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AU2002220460A1 - The polypeptide fragments of hepatitis e virus, the vaccine composition comprising said fragments and the diagnostic kits - Google Patents

The polypeptide fragments of hepatitis e virus, the vaccine composition comprising said fragments and the diagnostic kits

Info

Publication number
AU2002220460A1
AU2002220460A1 AU2002220460A AU2046002A AU2002220460A1 AU 2002220460 A1 AU2002220460 A1 AU 2002220460A1 AU 2002220460 A AU2002220460 A AU 2002220460A AU 2046002 A AU2046002 A AU 2046002A AU 2002220460 A1 AU2002220460 A1 AU 2002220460A1
Authority
AU
Australia
Prior art keywords
fragments
hepatitis
virus
vaccine composition
diagnostic kits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002220460A
Inventor
Shengxiang Ge
Ying Gu
Zhigiang He
Shaowei Li
Ningshao Xia
Jun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yang Sheng Tang Co Ltd
Original Assignee
Yang Sheng Tang Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yang Sheng Tang Co Ltd filed Critical Yang Sheng Tang Co Ltd
Publication of AU2002220460A1 publication Critical patent/AU2002220460A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/28011—Hepeviridae
    • C12N2770/28111—Hepevirus, e.g. hepatitis E virus
    • C12N2770/28122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/28011—Hepeviridae
    • C12N2770/28111—Hepevirus, e.g. hepatitis E virus
    • C12N2770/28134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/28011—Hepeviridae
    • C12N2770/28111—Hepevirus, e.g. hepatitis E virus
    • C12N2770/28171—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2002220460A 2000-09-30 2001-09-30 The polypeptide fragments of hepatitis e virus, the vaccine composition comprising said fragments and the diagnostic kits Abandoned AU2002220460A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN00130634 2000-09-30
CN00130634A CN1345775A (en) 2000-09-30 2000-09-30 Polypeptide for preventing, diagnosis and treating hepatitis E virus and used as diagnostic reagent and vaccine
PCT/CN2001/001469 WO2002040681A1 (en) 2000-09-30 2001-09-30 The polypeptide fragments of hepatitis e virus, the vaccine composition comprising said fragments and the diagnostic kits

Publications (1)

Publication Number Publication Date
AU2002220460A1 true AU2002220460A1 (en) 2002-05-27

Family

ID=4594225

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002220460A Abandoned AU2002220460A1 (en) 2000-09-30 2001-09-30 The polypeptide fragments of hepatitis e virus, the vaccine composition comprising said fragments and the diagnostic kits

Country Status (9)

