - 13 Fig. 2 is a graph depicting the % viable Epiderm cells vs Exposure Time using the composition of Example 2. Fig. 3 is a graph depicting the % viable Epiderm cells vs Exposure Time using a State-of-the-Art non-irritating Product (K-Y 5 Liquid ). Fig. 4 is a graph depicting the % viable Epiderm cells vs Exposure Time using a State-of-the-Art warming Product (Prosensualo) Fig. 5 is a graph comparing the Lubricity vs Time (Seconds) of the composition of Example 1 and three leading Personal 10 Lubricants on the market. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 15 The compositions of this invention are substantially anhydrous, preferably containing less than about 20% water, more preferably containing less than about 5% water and, most preferably, containing less than about 3% water. Preferably, the compositions of this invention contain at 20 least one polyhydric alcohol, and more preferably, two polyhydric alcohols. Preferably, at least one of the polyhydric alcohols of the compositions of this invention is a polyalkylene glycols or others selected from the following group: glycerine, propylene glycol, Outylenes glycol, hexalene glycol or polyethylene glycol of 25 various molecular weight and the like and/or combination thereof. More preferably, the compositions of this invention contain a polyethylene glycol; most preferably, the polyethylene glycol may WO 03/092652 PCT/USO3/13554 - 14 be selected from the following group: polyethylene glycol 400 or polyethylene glycol 300. The compositions of this invention should contain polyhydric alcohols in an amount from about 80% to about 98% by weight of the composition. 5 The compositions of this invention should also preferably contain one or more water-soluble cellulose-derived film-forming polymers, gums, chitosans or the like. Preferably, such cellulose derived polymers are hydroxyalkylcellulose polymers. More preferably, the hydroxyalkylcellulose polymer is selected from the 10 following group: hydroxyethylcellulose, carboxyboxymethylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose and the like. Most preferably, the hydroxyalkylcellulose polymer is hydroxypropylcellulose, such as Klucel ® which is available commercially from Hercules Incorporated 15 of Wilmington, Delaware. Most of the cellulose-derived polymers are water soluble and insoluble in anhydrous solvents but for hydroxypropylcellulose, which is completely soluble in the anhydrous polyhydric portion of the compositions of this invention. Preferably, the compositions of this invention contain from about 20 0.15% to about 0.6% by weight of hydroxypropylcellulose to yield pourable gels and from about 1% to about 4% of hydroxpropylcellulose to yield thixotropic jellies. The compositions of this invention preferably also contain an insulating agent. More preferably, the insulating agent should be 25 honey or esters of isopropyl alcohol and saturated high molecular weight fatty acids such as myristic or palmitic acid, WO 03/092652 PCT/USO3/13554 - 15 e.g.,isopropyl myristate and isopropyl palmitate . The insulating agent should be present in the compositions of this invention in an amount of from about 1% to about 5% by weight of the composition. The compositions of this invention are unexpectedly self 5 preserving and may not require a preservative. However, a preservative may be added to impart an additional guarantee against microbial growth. A preservative may be selected from preservatives known to those of skill in the art, including, but not limited to, one or more of the following: methylparaben, benzoic acid, sorbic 10 acid, gallic acid, propylparaben or the like. The preservative may be present in the compositions of this invention in an amount from about 0.01% to about 0.75% by weight of the composition. The compositions of this invention may also preferably contain an ester. More preferably, the ester is a fatty acid ester. 15 Most preferably, the ester may include, but is not limited to: isopropyl stearate, isopropyl myristate, isopropyl palmitate, isopropyl laurate and the like. Most preferably, the ester is isopropyl myristate. The compositions of this invention may contain one or more 20 water-soluble cellulose-derived polymers, gums, chitosans or the like. Such polymers contribute to the viscosity and bioadhesiveness of the compositions of this invention. Preferably, such cellulose derived polymers are hydroxyalkylcellulose polymers. More preferably, the hydroxyalkylcellulose polymer is 25 hydroxypropylcellulose or Klucel®, available commercially from Hercules Incorporated, Wilmington, Delaware.

WO 03/092652 PCT/USO3/13554 - 16 The polyhydric alcohols used in the compositions of this invention are theorized to be useful as warming and heat-generating agents. Honey functions as an insulating agent, protecting the compositions from becoming too cold. The ester, preferably a fatty 5 acid ester, functions as an emollient and lubricant. The cellulose polymer is useful as a viscosity building agent. The compositions of this invention are unique in that they lubricate, warm and soothe the tissues of the user, especially the oral and vaginal mucous membranes, without conveying a feeling of cold. Moreover, 10 they are smooth and lubricating. The compositions of this invention may be a liquid, a semi solid, or a solid depending upon the particular intended use thereof. The compositions of this invention may be formulated as syrupy liquid-gels, pourable gel or thick jellies. Preferably, 15 their viscosities should range from about 1,000 cps to about 7,000 cps for the gels and from about 60,000 cps to about 500,000 cps for the jellies. The compositions of this invention may also be formulated into soft or hard gelatin capsules, suppositories and impregnated into fabrics or polymers. 20 The compositions of this invention may be used as personal lubricants which convey a feeling of warmth. The feeling of warmth generated by the compositions of this invention is soothing to the skin or mucous membranes where they are applied. The compositions of the invention also possess a sweet and pleasant taste, which is 25 of particular benefit when these compositions are used orally.

