ATE71111T1 - Peptid-derivate, renin- und saeureprotease hemmende mittel. - Google Patents

Peptid-derivate, renin- und saeureprotease hemmende mittel.

Info

Publication number: ATE71111T1
Authority: AT; Austria
Prior art keywords: renin; peptide derivatives; protease inhibitors; acid protease; derivatives
Prior art date: 1985-02-12

Application number

AT86400271T

Other languages

English (en)

Inventor

Jean Wagnon

Georges Callet

Jean Pierre Gagnol

Dino Nisato

Catherine Cazaubon

Original Assignee

Sanofi Sa

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-12

Filing date

1986-02-10

Publication date

1992-01-15

1985-02-12 Priority claimed from FR8501981A external-priority patent/FR2577225B1/fr

1985-02-12 Priority claimed from FR8501982A external-priority patent/FR2577226B1/fr

1986-02-10 Application filed by Sanofi Sa, Inst Nat Sante Rech Med filed Critical Sanofi Sa

1992-01-15 Application granted granted Critical

1992-01-15 Publication of ATE71111T1 publication Critical patent/ATE71111T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT86400271T 1985-02-12 1986-02-10 Peptid-derivate, renin- und saeureprotease hemmende mittel. ATE71111T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR8501981A FR2577225B1 (fr)	1985-02-12	1985-02-12	Derives peptidiques inhibiteurs de la renine et des proteases acides
FR8501982A FR2577226B1 (fr)	1985-02-12	1985-02-12	Analogues de pepstatine inhibiteurs de la renine et des proteases acides
EP86400271A EP0192554B1 (de)	1985-02-12	1986-02-10	Peptid-Derivate, Renin- und Säureprotease hemmende Mittel

Publications (1)

Publication Number	Publication Date
ATE71111T1 true ATE71111T1 (de)	1992-01-15

Family

ID=26224369

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT86400272T ATE52518T1 (de)	1985-02-12	1986-02-10	Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel.
AT86400271T ATE71111T1 (de)	1985-02-12	1986-02-10	Peptid-derivate, renin- und saeureprotease hemmende mittel.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT86400272T ATE52518T1 (de)	1985-02-12	1986-02-10	Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel.

Country Status (11)

Country	Link
US (2)	US4725580A (de)
EP (2)	EP0192554B1 (de)
AT (2)	ATE52518T1 (de)
AU (2)	AU606312B2 (de)
CA (2)	CA1286846C (de)
DE (2)	DE3671021D1 (de)
DK (2)	DK64186A (de)
ES (2)	ES8701783A1 (de)
GR (2)	GR860398B (de)
NZ (2)	NZ215096A (de)
PT (2)	PT81990B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2585708B1 (fr) *	1985-07-31	1989-07-07	Sanofi Sa	Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
US4599198A (en) *	1985-08-02	1986-07-08	Pfizer Inc.	Intermediates in polypeptide synthesis
DE3626130A1 (de) *	1986-08-01	1988-02-11	Merck Patent Gmbh	Aminosaeurederivate
DE3640535A1 (de) *	1986-11-27	1988-06-01	Merck Patent Gmbh	Peptide
EP0284510A3 (de) *	1987-03-24	1990-08-22	Asahi Breweries, Ltd.	N-[N-alpha-(1(S)-carboxy-3-cyclohexylpropyl)-L-lysyl]-N-cyclopentylglycin als antihypertensives Mittel
US4874745A (en) *	1987-10-01	1989-10-17	Merck & Co., Inc.	Renin-inhibitory pepstatin phenyl derivatives
US4980283A (en) *	1987-10-01	1990-12-25	Merck & Co., Inc.	Renin-inhibitory pepstatin phenyl derivatives
US5162527A (en) *	1987-10-26	1992-11-10	Warner-Lambert Company	Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
KR890701619A (ko) *	1987-10-26	1989-12-22	크리스틴 에이.트러트웨인	레닌 억제제, 그의 제조 방법, 그 사용 방법 및 이들을 함유한 조성물
IL92011A0 (en) *	1988-10-19	1990-07-12	Abbott Lab	Heterocyclic peptide renin inhibitors
US5164388A (en) *	1988-10-19	1992-11-17	Abbott Laboratories	Heterocyclic peptide renin inhibitors
DK0383635T3 (da) *	1989-02-16	1995-11-20	Sankyo Co	Peptider med renin-inhiberende virkning samt deres fremstilling og anvendelse
FR2646354B1 (fr) *	1989-04-27	1994-06-10	Sanofi Sa	Utilisation de peptides inhibiteurs de proteases acides pour la preparation de medicaments utiles pour le traitement de maladies virales
US5238923A (en) *	1989-05-26	1993-08-24	Warner-Lambert Company	Amino-substituted heterocycles as renin inhibitors
US5149692A (en) *	1989-12-21	1992-09-22	Warner-Lambert Company	Bisalkoxyphosphinyl compounds as renin inhibitors
US5071837A (en) *	1990-11-28	1991-12-10	Warner-Lambert Company	Novel renin inhibiting peptides
US5833946A (en) *	1995-06-06	1998-11-10	Bayer Corporation	Dissemination of fungal infections: animal model and method of prophylaxis
AT407043B (de) *	1998-01-23	2000-11-27	Martin Dr Kratzel	Simplifizierte pepstatin-a-analoga, deren herstellung und verwendung
US7247704B2 (en) *	2000-12-18	2007-07-24	Arriva Pharmaceuticals, Inc.	Multifunctional protease inhibitors and their use in treatment of disease
US7929913B2 (en)	2002-12-16	2011-04-19	Intel Corporation	Adaptive receiver architecture
KR20140053855A (ko)	2011-02-08	2014-05-08	메르크 파텐트 게엠베하	관절증의 치료를 위한 아미노스타틴 유도체
EP2877485B1 (de)	2012-07-24	2018-03-14	Merck Patent GmbH	Hydroxystatin-derivate zur behandlung von arthrose
ES2612982T3 (es)	2013-02-25	2017-05-19	Merck Patent Gmbh	Derivados de 2-amino-3,4-dihidroquinazolina y su aplicación como inhibidores de la catepsina D
EP3030250B1 (de)	2013-08-06	2019-08-28	Merck Patent GmbH	Intraartikuläre applikation von pepstatin bei arthrose

