[go: up one dir, main page]

AU2001249918A1 - Inhibitors of inflammation and reperfusion injury and methods of use thereof - Google Patents

Inhibitors of inflammation and reperfusion injury and methods of use thereof

Info

Publication number
AU2001249918A1
AU2001249918A1 AU2001249918A AU4991801A AU2001249918A1 AU 2001249918 A1 AU2001249918 A1 AU 2001249918A1 AU 2001249918 A AU2001249918 A AU 2001249918A AU 4991801 A AU4991801 A AU 4991801A AU 2001249918 A1 AU2001249918 A1 AU 2001249918A1
Authority
AU
Australia
Prior art keywords
inflammation
inhibitors
methods
reperfusion injury
reperfusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001249918A
Inventor
Prakash Japtap
Siya Ram
Andrew Salzman
Garry Southan
Csaba Szabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inotek Corp
Original Assignee
Inotek Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Corp filed Critical Inotek Corp
Publication of AU2001249918A1 publication Critical patent/AU2001249918A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001249918A 2000-04-06 2001-04-06 Inhibitors of inflammation and reperfusion injury and methods of use thereof Abandoned AU2001249918A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19562200P 2000-04-06 2000-04-06
US60195622 2000-04-06
US09766053 2001-01-19
US09/766,053 US6534651B2 (en) 2000-04-06 2001-01-19 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
PCT/US2001/011288 WO2001077075A2 (en) 2000-04-06 2001-04-06 Inhibitors of inflammation and reperfusion injury

Publications (1)

Publication Number Publication Date
AU2001249918A1 true AU2001249918A1 (en) 2001-10-23

Family

ID=26891147

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001249918A Abandoned AU2001249918A1 (en) 2000-04-06 2001-04-06 Inhibitors of inflammation and reperfusion injury and methods of use thereof

Country Status (3)