Country Link
US (3) US7615228B2 (en)
EP (2) EP2298793A3 (en)
JP (3) JP5681337B2 (en)
KR (2) KR101121754B1 (en)
CN (2) CN101367869B (en)
AU (1) AU2002220460A1 (en)
BR (2) BRPI0114510B8 (en)
MX (1) MXPA03002751A (en)
WO (1) WO2002040681A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101367869B (en) * 2000-09-30 2012-12-05 北京万泰生物药业股份有限公司 Polypeptide for preventing, diagnosing and treating hepatitis E virus, and vaccine as diagnosis agent of the same
US7786264B2 (en) 2001-11-08 2010-08-31 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd Monoclonal antibody against hepatitis E virus or its fragment with binding activity and use thereof
CN1850855B (en) * 2006-05-26 2012-08-29 厦门大学 Method and composition for immuning or preparing monoclonal antibody
WO2010099547A1 (en) * 2009-02-27 2010-09-02 The Regents Of The University Of California Multiple antigen delivery system using hepatitis e virus-like particle
US8906862B2 (en) 2009-02-27 2014-12-09 The Regents Of The University Of California Multiple antigen delivery system using hepatitis E virus-like particle
US8906863B2 (en) 2009-02-27 2014-12-09 The Regents Of The University Of California Proteolysis-resistant capsid of chimeric hepatitis E virus as an oral delivery vector
CN103168277B (en) * 2010-08-31 2016-06-08 Abb技术有限公司 For debugging the process including multiple subsystem or the method for maker solution
CN102453748A (en) * 2010-10-18 2012-05-16 北京雅康博生物科技有限公司 Plasmid standard substance for fluorescent quantitative PCR quantitative detection
CN102565410B (en) * 2012-01-12 2014-08-06 吉林大学 Immunologic detection method for sika deer prion protein
US10058605B2 (en) * 2012-05-09 2018-08-28 Bharat Biotech International Limited Vaccine combinations
CN104031144B (en) * 2013-03-05 2017-08-25 厦门大学 Specific bond HEV 3, antibody of 4 types and application thereof
CN104789534B (en) * 2015-04-10 2017-10-17 浙江中医药大学 A kind of hybridoma, monoclonal antibody and application thereof
FR3044312B1 (en) * 2015-11-30 2017-12-08 Biomerieux Sa MUTUATED HEV POLYPEPTIDES AND THEIR USE FOR THE ASSAY OF ANTI-HEV ANTIBODIES
EP3463443B1 (en) * 2016-05-25 2022-08-03 Intervet International B.V. Hev vaccine
KR101924093B1 (en) 2017-04-18 2018-11-30 건국대학교 산학협력단 Primer set for diagnosis of hapatitis E virus genotype 3 and 4 and method for diagnosing the same
CN110501505B (en) * 2018-05-18 2022-06-10 中国兽医药品监察所 Peste des petits ruminants diagnostic kit
WO2020011755A1 (en) * 2018-07-10 2020-01-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity for the orf2i protein of hepatitis e virus and uses thereof for diagnostic purposes
ES2970072T3 (en) * 2018-07-10 2024-05-24 Inst Nat Sante Rech Med Antibodies that have specificity for the ORF2i protein of the hepatitis E virus and uses thereof for diagnostic purposes
CN109942702B (en) * 2019-03-20 2019-11-08 南京医科大学 A kind of full molecule IgG of people mouse inosculating antibody HEV and its application
EP4372378A4 (en) * 2021-07-06 2025-01-08 Advanced Life Science Institute, Inc. METHOD FOR DETECTING HEPATITIS E VIRUS INFECTION, AND ANTIGENIC POLYPEPTIDE AND KIT FOR DETECTING HEPATITIS E VIRUS INFECTION

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NZ219515A (en) * 1987-02-10 1989-09-27 Wellcome Found Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope
US5110730A (en) * 1987-03-31 1992-05-05 The Scripps Research Institute Human tissue factor related DNA segments
US5885768A (en) 1988-06-17 1999-03-23 The United States Of America As Represented By The Department Of Health And Human Services Hepatitis E virus peptide antigen and antibodies
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US5714374A (en) * 1990-09-12 1998-02-03 Rutgers University Chimeric rhinoviruses
WO1996010580A2 (en) * 1994-10-03 1996-04-11 The Government Of The United States Of America, Re Recombinant proteins of a pakistani strain of hepatitis e and their use in diagnostic methods and vaccines
US5563032A (en) * 1992-10-21 1996-10-08 The United States Of America As Represented By The Department Of Health And Human Services Mosaic polypeptide and methods for detecting the hepatitis E virus
CA2179609A1 (en) * 1993-12-22 1995-06-29 Deborah A. Paul Monoclonal antibodies against hev orf-2 and methods for using same
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US6054567A (en) 1997-04-11 2000-04-25 The United States Of America As Represented By The Department Of Health And Human Services Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
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Also Published As

Publication number Publication date
JP2004525613A (en) 2004-08-26
US8524868B2 (en) 2013-09-03
KR100927221B1 (en) 2009-11-16
US8715695B2 (en) 2014-05-06
JP2014138593A (en) 2014-07-31
JP5681337B2 (en) 2015-03-04
BRPI0114510B1 (en) 2019-09-03
CN101367869A (en) 2009-02-18
US20040052813A1 (en) 2004-03-18
US20100143410A1 (en) 2010-06-10
EP2298793A3 (en) 2011-06-29
EP1331271A4 (en) 2005-04-06
EP1331271A1 (en) 2003-07-30
CN1345775A (en) 2002-04-24
JP2011201881A (en) 2011-10-13
BR0114510A (en) 2004-02-17
EP2298793A2 (en) 2011-03-23
JP5829830B2 (en) 2015-12-09
US7615228B2 (en) 2009-11-10
WO2002040681A1 (en) 2002-05-23
CN101367869B (en) 2012-12-05
US20100150962A1 (en) 2010-06-17
MXPA03002751A (en) 2004-05-04
EP1331271B1 (en) 2014-03-19
KR20090088429A (en) 2009-08-19
BRPI0114510B8 (en) 2021-05-25
KR20030048052A (en) 2003-06-18
KR101121754B1 (en) 2012-03-23

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