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AU2001249161A1 - Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors - Google Patents

Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors

Info

Publication number
AU2001249161A1
AU2001249161A1 AU2001249161A AU4916101A AU2001249161A1 AU 2001249161 A1 AU2001249161 A1 AU 2001249161A1 AU 2001249161 A AU2001249161 A AU 2001249161A AU 4916101 A AU4916101 A AU 4916101A AU 2001249161 A1 AU2001249161 A1 AU 2001249161A1
Authority
AU
Australia
Prior art keywords
quinazolin
reverse transcriptase
transcriptase inhibitors
asymmetric synthesis
hiv reverse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001249161A
Inventor
Akin H. Davulcu
Roberta L. Dorow
Joseph M. Fortunak
Gregory D. Harris
Goss S. Kauffman
William A. Nugent
Rodney L. Parsons
Lilian A. Radesca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of AU2001249161A1 publication Critical patent/AU2001249161A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2001249161A 2000-03-23 2001-03-13 Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors Abandoned AU2001249161A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19157200P 2000-03-23 2000-03-23
US60191572 2000-03-23
PCT/US2001/007865 WO2001070707A2 (en) 2000-03-23 2001-03-13 Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
AU2001249161A1 true AU2001249161A1 (en) 2001-10-03

Family

ID=22706022

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001249161A Abandoned AU2001249161A1 (en) 2000-03-23 2001-03-13 Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors

Country Status (5)

Country Link
US (1) US20010044540A1 (en)
EP (1) EP1268447A2 (en)
AU (1) AU2001249161A1 (en)
CA (1) CA2403230A1 (en)
WO (1) WO2001070707A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362373B1 (en) * 2000-09-13 2002-03-26 The Dow Chemical Company Chiral amino alcohols and process for preparation of same
CN1331601C (en) * 2003-05-16 2007-08-15 中国科学院上海有机化学研究所 Method of Chiral alkamine ligand used as catalyst of asymmetric addition process for terminal alkyne to fluoroalkylaryl ketone
EP1614672B1 (en) 2003-04-04 2010-09-22 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences An amino alcohol ligand and its use in preparation of chiral proparglic tertiary alkohols and tertiary amines via enantioselective additon reaction
CN1827605B (en) * 2006-04-07 2012-03-28 中国科学院上海有机化学研究所 4,4-disubstituted-3,4-dihydro-2(1H)-quinolinone compounds, synthesis method and application
JP6129598B2 (en) * 2013-03-17 2017-05-17 日本ポリエチレン株式会社 Diol compound, catalyst for olefin polymerization using the same, and method for producing olefin polymer
US20240043402A1 (en) * 2020-12-10 2024-02-08 Merck Sharp & Dohme Llc Tetrahydroquinazoline derivatives as selective cytotoxic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434152A (en) * 1993-11-08 1995-07-18 Merck & Co., Inc. Asymmetric synthesis of (S)-(-)-6-chloro-4- cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-quinazolinone
HRP980143A2 (en) * 1997-04-09 1999-02-28 Soo Sung Ko 4,4-disubstituted-3,4-dihydro-2 (1h)-quinazolinones useful as hiv reverse transcriptase inhibitors

Also Published As

Publication number Publication date
US20010044540A1 (en) 2001-11-22
CA2403230A1 (en) 2001-09-27
WO2001070707A2 (en) 2001-09-27
EP1268447A2 (en) 2003-01-02
WO2001070707A3 (en) 2002-03-07

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