AU2003203452A8 - Topical composition - Google Patents
Topical composition Download PDFInfo
- Publication number
- AU2003203452A8 AU2003203452A8 AU2003203452A AU2003203452A AU2003203452A8 AU 2003203452 A8 AU2003203452 A8 AU 2003203452A8 AU 2003203452 A AU2003203452 A AU 2003203452A AU 2003203452 A AU2003203452 A AU 2003203452A AU 2003203452 A8 AU2003203452 A8 AU 2003203452A8
- Authority
- AU
- Australia
- Prior art keywords
- topical composition
- composition according
- emollient
- microbial
- topical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims description 132
- 230000000699 topical effect Effects 0.000 title claims description 130
- 239000003974 emollient agent Substances 0.000 claims description 39
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 230000000845 anti-microbial effect Effects 0.000 claims description 27
- 239000004599 antimicrobial Substances 0.000 claims description 23
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 22
- 239000006210 lotion Substances 0.000 claims description 21
- 241000894007 species Species 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 19
- 239000000645 desinfectant Substances 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- 244000005700 microbiome Species 0.000 claims description 15
- 239000002202 Polyethylene glycol Substances 0.000 claims description 14
- 229920001223 polyethylene glycol Polymers 0.000 claims description 14
- 239000003906 humectant Substances 0.000 claims description 12
- -1 polysiloxane copolymers Polymers 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 230000002421 anti-septic effect Effects 0.000 claims description 8
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 8
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 8
- 150000001298 alcohols Chemical class 0.000 claims description 7
- 150000007860 aryl ester derivatives Chemical class 0.000 claims description 7
- 230000005540 biological transmission Effects 0.000 claims description 7
- 229920001451 polypropylene glycol Polymers 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 229960003260 chlorhexidine Drugs 0.000 claims description 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 6
- 241000191967 Staphylococcus aureus Species 0.000 claims description 5
- 210000004400 mucous membrane Anatomy 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 239000004166 Lanolin Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- 150000002009 diols Chemical class 0.000 claims description 4
- 150000002170 ethers Chemical class 0.000 claims description 4
- 235000019388 lanolin Nutrition 0.000 claims description 4
- 229940039717 lanolin Drugs 0.000 claims description 4
- 239000000865 liniment Substances 0.000 claims description 4
- 230000000813 microbial effect Effects 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 229920001296 polysiloxane Polymers 0.000 claims description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 3
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 3
- 125000005907 alkyl ester group Chemical group 0.000 claims description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 239000000499 gel Substances 0.000 claims description 3
- 238000000265 homogenisation Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
- 239000011619 pantothenol Substances 0.000 claims description 3
- 235000020957 pantothenol Nutrition 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 235000010356 sorbitol Nutrition 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims description 2
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 235000010654 Melissa officinalis Nutrition 0.000 claims description 2
- 244000062730 Melissa officinalis Species 0.000 claims description 2
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 2
- 150000001336 alkenes Chemical class 0.000 claims description 2
- 125000005376 alkyl siloxane group Chemical group 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 235000006708 antioxidants Nutrition 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 235000013871 bee wax Nutrition 0.000 claims description 2
- 239000012166 beeswax Substances 0.000 claims description 2
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 2
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- 229940119170 jojoba wax Drugs 0.000 claims description 2
- 229940040145 liniment Drugs 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- 229940042472 mineral oil Drugs 0.000 claims description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical class C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229920001281 polyalkylene Polymers 0.000 claims description 2
- 229920000570 polyether Polymers 0.000 claims description 2
- 239000003380 propellant Substances 0.000 claims description 2
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 229940032094 squalane Drugs 0.000 claims description 2