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1245217A (en) *	1981-12-10	1988-11-22	Joshua S. Boger	Renin inhibitory peptides having phe su13 xx deletion
FR2531951A1 (fr) *	1982-08-17	1984-02-24	Sanofi Sa	Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
DE3381565D1 (de) *	1982-12-27	1990-06-21	Merck & Co Inc	Reninhemmende tripeptide.

1986
- 1986-02-03 CA CA000500927A patent/CA1286846C/en not_active Expired - Lifetime
- 1986-02-05 CA CA000501163A patent/CA1286847C/en not_active Expired - Lifetime
- 1986-02-05 US US06/826,349 patent/US4725580A/en not_active Expired - Fee Related
- 1986-02-05 US US06/826,375 patent/US4746648A/en not_active Expired - Fee Related
- 1986-02-06 AU AU53272/86A patent/AU606312B2/en not_active Ceased
- 1986-02-06 AU AU53273/86A patent/AU606572B2/en not_active Ceased
- 1986-02-07 PT PT81990A patent/PT81990B/pt not_active IP Right Cessation
- 1986-02-07 PT PT81991A patent/PT81991B/pt not_active IP Right Cessation
- 1986-02-10 AT AT86400272T patent/ATE52518T1/de not_active IP Right Cessation
- 1986-02-10 DK DK64186A patent/DK64186A/da not_active Application Discontinuation
- 1986-02-10 DK DK64086A patent/DK64086A/da not_active Application Discontinuation
- 1986-02-10 EP EP86400271A patent/EP0192554B1/de not_active Expired - Lifetime
- 1986-02-10 AT AT86400271T patent/ATE71111T1/de not_active IP Right Cessation
- 1986-02-10 DE DE8686400272T patent/DE3671021D1/de not_active Expired - Lifetime
- 1986-02-10 EP EP86400272A patent/EP0193445B1/de not_active Expired - Lifetime
- 1986-02-10 DE DE8686400271T patent/DE3683170D1/de not_active Expired - Lifetime
- 1986-02-11 GR GR860398A patent/GR860398B/el unknown
- 1986-02-11 ES ES551821A patent/ES8701783A1/es not_active Expired
- 1986-02-11 GR GR860399A patent/GR860399B/el unknown
- 1986-02-11 NZ NZ215096A patent/NZ215096A/xx unknown
- 1986-02-11 ES ES551820A patent/ES8701782A1/es not_active Expired
- 1986-02-11 NZ NZ215097A patent/NZ215097A/en unknown

Also Published As

Publication number	Publication date
DK64186D0 (da)	1986-02-10
PT81991A (fr)	1986-03-01
PT81990B (pt)	1988-03-03
NZ215096A (en)	1989-10-27
DK64086D0 (da)	1986-02-10
NZ215097A (en)	1990-04-26
EP0193445A1 (de)	1986-09-03
EP0192554A1 (de)	1986-08-27
PT81990A (fr)	1986-03-01
DE3683170D1 (de)	1992-02-13
DK64086A (da)	1986-08-13
GR860398B (en)	1986-06-12
ES8701782A1 (es)	1986-12-16
GR860399B (en)	1986-06-12
AU606572B2 (en)	1991-02-14
DK64186A (da)	1986-08-13
EP0192554B1 (de)	1992-01-02
DE3671021D1 (de)	1990-06-13
AU5327286A (en)	1986-08-14
EP0193445B1 (de)	1990-05-09
US4746648A (en)	1988-05-24
AU606312B2 (en)	1991-02-07
AU5327386A (en)	1986-08-21
PT81991B (pt)	1988-03-03
ES551820A0 (es)	1986-12-16
CA1286847C (en)	1991-07-23
ATE52518T1 (de)	1990-05-15
CA1286846C (en)	1991-07-23
ES551821A0 (es)	1987-01-01
ES8701783A1 (es)	1987-01-01
US4725580A (en)	1988-02-16

Publication	Publication Date	Title
ATE71111T1 (de)	1992-01-15	Peptid-derivate, renin- und saeureprotease hemmende mittel.
DE3878991D1 (de)	1993-04-15	Peptide boronsaeure-hemmungsstoffe von trypsintyp-proteasen.
DE3689314D1 (de)	1994-01-05	Peptidasehemmungsmittel.
NL300039I2 (nl)	2001-09-03	Sulfonamideremmers van HIV-aspartylprotease.
IT1226576B (it)	1991-01-24	Tenuta di flusso senza contatto.
ATE377006T1 (de)	2007-11-15	Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
FI925167A (fi)	1993-05-16	2-substituerade sackarinderivat, som aer inhibitorer foer proteolytiska enzymer
BR9712544B1 (pt)	2013-10-22	Inibidores de proteases de serina, composição farmacêutica compreendendo os mesmos e seus usos
NO302883B1 (no)	1998-05-04	N-(alkanoylamino-2-hydroksypropyl)-sulfonamider som er nyttige som retrovirale proteaseinhibitorer, samt preparater inneholdene forbindelsene
NO971875L (no)	1997-06-12	Cathepsin 02 protease
DE3785615D1 (de)	1993-06-03	Hemmungsstoffe der serin-protease.
ES2196436T3 (es)	2003-12-16	Acidos sulfonilalcanoilamino-hidroxietilamino-sulfamicos utiles como inhibidores de proteasas retrovirales.
NO914217D0 (no)	1991-10-28	Sakkarinderivater nyttige som proteolytiske enzyminhibitorer og fremstilling derav
HK1025511A1 (en)	2000-11-17	Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors
DK0495918T3 (da)	1996-02-19	Aminosyre-beta-lyaseenzyminhibitorer som deodoranter
DE3667273D1 (de)	1990-01-11	Von hydroxycarbonsaeuren abgeleitete oberflaechenaktive mittel.
ATE90359T1 (de)	1993-06-15	Peptide.
DE59812724D1 (de)	2005-05-12	Serin-proteinase-inhibitoren
ATE86628T1 (de)	1993-03-15	Peptide boronsaeure-hemmungsstoffe von trypsintyp- proteasen.
DE3774947D1 (de)	1992-01-16	Alpha-acylamino-aminoalkyl-phosphonat-inhibitor des angiotensin umwandelnden enzyms.
ZA86960B (en)	1986-10-29	Peptide derivatives,analogous to pepstatin,which inhibit renin and acid proteases
NL185364C (nl)	1990-03-16	Afsluiter voor agressieve gassen.
WO1998029436A3 (en)	1998-09-03	Lebetin peptides as platelet aggregation inhibitors
ATE88720T1 (de)	1993-05-15	Hemmungsstoffe der serin-protease.

Legal Events

Date	Code	Title	Description
1992-10-15	UEP	Publication of translation of european patent specification
1994-11-15	REN	Ceased due to non-payment of the annual fee