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AU2002217356A1 - Novel 2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient - Google Patents

Novel 2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient

Info

Publication number
AU2002217356A1
AU2002217356A1 AU2002217356A AU1735602A AU2002217356A1 AU 2002217356 A1 AU2002217356 A1 AU 2002217356A1 AU 2002217356 A AU2002217356 A AU 2002217356A AU 1735602 A AU1735602 A AU 1735602A AU 2002217356 A1 AU2002217356 A1 AU 2002217356A1
Authority
AU
Australia
Prior art keywords
sup
sub
novel
group
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002217356A
Inventor
Jozsef Barkoczy
Gabor Gigler
Zoltan Greff
Laszlo Gabor Harsing
Gyorgy Levay
Istvan Ling
Bernadett Martonne Marko
Zoltan Ratkai
Gyula Simig
Geza Szabo
Gabor Szenasi
Miklos Vegh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of AU2002217356A1 publication Critical patent/AU2002217356A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a C<SUB>1-4 </SUB>alkyl group or a group of the formula -NR<SUP>1</SUP>R<SUB>2</SUB>, wherein R<SUP>1 </SUP>and R<SUP>2 </SUP>represent, independently, a hydrogen atom, a C<SUB>1-4 </SUB>alkyl group, a C<SUB>1-4 </SUB>alkoxy group or a C<SUP>3-6 </SUP>cycloalkyl group.
AU2002217356A 2000-12-21 2001-12-19 Novel 2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient Abandoned AU2002217356A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0004994A HU225100B1 (en) 2000-12-21 2000-12-21 2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and their use
HU0004994 2000-12-21
PCT/HU2001/000151 WO2002050044A1 (en) 2000-12-21 2001-12-19 Novel 2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient

Publications (1)

Publication Number Publication Date
AU2002217356A1 true AU2002217356A1 (en) 2002-07-01

Family

ID=89978876

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002217356A Abandoned AU2002217356A1 (en) 2000-12-21 2001-12-19 Novel 2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient

Country Status (20)

Country Link
US (1) US7189711B2 (en)
EP (1) EP1351942B1 (en)
JP (1) JP4201252B2 (en)
AT (1) ATE271548T1 (en)
AU (1) AU2002217356A1 (en)
BG (1) BG66199B1 (en)
CA (1) CA2431761C (en)
CZ (1) CZ301371B6 (en)
DE (1) DE60104448T2 (en)
DK (1) DK1351942T3 (en)
EA (1) EA005867B1 (en)
ES (1) ES2225412T3 (en)
HU (1) HU225100B1 (en)
PL (1) PL211495B1 (en)
PT (1) PT1351942E (en)
RO (1) RO121268B1 (en)
SK (1) SK286620B6 (en)
TR (1) TR200402493T4 (en)
UA (1) UA74615C2 (en)
WO (1) WO2002050044A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
US20090233913A1 (en) * 2005-12-30 2009-09-17 Istvan Ling Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
JP6333251B2 (en) * 2012-08-16 2018-05-30 バイエル ファーマ アクチエンゲゼルシャフト 2,3-Benzodiazepines
CN105492436A (en) * 2013-06-17 2016-04-13 拜耳制药股份公司 Substituted phenyl-2,3-benzodiazepines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU219778B (en) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Process for the preparation of N-acyl-2,3-benzodiazepines, their acid addition salts and pharmaceutical compositions containing them, and a group of compounds and pharmaceutical compositions containing them.
DE19604920A1 (en) 1996-02-01 1997-08-07 Schering Ag New 2,3-benzodiazepine derivatives, their production and use as medicines
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
RU2325811C2 (en) 2006-06-28 2008-06-10 Общество С Ограниченной Ответственностью "Фито-Маг" Method of storing fruits, vegetables and crop products

Also Published As

Publication number Publication date
PL211495B1 (en) 2012-05-31
RO121268B1 (en) 2007-02-28
SK286620B6 (en) 2009-02-05
ES2225412T3 (en) 2005-03-16
PT1351942E (en) 2004-11-30
JP2004516284A (en) 2004-06-03
ATE271548T1 (en) 2004-08-15
HUP0004994A2 (en) 2002-11-28
SK7882003A3 (en) 2003-11-04
DE60104448D1 (en) 2004-08-26
CA2431761C (en) 2010-05-25
JP4201252B2 (en) 2008-12-24
TR200402493T4 (en) 2004-12-21
CZ301371B6 (en) 2010-02-03
DK1351942T3 (en) 2004-11-22
WO2002050044A1 (en) 2002-06-27
US7189711B2 (en) 2007-03-13
EP1351942B1 (en) 2004-07-21
UA74615C2 (en) 2006-01-16
CZ20031680A3 (en) 2003-11-12
EA005867B1 (en) 2005-06-30
BG66199B1 (en) 2012-01-31
HU225100B1 (en) 2006-06-28
HU0004994D0 (en) 2001-03-28
PL362029A1 (en) 2004-10-18
BG107932A (en) 2004-02-27
CA2431761A1 (en) 2002-06-27
EA200300691A1 (en) 2003-12-25
DE60104448T2 (en) 2005-07-28
EP1351942A1 (en) 2003-10-15
US20040092510A1 (en) 2004-05-13

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