- 229940031439 squalene Drugs 0.000 claims description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- CCPHAMSKHBDMDS-UHFFFAOYSA-N Chetoseminudin B Natural products C=1NC2=CC=CC=C2C=1CC1(SC)NC(=O)C(CO)(SC)N(C)C1=O CCPHAMSKHBDMDS-UHFFFAOYSA-N 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 210000004379 membrane Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 description 9
- 208000015181 infectious disease Diseases 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 239000000344 soap Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- VRACDWUCKIDHCO-UHFFFAOYSA-N 16-methylheptadecyl 10-[5,6-dihexyl-2-[8-(16-methylheptadecoxy)-8-oxooctyl]cyclohex-3-en-1-yl]dec-9-enoate Chemical class CCCCCCC1C=CC(CCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C)C(C=CCCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C)C1CCCCCC VRACDWUCKIDHCO-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- 206010041925 Staphylococcal infections Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000003655 tactile properties Effects 0.000 description 1
- 229940100613 topical solution Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
AUSTRALIA Patents Act 1990 COMPLETE SPECIFICATION STANDARD PATENT Applicant: AUSTIN & REPATRIATION MEDICAL CENTRE Invention Title: TOPICAL COMPOSITION The following statement is a full description of this invention, including the best method of performing it known to
US:
-2 FIELD OF THE INVENTION The present invention relates to topical compositions, which may be used as an antiseptic and/or 5 disinfectant. BACKGROUND OF THE INVENTION Control of nosocomial infection and exposure to 10 infectious disease is of paramount concern to doctors, nurses, and clinicians that work in hospitals, clinics and surgical and medical centres. One of the most effective methods for controlling infection is regimented hand disinfection before and after each patient contact and 15 before invasive procedures. Hand disinfection is generally accomplished using anti-microbial soaps with water. These soaps are usually formulated to include either povidone-iodine or 20 chlorhexidine gluconate as the active anti-microbial agent. In addition, these formulated soaps may contain surfactants and possibly low levels of humectants such as glycerin. 25 Hand disinfection is also accomplished using hand wash replacements. These are used instead of the soap and water scrub. Hand wash replacements ideally achieve bacterial kill equal to or better than a traditional soap and water scrub and in a shorter period of time. 30 Additionally, they maintain or improve the skin's natural barrier to microbial and chemical contamination while providing acceptable tactile properties. Examples of hand wash replacements include hydroalcoholic gels, which H:\Shona1\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 -3 generally include high levels of either ethanol or isopropanol as the disinfecting agent and also include a thickener and/or surfactant and optionally include a humectant (e.g. glycerin). 5 SUMMARY OF THE INVENTION The present invention provides a topical composition comprising: 10 at least one C 1 to C 4 alcohol; at least one anti-microbial; and at least one emollient. The C 1 to C 4 alcohols may include straight or 15 branched chain alcohols. Preferably, the alcohols are selected from ethanol, n-propanol and isopropanol. Preferably, the alcohol is isopropanol. The alcohol concentration is preferably about 20 60% v/v to about 90% v/v, more preferably about 65% v/v to about 75% v/v, most preferably about 70% v/v of the total concentration of the topical composition. The anti-microbial may be selected from 25 chlorhexidine and its salts. A preferred anti-microbial is chlorhexidine gluconate. The anti-microbial is preferably present in an amount of about 3 g/L to about 10 g/L, more preferably 30 about 4 g/L to about 7 g/L, most preferably about 5 g/L of the topical composition. The emollient may be selected from general H.\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 -4 emollients, occlusive emollients and humectants. Preferably, the emollient is a humectant. More preferably, the emollient is selected from humectants such 5 as glycerol, propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, pantothenol and gluconic acid salts. Most preferably, the emollient is polyethylene glycol. 10 The concentration of the emollient in the topical composition is preferably about 1.0% to about 2.0%, more preferably about 1.5%'to about 1.8%, most preferably about 1.5%. 15 The present invention also provides a method of reducing and/or preventing the transmission of a microorganism by applying an effective amount of a topical composition as defined above to any part of the body excluding mucous membranes. 20 The topical composition as defined above may therefore be used to reduce and/or prevent the transmission of a microorganism. 25 The topical composition may also be used in the manufacture of a disinfectant and/or antiseptic to reduce and/or prevent the transmission of a microorganism. The microorganism is preferably a multi 30 resistant organism such as, for example, methicillian resistant staphylococcus aureus. The topical composition may be applied before H:\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 -5 and after routine or specialised health-care delivery or preparatory to invasive procedures. An effective amount of the topical composition 5 is preferably about 1 ml to about 3 ml. The present invention further provides a method of preparing a topical composition as defined above comprising the step of mixing at least one C 1 to C 4 10 alcohol, at least one anti-microbial, and at least one emollient, with stirring, until complete homogenisation is achieved. DETAILED DESCRIPTION OF THE INVENTION 15 The present invention provides a topical composition comprising at least one C 1 to C 4 alcohol, at least one anti-microbial, and at least one emollient. 20 Alcohols Alcohol is an effective vehicle for a disinfectant. It provides a broad spectrum bactericidal effect and is fast drying. 25 The C 1 to C 4 alcohols in the topical composition of the present invention may include straight or branched chain alcohols. Suitable alkanols include ethanol, n propanol and isopropanol. 30 While the topical composition of the present invention may comprise only one alcohol, a combination of alcohols may be used. H:\Shona1\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 -6 Isopropanol is a good disinfectant with a pleasant odour and, compared to other alcohols, it has a less cutaneous drying effect of the skin. Therefore, 5 isopropanol is a preferred alcohol for the topical composition of the present invention. The alcohol concentration of the topical composition should provide the greatest possible bacterial 10 kill effect. Therefore, the alcohol concentration is preferably about 60% v/v to about 90% v/v, more preferably about 65% v/v to about 75% v/v, most preferably about 70% v/v of the total concentration of the topical composition. 15 Anti-microbials The term "anti-microbials" is used herein in its broadest sense and refers to any agent that can treat any infection caused by a microorganism and includes viral and 20 bacterial infections. Examples of such infectious microorganisms may be found in a number of well known texts such as 'Medical Microbiology' (Greenwood, D., Slack, R., Peutherer, J., Churchill Livingstone Press, 2002); 'Mims' Pathogenesis of Infectious Disease' (Mims, 25 C., Nash, A., Stephen, J., Academic Press, 2000); '"Fields" Virology. (Fields, B.N., Knipe, D.M., Howley, P.M., Lippincott Williams and Wilkins, 2001). Chlorhexidine and its salts are is an anti 30 microbial effective against a wide-range of Gram-positive and Gram-negative bacteria. While chlorhexidine may be used as an anti H.\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 -7 microbial in the topical composition of the present invention, a salt of chlorhexidine is preferred due to its solubility properties. Preferred salts of chlorhexidine include chlorhexidine gluconate, chlorhexidine acetate and 5 chlorhexidine hydrochloride. The most preferred anti microbial for the topical composition of the present invention is chlorhexidine gluconate because it has excellent instantaneous bacterial effect that persists after use. 10 The amount of anti-microbial present in the topical composition should provide a balance between the desired antibacterial effect and unwanted adverse effects. 15 The anti-microbial is preferably present in an amount of about 3 g/L to about 10 g/L, more preferably about 4 g/L to about 7 g/L, most preferably about 5 g/L of the topical composition. 20 While a single anti-microbial may be used in the topical composition of the present invention, additional anti-microbials may be added to enhance the anti-microbial action of the topical composition. This may be particularly desirable in critical uses such as 25 preparatory to invasive procedures. Emollients Emollients are typically added to topical 30 compositions because they act to increase the moisture content of the stratum corneum. Emollients are generally separated into two H:\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 -8 broad classes based on their function. The first class of emollients function by forming an occlusive barrier to prevent water evaporation from the stratum corneum. The second class of emollients penetrate into the stratum 5 corneum and physically bind water to prevent evaporation. The first class of emollients is subdivided into compounds that are waxes at room temperature and compounds that are liquid oils. The second class of emollients includes those that are water-soluble and are often referred to as 10 humectants. The emollient may be selected from the following non-limiting list of general emollients, occlusive emollients and humectants. 15 Examples of general emollients includes short chain alkyl or aryl esters (Ci-C 6 ) of long straight or branched chain alkyl or alkenyl alcohols or acids (Cs-C 32 ) and their polyethoxylated derivatives; short chain alkyl 20 or aryl esters (Ci-C 6 ) or C 4
