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AU2001253127A1 - Soluble zalpha11 cytokine receptors - Google Patents

Soluble zalpha11 cytokine receptors

Info

Publication number
AU2001253127A1
AU2001253127A1 AU2001253127A AU5312701A AU2001253127A1 AU 2001253127 A1 AU2001253127 A1 AU 2001253127A1 AU 2001253127 A AU2001253127 A AU 2001253127A AU 5312701 A AU5312701 A AU 5312701A AU 2001253127 A1 AU2001253127 A1 AU 2001253127A1
Authority
AU
Australia
Prior art keywords
methods
vitro
vivo
soluble zalpha11
cytokine receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001253127A
Inventor
Richard D Holly
Andrew J. Nelson
Julia E. Novak
Scott R. Presnell
Cindy A Sprecher
James W. West
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of AU2001253127A1 publication Critical patent/AU2001253127A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonist, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
AU2001253127A 2000-04-05 2001-04-03 Soluble zalpha11 cytokine receptors Abandoned AU2001253127A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19473100P 2000-04-05 2000-04-05
US60194731 2000-04-05
US22212100P 2000-07-28 2000-07-28
US60222121 2000-07-28
PCT/US2001/010872 WO2001077171A2 (en) 2000-04-05 2001-04-03 Soluble zalpha11 cytokine receptors

Publications (1)

Publication Number Publication Date
AU2001253127A1 true AU2001253127A1 (en) 2001-10-23

Family

ID=26890341

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001253127A Abandoned AU2001253127A1 (en) 2000-04-05 2001-04-03 Soluble zalpha11 cytokine receptors

Country Status (9)

Country Link
US (9) US6777539B2 (en)
EP (2) EP1303602B1 (en)
AT (2) ATE349522T1 (en)
AU (1) AU2001253127A1 (en)
CA (1) CA2420992C (en)
DE (2) DE60141234D1 (en)
DK (2) DK1749888T3 (en)
ES (2) ES2339959T3 (en)
WO (1) WO2001077171A2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
US7189400B2 (en) * 1998-03-17 2007-03-13 Genetics Institute, Llc Methods of treatment with antagonists of MU-1
US7198789B2 (en) 1998-03-17 2007-04-03 Genetics Institute, Llc Methods and compositions for modulating interleukin-21 receptor activity
CA2237915A1 (en) * 1998-05-19 1999-11-19 Stephen Shaughnessy Osteoporosis treatment
DE60141234D1 (en) * 2000-04-05 2010-03-18 Zymogenetics Inc Soluble cytokine receptor zalpfa11
EP1787997A1 (en) * 2000-05-11 2007-05-23 Genetics Institute, LLC MU-1, member of the cytokine receptor family
US7105723B2 (en) * 2001-03-16 2006-09-12 Basf Plant Science Gmbh Sugar and lipid metabolism regulators in plants
NZ532021A (en) * 2001-10-04 2008-05-30 Genetics Inst Llc Methods and compositions for modulating interleukin-21 receptor activity
WO2003082212A2 (en) * 2002-03-27 2003-10-09 The Governement Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method for treating cancer in humans
EP2289525A1 (en) 2002-06-07 2011-03-02 ZymoGenetics, Inc. Use of IL-21 for expanding lymphoid cells and for anticancer adoptive immunotherapy
AU2003251633A1 (en) 2002-07-01 2004-01-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Il-21 as a regulator of immunoglobin production
CN1688340A (en) 2002-07-15 2005-10-26 韦思公司 Methods and compositions for modulating T helper (TH) cell development and function
ES2340280T3 (en) * 2003-03-14 2010-06-01 Wyeth Llc DIRECTED ANTIBODIES AGAINST THE RECEIVER OF HUMAN IL-21 AND USE OF THE SAME.
AU2004224277A1 (en) * 2003-03-21 2004-10-07 Wyeth Treating immunological disorder using agonists of interleukin-21/ interleukin-21 receptor
DK1692276T3 (en) 2003-11-19 2010-11-01 Us Gov Health & Human Serv Method for Induction of Development and Terminal Differentiation of Memory B Cells
CN1980698A (en) * 2004-05-19 2007-06-13 惠氏公司 Modulation of immunoglobulin production and atopic disorders
PT1758610E (en) 2004-05-20 2012-10-01 Zymogenetics Inc Methods of treating cancer using il-21 and monoclonal antibody therapy
AU2005332996A1 (en) * 2004-08-05 2006-12-21 Wyeth Antagonizing interleukin-21 receptor activity
JP2008515434A (en) * 2004-10-08 2008-05-15 ジョージア テック リサーチ コーポレイション Microencapsulation of cells in hydrogels using electrostatic potential
GT200600148A (en) * 2005-04-14 2006-11-22 METHODS FOR THE TREATMENT AND PREVENTION OF FIBROSIS
PL1963369T3 (en) 2005-11-28 2013-10-31 Zymogenetics Inc Il-21 antagonists
EP1960433A2 (en) 2005-11-28 2008-08-27 Zymogenetics, Inc. Il-21 receptor antagonists
AU2007233092B2 (en) * 2006-03-31 2014-03-20 Karima Ferrani-Kile Methods and compositions for obtaining and using biologically active multi-protein complexes
BRPI0821168B8 (en) * 2007-12-07 2021-05-25 Zymogenetics Inc isolated antibody that binds to human IL-21, or a fragment thereof, uses of said antibody or fragment, and, hybridoma
PE20100141A1 (en) * 2008-05-23 2010-02-22 Wyeth Corp BINDING PROTEIN TO THE INTERLEUQUIN RECEPTOR 21
US8178097B2 (en) * 2008-05-23 2012-05-15 Wyeth Llc Methods of treatment utilizing binding proteins of the interleukin-21 receptor
CN102186787B (en) 2008-10-16 2014-05-07 豪雅冠得股份有限公司 Polarizing glass and optical isolator
WO2010096394A2 (en) 2009-02-17 2010-08-26 Redwood Biosciences, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
KR20130139255A (en) * 2010-09-03 2013-12-20 꽁파르마 프랑스 Quantification of residual host cell dna by real-time quantitative pcr
WO2012097333A2 (en) 2011-01-14 2012-07-19 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
WO2013169693A1 (en) 2012-05-09 2013-11-14 Bristol-Myers Squibb Company Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody
CA3019398A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
WO2025038726A2 (en) * 2023-08-14 2025-02-20 A-Alpha Bio Interleukin 21 variants

