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AU1012988A - New N-(1H-indol-4-yl)benzamide derivatives and also their salts, their application by way of medicinal products and the compositions containing them - Google Patents

New N-(1H-indol-4-yl)benzamide derivatives and also their salts, their application by way of medicinal products and the compositions containing them

Info

Publication number
AU1012988A
AU1012988A AU10129/88A AU1012988A AU1012988A AU 1012988 A AU1012988 A AU 1012988A AU 10129/88 A AU10129/88 A AU 10129/88A AU 1012988 A AU1012988 A AU 1012988A AU 1012988 A AU1012988 A AU 1012988A
Authority
AU
Australia
Prior art keywords
salts
indol
new
way
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU10129/88A
Other versions
AU619728B2 (en
Inventor
Francois Clemence
Jacques Guillaume
Gilles Hamon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU1012988A publication Critical patent/AU1012988A/en
Application granted granted Critical
Publication of AU619728B2 publication Critical patent/AU619728B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Products of formula (I): <IMAGE> in which one of the substituents X and Y denotes alkyl (C1-C5), alkoxy (C1-C3), chlorine, bromine, iodine, nitro or amino optionally substituted by an aliphatic acyl (C2-C5) or 2 alkyls (C1-C5) and the other substituent denotes a hydrogen, it being understood that Y does not denote methoxy and X chlorine, and their addition salts with acids. The products (I) are endowed with antiarrhythmic properties and some have anticalcic properties.
AU10129/88A 1987-01-09 1988-01-08 New N-(1H-indol-4-yl)benzamide derivatives and also their salts, their application by way of medicinal products and the compositions containing them Ceased AU619728B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8700151A FR2609464B1 (en) 1987-01-09 1987-01-09 NOVEL N- (1H-INDOL 4-YL) BENZAMIDE DERIVATIVES AND THEIR SALTS, THEIR USE AS MEDICAMENTS, AND THE COMPOSITIONS CONTAINING THEM
FR8700151 1987-01-09

Publications (2)

Publication Number Publication Date
AU1012988A true AU1012988A (en) 1988-07-14
AU619728B2 AU619728B2 (en) 1992-02-06

Family

ID=9346770

Family Applications (1)

Application Number Title Priority Date Filing Date
AU10129/88A Ceased AU619728B2 (en) 1987-01-09 1988-01-08 New N-(1H-indol-4-yl)benzamide derivatives and also their salts, their application by way of medicinal products and the compositions containing them

Country Status (14)

Country Link
EP (1) EP0275221B1 (en)
JP (1) JPS63188664A (en)
KR (1) KR880008988A (en)
AT (1) ATE62673T1 (en)
AU (1) AU619728B2 (en)
DE (1) DE3862380D1 (en)
DK (1) DK168377B1 (en)
ES (1) ES2029033T3 (en)
FI (1) FI85140C (en)
FR (1) FR2609464B1 (en)
GR (1) GR3002185T3 (en)
HU (1) HU201910B (en)
IE (1) IE60779B1 (en)
ZA (1) ZA8837B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234942A (en) * 1984-10-19 1993-08-10 Ici Americas Inc. Heterocyclic amides and leucotriene antagonistic use thereof
DE4119611A1 (en) * 1991-06-14 1992-12-17 Bayer Ag AGENTS FOR CONTROLLING PESTS BASED ON SUBSTITUTED OXAZOLIDINONE, NEW SUBSTITUTED OXAZOLIDINONE, THEIR PRODUCTION AND USE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853408A (en) * 1985-04-23 1989-08-01 Roussel Uclaf 4-phenylpropyl-indoles having antiarythmic activity
FR2583047B1 (en) * 1985-06-05 1988-01-08 Roussel Uclaf PROCESS FOR THE PREPARATION OF INDOLE 4-PHENYLPROPYL DERIVATIVES AND INTERMEDIATES
FR2584713B1 (en) * 1985-07-11 1988-09-09 Roussel Uclaf NOVEL CARBOXAMIDE INDOLE DERIVATIVES, SALTS THEREOF, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM
ATE97403T1 (en) * 1986-12-19 1993-12-15 Roussel Uclaf INDOL CARBOXAMIDE DERIVATIVES AND THEIR SALTS, PROCESSES AND INTERMEDIATE PRODUCTS FOR THE MANUFACTURE, MEDICINAL USE AND COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
EP0275221A2 (en) 1988-07-20
GR3002185T3 (en) 1992-12-30
FI880064A0 (en) 1988-01-08
AU619728B2 (en) 1992-02-06
FI85140C (en) 1992-03-10
FI880064A (en) 1988-07-10
DK3288D0 (en) 1988-01-06
IE60779B1 (en) 1994-08-10
FR2609464B1 (en) 1990-12-07
DE3862380D1 (en) 1991-05-23
HU201910B (en) 1991-01-28
HUT45491A (en) 1988-07-28
ES2029033T3 (en) 1992-07-16
FR2609464A1 (en) 1988-07-15
ATE62673T1 (en) 1991-05-15
IE880039L (en) 1988-07-09
KR880008988A (en) 1988-09-13
EP0275221A3 (en) 1988-08-24
DK3288A (en) 1988-07-10
DK168377B1 (en) 1994-03-21
ZA8837B (en) 1989-03-29
EP0275221B1 (en) 1991-04-17
FI85140B (en) 1991-11-29
JPS63188664A (en) 1988-08-04

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