Country Link
US (2) US6534651B2 (en)
AU (1) AU2001249918A1 (en)
WO (1) WO2001077075A2 (en)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903885D0 (en) * 1999-10-26 1999-10-26 Diabact Ab Method and means for detecting inflammatory processes
US20020048550A1 (en) * 2000-07-20 2002-04-25 Vallera Daniel A. Radiolabeled immunotoxins
US6759427B2 (en) 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
DE10137163A1 (en) 2001-07-30 2003-02-13 Bayer Ag New thiophenecarboxamido-substituted isoindole derivatives, useful as Factor XIa inhibitors for treatment or prophylaxis of, e.g. thromboembolic diseases, atherosclerosis, arthritis, Alzheimer's disease or cancer
SE0102764D0 (en) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US20030096833A1 (en) * 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2830447B1 (en) * 2001-10-09 2004-04-16 Flamel Tech Sa MICROPARTICULAR ORAL GALENIC FORM FOR DELAYED AND CONTROLLED RELEASE OF PHARMACEUTICAL ACTIVE INGREDIENTS
US20070160645A1 (en) * 2001-10-25 2007-07-12 Jakob Vinten-Johansen PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs
EP1438085B1 (en) 2001-10-25 2008-10-15 Emory University Catheter for modified perfusion
WO2006069170A2 (en) * 2004-12-22 2006-06-29 Emory University Therapeutic adjuncts to enhance the organ protective effects of postconditioning
US7414036B2 (en) 2002-01-25 2008-08-19 Muscagen Limited Compounds useful as A3 adenosine receptor agonists
ATE407674T1 (en) * 2002-04-09 2008-09-15 Flamel Tech Sa ORAL PHARMACEUTICAL FORMULATION IN THE FORM OF AN AQUEOUS SUSPENSION OF MICROCAPSULES FOR THE MODIFIED RELEASE OF AMOXICILLIN
ES2320438T7 (en) 2002-04-09 2013-02-14 Flamel Technologies Oral pharmaceutical formulation of aqueous suspension of microcapsules that allow the modified release of active ingredient (s)
FR2840302B1 (en) 2002-06-03 2004-07-16 Aventis Pharma Sa ISOINDOLONE DERIVATIVES, PREPARATION METHOD AND INTERMEDIARY THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
DE10238722A1 (en) 2002-08-23 2004-03-11 Bayer Ag Improving attention, concentration, cognition, learning and/or memory performance, using selective phosphodiesterase 9A inhibitors, preferably 4H-pyrazolo-(3,4-d)-pyrimidin-4-one derivatives
AU2002951247A0 (en) * 2002-09-06 2002-09-19 Alchemia Limited Compounds that interact with kinases
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
SE0301446D0 (en) * 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
US7531569B2 (en) 2003-12-02 2009-05-12 Sanofi-Aventis Deutschland Gmbh Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
DE602005013491D1 (en) * 2004-02-18 2009-05-07 Astrazeneca Ab BENZAMID DERIVATIVES AND THEIR USE AS GLUCCOINASE-ACTIVATING AGENTS
AU2005214137B2 (en) * 2004-02-18 2008-05-29 Astrazeneca Ab Compounds
EP1722797A4 (en) * 2004-02-26 2008-03-19 Inotek Pharmaceuticals Corp ISOQUINOLINE DERIVATIVES AND METHODS OF USE
EP1758596B9 (en) * 2004-05-26 2010-09-15 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
PE20060426A1 (en) 2004-06-02 2006-06-28 Schering Corp TARTARIC ACID DERIVATIVES AS INHIBITORS OF MMPs, ADAMs, TACE AND TNF-alpha
US7638513B2 (en) 2004-06-02 2009-12-29 Schering Corporation Compounds for the treatment of inflammatory disorders
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
JP2008503466A (en) * 2004-06-16 2008-02-07 イノテック ファーマシューティカルズ コーポレイション How to treat or prevent erectile dysfunction or urinary incontinence
SE0402284D0 (en) * 2004-09-21 2004-09-21 Astrazeneca Ab New heterocyclic amides
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
US7700640B2 (en) 2004-10-16 2010-04-20 Astrazeneca Ab Process for making phenoxy benzamide compounds
EP1891069A1 (en) * 2005-05-24 2008-02-27 AstraZeneca AB 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
US20070166378A1 (en) * 2005-06-09 2007-07-19 Flamel Technologies, Inc. Oral ribavirin pharmaceutical compositions
EP2027113A1 (en) * 2005-07-09 2009-02-25 AstraZeneca AB Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
EP1910350A1 (en) * 2005-07-09 2008-04-16 AstraZeneca AB 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
NZ575513A (en) * 2005-07-09 2009-11-27 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
UY30048A1 (en) * 2005-12-23 2007-07-31 Astrazeneca Ab SUBSTITUTED DERIVATIVES OF THE N, 2- (1H-BENZIMIDAZOL-1-IL) ACETAMIDE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PREPARATION PROCESSES AND APPLICATIONS
TWI433839B (en) * 2006-08-11 2014-04-11 Neomed Inst Novel benzimidazole derivatives 290
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
CL2007003061A1 (en) * 2006-10-26 2008-08-01 Astrazeneca Ab COMPOUNDS DERIVED FROM 3,5-DIOXI-BENZAMIDA; PREPARATION PROCESS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT A MEDIUM DISEASE THROUGH GLK, SUCH AS TYPE 2 DIABETES.
US20100094009A1 (en) * 2006-12-21 2010-04-15 Mccabe James Novel crystalline compound useful as glk activator
PE20091211A1 (en) 2007-11-30 2009-09-14 Boehringer Ingelheim Int PYRAZOLOPYRIMIDINE DERIVATIVES AS PDE9A MODULATORS
WO2009111264A2 (en) * 2008-02-29 2009-09-11 Alseres Pharmaceuticals, Inc. Systemic purine administration:modulating axonal outgrowth of central nervous system neurons
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
EP2324028A2 (en) 2008-08-04 2011-05-25 AstraZeneca AB Therapeutic agents 414
JP5453431B2 (en) 2008-09-08 2014-03-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Pyrazolopyrimidines and their use for the treatment of CNS disorders
US20100137976A1 (en) * 2008-12-02 2010-06-03 Medtronic Vascular, Inc. Systems and Methods for Treating Heart Tissue Via Localized Delivery of Parp Inhibitors
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
EP2414363B1 (en) 2009-03-31 2014-01-08 Boehringer Ingelheim International GmbH 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators
WO2010116177A1 (en) 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
AR076221A1 (en) * 2009-04-09 2011-05-26 Astrazeneca Ab DERIVED FROM PIRAZOL [4,5-E] PYRIMIDINE AND ITS USE TO TREAT DIABETES AND OBESITY
CN101580501B (en) * 2009-06-01 2011-03-09 南京卡文迪许生物工程技术有限公司 Synthetic method of 3-(substituted dihydro-isoindolone-2-group)-2,6-dioxopiperidine and intermediate thereof
PH12012501320A1 (en) 2010-01-11 2013-01-21 Inotek Pharmaceuticals Corp Combination, kit and method of reducing intraocular pressure
WO2011119969A1 (en) 2010-03-26 2011-09-29 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
HUP1000243A2 (en) 2010-05-06 2012-01-30 Avidin Kft 8-hidroxy-quinoline derivatives
JP2013526514A (en) 2010-05-10 2013-06-24 ラディカル・セラピューティックス・インコーポレイテッド Lipoic acid and nitroxide derivatives and uses thereof
PE20130602A1 (en) 2010-08-12 2013-05-25 Boehringer Ingelheim Int 6-CYCLOALKYL-1,5-DIHYDRO-PYRAZOLE (3,4-D) PYRIMIDIN-4-ONAS DERIVATIVES AND THEIR USE AS PDE9A INHIBITORS
MX2013006251A (en) 2010-12-03 2013-10-01 Epizyme Inc Substituted purine and 7 - deazapurine compounds as modulators of epigenetic enzymes.
EP2646455A4 (en) * 2010-12-03 2014-04-02 Epizyme Inc HISTONE METHYLTRANSFERASE MODULATORS AND METHODS OF USE
BR112013013668A2 (en) 2010-12-03 2016-09-06 Epizyme Inc 7-deazapurine histone methyltransferase modulators, and methods of using them
EP2486923B1 (en) * 2011-02-11 2015-09-09 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Histone deacetylase (HDAC) inhibiting compounds and method of making same
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
HRP20171204T1 (en) 2012-01-26 2017-10-06 Inotek Pharmaceuticals Corporation ANHYDRID POLYMORPHES FROM [(2R, 3S, 4R, 5R) -5- (6- (CYCLOPENTYLAMINO) -9H-PURIN-9-IL) -3,4-Dihydroxytetrahydrofuran-2-yl)] METHYL-NITRATE AND THEIR PRODUCTS
EP2882750A4 (en) 2012-08-10 2016-08-17 Epizyme Inc DOT1L PROTEIN METHYLTRANSFERASE INHIBITORS AND METHODS OF USE
CA2883781A1 (en) 2012-09-06 2014-03-13 Epizyme, Inc. Method of treating leukemia
WO2014152566A2 (en) 2013-03-15 2014-09-25 Epizyme, Inc. Methods of synthesizing substituted purine compounds
EP2968389A4 (en) 2013-03-15 2016-08-24 Inotek Pharmaceuticals Corp OPHTHALMIC FORMULATIONS
JP7377718B2 (en) 2017-05-12 2023-11-10 エナンタ ファーマシューティカルズ インコーポレイテッド Apoptosis signal-regulated kinase 1 inhibitor and methods of use thereof
WO2018218042A1 (en) 2017-05-25 2018-11-29 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2018218051A1 (en) 2017-05-25 2018-11-29 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10246439B2 (en) 2017-05-25 2019-04-02 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10597382B2 (en) 2017-08-28 2020-03-24 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CA3073656C (en) 2017-09-22 2024-03-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
KR102782563B1 (en) 2017-10-18 2025-03-14 주빌런트 에피파드 엘엘씨 Imidazo-pyridine compounds as PAD inhibitors
CA3080677A1 (en) 2017-11-06 2019-05-09 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
FI3704120T3 (en) 2017-11-24 2024-06-03 Jubilant Episcribe Llc Heterocyclic compounds as prmt5 inhibitors
JP7279063B6 (en) 2018-03-13 2024-02-15 ジュビラント プローデル エルエルシー Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation
BR112020022114A2 (en) 2018-05-02 2021-01-26 Enanta Pharmaceuticals, Inc. tetrazole containing kinase-1 inhibitors regulating apoptosis signal and methods of using it
US10683289B2 (en) 2018-05-02 2020-06-16 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10968199B2 (en) 2018-08-22 2021-04-06 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020106707A1 (en) 2018-11-19 2020-05-28 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020198214A1 (en) 2019-03-25 2020-10-01 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
TW202317546A (en) 2021-07-09 2023-05-01 美商普萊克斯姆公司 Aryl compounds and pharmaceutical compositions that modulate ikzf2

