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AU2002210990A1 - Novel pyrazole derivatives and diabetes remedies containing the same - Google Patents

Novel pyrazole derivatives and diabetes remedies containing the same

Info

Publication number
AU2002210990A1
AU2002210990A1 AU2002210990A AU1099002A AU2002210990A1 AU 2002210990 A1 AU2002210990 A1 AU 2002210990A1 AU 2002210990 A AU2002210990 A AU 2002210990A AU 1099002 A AU1099002 A AU 1099002A AU 2002210990 A1 AU2002210990 A1 AU 2002210990A1
Authority
AU
Australia
Prior art keywords
group
lower alkyl
perfluoro
alkyl group
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002210990A
Inventor
Toshihiro Hatanaka
Yoko Kageyama
Nobuo Kondo
Katsumi Maezono
Hiroyuki Matsueda
Koji Ohsumi
Akiko Onuki
Takashi Umemura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of AU2002210990A1 publication Critical patent/AU2002210990A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention provides a pyrazole derivative of formula 1A or 1B which is useful in treating diabetes: wherein X represents a ²-D-glucopyranosyl group, of which one or more hydroxyl groups may be acylated or ²-D-glucuronyl group, of which one or more hydroxyl groups may be acylated and carboxyl group may be esterified; Y represents a lower alkyl group or perfluoro lower alkyl group; Z represents a hydrogen atom, lower alkyl group, perfluoro lower alkyl group, aralkyl group or phenyl group; R1 to R5 may be the same or different and represent a hydrogen atom, lower alkyl group, perfluoro lower alkyl group, lower alkoxy group, perfluoro lower alkoxy group, lower alkylthio group, perfluoro lower alkylthio group, lower alkyl amino group, halogeno group, lower alkanoyl group, lower alkenyl group or lower alkynyl group, and n represents an integer from 0 to 3; wherein the term "lower" indicates 1 to 6 carbon atoms.
AU2002210990A 2000-11-02 2001-10-31 Novel pyrazole derivatives and diabetes remedies containing the same Abandoned AU2002210990A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000335851 2000-11-02
JP2000-335851 2000-11-02
JP2001-131264 2001-04-27
JP2001131264 2001-04-27
PCT/JP2001/009555 WO2002036602A1 (en) 2000-11-02 2001-10-31 Novel pyrazole derivatives and diabetes remedies containing the same

Publications (1)

Publication Number Publication Date
AU2002210990A1 true AU2002210990A1 (en) 2002-05-15

Family

ID=26603344

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002210990A Abandoned AU2002210990A1 (en) 2000-11-02 2001-10-31 Novel pyrazole derivatives and diabetes remedies containing the same

Country Status (8)

Country Link
US (6) US6815428B2 (en)
EP (2) EP2163555A1 (en)
JP (1) JP3915116B2 (en)
AT (1) ATE455785T1 (en)
AU (1) AU2002210990A1 (en)
DE (1) DE60141156D1 (en)
ES (1) ES2337127T3 (en)
WO (1) WO2002036602A1 (en)

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Also Published As

Publication number Publication date
US6815428B2 (en) 2004-11-09
ATE455785T1 (en) 2010-02-15
US20070099979A1 (en) 2007-05-03
US20070270479A1 (en) 2007-11-22
US7247616B2 (en) 2007-07-24
DE60141156D1 (en) 2010-03-11
EP2163555A1 (en) 2010-03-17
US20040006025A1 (en) 2004-01-08
ES2337127T3 (en) 2010-04-21
WO2002036602A1 (en) 2002-05-10
US20060058244A1 (en) 2006-03-16
US7256209B2 (en) 2007-08-14
EP1338603A1 (en) 2003-08-27
JP3915116B2 (en) 2007-05-16
US7015201B2 (en) 2006-03-21
JPWO2002036602A1 (en) 2004-03-11
US7645787B2 (en) 2010-01-12
US20100063124A1 (en) 2010-03-11
EP1338603B1 (en) 2010-01-20
EP1338603A4 (en) 2007-03-28
US20050043249A1 (en) 2005-02-24

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