C
12 diacids or diols optionally substituted in available positions by -OH; alkyl or aryl
C
1
-C
10 esters of glycerol, pentaerythritol, ethylene glycol, propylene glycol, as well as polyethoxylated derivatives of these and polyethylene glycol; C1 2
-C
22 alkyl 25 esters or ethers of polypropylene glycol; C 12
-C
2 2 alkyl esters or ethers of polypropylene glycol/polyethylene glycol copolymer; and polyether polysiloxane copolymers. Examples of occulsive emollients include cyclic 30 and linear dimethicones, polydialkysiloxanes, polyaryl/alkylsiloxanes, long chain (Cs-C 36 ) alkyl and alkenyl esters of long straight or branched chain alkyl or alkenyl alcohols or acids; long chain (C8-C 36 ) alkyl and H.\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 -9 alkenyl amides of long straight or branched chain alkanes and alkenes such as squalene, squalane and mineral oil; jojoba oil polysiloxane polyalkylene copolymers, dialkoxy dimethyl polysiloxanes, short chain alkyl or aryl esters 5 (Cl-C) of C 12
-C
2 2 diacids or diols optionally substituted in available positions by -OH, such as diisostearyl dimer dilinoleate; lanolin and lanolin derivatives, and beeswax and its derivatives. 10 Examples of humectant type emollients include glycerol, propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, pantothenol, gluconic acid salts and the like. 15 Humectant type emollients are preferred for the topical composition of the present invention. The most preferred humectant is polyethylene glycol. Polyethylene glycol is pleasant to use, readily available and economical. 20 The concentration of the emollient in the topical composition is preferably about 1.0% to about 2.0%, more preferably about 1.5% to about 1.8%, most preferably about 1.5%. 25 The inventors have determined that having a 1.5% concentration of polyethylene glycol in the topical composition of the present invention provides adequate moisturising while not causing irritation and/or allergic 30 reactions. There are also no unwanted abnormal feelings after application such as sliminess or stickiness. Hs\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 10 Additional ingredients The topical composition may optionally comprise ingredients such as water, oils, salts, fragrances, 5 perfumes, colorants, stabilisers, emulsifiers, propellants, additives, preservatives or preserving agents, anti-oxidants, surfactants, thickeners and other excipients normally used in topical compositions. If additional ingredients are included in the topical 10 composition, ingredients that are known to cause skin irritation and/or sensitisation reactions should be avoided. Formulations 15 The topical composition may be formulated into the form of an aerosol, balm, cream, emolument, foam, gel, liniment, lotion, ointment, salve, solution, spray, suspension, unguent or the like. 20 Application The present invention is a topical composition, which is useful as a broad-spectrum antiseptic and/or 25 disinfectant for use in many environments including hospitals and clinics, veterinarian, industrial, food industry, livestock and home environments. The topical composition may be used, for example, as a skin disinfectant. 30 The topical compositions of the present invention are highly efficacious in preventing the transmission of microorganisms within hospitals. H:\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 11 The term "microorganism" includes any microscopic organism or taxonomically related macroscopic organism within the categories algae, bacteria, fungi, 5 protozoa, viruses and subviral agents or the like. The microorganism is preferably a multi-resistant organism such as, for example, methicillian-resistant staphylococcus aureus. 10 In addition, preferred topical compositions of this invention maintain moisture after both single and multiple applications without allergic reaction or unwanted side effects such as abnormal feelings of sliminess or stickiness. 15 Topical compositions of the present invention are suitable for frequent and repeated usage during routine and specialised health-care delivery in environments such as hospital or clinic. In hospitals and 20 clinics, these topical compositions may be used before and after each patient contact or preparatory to invasive procedures. If topical compositions of the present invention 25 are formulated into a hand lotion, only a small amount, about 1 ml to about 3 ml, of the hand lotion would be needed to be effective disinfectant and/or antiseptic. Topical compositions of the present invention 30 have advantages over known topical compositions in that they may be applied frequently with minimal adverse effects, dry rapidly, provide both instantaneous and prolonged anti-microbial activity, and have a low toxicity Hs\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 12 profile. The term "topical composition" as used herein generally refers to a composition that is applied S externally