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029884A (en) 1971-03-18 1977-06-14 Abbott Laboratories Adenosine-5'-carboxylic acid amides
CA1019727A (en) 1971-03-18 1977-10-25 Abbott Laboratories Adenosine-5'-carboxylic acid amides
CH565151A5 (en) * 1971-03-19 1975-08-15 Sandoz Ag
US3864483A (en) 1972-03-22 1975-02-04 Abbott Lab Adenosine-5{40 -carboxylic acid amides
US3857947A (en) 1972-08-14 1974-12-31 Stauffer Chemical Co Fungicidal active phthalimides
US3855206A (en) 1973-04-11 1974-12-17 Abbott Lab Adenosine-5{40 -carbohydroxamic esters
US3914414A (en) 1973-06-14 1975-10-21 Abbott Lab Method of increasing coronary pO{HD 2 {B in mammals
US3914415A (en) 1973-06-14 1975-10-21 Abbott Lab Adenosine-5{40 -carboxylic acid amides
US3966917A (en) 1974-07-30 1976-06-29 Abbott Laboratories Platelet aggregation inhibitors
ZA811555B (en) * 1980-03-25 1982-03-31 Merrell Toraude & Co Substituted deoxyadenosine derivatives
EP0351475A1 (en) * 1988-07-21 1990-01-24 Merrell Dow Pharmaceuticals Inc. S-Adenosylmethionine decarboxylase inhibitors
EP0679396A1 (en) 1994-03-02 1995-11-02 Pfizer Inc. Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury
WO1998054135A1 (en) 1997-05-30 1998-12-03 Meiji Seika Kaisha, Ltd. Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same
US20020022636A1 (en) 1997-09-03 2002-02-21 Jia-He Li Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity
WO1999011644A1 (en) 1997-09-03 1999-03-11 Guilford Pharmaceuticals Inc. Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
AU9298098A (en) 1997-09-03 1999-03-22 Guilford Pharmaceuticals Inc. Amino-substituted compounds, methods, and compositions for inhibiting parp activity
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US20020028813A1 (en) 1997-09-03 2002-03-07 Paul F. Jackson Thioalkyl compounds, methods, and compositions for inhibiting parp activity
US6087480A (en) 1998-01-13 2000-07-11 Ciba Specialty Chemcals Corporation Process for preparing sparingly soluble aromatic amines
AU748887B2 (en) 1998-02-12 2002-06-13 Myriad Genetics, Inc. Beta-sheet mimetics and methods relating to the use thereof
AU9298798A (en) 1998-05-15 1999-12-06 Guilford Pharmaceuticals Inc. Fused tricyclic compounds which inhibit parp activity
EP1077944A1 (en) 1998-05-15 2001-02-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, compositions, and methods for inhibiting parp activity
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6201020B1 (en) 1998-12-31 2001-03-13 Guilford Pharmaceuticals, Inc. Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp
AP1538A (en) 1999-01-11 2006-01-10 Agouron Pharma Tricyclic inhibitors of poly (adp-ribose) polymerases.
US6277847B1 (en) * 1999-04-02 2001-08-21 Fmc Corporation Herbicidal isoindolinonyl-and 3,4-dihydroisoquinolonyl-substituted heterocycles