WO 03/092652 PCT/USO3/13554 - 17 The compositions of this invention may also be used as personal moisturizers, which convey a feeling of warmth when applied to vaginal or oral mucosa. They may be used as moisturizers which convey a feeling of warmth and relieve vaginal 5 dryness or dry mouth. The compositions of this invention may also be used as a vehicle to deliver medication or other treatment agents to biomembranes including, but not limited to, hormones, antimicrobials, antibacterials, antibiotics, non-steroidal anti 10 inflammatory agents, spermicides, immunodilators, anaesthetics, plant extracts, vitamins, corticosteroids or antifungal agents and the like. Antifungal agents are preferably azoles or imidazoles, including but not limited to, miconazole, econazole, terconazole, 15 saperconazole, itraconazole, butaconazole, clotrimazole, tioconazole, fluconazole and ketoconazole, vericonazole, fenticonazole, sertaconazole, posaconazole, bifonazole, oxiconazole, sulconazole, elubiol, vorconazole, isoconazole, flutrimazole, tioconazole and their pharmaceutically acceptable 20 salts and the like. Other antifungal agents may include an allylamine or one from other chemical families, including but not limited to, ternafine, naftifine, amorolfine, butenafine, ciclopirox, griseofulvin, undecyclenic acid, haloprogin, tolnaftate, nystatin, iodine, rilopirox, BAY 108888, purpuromycin 25 and their pharmaceutically acceptable salts.

WO 03/092652 PCT/USO3/13554 - 18 Another embodiment of the invention are compositions for vulvovaginal or other mucosal use containing one or more antibiotics. The antibiotic may be chosen from the group including, but not limited to, metronidazole, clindamycin, tinidazole, 5 ornidazole, secnidazole, refaximin, trospectomycin, purpuromycin and their pharmaceutically acceptable salts and the like. Another embodiment of the compositions of this invention include compositions for vulvovaginal or other mucosal use containing one or more antiviral agents. Antiviral agents may 10 preferably include, but are not limited to, immunomodulators, more preferably imiquimod, its derivatives, podofilox, podophyllin, interferon alpha, reticolos, cidofovir, nonoxynol-9 and their pharmaceutically acceptable salts and the like. Still other embodiments of the compositions of this invention 15 are compositions that include one or more spermicides. The spermicides may preferably include, but are not limited to, nonoxynol-9, octoxynol-9, dodecaethyleneglycol monolaurate, Laureth 10S, and Methoxypolyoxyethyleneglycol 550 Laurate and the like. Still other embodiments of the compositions of this invention 20 are compositions containing antimicrobial agents. The antimicrobial agents may preferably include, but are not limited to, chlorohexidine gluconate, sodium polystyrene sulfonate, sodium cellulose sulfate, silver particles of micro- and sub-micrometer sizes, silver salts and other antibacterial agents known to the 25 art.

WO 03/092652 PCT/USO3/13554 - 19 Yet other embodiments of the compositions of this invention are compositions that may include local anesthetics. The local anesthetics may preferably include, but are not limited to, benzocaine, lidocaine, dibucaine, benzyl alcohol, camphor, 5 resorcinol, menthol and diphenylhydramine hydrochloride and the like. Compositions of the invention may also include plant extracts such as aloe, witch hazel, chamomile, hydrogenated soy oil and colloidal oatmeal, vitamins such as vitamin A, D or E and 10 corticosteroids such as hydrocortisone acetate. Another embodiment of the compositions and methods of this invention include compositions for vulvovaginal use containing one or more hormones for treating a decrease in estrogen secretion in the woman in need of estrogen replacement such as women with 15 vaginal atrophy. The hormones may preferably include, but are not limited to, estrogen selected from the group consisting of estradiol, estradiol benzoate, estradiol cypionate, estradiol dipropionate, estradiol enanthate, conjugated estrogen, estriol, estrone, estrone sulfate, ethinyl estradiol, estrofurate, 20 quinestrol and mestranol. Another embodiment of the compositions and methods of this invention include compositions for vulvovaginal use containing one or more analgesics and/or nonsteroidal anti-inflammatory agents for treating dysmenorrhea or mentrual cramping. The analgesics and 25 nonsteroidal anti-inflammatory agents may preferably include, but are not limited to, aspirin, ibuprofen, indomethacin, WO 03/092652 PCT/USO3/13554 - 20 phenylbutazone, bromfenac, fenamate, sulindac, nabumetone, ketorolac, and naproxen and the like. In another embodiment of the compositions and methods of this invention, the compositions may be useful for treating female 5 sexual dysfunction by themselves as they may serve to increase blood flow to areas on which they are applied by increasing temperature thereon. Alternatively, they may contain agents known to those of skill in the art to treat female sexual dysfunction (including different aspects of female sexual dysfunction such as 10 female sexual arousal disorder, hypoactive sexual desire disorder, orgasmic disorder and the like) as well as those that treat dyspareunia and/or vaginismus, or vulvodynia and to relieve pain upon intercourse. Such agents include hormones such as estrogen, prostaglandin, testosterone; calcium channel blockers, cholinergic 15 modulators, alpha-adrenergic receptor antagonist, beta-adrenergic receptor agonists, camp-dependent protein kinase activtors, superoxide scavengers, potassium channel activators, estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, HMG-CoA reductase inhibitors, smooth muscle 20 relaxants, adenosine receptor modulators and adenylyl cyclase activators. Such agents include phosphodiesterase-5 inhibitors and the like. Yet another embodiment of the compositions and methods of this invention include compositions for oral and vulvovaginal or 25 other mucosal use relates to a method of enhancing the absorption of active agents from the applied compositions into the mucosal WO 03/092652 PCT/USO3/13554 - 21 membrane by increasing the composition and mucosal tissue temperature via interaction of the polyhydric alcohols in the compositions and moisture on the mucosa and subsequently released heat. 5 Yet another embodiment of the compositions of this invention include compositions for vulvovaginal use relates to compositions and methods for preventing and/or treating dysmenorrhea by intravaginal warming or heating. Preferably, the composition heats the intravaginal area to a temperature preferably between about 37 0 C 10 and about 42 0 C, more preferably between about 38 0 C and about 41 0 C. The compositions of invention for use in such a method may optionally contain active agents such as analgesics and nonsteroidal anti-inflammatory agents for dysmenorrhea treatment. The composition of the invention may be administered directly into 15 the vagina by an applicator, or be impregnated into vaginal devices such as tampon for intravaginal applications. The compositions of this invention may be manufactured as a coating of a tampon, or dispersing throughout the absorbent tampon material, or enclosed inside as a core of a tampon. The 20 compositions of this invention for the warming tampon for preventing and/or treating dysmenorrhea preferably include a mixture of polyethylene glycols of various molecular weights ,produced by The Dow Chemical Company (Midland, MI) under the trade names of CARBOWAX SENTRY PEG 300 NF, CARBOWAX SENTRY PEG 400 NF, 25 CARBOWAX SENTRY PEG 600 NF, CARBOWAX SENTRY PEG 900 NF, CARBOWAX WO 03/092652 PCT/USO3/13554 - 22 SENTRY PEG 1000 NF, CARBOWAX SENTRY PEG 1450 NF, CARBOWAX SENTRY PEG 3500 NF, CARBOWAX SENTRY PEG 4000 NF, CARBOWAX SENTRY PEG 4600 NF, and CARBOWAX SENTRY PEG 8000 NF. The compositions of this invention for dysmenorrhea prophylaxis and treatment may contain 5 one or more water-soluble cellulose-derived polymers and gums that form gels around the polyhydric alcohols such as glycerin, propylene glycol and polyethylene glycols thus reducing the dissolution of the polyhydric alcohols, prolonging the solvation heat release, and regulating the elevated temperature in the 10 preferred temperature range. This invention also relates to a method of determining and comparing relative amounts of irritation caused by particular sources using the EpiDerm T M Skin Model Assay as described in Example 1, such as compositions applied to skin or mucosal cells. The 15 following Example I exemplifies the use of the method of this invention. Example 1: EpiDerm M Skin Model Assay to Test Irritation of Lubricants 20 The method designated as EpiDer TM Skin Model assay uses the epithelial cells derived from human skin as target cells and is commercially available from the MatTek Corporation. This assay is described in Berridge, M.V., et al. (1996) The Biochemical and Cellular Basis of Cell Proliferation Assays That Use Tetrazolium 25 Salts. Biochemica 4: 14-19. The test materials are applied directly to the epithelial cell culture surface. This test has not previously been used for determining toxicity of test materials.