to any part of the body excluding mucous membranes such as the eyes, mouth, and so on. The topical composition may, therefore, be applied directly to any part of the body excluding mucous membranes such as the eyes, mouth, and so on. However, topical compositions of 10 the present invention may also be incorporated into sponges, swabs, pads and/oriwipes, which are then used to apply the topical solution to any part of the body excluding mucous membranes such as the eyes, mouth, and so on. The topical compositions may also be incorporated into 15 cosmetic products. Stability The topical composition of the invention 20 conserves its activity for, at least, two years from its production. However, it is preferable to use it at least within 12 months of being prepared. Even so, incorporating appropriate preserving agents can extend the period to sustain activity. 25 In this specificat ion, except where the context requires otherwise, the words "comprise", "comprises", and "comprising" mean "include", "includes", and "including", respectively, i.e. when the invention is described or 30 defined as comprising specified features, various embodiments of the same invention may also include additional features. H;\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 13 EXAMPLES The invention will now be further described with reference to the following Examples. These Examples are 5 not intended to limit the invention in any way. The topical composition of the present invention may be prepared by a variety of techniques. 10 One method of preparing the topical composition of the present invention involves mixing the components of the topical composition, in suitable quantities, with stirring, until complete homogenisation is achieved. 15 The following examples are topical compositions of the present invention that were prepared according to the above method. Example 1 20 isopropyl alcohol 70% v/v chlorhexidine gluconate 5 g/L polyethylene glycol 1.5% concen. water balance 25 The topical composition of Example 1 was formulated into the form of a lotion, in particular a hand lotion. 30 The hand lotion was shown to be an effective disinfectant and/or antiseptic. It was also gentle on the skin, dried rapidly and provided both instantaneous and prolonged anti-microbial activity. The hand lotion showed H:\Shona1\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 14 no unwanted side effects such as abnormal feelings of sliminess or stickiness. The hand lotion of Example 1 was also trialed as 5 a disinfectant hand lotion in an intervention/study ward of the Austin & Repatriation Medical Centre, Victoria, Australia. The trial was conducted over a period of ten or 10 so months. The staff of the intervention/study ward were instructed to use about 1 ml to about 3 ml of the disinfectant hand lotion before and after each patient 15 contact. The results of the trial showed that there was an approximately 21% to 25% reduction in clinical infections with methicillian-resistant staphylococcus 20 aureus ("MRSA"). Since the disinfectant hand lotion was easy to use, there was also a 25% to 100% improvement in hand hygiene compliance. Hand hygiene compliance refers to the 25 rates of hand washing, which in the present case would refer to the rates of use of the topical composition as a disinfectant hand lotion. Furthermore, there were no allergic reactions 30 identified through repeated use of the hand lotion during the trial. Accordingly, this trial showed that the topical H:\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 15 composition of the present invention would be very effective as a disinfectant hand lotion in hospitals, clinics, surgical and medical centres and the like. 5 Example 2 isopropyl alcohol 70% v/v chlorhexidine gluconate 5 g/L polyethylene glycol 2.0% concen. 10 water balance The topical composition of Example 2 was formulated into the form of a lotion, in particular a hand lotion. 15 The hand lotion was shown to be an effective disinfectant and/or antiseptic. It was also gentle on the skin, dried rapidly and provided both instantaneous and prolonged anti-microbial activity. 20 The hand lotion was found, however, to have a slight unwanted after effect. Specifically, after repeated use of the hand lotion, there was a feeling of stickiness. 25 It will be appreciated by persons skilled in the art that numerous variations and/or modifications may be made to the invention as shown in the specific embodiments without departing from the spirit or scope of the invention as broadly described. The present embodiments 30 are, therefore, to be considered in all respects as illustrative and not restrictive. H.\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03
Claims (45)
1. A topical composition comprising: at least one C 1 to C 4 alcohol; 5 at least one anti-microbial; and at least one emollient.
2. A topical composition according to claim 1, wherein the C 1 to C 4 alcohol is a straight or branched 10 chain alcohol.