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
US5298418A (en) 1991-09-16 1994-03-29 Boyce Thompson Institute For Plant Research, Inc. Cell line isolated from larval midgut tissue of Trichoplusia ni
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5783672A (en) * 1994-05-26 1998-07-21 Immunex Corporation Receptor for oncostatin M
JP2001508309A (en) 1997-01-16 2001-06-26 ジェネティックス・インスチチュート・インコーポレーテッド Member of the hematopoietin receptor superfamily
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
WO1999067290A1 (en) * 1998-06-24 1999-12-29 Chugai Research Institute For Molecular Medicine, Inc. Novel hemopoietin receptor proteins
WO2000008152A1 (en) 1998-08-04 2000-02-17 Regeneron Pharmaceuticals, Inc. Novel orphan cytokine receptors
ES2329741T3 (en) * 1998-09-23 2009-11-30 Zymogenetics, Inc. ZALPHA CYTOKIN RECEIVER11.
US6576744B1 (en) * 1998-09-23 2003-06-10 Zymogenetics, Inc. Cytokine receptor zalpha11
CA2350235A1 (en) 1998-11-06 2000-05-18 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
US6307024B1 (en) 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
WO2000069880A1 (en) * 1999-05-18 2000-11-23 Millennium Pharmaceuticals, Inc. Il-9/il-2 receptor-like molecules and uses thereof
DE60141234D1 (en) * 2000-04-05 2010-03-18 Zymogenetics Inc Soluble cytokine receptor zalpfa11

Also Published As

Publication number Publication date
DE60141234D1 (en) 2010-03-18
US20110189207A1 (en) 2011-08-04
US20020137677A1 (en) 2002-09-26
EP1749888A3 (en) 2007-03-14
US20100074905A1 (en) 2010-03-25
US6777539B2 (en) 2004-08-17
US20070224118A1 (en) 2007-09-27
DE60125543D1 (en) 2007-02-08
US7629452B2 (en) 2009-12-08
WO2001077171A2 (en) 2001-10-18
EP1749888B1 (en) 2010-01-27
US20110003973A1 (en) 2011-01-06
EP1749888A2 (en) 2007-02-07
ES2279809T3 (en) 2007-09-01
US20090196882A1 (en) 2009-08-06
US7763713B2 (en) 2010-07-27
US20080032333A1 (en) 2008-02-07
EP1303602B1 (en) 2006-12-27
ATE456654T1 (en) 2010-02-15
DK1749888T3 (en) 2010-05-10
WO2001077171A3 (en) 2002-05-16
CA2420992A1 (en) 2001-10-18
US20090221802A1 (en) 2009-09-03
CA2420992C (en) 2010-07-13
EP1303602A2 (en) 2003-04-23
ATE349522T1 (en) 2007-01-15
US7189695B2 (en) 2007-03-13
DK1303602T3 (en) 2007-05-07
ES2339959T3 (en) 2010-05-27
DE60125543T2 (en) 2007-10-04
US20040235743A1 (en) 2004-11-25

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