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AU2002210548A1 - Sulphur-containing indirubin derivatives, production and use thereof - Google Patents

Sulphur-containing indirubin derivatives, production and use thereof

Info

Publication number
AU2002210548A1
AU2002210548A1 AU2002210548A AU1054802A AU2002210548A1 AU 2002210548 A1 AU2002210548 A1 AU 2002210548A1 AU 2002210548 A AU2002210548 A AU 2002210548A AU 1054802 A AU1054802 A AU 1054802A AU 2002210548 A1 AU2002210548 A1 AU 2002210548A1
Authority
AU
Australia
Prior art keywords
sulphur
production
indirubin derivatives
containing indirubin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002210548A
Inventor
Rolf Jautelat
Olaf Prien
Martina Schafer
Gerhard Siemeister
Andreas Steinmeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU2002210548A1 publication Critical patent/AU2002210548A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2002210548A 2000-10-24 2001-10-17 Sulphur-containing indirubin derivatives, production and use thereof Abandoned AU2002210548A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10053474 2000-10-24
DE10053474A DE10053474A1 (en) 2000-10-24 2000-10-24 Indirubin derivatives containing sulfur, their production and use
PCT/EP2001/012007 WO2002034717A1 (en) 2000-10-24 2001-10-17 Sulphur-containing indirubin derivatives, production and use thereof

Publications (1)

Publication Number Publication Date
AU2002210548A1 true AU2002210548A1 (en) 2002-05-06

Family

ID=7661370

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002210548A Abandoned AU2002210548A1 (en) 2000-10-24 2001-10-17 Sulphur-containing indirubin derivatives, production and use thereof

Country Status (6)

Country Link
US (1) US20020107404A1 (en)
AU (1) AU2002210548A1 (en)
DE (1) DE10053474A1 (en)
PE (1) PE20030208A1 (en)
UY (1) UY26982A1 (en)
WO (1) WO2002034717A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6822267B1 (en) * 1997-08-20 2004-11-23 Advantest Corporation Signal transmission circuit, CMOS semiconductor device, and circuit board
DE10114138C2 (en) * 2001-03-16 2003-03-27 Schering Ag Cdk-inhibitory Indirubin derivatives with increased solubility
DE10125763A1 (en) * 2001-05-17 2002-11-28 Schering Ag New use of indirubin derivatives as VEGF inhibitors useful for preparing medicaments useful for e.g. treating cancer, autoimmune diseases, cardiovascular diseases or viral infections
US20050154046A1 (en) * 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
US7582670B2 (en) 2001-12-13 2009-09-01 Natrogen Therapeutics, Inc. Methods of treating an inflammatory-related disease
US8563525B2 (en) 2004-01-12 2013-10-22 Natrogen Therapeutics International, Inc. Methods of treating an inflammatory-related disease
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7169801B2 (en) 2003-03-17 2007-01-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
KR100588803B1 (en) * 2004-01-27 2006-06-12 학교법인조선대학교 Indirubin derivatives with anticancer activity in cancer cell lines
JP2008524246A (en) 2004-12-16 2008-07-10 タケダ サン ディエゴ インコーポレイテッド Histone deacetylase inhibitor
US20080207594A1 (en) 2005-05-04 2008-08-28 Davelogen Aktiengesellschaft Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders
WO2006122319A2 (en) 2005-05-11 2006-11-16 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2007011626A2 (en) 2005-07-14 2007-01-25 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20090081318A1 (en) * 2005-12-23 2009-03-26 Gelbard Harris A Treatment of neuroads using inhibitors of glycogen synthase kinase (gsk)-3
AR059066A1 (en) * 2006-01-27 2008-03-12 Amgen Inc COMBINATIONS OF THE ANGIOPOYETINE INHIBITOR -2 (ANG2) AND THE VASCULAR ENDOTELIAL GROWTH FACTOR INHIBITOR (VEGF)
JP2013537918A (en) 2010-09-27 2013-10-07 エクセリクシス， インク． Dual inhibitors of MET and VEGF for the treatment of castration resistant prostate cancer and osteoblastic bone metastases
CA2868302A1 (en) 2012-03-23 2013-09-26 Dennis M. Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
EP2708556B1 (en) 2012-09-12 2018-11-07 Samsung Electronics Co., Ltd Pharmaceutical composition for the use in a combination therapy for prevention or treatment of c-met or angiogenesis factor induced diseases
CN103333161B (en) * 2013-05-28 2015-09-30 滁州市洛达生物科技有限公司 The preparation of 1 '-oxo Indirubin and purposes
CN107517589A (en) 2015-01-08 2017-12-26 小利兰·斯坦福大学托管委员会 Provides inducible factors and cells for bone, bone marrow and cartilage
CN108486186A (en) * 2018-03-20 2018-09-04 合肥皖为生物科技有限公司 A kind of method that oxidizing ferment prepares indigo red with anti-tumor activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0102240A3 (en) * 1998-05-29 2003-05-28 Eisenbrand Gerhard Use of indigoid bisindole derivatives for the manufacture of a medicament to inhibit cyclin dependent kinases
EP0966963A1 (en) * 1998-05-29 1999-12-29 Gerhard Prof. Dr. Eisenbrand Use of indigoid bisindole derivatives as CDK1 inhibitors
PL351261A1 (en) * 1999-04-12 2003-04-07 Gerhard Eisenbrand Derivatives of indigoid bisindoles

Also Published As

Publication number Publication date
DE10053474A1 (en) 2002-05-02
WO2002034717A1 (en) 2002-05-02
PE20030208A1 (en) 2003-04-03
UY26982A1 (en) 2002-06-20
US20020107404A1 (en) 2002-08-08

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