Also Published As

Publication number Publication date
US20030149050A1 (en) 2003-08-07
US20020095044A1 (en) 2002-07-18
WO2001077075A2 (en) 2001-10-18
US6534651B2 (en) 2003-03-18
WO2001077075A3 (en) 2002-03-28
US6903079B2 (en) 2005-06-07

Similar Documents

Publication Publication Date Title
AU2001249918A1 (en) Inhibitors of inflammation and reperfusion injury and methods of use thereof
AU2001244355A1 (en) Heterobiarylsulphonamides and their use as pde 7 inhibitors
AU2001259758A1 (en) Interleukin-1 inhibitors in the treatment of diseases
AU2001249670A1 (en) Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1
AU2001249969A1 (en) Inha inhibitors and their use as antibacterials
AU2001265008A1 (en) Caspase inhibitors and uses thereof
AU2003303128A1 (en) Inhibitors and methods of use thereof
AU2002225954A1 (en) Dipeptidylpeptidases and methods of use
AU6340600A (en) Telomerase inhibitors and methods of their use
AU2001285020A1 (en) P97-active agent conjugates and their methods of use
AU2001234437A1 (en) Deicing compositions and methods of use
AU2002230836A1 (en) Benzylamine derivatives and their use as thrombin inhibitors
AU2001216218A1 (en) Heterocyclic analgesic compounds and method of use thereof
AU2002247208A1 (en) Selective pde3b inhibitors and use of the same in therapy
AU2001233837A1 (en) Benzthiazoles as tnf and pde-iv inhibitors
AU2002213346A1 (en) Osteopontin-coated surfaces and methods of use
AU2002337913A1 (en) Glycosulfopeptide inhibitors and methods of use thereof
AU2001258381A1 (en) Use of parp inhibitors in cosmetic preparations
AU2002241661A1 (en) Multifunctional protease inhibitors and their use in treatment of disease
AU2001276907A1 (en) Inflating device and method of use
AU2002346594A1 (en) Use of hiv-1 protease inhibitors and their derivatives in the treatment of inflammation
AU2001255696A1 (en) Telomerase inhibitors and methods of their use
IL152792A0 (en) Heterocycle derivatives and methods of use
AU2001234962A1 (en) Mixtures of caspase inhibitors and complement inhibitors and methods of use thereof
AU2001292818A1 (en) Use of transcription factors for treating inflammation and other diseases