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AU2001259285A1 - Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method - Google Patents

Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method

Info

Publication number
AU2001259285A1
AU2001259285A1 AU2001259285A AU5928501A AU2001259285A1 AU 2001259285 A1 AU2001259285 A1 AU 2001259285A1 AU 2001259285 A AU2001259285 A AU 2001259285A AU 5928501 A AU5928501 A AU 5928501A AU 2001259285 A1 AU2001259285 A1 AU 2001259285A1
Authority
AU
Australia
Prior art keywords
immobilizing oligonucleotides
cycloaddition
oligonucleotides employing
bioconjugation
employing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001259285A
Inventor
Gregory M. Husar
Hallie A. Latham-Timmons
Michael Leuck
Wolfgang Pieken
John Pilon
David P Sebesta
Andreas Wolter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Aldrich Co LLC
Original Assignee
Proligo LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proligo LLC filed Critical Proligo LLC
Publication of AU2001259285A1 publication Critical patent/AU2001259285A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2404Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Structural Engineering (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
AU2001259285A 2000-05-01 2001-05-01 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method Abandoned AU2001259285A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20156100P 2000-05-01 2000-05-01
US60201561 2000-05-01
US26502001P 2001-01-30 2001-01-30
US60265020 2001-01-30
PCT/US2001/013956 WO2001084234A1 (en) 2000-05-01 2001-05-01 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method

Publications (1)

Publication Number Publication Date
AU2001259285A1 true AU2001259285A1 (en) 2001-11-12

Family

ID=26896865

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001259285A Abandoned AU2001259285A1 (en) 2000-05-01 2001-05-01 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method

Country Status (4)

Country Link
EP (1) EP1287404A4 (en)
JP (1) JP2003535317A (en)
AU (1) AU2001259285A1 (en)
WO (1) WO2001084234A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427678B2 (en) 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
WO2002012566A2 (en) * 2000-08-09 2002-02-14 Motorola, Inc. The use and evaluation of a [2+2] photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US20070154945A1 (en) * 2001-03-05 2007-07-05 Megumi Akiyama Immobilized biomolecule and method of detecting substance capable of interacting with biomolecule
WO2003062452A2 (en) 2002-01-23 2003-07-31 Proligo, Llc Methods for the integrated synthesis and purification of oligonucleotides
EP1585755B1 (en) 2002-12-31 2015-08-05 Sigma-Aldrich Co. LLC Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support
US7790835B2 (en) 2003-12-03 2010-09-07 Nektar Therapeutics Method of preparing maleimide functionalized polymers
US8758688B2 (en) 2003-12-22 2014-06-24 Imec Microelectronic structures for patterned deposition of molecules onto surfaces
JP4581571B2 (en) * 2004-09-06 2010-11-17 富士ゼロックス株式会社 Quantitative method for measuring the amount of maleimidyl groups in particles
ATE461960T1 (en) 2005-07-19 2010-04-15 Nektar Therapeutics METHOD FOR PRODUCING POLYMER MALEIMIDES
GB0619182D0 (en) * 2006-09-29 2006-11-08 Leuven K U Res & Dev Oligonucleotide arrays
WO2010064631A1 (en) * 2008-12-02 2010-06-10 和光純薬工業株式会社 Photobase generator
KR20150016334A (en) * 2012-05-21 2015-02-11 애질런트 테크놀로지스, 인크. Retro diels alder reaction as a cleavable linker in dna/rna applications
JP5986872B2 (en) * 2012-10-05 2016-09-06 公益財団法人微生物化学研究会 Compound, method for producing compound, method for producing acetate derivative, method for producing atorvastatin, and method for recovering asymmetric ligand
KR102177225B1 (en) 2013-07-01 2020-11-10 일루미나, 인코포레이티드 Catalyst-free surface functionalization and polymer grafting
EP3484908A4 (en) 2016-07-15 2020-04-08 AM Chemicals Llc Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis
CN108911941A (en) * 2018-05-25 2018-11-30 凯莱英生命科学技术(天津)有限公司 1,3- cyclohexadiene is continuously synthesizing to method
US20250215041A1 (en) * 2023-12-29 2025-07-03 Life Technologies Corporation System and Method for Aqueous Conjugation of Substrates Using Diels-Alder Chemistry

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08509751A (en) * 1993-01-21 1996-10-15 オレゴン州 Chemical functionalization of the surface
US5874532A (en) * 1997-01-08 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for solution phase synthesis of oligonucleotides and peptides
US6737236B1 (en) * 1997-01-08 2004-05-18 Proligo, Llc Bioconjugation of macromolecules
WO1998047910A1 (en) * 1997-04-21 1998-10-29 Proligo Llc Method for solution phase synthesis of oligonucleotides
US6171797B1 (en) * 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays

Also Published As

Publication number Publication date
EP1287404A1 (en) 2003-03-05
JP2003535317A (en) 2003-11-25
EP1287404A4 (en) 2003-10-15
WO2001084234A1 (en) 2001-11-08

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