3. A topical composition according to claim 1 or claim 2, wherein the alcohol is selected from ethanol, n propanol, isopropanol or a combination thereof. 15
4. A topical composition according to any one of the preceding claims, wherein the alcohol is isopropanol.
5. A topical composition according to any one of 20 the preceding claims, wherein the alcohol concentration is about 60% v/v to about 90% v/v of the total concentration of the topical composition.
6. A topical composition according to any one of 25 the preceding claims, wherein the alcohol concentration is about 65% v/v to about 75% v/v of the total concentration of the topical composition.
7. A topical composition according to any one of 30 the preceding claims, wherein the alcohol concentration of the topical composition is about 70% v/v of the total concentration of the topical composition. H,\Shona1\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 17
8. A topical composition according to any one of the preceding claims, wherein the anti-microbial is selected from chlorhexidine and its salts. 5
9. A topical composition according to any one of the preceding claims, wherein the anti-microbial is selected from chlorhexidine gluconate, chlorhexidine acetate and chlorhexidine hydrochloride.
10 10. A topical composition according to any one of the preceding claims, wherein the anti-microbial is chlorhexidine gluconate.
11. A topical composition according to any one of 15 the preceding claims, wherein additional anti-microbials are added to the topical composition to enhance its anti microbial action.
12. A topical composition according to any one of 20 the preceding claims, wherein the anti-microbial is present in an amount of about 3 g/L to about 10 g/L of the topical composition.
13. A topical composition according to any one of 25 the preceding claims, wherein the anti-microbial is present in an amount of about 4 g/L to about 7 g/L of the topical composition.
14. A topical composition according to any one of 30 the preceding claims, wherein the anti-microbial is present in an amount of about 5 g/L of the topical composition. H:\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 18
15. A topical composition according to any one of the preceding claims, wherein the emollient is selected from general emollients, occlusive emollients and humectants. 5
16. A topical composition according to any one of the preceding claims, wherein the emollient is a general emollient selected from short chain alkyl or aryl esters (Ci-C 6 ) of long straight or branched chain alkyl or alkenyl 10 alcohols or acids (CS-C 32 ) and their polyethoxylated derivatives; short chain alkyl or aryl esters (Ci-C) or C 4 -C 2 diacids or diols optionally substituted in available positions by -OH; alkyl or aryl Ci-Cio esters of glycerol, pentaerythritol, ethylene glycol, propylene glycol, as 15 well as polyethoxylated derivatives of these and polyethylene glycol; C 1 2 -C 2 2 alkyl esters or ethers of polypropylene glycol; C 12 -C 22 alkyl esters or ethers of polypropylene glycol/polyethylene glycol copolymer; and polyether polysiloxane copolymers. 20
17. A topical composition according to any one of the preceding claims, wherein the emollient is an occlusive emollient selected from cyclic and linear dimethicones, polydialkysiloxanes, 25 polyaryl/alkylsiloxanes, long chain (C8-C 3 6 ) alkyl and alkenyl esters of long straight or branched chain alkyl or alkenyl alcohols or acids; long chain (Cs-C 36 ) alkyl and alkenyl aides of long straight or branched chain alkanes and alkenes such as squalene, squalane and mineral oil; 30 jojoba oil polysiloxane polyalkylene copolymers, dialkoxy dimethyl polysiloxanes, short chain alkyl or aryl esters (Cl-C 6 ) of C 12 -C 22 diacids or diols optionally substituted in available positions by -OH, such as diisostearyl dimer H:\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 19 dilinoleate; lanolin and lanolin derivatives, and beeswax and its derivatives.
18. A topical composition according to any one of 5 the preceding claims, wherein the emollient is a humectant selected from glycerol, propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, pantothenol and gluconic acid salts. 10
19. A topical composition according to any one of the preceding claims, wherein the emollient is polyethylene glycol.
20. A topical composition according to any one of 15 the preceding claims, wherein the concentration of the emollient in the topical composition is about 1.0% to about 2.0%.
21. A topical composition according to any one of 20 the preceding claims, wherein the concentration of the emollient in the topical composition is about 1.5% to about 1.8%.
