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AU2001284051A1 - 3-spiro-cyanin fluorochromes and their use in bioassays - Google Patents

3-spiro-cyanin fluorochromes and their use in bioassays

Info

Publication number
AU2001284051A1
AU2001284051A1 AU2001284051A AU8405101A AU2001284051A1 AU 2001284051 A1 AU2001284051 A1 AU 2001284051A1 AU 2001284051 A AU2001284051 A AU 2001284051A AU 8405101 A AU8405101 A AU 8405101A AU 2001284051 A1 AU2001284051 A1 AU 2001284051A1
Authority
AU
Australia
Prior art keywords
cyanin
fluorochromes
bioassays
spiro
cyanin fluorochromes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284051A
Inventor
Erk Gedig
Lutz Haalck
Hans-Jurgen Holpert
Viola Podsadlowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut fuer Chemo und Biosensorik Muenster eV ICB
Original Assignee
Institut fuer Chemo und Biosensorik Muenster eV ICB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut fuer Chemo und Biosensorik Muenster eV ICB filed Critical Institut fuer Chemo und Biosensorik Muenster eV ICB
Publication of AU2001284051A1 publication Critical patent/AU2001284051A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AU2001284051A 2000-09-19 2001-09-03 3-spiro-cyanin fluorochromes and their use in bioassays Abandoned AU2001284051A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10046215 2000-09-19
DE10046215A DE10046215B4 (en) 2000-09-19 2000-09-19 Fluorochromes and their use
PCT/EP2001/010130 WO2002026890A1 (en) 2000-09-19 2001-09-03 3-spiro-cyanin fluorochromes and their use in bioassays

Publications (1)

Publication Number Publication Date
AU2001284051A1 true AU2001284051A1 (en) 2002-04-08

Family

ID=7656704

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284051A Abandoned AU2001284051A1 (en) 2000-09-19 2001-09-03 3-spiro-cyanin fluorochromes and their use in bioassays

Country Status (6)

Country Link
US (1) US7855293B2 (en)
EP (1) EP1320571B1 (en)
AU (1) AU2001284051A1 (en)
CA (1) CA2422758A1 (en)
DE (2) DE10046215B4 (en)
WO (1) WO2002026890A1 (en)

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DE60126297T2 (en) 2000-09-29 2007-11-15 Molecular Probes, Inc., Eugene MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES
JP2003048879A (en) * 2001-05-31 2003-02-21 Nisshinbo Ind Inc Fluorescent group-containing carbodiimide compound and method for producing the compound
US8512971B2 (en) * 2002-12-10 2013-08-20 Echelon Biosciences, Inc. Compounds and methods of use thereof for assaying lysophospholipase D activity
DE102006029454A1 (en) 2005-12-05 2007-06-06 Dyomics Gmbh Hydrophilic markers based on diastereomeric
EP2223086B2 (en) 2007-12-14 2016-06-01 Biotium Inc. Fluorescent compounds - labeling dyes
US7951959B2 (en) 2008-09-17 2011-05-31 Thermo Fisher Scientific (Milwaukee) LLC Hydrophilic labels for biomolecules
WO2010085844A1 (en) 2009-01-29 2010-08-05 Commonwealth Scientific Industrial Research Organisation Measuring g protein coupled receptor activation
JP5733715B2 (en) * 2009-12-25 2015-06-10 キヤノン株式会社 Nasal central nervous system tissue labeling composition, labeling method and screening method using nasal central nervous system tissue labeling composition
US10053447B2 (en) 2010-12-21 2018-08-21 Pierce Biotechnology, Inc Fluorescent compounds
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
US20140072515A9 (en) 2012-03-02 2014-03-13 Greg Hermanson Cyanine compounds
EP2850078B1 (en) 2012-08-28 2018-04-25 Pierce Biotechnology, Inc. Benzopyrylium compounds
CN110132915B (en) * 2019-05-10 2020-09-22 华南理工大学 An aggregation-induced luminescent probe and a method for dual detection of heavy metal ion pollutants
CN110591054B (en) * 2019-09-17 2021-05-18 江苏泰特尔新材料科技股份有限公司 Epoxide with low total chlorine content and no heavy metal residue and synthesis process thereof

