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ATE71627T1 - Bryostatine. - Google Patents

Bryostatine.

Info

Publication number
ATE71627T1
ATE71627T1 AT87306552T AT87306552T ATE71627T1 AT E71627 T1 ATE71627 T1 AT E71627T1 AT 87306552 T AT87306552 T AT 87306552T AT 87306552 T AT87306552 T AT 87306552T AT E71627 T1 ATE71627 T1 AT E71627T1
Authority
AT
Austria
Prior art keywords
bryostatin
bryostatins
linneaeus
bryozoan
phylum
Prior art date
Application number
AT87306552T
Other languages
English (en)
Inventor
George R Pettit
Cherry L Herald
Yoshiaki Kamano
John E Leet
Original Assignee
Univ Arizona State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona State filed Critical Univ Arizona State
Application granted granted Critical
Publication of ATE71627T1 publication Critical patent/ATE71627T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Vending Machines For Individual Products (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT87306552T 1986-07-28 1987-07-24 Bryostatine. ATE71627T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/889,946 US4833257A (en) 1986-07-28 1986-07-28 Compositions of matter and methods of using same
EP87306552A EP0264173B1 (de) 1986-07-28 1987-07-24 Bryostatine

Publications (1)

Publication Number Publication Date
ATE71627T1 true ATE71627T1 (de) 1992-02-15

Family

ID=25396026

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87306552T ATE71627T1 (de) 1986-07-28 1987-07-24 Bryostatine.

Country Status (8)

Country Link
US (1) US4833257A (de)
EP (1) EP0264173B1 (de)
JP (1) JP2626889B2 (de)
AT (1) ATE71627T1 (de)
CA (1) CA1305476C (de)
DE (1) DE3776063D1 (de)
ES (1) ES2038664T3 (de)
GR (1) GR3004061T3 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256646A (en) * 1990-07-27 1993-10-26 Bristol-Myers Squibb Company Antiviral antibiotic BU-4224V
US5072004A (en) * 1990-12-31 1991-12-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthetic conversion of bryostatin 2 into bryostatin 1
US5196447A (en) * 1991-08-08 1993-03-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting On Behalf Of Arizona State University Neristatin 1
US5436400A (en) * 1993-01-19 1995-07-25 Arizona Board Of Regents Isolation and structure of spongistatin 1
US5393897A (en) * 1993-07-02 1995-02-28 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structure of spongistatins 5,7,8 and 9
US5478861A (en) * 1994-02-18 1995-12-26 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
US5684036A (en) * 1994-02-18 1997-11-04 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
US6060505A (en) * 1996-03-20 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Method of treating cancer using C-26 modified bryostatin
AU784589B2 (en) * 1999-11-30 2006-05-04 Board Of Trustees Of The Leland Stanford Junior University Bryostatin analogues, synthetic methods and uses
US7256286B2 (en) * 1999-11-30 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Bryostatin analogues, synthetic methods and uses
US20030148924A1 (en) * 2002-07-09 2003-08-07 Tamar Tennenbaum Methods and pharmaceutical compositions of healing wounds
EP1383540B1 (de) * 2000-07-31 2009-04-29 Bar-Ilan University Methoden und pharmazeutische zusammensetzungen zur wundheilung
US20040037828A1 (en) * 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
US20100129332A1 (en) * 2000-07-31 2010-05-27 Tamar Tennenbaum Methods and pharmaceutical compositions for healing wounds
US20060258562A1 (en) * 2000-07-31 2006-11-16 Healor Ltd. Methods and pharmaceutical compositions for healing wounds
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) * 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
ATE411019T1 (de) * 2001-05-02 2008-10-15 Brni Neurosciences Inst Kohlensäureanhydrase-aktivatoren zur verbesserung der lern- und gedächtnisleistung
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
WO2004004641A2 (en) * 2002-07-02 2004-01-15 Blanchette Rockefeller Neurosciences Institute PKC ACTIVATION AS A MEANS FOR ENHANCING sAPPα SECRETION AND IMPROVING COGNITION USING BRYOSTATIN TYPE COMPOUNDS
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
US6900339B2 (en) 2002-04-30 2005-05-31 The University Of North Carolina At Chapel Hill Bryostatin composition and bryostatin acquisition methodologies
WO2003099272A1 (en) * 2002-05-22 2003-12-04 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
EP1567142A4 (de) * 2002-11-20 2005-12-14 Errant Gene Therapeutics Llc Behandlung von lungenzellen mit histondeacetylase-hemmern
CN102120031B (zh) * 2003-08-07 2012-12-05 希尔洛有限公司 用于加速伤口愈合的药物组合物和方法
TW201207390A (en) * 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
CA2587013A1 (en) * 2004-11-08 2006-05-18 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
EP1915145A1 (de) 2005-07-29 2008-04-30 Blanchette Rockefeller Neurosciences Institute Verwendung eines pkc-aktivators, allein oder in kombination mit einem pkc-hemmer zur verbesserung des langzeitgedächtnisses
AU2006286152B2 (en) * 2005-08-29 2012-05-31 Healor Ltd. Methods and compositions for prevention and treatment of diabetic and aged skin
JP2009544753A (ja) 2006-07-28 2009-12-17 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート 細胞成長、シナプスリモデリング及び長期記憶の固定を刺激する方法
EP2121001B1 (de) 2007-02-09 2014-12-17 Blanchette Rockefeller Neurosciences, Institute Therapeutische wirkungen von bryostatinen auf durch ischämie/schlaganfall herbeigeführte gedächtnisstörungen und hirnverletzungen
ES2548766T3 (es) 2007-02-09 2015-10-20 Blanchette Rockefeller Neurosciences Institute Efectos terapéuticos de las briostatinas, briólogos y otras sustancias relacionadas en alteraciones de la memoria inducidas por trauma craneal y por lesiones cerebrales
NZ582556A (en) * 2007-07-30 2013-02-22 Healor Ltd Pharmaceutical composition for treating wounds and related methods
NZ600583A (en) * 2009-02-24 2013-08-30 Healor Ltd Visfatin therapeutic agents for the treatment of acne and other conditions
EP2536421A4 (de) 2010-01-11 2013-10-09 Healor Ltd Verfahren zur behandlung von schuppenflechte
US20120020948A1 (en) 2010-07-08 2012-01-26 Alkon Daniel L Dag-type and indirect protein kinase c activators and anticoagulant for the treatment of stroke
US9597312B2 (en) 2010-08-19 2017-03-21 Cognitive Research Enterprises, Inc. Treatment of cognitive disorders associated with abnormal dendritic spines using PKC activators
CA2855932A1 (en) 2011-11-13 2013-05-16 Blanchette Rockefeller Neurosciences Institute Pkc activators and combinations thereof
JP6440628B2 (ja) * 2012-11-27 2018-12-19 アフィオス コーポレーション 蘚苔地衣類組成物、その作製方法及び使用
WO2016130969A1 (en) 2015-02-13 2016-08-18 George Robert Pettit Silstatin compounds
US20180217163A1 (en) 2015-05-11 2018-08-02 Daniel L. Alkon Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele
US11629167B2 (en) 2017-11-09 2023-04-18 Arizona Board Of Regents On Behalf Of Arizona State University Betulastatin compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560774A (en) * 1982-11-17 1985-12-24 Arizona State University Macrocyclic lactones
JPS60174418A (ja) * 1984-02-18 1985-09-07 Ishikawajima Harima Heavy Ind Co Ltd 下水あるいはし尿汚泥等の流動層式焼却装置
US4611066A (en) * 1984-08-10 1986-09-09 Arizona State University Bryostatins 4 to 8

Also Published As

Publication number Publication date
US4833257A (en) 1989-05-23
JPS63183585A (ja) 1988-07-28
DE3776063D1 (en) 1992-02-27
GR3004061T3 (de) 1993-03-31
EP0264173B1 (de) 1992-01-15
CA1305476C (en) 1992-07-21
ES2038664T3 (es) 1993-08-01
EP0264173A2 (de) 1988-04-20
EP0264173A3 (en) 1988-07-13
JP2626889B2 (ja) 1997-07-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee