AU2001284322A1 - Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem - Google Patents
Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidemInfo
- Publication number
- AU2001284322A1 AU2001284322A1 AU2001284322A AU8432201A AU2001284322A1 AU 2001284322 A1 AU2001284322 A1 AU 2001284322A1 AU 2001284322 A AU2001284322 A AU 2001284322A AU 8432201 A AU8432201 A AU 8432201A AU 2001284322 A1 AU2001284322 A1 AU 2001284322A1
- Authority
- AU
- Australia
- Prior art keywords
- zolpidem
- dimethyl
- synthesis
- methyl
- key intermediate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- KILJGOYISSXUOS-UHFFFAOYSA-N 2-methyl-3-oxo-3-phenylpropanamide Chemical compound NC(=O)C(C)C(=O)C1=CC=CC=C1 KILJGOYISSXUOS-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 title 1
- 229960001475 zolpidem Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN782DE2000 | 2000-08-29 | ||
IN782/DEL/2000 | 2000-08-29 | ||
PCT/IB2001/001558 WO2002018303A2 (en) | 2000-08-29 | 2001-08-28 | Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001284322A1 true AU2001284322A1 (en) | 2002-03-13 |
Family
ID=11097088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001284322A Abandoned AU2001284322A1 (en) | 2000-08-29 | 2001-08-28 | Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem |
Country Status (4)
Country | Link |
---|---|
US (1) | US6921839B2 (en) |
EP (1) | EP1370515A2 (en) |
AU (1) | AU2001284322A1 (en) |
WO (1) | WO2002018303A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1370515A2 (en) | 2000-08-29 | 2003-12-17 | Ranbaxy Laboratories, Ltd. | Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem |
MXPA05006438A (en) | 2002-12-18 | 2005-09-08 | Mallinckrodt Inc | Synthesis of heteroaryl acetamides. |
EP1660496A1 (en) * | 2003-07-31 | 2006-05-31 | Ranbaxy Laboratories Limited | Process for the synthesis of zolpidem |
US20110077200A1 (en) * | 2006-12-06 | 2011-03-31 | Somaxon Pharmaceuticals, Inc. | Combination therapy using low-dose doxepin for the improvement of sleep |
CN110272414B (en) * | 2018-03-14 | 2020-07-17 | 新发药业有限公司 | Preparation method of zolpidem |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2492382A1 (en) * | 1980-10-22 | 1982-04-23 | Synthelabo | IMIDAZO (1,2-A) PYRIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
EP1005863A1 (en) | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
ES2159260B1 (en) | 1999-06-22 | 2002-05-01 | Smithkline Beechan Plc | NEW PAROXETINE METHANOSULPHONATE COMPOSITION |
PT1475093E (en) | 2000-04-24 | 2006-11-30 | Teva Pharma | Micronized zolpidem hemitartrate |
EP1370515A2 (en) | 2000-08-29 | 2003-12-17 | Ranbaxy Laboratories, Ltd. | Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem |
US20020183522A1 (en) * | 2001-05-03 | 2002-12-05 | Markus Sauter | Process for preparing zolpidem |
DE10121638A1 (en) | 2001-05-03 | 2002-11-14 | Boehringer Ingelheim Pharma | Process for the preparation of imidazopyridines |
-
2001
- 2001-08-28 EP EP01963296A patent/EP1370515A2/en not_active Withdrawn
- 2001-08-28 AU AU2001284322A patent/AU2001284322A1/en not_active Abandoned
- 2001-08-28 WO PCT/IB2001/001558 patent/WO2002018303A2/en not_active Application Discontinuation
- 2001-08-28 US US10/363,377 patent/US6921839B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2002018303A2 (en) | 2002-03-07 |
US20040054230A1 (en) | 2004-03-18 |
WO2002018303A3 (en) | 2003-10-02 |
EP1370515A2 (en) | 2003-12-17 |
US6921839B2 (en) | 2005-07-26 |
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