Family Cites Families (30)

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DE499967C (en) * 1928-06-28 1930-06-25 I G Farbenindustrie Akt Ges Process for the preparation of polymethine dyes
US5569587A (en) * 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US5627027A (en) * 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US6048982A (en) * 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
DE3912046B4 (en) * 1988-09-02 2004-03-25 Carnegie Mellon University Method of labeling a component of an aqueous liquid and luminescent photostable reaction product
IL91673A0 (en) * 1988-09-20 1990-04-29 Us Health Method for tagging an oligodeoxynucleotide
US4981977A (en) * 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
EP0605655B1 (en) * 1991-09-16 1997-05-07 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes
US5556959A (en) * 1993-01-22 1996-09-17 Pharmacia P-L Biochemicals Inc. Indocarbocyanine-linked phosphoramidites
US5534416A (en) 1993-04-13 1996-07-09 Molecular Probes, Inc. Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes
JPH07114140A (en) * 1993-10-18 1995-05-02 Mitsubishi Paper Mills Ltd Absorption dye for photography
JPH07271065A (en) * 1994-02-09 1995-10-20 Mitsubishi Paper Mills Ltd Electrophotographic photoreceptor
US5597696A (en) * 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
DE4445065A1 (en) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Methods for in-vivo diagnostics using NIR radiation
JPH08292590A (en) * 1995-04-20 1996-11-05 Mitsubishi Paper Mills Ltd Electrophotographic photoreceptor
DE19539409C2 (en) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Contrast agent for near infrared diagnostics
US6004536A (en) * 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
JP3414928B2 (en) * 1996-04-25 2003-06-09 三菱製紙株式会社 Thermal recording material for infrared laser
DE19649971A1 (en) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optical diagnostics for the diagnosis of neurodegenerative diseases using near-infrared radiation (NIR radiation)
US6027709A (en) * 1997-01-10 2000-02-22 Li-Cor Inc. Fluorescent cyanine dyes
JPH10195319A (en) 1997-01-13 1998-07-28 Mitsubishi Paper Mills Ltd Method for producing polymethine cyanine compound
JPH10219124A (en) * 1997-02-12 1998-08-18 Mitsubishi Paper Mills Ltd Spiroindolenine ring-containing methine dye
DE19717904A1 (en) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Acid-labile and enzymatically cleavable dye constructs for diagnostics with near infrared light and for therapy
US5986086A (en) * 1997-06-20 1999-11-16 Amersham Pharmacia Biotech Inc. Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides
US6974698B1 (en) * 1999-01-15 2005-12-13 The United States Of America As Represented By The Department Of Health And Human Services Methods for delivering biologically active molecules into cells
US6114350A (en) * 1999-04-19 2000-09-05 Nen Life Science Products, Inc. Cyanine dyes and synthesis methods thereof
DE19940394C2 (en) 1999-08-25 2002-03-21 Inst Chemo Biosensorik Fluorochromes and their use
DE60126297T2 (en) * 2000-09-29 2007-11-15 Molecular Probes, Inc., Eugene MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES
EP1209205A1 (en) * 2000-11-28 2002-05-29 Innosense S.r.l. Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds

Also Published As

Publication number Publication date
US7855293B2 (en) 2010-12-21
WO2002026890A1 (en) 2002-04-04
EP1320571B1 (en) 2007-11-21
CA2422758A1 (en) 2003-03-18
DE10046215A1 (en) 2002-04-04
US20030138791A1 (en) 2003-07-24
DE10046215B4 (en) 2004-04-15
EP1320571A1 (en) 2003-06-25
DE50113301D1 (en) 2008-01-03

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