WO 03/092652 PCT/USO3/13554 - 23 The toxicity of the test material is evaluated on the basis of relative tissue viability vs time. The actual Tissue viability is determined by NAD(P)H-dependent microsomal enzyme reduction of MTT in control and test article treated cultures. The negative control 5 used in this assay was deionized water and the positive control was Triton X-100. The exposed cell cultures were incubated for 4, 8, 16 and 24 hours and assayed for reduction of MTT. The data is presented below in Figures 1 through 4 in the form of Relative Survival (relative MTT reduction) versus Exposure Time. Relative 10 irritation in this assay is expressed by the percent survival rate of epiderm cells over a period of 24 hours. Products with higher relative survival rates are less toxic or less irritating while the ones with lower survival rates are more toxic or irritating. The survival rate of four compositions of this invention ranged between 15 81.3% and 90.3%, indicating that the compositions of this invention are essentially non-irritating. Figures 1 through 4 summarize the results of Epiderm Skin Model Bioassay. The data is plotted as % Viable Cells vs the Exposure Time ranging from 4 to 24 hours. Figures 1 and 2 20 represent the results for two compositions of this invention, Composition 1 and Composition 2 respectively. Figure 3 represents the results of K-Y® Liquid that is an established personal lubricant on the market. K-Y® Liquid is established as safe and nonirritating in animal and human testing and long-term human use 25 history. Results for K-YO Liquid showed 100.3% viable cells after 24 hour of exposure (Figure 3).

WO 03/092652 PCT/USO3/13554 - 24 Example 1 of the invention (Figure 1) and Example 2 of the invention (Figure 2) showed 91.1% and 96.9% viable cells respectively. Figure 4 shows the results of a warming composition known to the trade. This product uses plant materials like 5 cinnamon, clove, ginger cloves and orange and others for a warming sensation. The results show only 37.6% viable cells after 24 hours of exposure to this product. This indicates that such compositions will be irritating to the skin and mucous membranes. Compositions 1 and 2 of this invention, with 91.1% and 96.9% viable cells 10 respectively, will be practically nonirritating. Positive control (Triton X-100) has only 22.4% viable cells at the 8-hour interval. Example 2: Generation Of Warmth The compositions of this invention are anhydrous and contain 15 one or more polyhydric alcohol. When combined with water, the polyhydric alcohols used in the compositions of this invention generate an increase in temperature that has a soothing effect on the tissues these compositions are applied. In actual use the compositions of the invention interact with the moisture of the 20 vaginal or oral mucosa, thereby increasing the temperature or generating feeling of warmth. The "Generation of warmth" data summarized in Table 1 below, was generated by mixing 20 ml of each of the ingredients in Composition 1 and Composition 1 of this invention with 20 ml of 25 water. The temperature of the product and that of water were recorded before water was added to the product. After the addition WO 03/092652 PCT/USO3/13554 - 25 of water the mixture was mixed for two minutes and the actual temperature was recorded. Glycerin, Propylene Glycol and Honey are the ingredients in Composition 1. It is clear from Table 1. that when mixed with water the temperature of the mixture rises by 9.00 5 F for Glycerin, 13.5' F for Propylene Glycol, 17.00 F for Polyethylene Glycol 400 and 12.50 F for composition Examplel of this invention. The calculated rise in temperature for Composition 1, based on the rise in temperature and the % w/w quantity of each individual ingredient in the composition was 10.8750 F. The actual 10 recorded temperature rise for Composition 1. was 12.5' F which is 1.6250 F higher than expected which indicates that there is an unexpected increase in temperature resulting from the combination of ingredients. 15 GENERATION OF WARMTH (RISE IN TEMPERATURE OF) DATA BY MIXING EQUAL QUANTITY OF EACH PRODUCT WITH WATER Product Name Temperature Temperature Average Actual Rise in of the Product of Water (oF) Expected Temperature Temperature (oF) Temperature ('F) (OF) (F) (Expected Minus Actual) Glycerin Assay 69.0 71.0 70.0 79.0 9.0 Propylene Glycol 72.4 71.0 71.7 85.2 13.5 Assay Honey 74.0 71.0 72.5 74.0 1.5 K - Y Warmn® 74.0 71.0 72.5 85.0 12.5 Isopropyl WO 03/092652 PCT/USO3/13554 - 26 Myristate 75.0 74.1 74.5 75.2 0.7 Polysorbate 60 70.9 74.1 72.5 83.1 10.6 Polyethylene Glycol 400 72.0 71.0 71.5 88.5 17.0 Calculated Rise in Temperature: In order to determine the expected rise in temperature from each composition, the percentage of each 5 component in such composition was multiplied by the temperature increase generated by such component alone to obtain its expected contribution to the temperature increase. These values were added together to calculate the total expected temperature rise. These values were then compared with the actual temperature rise 10 generated by each composition. For example, the calculated rise in temperature generated by the "K-Y Warm® " composition in the table above was found as follows and compared with the actual temperature rise to determine the unexpectedly higher generation of warmth of the composition: 15 Propylene Glycol (50% of 13.5) = 6.75 Glycerin (45% Of 9.0) = 4.05 Honey (5% of 1.5) = 0.075 20 Total 10.875 Difference: 12.5 - 10.875 = 1.625 WO 03/092652 PCT/USO3/13554 - 27 Example 3: Effect of Water Content on Generation of Warmth On contact with moisture or water the heat of solution is responsible for the warming action of the compositions of this invention. There is a concern that accidental contamination with 5 water or prolonged exposure to excessive moisture, the warming capacity of the product may be adversely effected. According to this example, water was added to compositions of this invention varying from about 1% to about 10% as outlined in Table 2 below. The contents were thoroughly mixed and the samples were allowed to 10 stay at room temperature for 24 hour following which the generation of warmth was determined as outlined in the following paragraph. The results show that rise in temperature is proportionately decreased depending on the quantity of water added but there is still an 8.5 0 F increase in temperature at about 10% water addition. 15 The results of this example are set forth in Table 2 below. Table 2: Effect Of Water Content On Generation Of Warmth For K-Y Warm. Product Temperature Temperature Average Actual Rise in Name of the of Water Expected Temperature Temperature Sample (IF) (IF) Temperature ( 0 F) (°F)

(

0 F) (Expected Minus Actual) No Water 73.80 70.00 71.90 83.50 11.60 1% Water 73.90 70.00 71.95 82.20 10.25 2% Water 72.30 70.00 71.95 81.70 9.85 3% Water 72.30 70.00 71.15 80.40 9.25 4% water 72.20 70.00 71.10 80.70 9.60 5% Water 71.60 70.00 70.80 80.40 9.60 6% Water 71.60 70.00 70.80 80.40 9.60 7% Water 71.50 70.00 70.75 80.20 9.45 8% Water 71.60 70.00 70.80 80.20 9.40 9% Water 70.90 70.00 70.45 79.50 9.05 10% Water 70.50 70.00 70.25 79.00 8.50 WO 03/092652 PCT/USO3/13554 - 28 Example 4: Perception Of Warmth In Human Use A Human Use Study was conducted with 246 subjects. The data generated by this study are summarized below in Table 2. The 5 subjects were asked to use compositions of this invention. They were asked three questions regarding the perception of warmth while using the product, as follows: 1. Does it warm on contact? 2. Does it feel warm? 10 3. Does it not feel cold? The subjects were asked to register their response as Excellent, Very Good, Good, Fair and Poor. The positive responses are summarized in Table 2. 15 Table 3: PERCEPTION OF WARMTH IN HUMAN USE STUDY WITH 246 HUMAN SUBJECTS USING COMPOSITION EXAMPLE 1 OF THE INVENTION QUESTION ASKED POSITIVE RESPONSE (%) Warms on Contact Excellent 25.12 Very Good 31.88 Good 24.64 Total 81.64 Feels Warm Excellent 30.88 Very Good 28.92 Good 25.98 Total 85.78 Does Not Feel Cold Excellent 54.37 Very Good 29.61 Good 10.19 Total 94.53 WO 03/092652 PCT/USO3/13554 - 29 As set forth in Table 3 above, 81.64% of the subjects registered a positive response that the product "warms on contact", 85.78% subjects felt that the product "feels warm" while 94.53% subjects registered that the product "does not feel cold". 5 Example 5: Comparison Of Lubricity Ahmad et al. in U.S. Patent No. 6,139,848, which is hereby incorporated herein by reference, describe a method to test lubricity of various personal lubricants known to the trade. In the 10 described test method, the lubricity of various marketed personal lubricants was determined over a period of 300 seconds (5 minutes). The lubricity data disclosed in this patent indicates that K-Y Liquid lubricant had a higher lubricity and was longer lasting during the 300 seconds test period than the competitive products. 15 The lubricity data set forth in U.S. Patent No. 6,139,848 has a negative (-) sign during the "push" and positive (+) sign during the "pull" phase of the experiment. Compositions of this invention were tested using the lubricity test set forth in U.S. Patent No. 6,129,848. However, the test duration was successfully extended to 20 16 minutes (960 seconds) and the data was treated to "curve-fit" to eliminate the negative (-) sign. The lubricity data for the composition 1 of this invention is compared with the data for K-Y Liquid in Figure 5. The data indicate that Composition 1 of this invention has a higher lubricity as compare to K-Y Liquid and that 25 Composition 1 maintains the high lubricity for an extended period of 16 minutes (960 minutes) and is therefore longer lasting.

WO 03/092652 PCT/USO3/13554 - 30 Example 6: Heat of Solution The warming effect of the compositions of this invention is believed to be caused by generating heat of solution, as opposed to 5 creating the conditions for exothermic reactions. Exothermic reactions result in evolution of heat due to a chemical reaction between two chemicals and are uncontrolled. Such an exothermic chemical reaction may generate new products or chemical entities, some of which may not be suitable for human tissues. In contrast, 10 when a solution is formed there is an energy change because of the difference between the forces of attraction of unlike and like molecules. Specifically, bonds are broken between molecules of the each component being mixed and new bonds are formed between neighboring molecules of the product mixture or solution. This 15 mechanism is different from a Heat of Reaction because there is no chemical rearrangement of the constituent atoms to form products from reactants. As can be seen from the following experiment, maximum heat generated or the maximum rise in temperature is no more than 18.8 OF, which makes these compositions very mild and 20 safe. The solution process for the compositions of this invention (COMPOSITION 15 of Example 9 below) in, for example, vaginal fluids ("X H 2 0") can be represented by the following physical equation: COMPOSITION 15 (1) + X H 2 0 (1) -> COMPOSITION 15 (X H 2 0) 25 WO 03/092652 PCT/USO3/13554 - 31 The designation "COMPOSITION 15 (X H 2 0)" represents that the product is a solution of 1 (mol) of COMPOSITION 15 in X (mol) of H 2 0. Thus, using COMPOSITION 15, a composition according to this invention, as a personal lubricant does not change the existing 5 amount of naturally occurring vaginal fluids. It simply forms a solution with them. The maximum temperature increase possible from the generation of heat by use of the compositions of this invention may be measured using thermodynamic principles. For example, Differential 10 Scanning Calorimetry (DSC) was employed to characterize the heat released by the compositions of this invention when they come into contact with water to form a solution. In this testing, the energy released when a thin film of a particular composition was applied to a thin film of water was measured. The results of a typical 15 test are presented in Figure 6. The area of the exothermic (i.e., negative) peak represents the total energy released during the formation of a solution of the composition of this invention and water. Table 1 summarizes the energy released for this series of experiments. 20 Table 1: Summary of DSC Measurements of Heat Released By COMPOSITION 15 / Water Experiment # Composition of the Energy Released Invention (mJ) (mg) 1 17.85 398.878 2 22.5 355.108 3 28.32 267.229 WO 03/092652 PCT/USO3/13554 - 32 Average 22.89 340.405 Standard Deviation 5.25 67.045 The energy release measured by the DSC is representative of the maximum energy which would be seen on the surface of the vaginal tissue. This is because the heat flux (energy flow) into the thin 5 film of water during the formation of the solution measured by the DSC is equivalent to the heat flux (energy flow) which would be in the fluid on the surface of the vaginal tissue. Therefore, thermodynamics can be used to calculate the maximum possible temperature rise as follows: 10 Qax = Cpm ATmax (Equation 1) where, Qmax represents the Maximum Energy Released during contact (formation of solution) of Composition 15 and water; Cpm represents Heat Capacity of Solution of Composition 15 and Water; and ATmx represents Maximum Temperature Rise. Thus, rearranging Equation 1, 15 we can calculate ATmx, the Maximum Temperature Rise, based upon the known or measured values of the Maximum Energy Released and the Heat Capacity of Solution of Composition 15, as follows: ATmax = Q.m / CP (Equation 2) By assuming a normal distribution, the experimental results in 20 Table 1 can be used to arrive at a worst case estimate for the maximum value of Qx as follows: Qmax = {Average Experimental Energy Release + 3 x (Standard Deviation of Experimental Energy Release)} / (Average Quantity of Composition 15) 25 = {(340.405 mJ) + (3) ( 67.045 mJ)} / (22.89 mg) WO 03/092652 PCT/USO3/13554 - 33 = (541.539 mJ / 22.89mg) (Equation 3) (Using this as the upper limit represents the 99.73% upper 5 confidence limit for the normal distribution.) In the case of Cpm, the smaller of the Cp, for Composition 15 and the CP for Water can be used to arrive at a worst case estimate for its minimum value. Since, 10 Cp, (Composition 15) = 0.54 cal / (g - oC) C, (Composition 15) = 1.00 cal / (g - aC) then, Cpm (worst case minimum) = 0.54 cal / (g - 0 C) (Equation 4) 15 Therefore, a worst case estimate of the maximum temperature increase possible from the generation of heat by for Composition 15 can be arrived at by using the combining Equations 2, 3, and 4 as follows: 20 ATmax = Qmax / Cpm = ((541.539 mJ)/(22.89 mg))/( 0.54 cal / (g - 'C) x 0.23901 cal / J = 10.5 OC or = 18.8 OF 25 Thus, the maximum heat released upon use of Composition 15 is, at the most, about 10.5 0 C or 18.8 OF, a relatively small increase in heat, indicating that the temperature increase effected by the compositions of this invention are safe and comfortable to the user.

WO 03/092652 PCT/USO3/13554 - 34 Example 7: Generation of Warmth Compositions 10, 11 and 12 were tested in accordance with the following procedure to determine the extent to which said 5 compositions generate warmth upon mixture with water. Data was generated by mixing 20 ml of each composition with 20 ml of water. The temperature of the composition and that of water were recorded before water was added to the composition After the addition of water the contents were mixed for two minutes and the actual 10 temperature was recorded. The results are set forth in the following Table: GENERATION OF WARMTH (RISE IN TEMPERATURE OF) DATA BY MIXING EQUAL QUANTITY OF EACH COMPOSITION WITH WATER. 15 Product Name Temperature Temperature Average Actual Rise in of the of Water Expected Temperature Temperature Product (IF) (oF) Temperature (IF) (°F) (oF) (Expected Minus Actual) Rise In Temperature For Compositions For Compositions Of The Invention Composition 10 73.00 703 71.6 87.3 15.7 Composition 11 73.00 70.3 71.6 83.2 11.6 Composition 12 73.00 70.3 71.6 87.1 15.5 Rise In Temperature For The Individual Components Of The Compositions Polyethylene 72.0 71.0 71.5 88.5 17.0 Glycol 400 Propylene 72.4 71.0 71.7 85.2 13.5 Glycol Glycerin 69.0 71.0 70.0 79.0 9.0 WO 03/092652 PCT/USO3/13554 - 35 We calculated the rise in temperature For Compositions 10, 11 and 12: Composition 10 Propylene Glycol (38 % of 13.5) = 5.13 5 Polyethylene Glycol 400 (61.5% Of 17.0) = 10.45 Total: 15.58 IF Composition 11 For Composition 11 the calculated Rise in Temperature is 15.58 IF 10 Composition 12 For Composition 12 the calculated Rise in Temperature is 15.15 oF Calculated temperature for all three compositions is very close to 15 the Actual Rise in Temperature Example 8: Comparison of Lubricity Using the method to test and compare lubricity of various personal lubricants set forth in Example 3 above, the lubricity of 20 the compositions of this invention was determined. The following is the summary of the results: The Gel compositions of this invention are as lubricating as the aqueous gel compositions described in the US Patent No. 6,139,848 by Ahmad et al. In Figure 7, the lubricity of 25 commercially available KY® Jelly was measured both in its commercially-available form and in a 1:1 dilution with water. Upon dilution, the lubricity did not increase substantially. The Jelly compositions of this invention are more lubricating WO 03/092652 PCT/USO3/13554 - 36 as compared to the state of the art aqueous jellies known to the trade. Composition 14 of this invention was measured with respect to lubricity as initially made and in a 1:1 dilution with water. Surprisingly, its lubricity increases substantially (about four 5 fold) upon dilution. These data are represented in Figure 8. Thus, the jelly compositions of this invention become more lubricious or their lubricity is increased when these compositions are diluted with water in a 1:1 ratio. Figure 9 demonstrates a comparison of the lubricities of KY® Jelly and Composition 14 in 10 their initial forms. Figure 10 illustrates the lubricities of two warming gel compositions of this invention, Compositions 13 and 14, showing their high lubricities. Figure 11 shows KY* Ultragel and diluted Composition 14. 15 Example 9: Compositions Of The Invention The following compositions of this invention were made as follows: first, propylene glycol and glycerin were mixed. A preservative and the insulating agent were then added to the mixture in the same container. The mixture was then heated to from 20 about 350 C to about 45 O C to completely dissolve the preservative. The mixture was then cooled. The gel and jelly compositions were made by mixing propylene glycol, polyethylene glycol and hydroxypropylcellulose in a high-speed mixer at a temperature of between about 600 C to about 70 o C until a smooth gel or jelly was 25 obtained. The resulting gel or jelly was cooled to a temperature of between about 450 C and about 55 0 C and lactic acid was added. The mass was continuously mixed for about 15 minutes or until the lactic acid was dissolved. The mass was then cooled to room temperature.

