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AU1851697A - Inhibitors of farnesyl-protein transferase - Google Patents

Inhibitors of farnesyl-protein transferase

Info

Publication number
AU1851697A
AU1851697A AU18516/97A AU1851697A AU1851697A AU 1851697 A AU1851697 A AU 1851697A AU 18516/97 A AU18516/97 A AU 18516/97A AU 1851697 A AU1851697 A AU 1851697A AU 1851697 A AU1851697 A AU 1851697A
Authority
AU
Australia
Prior art keywords
farnesyl
inhibitors
protein transferase
transferase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU18516/97A
Other versions
AU712504B2 (en
Inventor
Christopher J. Dinsmore
George D. Hartman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605699.9A external-priority patent/GB9605699D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU1851697A publication Critical patent/AU1851697A/en
Application granted granted Critical
Publication of AU712504B2 publication Critical patent/AU712504B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU18516/97A 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase Ceased AU712504B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1086096P 1996-01-30 1996-01-30
US60/010860 1996-01-30
GB9605699 1996-03-19
GBGB9605699.9A GB9605699D0 (en) 1996-03-19 1996-03-19 Inhibitors of farnesyl-protein transferase
PCT/US1997/001599 WO1997027752A1 (en) 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
AU1851697A true AU1851697A (en) 1997-08-22
AU712504B2 AU712504B2 (en) 1999-11-11

Family

ID=26308951

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18516/97A Ceased AU712504B2 (en) 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase

Country Status (4)

Country Link
EP (1) EP0880320A4 (en)
AU (1) AU712504B2 (en)
CA (1) CA2243507A1 (en)
WO (1) WO1997027752A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929250A (en) * 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
CA2336448A1 (en) 1998-07-02 2000-01-13 Christopher J. Dinsmore Inhibitors of prenyl-protein transferase
EP1091736A4 (en) 1998-07-02 2001-10-24 Merck & Co Inc Inhibitors of prenyl-protein transferase
FR2780892B1 (en) * 1998-07-08 2001-08-17 Sod Conseils Rech Applic USE OF PRENYLTRANSFERASE INHIBITORS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR TREATING CONDITIONS RESULTING FROM MEMBRANE FIXATION OF HETEROTRIMERIC PROTEIN
EP1158980B1 (en) 1998-12-18 2005-08-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
IL142768A0 (en) 1998-12-18 2002-03-10 Du Pont Pharm Co N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
CA2347769A1 (en) 1998-12-18 2000-06-22 Dean A. Wacker 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity
WO2000035454A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6331541B1 (en) 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6897234B2 (en) 1999-12-17 2005-05-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6380228B1 (en) 2000-04-10 2002-04-30 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
DE10025782A1 (en) 2000-05-26 2001-12-06 Basf Ag Liquid crystalline mixture
EP1162194A1 (en) * 2000-06-06 2001-12-12 Aventis Pharma Deutschland GmbH Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use
AU2001273129A1 (en) 2000-06-30 2002-01-14 Bristol-Myers Squibb Pharma Company N-ureidoheterocycloaklyl-piperidines as modulators of chemokine receptor activity
US6974869B2 (en) 2001-09-18 2005-12-13 Bristol-Myers Squibb Pharma Company Piperizinones as modulators of chemokine receptor activity
TW200409630A (en) 2002-09-12 2004-06-16 Bristol Myers Squibb Co N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6919356B2 (en) 2002-09-26 2005-07-19 Bristol Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
US7645903B2 (en) 2002-10-31 2010-01-12 Ge Healthcare Bio-Sciences Ab Use of urea variants as affinity ligands
EP2095819A1 (en) 2008-02-28 2009-09-02 Maastricht University N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576957A (en) * 1984-07-05 1986-03-18 American Cyanamid Company N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas
CA2172125A1 (en) * 1993-09-30 1995-04-06 S. Jane Desolms Inhibitors of farnesyl-protein transferase
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Pharmaceutical compositions for inhibition of g-protein function and for treatment of proliferative diseases containing tricyclic compounds some such compounds and process for preparing part of them
AU1615895A (en) * 1994-03-31 1995-10-12 Bristol-Myers Squibb Company Imidazole-containing inhibitors of farnesyl protein transferase
JPH10508005A (en) * 1994-09-29 1998-08-04 メルク エンド カンパニー インコーポレーテッド Thiol-free farnesyl-protein transferase inhibitors
US5756528A (en) * 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0862435A4 (en) * 1995-11-22 1999-02-03 Merck & Co Inc Inhibitors of farnesyl-protein transferase
JP2000505797A (en) * 1996-01-30 2000-05-16 メルク エンド カンパニー インコーポレーテッド Farnesyl-protein transferase inhibitor
JP2000504014A (en) * 1996-01-30 2000-04-04 メルク エンド カンパニー インコーポレーテッド Farnesyl-protein transferase inhibitor
AU704087B2 (en) * 1996-01-30 1999-04-15 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0891334A1 (en) * 1996-04-03 1999-01-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0959883A4 (en) * 1996-04-03 2001-05-09 Merck & Co Inc Inhibitors of farnesyl-protein transferase
EP0935464A1 (en) * 1996-04-03 1999-08-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU716153B2 (en) * 1996-04-03 2000-02-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase

Also Published As

Publication number Publication date
WO1997027752A1 (en) 1997-08-07
AU712504B2 (en) 1999-11-11
EP0880320A4 (en) 1999-06-16
EP0880320A1 (en) 1998-12-02
CA2243507A1 (en) 1997-08-07

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired