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AU2001275378A1 - Methods and compositions for inhibiting immunoglobulin-mediated reperfusion inj ury - Google Patents

Methods and compositions for inhibiting immunoglobulin-mediated reperfusion inj ury

Info

Publication number
AU2001275378A1
AU2001275378A1 AU2001275378A AU7537801A AU2001275378A1 AU 2001275378 A1 AU2001275378 A1 AU 2001275378A1 AU 2001275378 A AU2001275378 A AU 2001275378A AU 7537801 A AU7537801 A AU 7537801A AU 2001275378 A1 AU2001275378 A1 AU 2001275378A1
Authority
AU
Australia
Prior art keywords
methods
compositions
immunoglobulin
mediated reperfusion
inj ury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001275378A
Inventor
Michael C. Carroll
Herbert B. Hechtman
Francis D. Moore Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Original Assignee
Immune Disease Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immune Disease Institute Inc filed Critical Immune Disease Institute Inc
Publication of AU2001275378A1 publication Critical patent/AU2001275378A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Methods and compositions for treating or preventing immunoglobulin-mediated reperfusion or ischemic injury, in a subject, are provided. Methods for identifying inhibitors of an interaction between a pathogenic immunoglobulin and an ischemic antigen or a component of the complement pathway are provided. Pathogenic immunoglobulins and mutated forms thereof are also disclosed.
AU2001275378A 2000-06-08 2001-06-08 Methods and compositions for inhibiting immunoglobulin-mediated reperfusion inj ury Abandoned AU2001275378A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21027200P 2000-06-08 2000-06-08
US60210272 2000-06-08
PCT/US2001/018510 WO2001093892A1 (en) 2000-06-08 2001-06-08 Methods and compositions for inhibiting immunoglobulin-mediated__reperfusion injury

Publications (1)

Publication Number Publication Date
AU2001275378A1 true AU2001275378A1 (en) 2001-12-17

Family

ID=22782260

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001275378A Abandoned AU2001275378A1 (en) 2000-06-08 2001-06-08 Methods and compositions for inhibiting immunoglobulin-mediated reperfusion inj ury

Country Status (9)

Country Link
EP (2) EP1286682B1 (en)
JP (1) JP2004502412A (en)
CN (1) CN1443074A (en)
AT (1) ATE459367T1 (en)
AU (1) AU2001275378A1 (en)
CA (1) CA2410458A1 (en)
DE (1) DE60141463D1 (en)
ES (1) ES2343351T3 (en)
WO (1) WO2001093892A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100136684A1 (en) * 2004-03-01 2010-06-03 Carroll Michael C Natural IgM Antibodies
AU2005219839B9 (en) * 2004-03-01 2011-12-22 Immune Disease Institute, Inc Natural IgM antibodies and inhibitors thereof
AU2012200909B2 (en) * 2004-03-01 2013-10-03 Immune Disease Institute, Inc Natural lgM antibodies and inhibitors thereof
WO2009035055A1 (en) * 2007-09-14 2009-03-19 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Insulin-like growth factor-1 (igf-1) production promoter

Family Cites Families (35)

* Cited by examiner, † Cited by third party
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US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DE768377T1 (en) 1988-09-02 1998-01-02 Dyax Corp Production and selection of recombinant proteins with different binding sites
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1991000906A1 (en) 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
WO1991007087A1 (en) 1989-11-13 1991-05-30 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
DK0463151T3 (en) 1990-01-12 1996-07-01 Cell Genesys Inc Generation of xenogenic antibodies
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE185601T1 (en) 1990-07-10 1999-10-15 Cambridge Antibody Tech METHOD FOR PRODUCING SPECIFIC BONDING PAIRS
CA2090473A1 (en) 1990-08-29 1992-03-01 Robert M. Kay Homologous recombinatin in mammalian cells
JP2938569B2 (en) 1990-08-29 1999-08-23 ジェンファーム インターナショナル，インコーポレイティド Method for producing xenogeneic immunoglobulin and transgenic mouse
DE69129154T2 (en) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. METHOD FOR ENRICHING PROTEIN VARIANTS WITH CHANGED BINDING PROPERTIES
CA2097708A1 (en) 1990-12-06 1992-06-07 Stephen P. A. Fodor Very large scale immobilized polymer synthesis
DK1279731T3 (en) 1991-03-01 2007-09-24 Dyax Corp Process for the development of binding mini-proteins
ATE269401T1 (en) 1991-04-10 2004-07-15 Scripps Research Inst LIBRARIES OF HETERODIMERIC RECEPTORS USING PHAGEMIDS
DE4122599C2 (en) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid for screening antibodies
EP0916396B1 (en) 1991-11-22 2005-04-13 Affymetrix, Inc. (a Delaware Corporation) Combinatorial strategies for polymer synthesis
US5233409A (en) 1992-02-25 1993-08-03 Schwab Karl W Color analysis of organic constituents in sedimentary rocks for thermal maturity
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
KR100310939B1 (en) 1992-10-01 2002-06-20 추후제출 Complex Combination Chemistry Library Encrypted with Tags
CA2163345A1 (en) 1993-06-16 1994-12-22 Susan Adrienne Morgan Antibodies
US5362899A (en) 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
CA2218898A1 (en) * 1995-05-17 1996-11-21 Duo Wang Immunoconjugates comprising single-chain variable region fragments of anti-cd19 antibodies
IT1395574B1 (en) 2009-09-14 2012-10-16 Guala Dispensing Spa DISTRIBUTION DEVICE

Also Published As

Publication number Publication date
CN1443074A (en) 2003-09-17
EP2251026A1 (en) 2010-11-17
EP1286682A4 (en) 2004-10-13
JP2004502412A (en) 2004-01-29
ATE459367T1 (en) 2010-03-15
ES2343351T3 (en) 2010-07-29
CA2410458A1 (en) 2001-12-13
DE60141463D1 (en) 2010-04-15
EP1286682A1 (en) 2003-03-05
EP1286682B1 (en) 2010-03-03
WO2001093892A1 (en) 2001-12-13

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