22. A topical composition according to any one of 25 the preceding claims, wherein the concentration of the emollient in the topical composition is about 1.5%.
23. A topical composition according to any one of the preceding claims, wherein further comprises water, 30 oils, salts, fragrances, perfumes, colorants, stabilisers, emulsifiers, propellants, additives, preservatives or preserving agents, anti-oxidants, surfactants, thickeners and other excipients normally used in topical H.\Shona1\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 20 compositions.
24. A topical composition according to any one of the preceding claims, wherein the topical composition is 5 formulated into the form of an aerosol, balm, cream, emolument, foam, gel, liniment, lotion, ointment, salve, solution, spray, suspension, unguent or the like.
25. A topical composition according to any one of 10 the preceding claims, wherein the topical composition is incorporated into sponges, swabs, pads and/or wipes.
26. A topical composition according to any one of the preceding claims, wherein the topical composition is 15 incorporated into cosmetic products.
27. A topical composition according to any one of the preceding claims, wherein the topical composition is used on any part of the body excluding mucous membranes. 20
28. A method of reducing and/or preventing the transmission of a microorganism by applying an effective amount of a topical composition as defined in any one of claims 1 to 27 to any part of the body excluding mucous 25 membranes.
29. The method according to claim 28, wherein the microorganism is a multi-resistant organism.
30 30. The method according to claim 29, wherein the multi-resistant organism is methicillian-resistant staphylococcus aureus. H \Shona1\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 21
31. The method according to any one of claims 28 to 30, wherein the topical composition is applied before and after routine or specialised health-care delivery or preparatory to invasive procedures. 5
32. The method according to any one of claims 28 to 31, wherein an effective amount is about 1 ml to about 3 ml. 10
33. Use of a topical composition as defined in any one of claims 1 to 27 to reduce and/or prevent the transmission of a microorganism.
34. The use according to claim 33, wherein the 15 microorganism is a multi-resistant organism.
35. The use according to claim 34, wherein the multi-resistant organism is methicillian-resistant staphylococcus aureus. 20
36. The use according to any one of claims 33 to 35, wherein the topical composition is used before and after routine or specialised health-care delivery or preparatory to invasive procedures. 25
37. The use according to any one of claims 33 to 36, wherein about 1 ml to about 3 ml of the topical composition is used. 30
38. Use of a topical composition as defined in any one of claims 1 to 27 in the manufacture of a disinfectant and/or antiseptic to reduce and/or prevent the transmission of a microorganism. H.\Shonal\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03 - 22
39. The use according to claim 38, wherein the microorganism is a multi-resistant organism.
40. The use according to claim 39, wherein the 5 multi-resistant organism is methicillian-resistant staphylococcus aureus.
41. A disinfectant and/or antiseptic comprising a topical composition as defined in any one of claims 1 to 10 27.
42. A method of preparing a topical composition as defined in any one of claims 1 to 27 comprising the step of mixing at least one C 1 to C 4 alcohol, at least one anti 15 microbial, and at least one emollient, with stirring, until complete homogenisation is achieved.
