ATE550648T1 - Adamts4 als blut-biomarker und therapeutisches ziel bei chronischem nierenversagen - Google Patents
Adamts4 als blut-biomarker und therapeutisches ziel bei chronischem nierenversagenInfo
- Publication number
- ATE550648T1 ATE550648T1 AT08768680T AT08768680T ATE550648T1 AT E550648 T1 ATE550648 T1 AT E550648T1 AT 08768680 T AT08768680 T AT 08768680T AT 08768680 T AT08768680 T AT 08768680T AT E550648 T1 ATE550648 T1 AT E550648T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic target
- blood biomarker
- adamts4
- chronic kidney
- kidney failure
- Prior art date
Links
- 208000020832 chronic kidney disease Diseases 0.000 title abstract 5
- 208000022831 chronic renal failure syndrome Diseases 0.000 title abstract 5
- 239000000090 biomarker Substances 0.000 title abstract 3
- 239000008280 blood Substances 0.000 title abstract 3
- 210000004369 blood Anatomy 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- 102000051403 ADAMTS4 Human genes 0.000 title 1
- 108091005664 ADAMTS4 Proteins 0.000 title 1
- 102100028965 Proteoglycan 4 Human genes 0.000 abstract 2
- 101710127913 Proteoglycan 4 Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000005084 renal tissue Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
- G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
- G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
- G01N2333/96419—Metalloendopeptidases (3.4.24)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93685007P | 2007-06-22 | 2007-06-22 | |
| PCT/US2008/007713 WO2009002451A2 (en) | 2007-06-22 | 2008-06-20 | Adamts4 as a blood biomarker and therapeutic target for chronis renal failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE550648T1 true ATE550648T1 (de) | 2012-04-15 |
Family
ID=40186208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08768680T ATE550648T1 (de) | 2007-06-22 | 2008-06-20 | Adamts4 als blut-biomarker und therapeutisches ziel bei chronischem nierenversagen |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8263072B2 (de) |
| EP (2) | EP2455755A3 (de) |
| AT (1) | ATE550648T1 (de) |
| WO (1) | WO2009002451A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ600922A (en) | 2009-12-17 | 2013-10-25 | Merial Ltd | Anti parasitic dihydroazole compounds and compositions comprising same |
| MY198581A (en) | 2011-09-12 | 2023-09-06 | Boehringer Ingelheim Animal Health Usa Inc | Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof |
| WO2013109829A1 (en) * | 2012-01-20 | 2013-07-25 | Glaxosmithkline Intellectual Property Development Ltd | Anti-adamts4 antibodies and methods of treatment |
| CN110251509A (zh) | 2012-02-06 | 2019-09-20 | 勃林格殷格翰动物保健美国公司 | 包含全身性地起作用的活性剂的杀寄生虫口服兽用组合物、方法及其用途 |
| US9447084B2 (en) | 2013-11-01 | 2016-09-20 | Merial, Inc. | Antiparisitic and pesticidal isoxazoline compounds |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| WO2017027858A1 (en) | 2015-08-12 | 2017-02-16 | The Trustees Of Columbia University In The City Of New York | Methods of treating volume depletion and kidney injury |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2021050089A1 (en) * | 2019-09-09 | 2021-03-18 | Washington State University | Genetic test for identifying cats at a high risk for developing tubulointerstitial fibrosis |
| WO2021242481A1 (en) | 2020-05-28 | 2021-12-02 | Boehringer Ingelheim Animal Health USA Inc. | Bi-modal release intra-ruminal capsule device and methods of use thereof |
| US11827657B2 (en) | 2020-12-18 | 2023-11-28 | Boehringer Ingelheim Animal Health USA Inc. | Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof |
| EP4262789A1 (de) | 2020-12-21 | 2023-10-25 | Boehringer Ingelheim Vetmedica GmbH | Parasitizide manschette mit isoxazolinverbindungen |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| ES2052027T5 (es) | 1988-11-11 | 2005-04-16 | Medical Research Council | Clonacion de secuencias de dominio variable de inmunoglobulina. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CA2228742A1 (en) | 1997-04-30 | 1998-10-30 | Smithkline Beecham Corporation | Crfg-1, a target and marker for chronic renal failure |
| AU3622600A (en) * | 1999-03-08 | 2000-09-28 | Neurocrine Biosciences, Inc. | Metalloproteinases and methods of use therefor |
| US6448388B1 (en) | 2000-08-16 | 2002-09-10 | Lexicon Genetics Incorporated | Human proteases and polynucleotides encoding the same |
| EP1136547A3 (de) | 2000-03-22 | 2002-09-25 | Pfizer Products Inc. | Adamts Polypeptide, Nucleinsäuren die dafür kodieren und deren Verwendungen |
| JPWO2002051998A1 (ja) | 2000-12-25 | 2004-04-30 | 山之内製薬株式会社 | 新規プロテアーゼ |
| US20060014931A1 (en) | 2002-06-20 | 2006-01-19 | Masayoshi Takeda | Novel promoter |
| JP2005534308A (ja) | 2002-07-29 | 2005-11-17 | ワイス | 修飾ａｄａｍｔｓ４分子およびその使用法 |
| JP2009537123A (ja) | 2006-05-18 | 2009-10-29 | サノフィ−アベンティス | Ａｄａｍｔｓ４遺伝子およびンパク質の多型の使用 |
| EP2049893B1 (de) | 2006-07-21 | 2016-11-30 | GENERA ISTRAZIVANJA d.o.o. | Anti-BMP-1-1 und anti-BMP-1-3 Antikörper zur Behandlung von chronischer Niereninsuffizienz |
-
2008
- 2008-06-20 AT AT08768680T patent/ATE550648T1/de active
- 2008-06-20 US US12/665,270 patent/US8263072B2/en not_active Expired - Fee Related
- 2008-06-20 WO PCT/US2008/007713 patent/WO2009002451A2/en not_active Ceased
- 2008-06-20 EP EP11194283A patent/EP2455755A3/de not_active Withdrawn
- 2008-06-20 EP EP08768680A patent/EP2171450B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| EP2455755A3 (de) | 2012-08-15 |
| US20100254997A1 (en) | 2010-10-07 |
| US8263072B2 (en) | 2012-09-11 |
| EP2455755A2 (de) | 2012-05-23 |
| EP2171450A2 (de) | 2010-04-07 |
| EP2171450A4 (de) | 2010-07-21 |
| WO2009002451A3 (en) | 2009-12-30 |
| EP2171450B1 (de) | 2012-03-21 |
| WO2009002451A2 (en) | 2008-12-31 |
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