WO 03/092652 PCT/USO3/13554 - 37 Composition 1: Propylene Glycol 50.00% Glycerin 45.00% 5 Honey 5.00% Composition 2: Propylene Glycol 50.00% Glycerin 20.00% 10 Isopropyl Myristate 27.00% Polysorbate 60 3.00% Composition 3: Propylene Glycol 95.00% 15 Honey 5.00% Composition 4: Propylene Glycol 50.00% Glycerin 20.00% 20 Isopropyl Myristate 29.50% Klucel HF 0.50% Composition 5: Propylene Glycol 99.50% 25 Klucel HF 0.50% WO 03/092652 PCT/USO3/13554 - 38 Composition 6: Propylene Glycol 49.80% Glycerin 45.00% Honey 5.00% 5 Preservative 0.20% Composition 7: Miconazole Nitrate 2.00% Propylene Glycol 49.80% 10 Glycerin 43.00% Honey 5.00% Preservative 0.20% Composition 8: 15 Fluconazole 2.00% Propylene Glycol 49.80% Glycerin 43.00% Honey 5.00% Preservative 0.20% 20 Composition 9: Metronidazole 3.00% Propylene Glycol 49.80% 25 Glycerin 42.00% Honey 5.00% WO 03/092652 PCT/USO3/13554 - 39 Preservative 0.20% Composition 10 (Gel): Propylene Glycol 38.00 5 Polyethylene Glycol 400 61.05 Lactic Acid 00.20 Hydroxypropylcellulose 0.75 Composition 11 (Jelly): 10 Propylene Glycol 37.00 Polyethylene Glycol 400 61.05 Lactic Acid 00.20 Hydroxypropylcellulose 1.75 15 Composition 12 (Gel): Propylene Glycol 48.00 Polyethylene Glycol 400 51.30 Lactic Acid 0.20 Hydroxypropylcellulose 0.50 20 Composition 13 (Jelly): Propylene Glycol 48.55 Polyethylene Glycol 4007 50.00 Lactic Acid 0.20 25 Hydroxypropylcellulose 1.25 WO 03/092652 PCT/USO3/13554 - 40 Composition 14 (Jelly: Propylene Glycol 98.55 Lactic Acid 0.20 Hydroxypropylcellulose 1.25 5 Composition 15 (Jelly): Polyethylene Glycol 400 98.55 Lactic Acid 0.20 Hydroxypropylcellulose 1.25 10 Composition 16 (Gel): Polyethylene Glycol 400 99.50 Lactic Acid 0.20 Hydroxypropylcellulose 0.30 15 Composition 17 (Gel): Propylene Glycol 74.50 Glycerin 25.00 Lactic Acid 0.20 20 Hydroxypropylcellulose 0.30 Composition 18 (Gel): Propylene Glycol 74.50 Polyethylene Glycol 400 25.00 25 Lactic Acid 0.20 Hydroxypropylcellulose 0.30 WO 03/092652 PCT/USO3/13554 - 41 Composition 19 (Gel): Propylene Glycol 69.50 Polyethylene Glycol 400 15.00 5 Glycerin 15.00 Lactic Acid 2.00 Hydroxypropylcellulose 0.30 Composition 20 (Jelly): 10 Propylene Glycol 73.55 Polyethylene Glycol 400 25.00 Lactic Acid 0.20 Hydroxypropylcellulose 1.25 15

Claims (10)

1. A substantially anhydrous lubricant composition comprising at least one polyhydric alcohol and a gelling agent. 5 2. A composition according to claim 1 wherein said composition further comprises a pH adjustment agent.

3. A composition according to claim 1 wherein said polyhydric alcohol is selected from the group consisting of: glycerin, alkylene glycol, polyethylene glycol and a mixture thereof. 10 4. A composition according to claim 1 wherein said gelling agent is hydroxypropylcellulose.

5. A composition according to claim 3 wherein said alkylene glycol is selected from the group consisting of: propylene glycol, butylene glycol and hexalene glycol. 15 6. A composition according to claim 4 wherein said polyethylene glycol is selected from the group consisting of polyethylene glycol 300, polyethylene glycol 400 and a mixture thereof.

7. A composition according to claim 1 wherein said gelling agent is lactic acid. 20 8. A composition according to claim 5 wherein said composition comprises from about 75% to about 99% byweight of polyhydric alcohol, from about 0.1% to about 4% by weight of hydroxypropylcellulose and from about 0.1% to about 1% by weight of lactic acid. 25 9. A composition according to claim 1 wherein said composition has a viscosity from about 1,000 cps to about 7,000 cps. WO 03/092652 PCT/USO3/13554 - 43 10. A composition according to claim 1 wherein said composition has a viscosity from about 60,000 cps to about 500,000.

11. A composition according to claim 1 which further comprises an antimicrobial agent. 5 12. A composition according to claim 11 wherein said antimicrobial agent is an antifungal agent.

13. A composition according to claim 11 wherein said antimicrobial agent is an antibacterial agent.

14. A composition according to claim 11 wherein said 10 antimicrobial agent is an antiviral agent.

15. A composition according to claim 1 wherein said composition further comprises a spermicide.

16. A composition according to claim 1 wherein said composition further comprises a local anesthetic. 15 17. A method of treating or preventing dysmenorrhea comprising applying a composition according to claim 1 intravaginally. 1I. A composition according to claim 1 wherein said composition increases in temperature upon exposure to moisture.

19. A composition according to claim 7 wherein the pH of said 20 composition is adjusted to between about 2 and about 6.