43. A topical composition substantially as herein described with reference to any one of the Examples. 20
44. A disinfectant hand lotion comprising a topical composition substantially as herein described with reference to any one of the Examples. 25
45. A method of preparing a topical composition substantially as herein described with reference to any one of the Examples. Dated this 28 day of March 2003 30 AUSTIN REPATRIATION MEDICAL CENTRE By their Patent Attorneys GRIFFITH HACK Fellows Institute of Patent and Trade Mark Attorneys of Australia H\Shona\Keep\Speci\P49134 TOPICAL COMPOSITION 28/03/03
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003203452A AU2003203452A1 (en) | 2003-03-28 | 2003-03-28 | Topical composition |
| AU2006235798A AU2006235798B2 (en) | 2003-03-28 | 2006-11-01 | Topical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003203452A AU2003203452A1 (en) | 2003-03-28 | 2003-03-28 | Topical composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006235798A Division AU2006235798B2 (en) | 2003-03-28 | 2006-11-01 | Topical composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003203452A1 AU2003203452A1 (en) | 2004-10-14 |
| AU2003203452A8 true AU2003203452A8 (en) | 2010-04-29 |
Family
ID=34318251
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003203452A Abandoned AU2003203452A1 (en) | 2003-03-28 | 2003-03-28 | Topical composition |
| AU2006235798A Expired AU2006235798B2 (en) | 2003-03-28 | 2006-11-01 | Topical composition |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006235798A Expired AU2006235798B2 (en) | 2003-03-28 | 2006-11-01 | Topical composition |
Country Status (1)
| Country | Link |
|---|---|
| AU (2) | AU2003203452A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004062775A1 (en) | 2004-12-21 | 2006-06-29 | Stockhausen Gmbh | Alcoholic pump foam |
| CN105147829B (en) * | 2015-08-28 | 2019-05-10 | 爱品尚客(北京)电子商务有限公司 | A kind of maca externally applied spray |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2224702C (en) * | 1995-06-22 | 2013-01-08 | Robert A. Asmus | Stable hydroalcoholic compositions |
| AU715827B2 (en) * | 1995-06-22 | 2000-02-10 | Minnesota Mining And Manufacturing Company | Stable hydroalcoholic compositions |
| WO2001041556A1 (en) * | 1999-12-06 | 2001-06-14 | Københavns Universitet | Method of using mapk4 and orthologues thereof to control plant disease resistance and plant growth |
-
2003
- 2003-03-28 AU AU2003203452A patent/AU2003203452A1/en not_active Abandoned
-
2006
- 2006-11-01 AU AU2006235798A patent/AU2006235798B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006235798B2 (en) | 2008-12-18 |
| AU2003203452A1 (en) | 2004-10-14 |
| AU2006235798A1 (en) | 2006-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20100029780A1 (en) | Topical composition | |
| US6123953A (en) | Cosmetic, dermopharmaceutical or veterinary compositions for disinfecting human or animal skin | |
| ES2360803T3 (en) | COMPOSITIONS AND ANTIMICROBIAL THERAPEUTIC METHODS. | |
| ES2234206T3 (en) | ANTIMOCROBIAL COMPOSITION. | |
| JPH11322591A (en) | Antiseptic microbicide and composition for applying to human body | |
| EP0820225A2 (en) | Fast acting and persistent topical antiseptic | |
| EP2496215B1 (en) | Antimicrobial and anti-acne formulations | |
| Laufman | Current use of skin and wound cleansers and antiseptics | |
| US20100273876A1 (en) | antibacterial formulation comprising a dialkyl sulphosuccinate and a carbanilide antibacterial agent | |
| WO2005044287A1 (en) | Disinfecting composition and methods of making and using same | |
| CN111836877A (en) | Antibacterial and preservative composition | |
| WO2020252433A1 (en) | Compositions, kits, methods and uses for preventing microbial growth | |
| JP2011074082A (en) | Antiseptic sterilizer and composition for application to human body | |
| RU2729982C1 (en) | Antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and an organic acid-based compound, and a cosmetic composition containing it | |
| US20100291168A1 (en) | Antimicrobial formulations comprising a combination of a pyridine thiol and a bis-quinolinium salt | |
| ES2465476T3 (en) | Disinfectant for soft, non-alcoholic, non-irritating skin | |
| JPH06157278A (en) | Skin external preparation for acne vulgaris | |
| JPS62502336A (en) | preservative composition | |
| EP3644738A1 (en) | Antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and an aromatic alcohol, and cosmetic composition containing same | |
| JP5264829B2 (en) | Antiseptic disinfectant and cosmetic composition | |
| JPH07165571A (en) | Disinfecting composition | |
| JP4734293B2 (en) | Antiseptic disinfectant and human body composition | |
| AU2006235798B2 (en) | Topical composition | |
| JP2009167139A (en) | External use composition | |
| JP2007145748A (en) | Antiseptic disinfectant, cosmetics or medicines containing the antiseptic disinfectant, and antiseptic disinfection method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Change of applicant's name (sec. 104) |
Owner name: AUSTIN HEALTH Free format text: FORMER NAME: AUSTIN AND REPATRIATION MEDICAL CENTRE |
|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |