ATE550025T1 - Behandlung neurodegenerativer erkrankungen mittels intrakranialer freisetzung von small- interfering-rna (sirna) - Google Patents
Behandlung neurodegenerativer erkrankungen mittels intrakranialer freisetzung von small- interfering-rna (sirna)Info
- Publication number
- ATE550025T1 ATE550025T1 AT09013626T AT09013626T ATE550025T1 AT E550025 T1 ATE550025 T1 AT E550025T1 AT 09013626 T AT09013626 T AT 09013626T AT 09013626 T AT09013626 T AT 09013626T AT E550025 T1 ATE550025 T1 AT E550025T1
- Authority
- AT
- Austria
- Prior art keywords
- small interfering
- sirna
- interfering rna
- intracranial
- release
- Prior art date
Links
- 108020004459 Small interfering RNA Proteins 0.000 title abstract 5
- 239000004055 small Interfering RNA Substances 0.000 title abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 238000007917 intracranial administration Methods 0.000 title 1
- 108091027967 Small hairpin RNA Proteins 0.000 abstract 2
- 108090000397 Caspase 3 Proteins 0.000 abstract 1
- 102100029855 Caspase-3 Human genes 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Psychology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42938702P | 2002-11-26 | 2002-11-26 | |
| US44461403P | 2003-02-03 | 2003-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE550025T1 true ATE550025T1 (de) | 2012-04-15 |
Family
ID=32397198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09013626T ATE550025T1 (de) | 2002-11-26 | 2003-11-26 | Behandlung neurodegenerativer erkrankungen mittels intrakranialer freisetzung von small- interfering-rna (sirna) |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7605249B2 (de) |
| EP (4) | EP1829547A3 (de) |
| JP (2) | JP4868854B2 (de) |
| AT (1) | ATE550025T1 (de) |
| AU (1) | AU2003293035A1 (de) |
| CA (1) | CA2507606A1 (de) |
| WO (1) | WO2004047872A2 (de) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2455424A1 (en) * | 2001-08-07 | 2003-02-20 | University Of Delaware | Compositions and methods for the prevention and treatment of huntington's disease |
| US20040096880A1 (en) * | 2001-08-07 | 2004-05-20 | Kmiec Eric B. | Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation |
| US20050106731A1 (en) * | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
| US20050042646A1 (en) | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
| US20050255086A1 (en) * | 2002-08-05 | 2005-11-17 | Davidson Beverly L | Nucleic acid silencing of Huntington's Disease gene |
| US20080274989A1 (en) | 2002-08-05 | 2008-11-06 | University Of Iowa Research Foundation | Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof |
| US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
| US7618948B2 (en) | 2002-11-26 | 2009-11-17 | Medtronic, Inc. | Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA |
| US7605249B2 (en) * | 2002-11-26 | 2009-10-20 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
| US7829694B2 (en) * | 2002-11-26 | 2010-11-09 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
| WO2006002283A1 (en) * | 2004-06-21 | 2006-01-05 | Medtronic, Inc. | Medical systems and methods for delivering compositions to cells |
| EP1581635A4 (de) * | 2002-12-17 | 2007-10-17 | Univ Iowa Res Found | Durch sirna vermitteltes gen-silencing |
| US7994149B2 (en) * | 2003-02-03 | 2011-08-09 | Medtronic, Inc. | Method for treatment of Huntington's disease through intracranial delivery of sirna |
| US7732591B2 (en) * | 2003-11-25 | 2010-06-08 | Medtronic, Inc. | Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna |
| WO2004101787A1 (ja) * | 2003-05-14 | 2004-11-25 | Japan Science And Technology Agency | ハンチンチン遺伝子の発現抑制 |
| US7595306B2 (en) * | 2003-06-09 | 2009-09-29 | Alnylam Pharmaceuticals Inc | Method of treating neurodegenerative disease |
| WO2005004794A2 (en) * | 2003-06-09 | 2005-01-20 | Alnylam Pharmaceuticals Inc. | Method of treating neurodegenerative disease |
| DK2821085T3 (da) * | 2003-09-12 | 2020-08-03 | Univ Massachusetts | Rna-interferens til behandling af "gain-of-function"-forstyrrelser |
| US8680063B2 (en) | 2003-09-12 | 2014-03-25 | University Of Massachusetts | RNA interference for the treatment of gain-of-function disorders |
| WO2005045034A2 (en) * | 2003-10-23 | 2005-05-19 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA) |
| US20050208090A1 (en) * | 2004-03-18 | 2005-09-22 | Medtronic, Inc. | Methods and systems for treatment of neurological diseases of the central nervous system |
| WO2005095622A2 (en) * | 2004-03-26 | 2005-10-13 | Van Andel Research Institute | c-met siRNA ADENOVIRUS VECTORS INHIBIT CANCER CELL GROWTH, INVASION AND TUMORIGENICITY |
| WO2005105995A2 (en) * | 2004-04-14 | 2005-11-10 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED TREATMENT OF POLYGLUTAMINE (POLYQ) REPEAT EXPANSION DISEASES USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP1799826B1 (de) * | 2004-09-29 | 2009-08-12 | Children's Memorial Hospital | siRNA-VERMITTELTES GEN-SILENCING VON ALPHA-SYNUKLEIN |
| CA2596588C (en) * | 2005-01-31 | 2017-06-27 | University Of Iowa Research Foundation | Nucleic acid silencing of huntington's disease gene |
| US7902352B2 (en) * | 2005-05-06 | 2011-03-08 | Medtronic, Inc. | Isolated nucleic acid duplex for reducing huntington gene expression |
| US9133517B2 (en) | 2005-06-28 | 2015-09-15 | Medtronics, Inc. | Methods and sequences to preferentially suppress expression of mutated huntingtin |
| EP2062980B1 (de) * | 2005-06-28 | 2011-08-31 | Medtronic, Inc. | Verfahren und Nukleotid-Sequenzen, die bevorzugt die Expression eines mutierten Huntingtin-Genes unterdrücken |
| EP1937066A4 (de) * | 2005-08-18 | 2008-12-24 | Alnylam Pharmaceuticals Inc | Verfahren und zusammensetzungen für die behandlung von nervenkrankheiten |
| GB0610183D0 (en) * | 2006-05-23 | 2006-06-28 | Isis Innovation | Treatment of neurodegenerative diseases |
| US9273356B2 (en) | 2006-05-24 | 2016-03-01 | Medtronic, Inc. | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
| US9375440B2 (en) | 2006-11-03 | 2016-06-28 | Medtronic, Inc. | Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity |
| CA2688514A1 (en) | 2007-04-26 | 2008-11-06 | University Of Iowa Research Foundation | Rna interference suppression of neurodegenerative diseases and methods of use thereof |
| WO2008143774A2 (en) * | 2007-05-01 | 2008-11-27 | University Of Massachusetts | Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy |
| WO2008150897A2 (en) | 2007-05-31 | 2008-12-11 | University Of Iowa Research Foundation | Reduction of off-target rna interference toxicity |
| WO2011087804A2 (en) | 2009-12-21 | 2011-07-21 | Medtronic, Inc. | Peptide-polynucleotide compositions, and methods for transfecting a cell with dna and treatment of neurodegenerative disease |
| WO2011133658A1 (en) | 2010-04-22 | 2011-10-27 | Boston Medical Center Corporation | Compositions and methods for targeting and delivering therapeutics into cells |
| CA2827380C (en) | 2011-02-12 | 2020-08-25 | University Of Iowa Research Foundation | Therapeutic nucleic acids |
| US9382542B2 (en) | 2012-01-04 | 2016-07-05 | Quark Pharmaceuticals, Inc. | Double-stranded RNA compounds to CASP2 and uses thereof |
| JP2016516804A (ja) | 2013-04-17 | 2016-06-09 | ファイザー・インク | 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体 |
| WO2015143245A1 (en) | 2014-03-19 | 2015-09-24 | Isis Pharmaceuticals, Inc. | Methods for modulating ataxin 2 expression |
| EP3978610A3 (de) | 2014-03-19 | 2022-08-24 | Ionis Pharmaceuticals, Inc. | Zusammensetzungen zur modulierung der ataxin-2-expression |
| CN106460062A (zh) | 2014-05-05 | 2017-02-22 | 美敦力公司 | 用于scd、crt、crt‑d或sca治疗识别和/或选择的方法和组合物 |
| WO2015179525A1 (en) | 2014-05-20 | 2015-11-26 | University Of Iowa Research Foundation | Huntington's disease therapeutic compounds |
| US11207461B2 (en) | 2015-07-30 | 2021-12-28 | Anoop U. R | Drug delivery system and method for controlled and continuous delivery of drugs into the brain by bypassing the blood brain barrier |
| EP3368054A4 (de) | 2015-10-28 | 2019-07-03 | Voyager Therapeutics, Inc. | Regulierbare expression unter verwendung des adeno-assoziierten virus (aav) |
| CN108603174A (zh) * | 2015-12-01 | 2018-09-28 | 星火治疗有限公司 | 在适用于临床应用的无血清悬浮细胞培养体系中产生重组腺相关病毒(aav)载体的可扩展方法 |
| WO2017117496A1 (en) | 2015-12-31 | 2017-07-06 | Ionis Pharmaceuticals, Inc. | Methods for reducing ataxin-2 expression |
| WO2017189504A1 (en) * | 2016-04-26 | 2017-11-02 | Saint Louis University | Highly selective adenosine a3 receptor subtype agonsists for the prevention and treatment of neurodegenerative disorders |
| JOP20190104A1 (ar) * | 2016-11-10 | 2019-05-07 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير عن atxn3 |
| US12054711B2 (en) | 2017-07-14 | 2024-08-06 | City Of Hope | Meta-stable oligonucleotides junctions for delivery of therapeutics |
| EP3662060A2 (de) | 2017-08-03 | 2020-06-10 | Voyager Therapeutics, Inc. | Zusammensetzungen und verfahren zur aav-freisetzung |
| US12385041B2 (en) | 2017-08-10 | 2025-08-12 | City Of Hope | Conditional-siRNAS and uses thereof in treating cardiac hypertrophy |
| CA3077426A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
| EP4454654A3 (de) | 2017-10-16 | 2025-02-19 | Voyager Therapeutics, Inc. | Behandlung von amyotropher lateralsklerose (als) |
| CA3099306A1 (en) | 2018-05-15 | 2019-11-21 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of parkinson's disease |
| US20210230632A1 (en) | 2018-05-15 | 2021-07-29 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
| US20210214749A1 (en) | 2018-05-16 | 2021-07-15 | Voyager Therapeutics, Inc. | Directed evolution |
| US20210207167A1 (en) | 2018-05-16 | 2021-07-08 | Voyager Therapeutics, Inc. | Aav serotypes for brain specific payload delivery |
| CN112912500A (zh) | 2018-06-05 | 2021-06-04 | 豪夫迈·罗氏有限公司 | 用于调节atxn2表达的寡核苷酸 |
| WO2020010035A1 (en) | 2018-07-02 | 2020-01-09 | Voyager Therapeutics, Inc. | Cannula system |
| EP3818161A1 (de) | 2018-07-02 | 2021-05-12 | Voyager Therapeutics, Inc. | Behandlung von amyotropher lateralsklerose und rückenmarksassoziierten erkrankungen |
| MX2021000810A (es) | 2018-07-24 | 2021-04-28 | Voyager Therapeutics Inc | Sistemas y metodos para producir formulaciones de terapia genetica. |
| AU2019310097A1 (en) | 2018-07-25 | 2021-02-04 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing ATXN2 expression |
| EP3833757A4 (de) | 2018-08-10 | 2022-05-18 | City of Hope | Programmierbare bedingte sirnas und verwendungen davon |
| TW202035689A (zh) | 2018-10-04 | 2020-10-01 | 美商航海家醫療公司 | 測量病毒載體粒子的效價及強度之方法 |
| WO2020077165A1 (en) | 2018-10-12 | 2020-04-16 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
| TW202039858A (zh) | 2019-01-18 | 2020-11-01 | 美商航海家醫療公司 | 用於生產aav顆粒之方法及系統 |
| US11286485B2 (en) | 2019-04-04 | 2022-03-29 | Hoffmann-La Roche Inc. | Oligonucleotides for modulating ATXN2 expression |
| AU2020259143A1 (en) * | 2019-04-19 | 2021-11-11 | Assistance Publique Hopitaux De Paris | pl6INK4a inhibitor for preventing or treating Huntington's disease |
| CN114555084A (zh) * | 2019-08-15 | 2022-05-27 | 费城儿童医院 | 用于治疗SCA1的转基因和内含子衍生miRNA联合疗法 |
| WO2021046155A1 (en) | 2019-09-03 | 2021-03-11 | Voyager Therapeutics, Inc. | Vectorized editing of nucleic acids to correct overt mutations |
| EP4135841A1 (de) | 2020-04-15 | 2023-02-22 | Voyager Therapeutics, Inc. | Tau-bindende verbindungen |
| AU2021264010A1 (en) | 2020-05-01 | 2022-12-08 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating ATXN1 |
| CA3182970A1 (en) | 2020-05-13 | 2021-11-18 | Voyager Therapeutics, Inc. | Redirection of tropism of aav capsids |
| CA3205586A1 (en) | 2020-12-16 | 2022-06-23 | Voyager Therapeutics, Inc. | Tau binding compounds |
| WO2022187548A1 (en) | 2021-03-03 | 2022-09-09 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
| WO2022206821A1 (zh) * | 2021-03-30 | 2022-10-06 | 南京大学 | 一种用于治疗帕金森的rna递送系统 |
| US20250223376A1 (en) | 2021-09-20 | 2025-07-10 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of her2 positive cancer |
| KR20240099322A (ko) * | 2021-10-21 | 2024-06-28 | 스위치 테라퓨틱스 인크. | 조건-활성화가능한 핵산 구축물 및 신경계 질환을 치료하기 위한 그의 용도 |
| JP2024540221A (ja) | 2021-11-02 | 2024-10-31 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖカプシドバリアント及びその使用 |
| WO2023091948A1 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Aav capsid variants and uses thereof |
| CN114259502A (zh) * | 2021-12-24 | 2022-04-01 | 南京鼓楼医院 | 一种基于脂肪组织的中枢靶向递送siRNA的方法及应用 |
| KR20240161976A (ko) | 2022-02-08 | 2024-11-13 | 보이저 테라퓨틱스, 인크. | Aav 캡시드 변이체 및 이의 용도 |
| WO2023230282A1 (en) * | 2022-05-25 | 2023-11-30 | The General Hospital Corporation | Modulation of bace1 as a therapy for spinocerebellar ataxia |
| IL316719A (en) | 2022-06-02 | 2024-12-01 | Voyager Therapeutics Inc | Adeno-associated virus capsid variants and their uses |
| US20250243263A1 (en) | 2022-06-22 | 2025-07-31 | Voyager Therapeutics, Inc. | Tau binding compounds |
| EP4547690A1 (de) | 2022-06-28 | 2025-05-07 | Voyager Therapeutics, Inc. | Aav-kapsidvarianten und verwendungen davon |
| TW202424201A (zh) | 2022-07-06 | 2024-06-16 | 美商航海家醫療公司 | Ａａｖ殼體變異體及其用途 |
| EP4565597A2 (de) | 2022-08-03 | 2025-06-11 | Voyager Therapeutics, Inc. | Zusammensetzungen und verfahren zur durchquerung der blut-hirn-schranke |
| CA3266790A1 (en) | 2022-09-15 | 2024-03-21 | Voyager Therapeutics, Inc. | TAU PROTEIN BINDING COMPOUNDS |
| IL320511A (en) | 2022-12-29 | 2025-06-01 | Voyager Therapeutics Inc | Compositions and methods for regulating MAPT |
| WO2024226790A1 (en) | 2023-04-26 | 2024-10-31 | Voyager Therapeutics, Inc. | Aav capsid variants and uses thereof |
| TW202444917A (zh) | 2023-05-04 | 2024-11-16 | 美商航海家醫療公司 | Ａａｖ衣殼變異體及其用途 |
| WO2025038430A1 (en) | 2023-08-16 | 2025-02-20 | Voyager Therapeutics, Inc. | Aav capsid variants and uses thereof |
| WO2025147436A1 (en) | 2024-01-03 | 2025-07-10 | Voyager Therapeutics, Inc. | Aav capsid variants and uses thereof |
Family Cites Families (156)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| GB2181691B (en) | 1985-10-21 | 1990-05-23 | Porvair Ltd | Gloves |
| US4800159A (en) * | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| WO1992020400A1 (fr) | 1991-05-24 | 1992-11-26 | Sumitomo Pharmaceuticals Company, Limited | Instrument pour appliquer un produit pharmaceutique a l'interieur du cerveau |
| US5236908A (en) | 1991-06-07 | 1993-08-17 | Gensia Pharmaceuticals, Inc. | Methods of treating injury to the central nervous system |
| AU687736B2 (en) | 1992-05-11 | 1998-03-05 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
| JPH07509133A (ja) | 1992-07-17 | 1995-10-12 | リボザイム・ファーマシューティカルズ・インコーポレイテッド | 動物疾患の処置のための方法および剤 |
| US5354326A (en) * | 1993-01-27 | 1994-10-11 | Medtronic, Inc. | Screening cable connector for interface to implanted lead |
| CA2116280A1 (en) * | 1993-03-05 | 1994-09-06 | Marcy E. Macdonald | Huntingtin dna, protein and uses thereof |
| JP4098355B2 (ja) | 1993-08-12 | 2008-06-11 | ニューロテック ユーエスエー， インコーポレイテッド | 遺伝的に改変された細胞を含む生体適合性免疫隔離カプセル |
| AU7676894A (en) * | 1993-08-27 | 1995-03-21 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Convection-enhanced drug delivery |
| US5624803A (en) * | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
| CA2179014C (en) * | 1993-12-17 | 2003-07-29 | Spinal Cord Society | Method for inducing dna synthesis in neurons |
| DE69535703T2 (de) * | 1994-04-13 | 2009-02-19 | The Rockefeller University | AAV-vermittelte Zufuhr von DNA an Zellen des Nervensystems |
| US6294202B1 (en) | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
| CA2207593A1 (en) | 1994-12-13 | 1996-06-20 | John Gustofson | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses |
| US5534350A (en) | 1994-12-28 | 1996-07-09 | Liou; Derlin | Powerfree glove and its making method |
| AU5545596A (en) * | 1995-04-28 | 1996-11-18 | Medtronic, Inc. | Intraparenchymal infusion catheter system |
| US7069634B1 (en) * | 1995-04-28 | 2006-07-04 | Medtronic, Inc. | Method for manufacturing a catheter |
| US5840059A (en) | 1995-06-07 | 1998-11-24 | Cardiogenesis Corporation | Therapeutic and diagnostic agent delivery |
| US5942455A (en) | 1995-11-14 | 1999-08-24 | Drexel University | Synthesis of 312 phases and composites thereof |
| JPH09268067A (ja) | 1996-03-29 | 1997-10-14 | Asahi Glass Co Ltd | 炭化ケイ素部材の製造方法 |
| CA2222453C (en) | 1996-04-26 | 2009-06-30 | Universite D'ottawa/ University Of Ottawa | Therapeutic and drug screening methods for the treatment and prevention of neuronal disease |
| US7189222B2 (en) * | 1996-04-30 | 2007-03-13 | Medtronic, Inc. | Therapeutic method of treatment of alzheimer's disease |
| US5976109A (en) | 1996-04-30 | 1999-11-02 | Medtronic, Inc. | Apparatus for drug infusion implanted within a living body |
| US5735814A (en) * | 1996-04-30 | 1998-04-07 | Medtronic, Inc. | Techniques of treating neurodegenerative disorders by brain infusion |
| WO2000062828A1 (en) | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
| AU4266597A (en) * | 1996-09-11 | 1998-04-14 | General Hospital Corporation, The | Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell |
| US5882561A (en) | 1996-11-22 | 1999-03-16 | Drexel University | Process for making a dense ceramic workpiece |
| GB9701684D0 (en) * | 1997-01-28 | 1997-03-19 | Smithkline Beecham Plc | Novel compounds |
| US5968059A (en) | 1997-03-06 | 1999-10-19 | Scimed Life Systems, Inc. | Transmyocardial revascularization catheter and method |
| GB9706463D0 (en) * | 1997-03-27 | 1997-05-14 | Medical Res Council | A model of inflamation in the central nervous system for use in the study of disease |
| US6436708B1 (en) | 1997-04-17 | 2002-08-20 | Paola Leone | Delivery system for gene therapy to the brain |
| WO1998046740A1 (en) | 1997-04-17 | 1998-10-22 | Antivirals, Inc. | Method of treating restenosis by antisense targeting of cmv |
| US5782892A (en) * | 1997-04-25 | 1998-07-21 | Medtronic, Inc. | Medical lead adaptor for external medical device |
| US5931861A (en) * | 1997-04-25 | 1999-08-03 | Medtronic, Inc. | Medical lead adaptor having rotatable locking clip mechanism |
| US6042579A (en) * | 1997-04-30 | 2000-03-28 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain |
| US6110459A (en) | 1997-05-28 | 2000-08-29 | Mickle; Donald A. G. | Transplants for myocardial scars and methods and cellular preparations |
| US20050282198A1 (en) | 1997-05-29 | 2005-12-22 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype |
| US6231969B1 (en) | 1997-08-11 | 2001-05-15 | Drexel University | Corrosion, oxidation and/or wear-resistant coatings |
| US6187906B1 (en) * | 1997-08-11 | 2001-02-13 | Aukland Uniservices Limited | Methods to improve neural outcome |
| WO1999018792A1 (en) * | 1997-10-10 | 1999-04-22 | Johns Hopkins University | Gene delivery compositions and methods |
| US6151525A (en) | 1997-11-07 | 2000-11-21 | Medtronic, Inc. | Method and system for myocardial identifier repair |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| JP3012923B2 (ja) * | 1998-01-26 | 2000-02-28 | 新潟大学長 | Ｃａｇリピート病の治療薬 |
| AU2970299A (en) | 1998-02-10 | 1999-08-23 | Ohio State University Research Foundation, The | Compositions and methods for polynucleotide delivery |
| DE19938960A1 (de) | 1998-03-10 | 2001-02-22 | Bisping Hans Juergen | Testkabelanordnung |
| AUPP249298A0 (en) * | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| AU3117799A (en) | 1998-03-30 | 1999-10-18 | Trustees Of The University Of Pennsylvania, The | Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders |
| US6436392B1 (en) * | 1998-05-20 | 2002-08-20 | University Of Iowa Research Foundation | Adeno-associated virus vectors |
| CA2329259C (en) | 1998-05-27 | 2003-08-05 | Avigen, Inc. | Convection-enhanced delivery of aav vectors |
| US6245884B1 (en) * | 1998-10-16 | 2001-06-12 | Vivian Y. H. Hook | Secretases related to alzheimer's dementia |
| US6313268B1 (en) * | 1998-10-16 | 2001-11-06 | Vivian Y. H. Hook | Secretases related to Alzheimer's dementia |
| US6585767B1 (en) | 1998-11-23 | 2003-07-01 | Agion Technologies, Inc. | Antimicrobial suturing ring for heart valve |
| US6319905B1 (en) * | 1998-12-29 | 2001-11-20 | Cell Genesys, Inc. | Method of controlling L-Dopa production and of treating dopamine deficiency |
| DE19910340A1 (de) | 1999-03-09 | 2000-09-21 | Juergen C Froelich | Verbessertes autologes Venentransplantat |
| US6835194B2 (en) | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| US6582715B1 (en) | 1999-04-27 | 2003-06-24 | Agion Technologies, Inc. | Antimicrobial orthopedic implants |
| JP2002542781A (ja) | 1999-04-28 | 2002-12-17 | ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ | Ｐ因子由来ベクター及びその使用法 |
| US6310058B1 (en) * | 1999-05-27 | 2001-10-30 | University Of Notre Dame Du Lac | Antimycobacterial agents |
| EP1212416A2 (de) | 1999-08-31 | 2002-06-12 | Ribozyme Pharmaceuticals, Inc. | Auf nukeinsäure-basierende modulatoren der expression von genen |
| GB9928248D0 (en) | 1999-12-01 | 2000-01-26 | Gill Steven S | An implantable guide tube for neurosurgery |
| US6310048B1 (en) | 1999-12-09 | 2001-10-30 | St. Louis University | Antisense modulation of amyloid beta protein expression |
| US6461989B1 (en) | 1999-12-22 | 2002-10-08 | Drexel University | Process for forming 312 phase materials and process for sintering the same |
| US20030092003A1 (en) | 1999-12-29 | 2003-05-15 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for the treatment of Alzheimer's disease |
| US20050229272A1 (en) * | 1999-12-30 | 2005-10-13 | Monica Driscoll | Compositions and methods for gene silencing |
| US20050032733A1 (en) | 2001-05-18 | 2005-02-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
| WO2002081628A2 (en) | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| WO2001060794A2 (en) | 2000-02-18 | 2001-08-23 | The Regents Of The University Of California | Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease |
| AU2001247244B2 (en) | 2000-02-28 | 2005-06-02 | Genesegues, Inc. | Nanocapsule encapsulation system and method |
| US6468524B1 (en) * | 2000-03-22 | 2002-10-22 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | AAV4 vector and uses thereof |
| US6855314B1 (en) | 2000-03-22 | 2005-02-15 | The United States Of America As Represented By The Department Of Health And Human Services | AAV5 vector for transducing brain cells and lung cells |
| US6945969B1 (en) | 2000-03-31 | 2005-09-20 | Medtronic, Inc. | Catheter for target specific drug delivery |
| US6551290B1 (en) * | 2000-03-31 | 2003-04-22 | Medtronic, Inc. | Catheter for target specific drug delivery |
| GB0009887D0 (en) | 2000-04-20 | 2000-06-07 | Btg Int Ltd | Cytotoxic agents |
| US6372250B1 (en) | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
| EP1301214A2 (de) | 2000-05-26 | 2003-04-16 | Chiron Corporation | Verfahren zur transduktion von neuronalen zellen unter verwendung von lentivirusvektoren |
| US20020042388A1 (en) | 2001-05-01 | 2002-04-11 | Cooper Mark J. | Lyophilizable and enhanced compacted nucleic acids |
| WO2002005804A1 (en) | 2000-07-19 | 2002-01-24 | Smithkline Beecham Corporation | Compounds and methods |
| WO2002007810A2 (en) | 2000-07-26 | 2002-01-31 | Medtronic, Inc. | Catheter for target specific drug delivery |
| US20050209179A1 (en) | 2000-08-30 | 2005-09-22 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
| US20030190635A1 (en) * | 2002-02-20 | 2003-10-09 | Mcswiggen James A. | RNA interference mediated treatment of Alzheimer's disease using short interfering RNA |
| US6866859B2 (en) * | 2000-08-30 | 2005-03-15 | Biocoat Incorporated | Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties |
| ATE423574T1 (de) | 2000-09-11 | 2009-03-15 | Univ California | Dominant-negativer plb mutant zur behandlung der herzerkrankungen |
| US6659995B1 (en) | 2000-11-17 | 2003-12-09 | Syde A. Taheri | Autologous myocyte micro granual retrieval and implantation (AMMGRI) |
| CA2327208A1 (en) | 2000-11-30 | 2002-05-30 | The Government Of The United States Of America | Methods of increasing distribution of therapeutic agents |
| US20040259247A1 (en) | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| EP1366368A2 (de) * | 2001-01-03 | 2003-12-03 | Ortho-Mcneil Pharmaceutical, Inc. | Alpha-synuklein-anhäufungsassays |
| CA2438832A1 (en) * | 2001-02-23 | 2002-09-06 | Elan Pharmaceuticals, Inc. | Transgenic knockouts of bace-1 |
| US7182944B2 (en) | 2001-04-25 | 2007-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of increasing distribution of nucleic acids |
| US20030095958A1 (en) | 2001-04-27 | 2003-05-22 | Bhisetti Govinda R. | Inhibitors of bace |
| WO2003102131A2 (en) | 2002-04-22 | 2003-12-11 | Sirna Therapeutics Inc. | Nucleic acid mediated disruption of hiv fusogenic peptide interactions |
| US20030152947A1 (en) | 2001-06-15 | 2003-08-14 | Crossman David C. | Methods for detecting and treating the early onset of aging-related conditions |
| CA2455424A1 (en) | 2001-08-07 | 2003-02-20 | University Of Delaware | Compositions and methods for the prevention and treatment of huntington's disease |
| US6944497B2 (en) | 2001-10-31 | 2005-09-13 | Medtronic, Inc. | System and method of treating stuttering by neuromodulation |
| WO2003042385A2 (en) | 2001-11-12 | 2003-05-22 | Epiclone, Inc. | Gene silencing using sense dna and antisense rna hybrid constructs |
| CN1242402C (zh) * | 2001-11-13 | 2006-02-15 | 新科实业有限公司 | 磁头堆组件的多用途装配设备和测试方法 |
| US20030105047A1 (en) | 2001-11-30 | 2003-06-05 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by brain infusion of mutational vectors |
| US20030120327A1 (en) | 2001-12-20 | 2003-06-26 | Mark Tobritzhofer | Medical lead adaptor assembly with retainer |
| US20030120282A1 (en) | 2001-12-24 | 2003-06-26 | Scouten Charles W. | Stereotaxic manipulator with retrofitted linear scales and digital display device |
| US7294504B1 (en) | 2001-12-27 | 2007-11-13 | Allele Biotechnology & Pharmaceuticals, Inc. | Methods and compositions for DNA mediated gene silencing |
| US7270653B2 (en) | 2002-02-20 | 2007-09-18 | Abbott Research Group | Methods of treating abnormal biological conditions using metal oxides |
| US20050096284A1 (en) | 2002-02-20 | 2005-05-05 | Sirna Therapeutics, Inc. | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
| US20030224512A1 (en) | 2002-05-31 | 2003-12-04 | Isis Pharmaceuticals Inc. | Antisense modulation of beta-site APP-cleaving enzyme expression |
| US20040023855A1 (en) | 2002-04-08 | 2004-02-05 | John Constance M. | Biologic modulations with nanoparticles |
| US20040018520A1 (en) | 2002-04-22 | 2004-01-29 | James Thompson | Trans-splicing enzymatic nucleic acid mediated biopharmaceutical and protein |
| AU2003237686A1 (en) | 2002-05-24 | 2003-12-12 | Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Rna interference mediating small rna molecules |
| CA2489174C (en) | 2002-07-10 | 2013-02-05 | Thomas Tuschl | Rna-interference by single-stranded rna molecules |
| US7008403B1 (en) | 2002-07-19 | 2006-03-07 | Cognitive Ventures Corporation | Infusion pump and method for use |
| US7148342B2 (en) * | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| JP3968365B2 (ja) | 2002-07-25 | 2007-08-29 | 日世株式会社 | ロールコーン製造装置 |
| US20050042646A1 (en) | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
| US20040023390A1 (en) * | 2002-08-05 | 2004-02-05 | Davidson Beverly L. | SiRNA-mediated gene silencing with viral vectors |
| US20050106731A1 (en) | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
| US20050255086A1 (en) | 2002-08-05 | 2005-11-17 | Davidson Beverly L | Nucleic acid silencing of Huntington's Disease gene |
| US7083620B2 (en) | 2002-10-30 | 2006-08-01 | Medtronic, Inc. | Electrosurgical hemostat |
| AU2003295600A1 (en) | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| US20040265849A1 (en) | 2002-11-22 | 2004-12-30 | Applera Corporation | Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof |
| US7829694B2 (en) | 2002-11-26 | 2010-11-09 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
| US20050048641A1 (en) | 2002-11-26 | 2005-03-03 | Medtronic, Inc. | System and method for delivering polynucleotides to the central nervous system |
| US7605249B2 (en) | 2002-11-26 | 2009-10-20 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
| JP2004232811A (ja) | 2003-01-31 | 2004-08-19 | Hitachi Unisia Automotive Ltd | 補機駆動用電磁クラッチ |
| US8946151B2 (en) | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
| US20040186528A1 (en) | 2003-03-20 | 2004-09-23 | Medtronic, Inc. | Subcutaneous implantable medical devices with anti-microbial agents for chronic release |
| US8512290B2 (en) | 2003-03-20 | 2013-08-20 | Boston Scientific Scimed, Inc. | Devices and methods for delivering therapeutic or diagnostic agents |
| US20040198640A1 (en) | 2003-04-02 | 2004-10-07 | Dharmacon, Inc. | Stabilized polynucleotides for use in RNA interference |
| US20040258666A1 (en) | 2003-05-01 | 2004-12-23 | Passini Marco A. | Gene therapy for neurometabolic disorders |
| EP2269658B1 (de) | 2003-05-01 | 2018-12-19 | Genzyme Corporation | Genetherapie für neuro-stoffwechsel krankheiten |
| US7917228B2 (en) | 2003-05-13 | 2011-03-29 | Medtronic, Inc. | Medical lead adaptor assembly |
| WO2004101787A1 (ja) | 2003-05-14 | 2004-11-25 | Japan Science And Technology Agency | ハンチンチン遺伝子の発現抑制 |
| US20060014165A1 (en) | 2003-07-14 | 2006-01-19 | Decode Genetics Ehf. | Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association |
| WO2008005562A2 (en) | 2006-07-07 | 2008-01-10 | University Of Massachusetts | Rna silencing compositions and methods for the treatment of huntington's disease |
| DK2821085T3 (da) | 2003-09-12 | 2020-08-03 | Univ Massachusetts | Rna-interferens til behandling af "gain-of-function"-forstyrrelser |
| WO2005045034A2 (en) | 2003-10-23 | 2005-05-19 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA) |
| US7678780B2 (en) | 2003-12-29 | 2010-03-16 | Allan Mishra | Method of treating cancer using platelet releasate |
| WO2005070104A2 (en) | 2004-01-09 | 2005-08-04 | The University Of Tennessee Research Foundation | REAL-TIME POLYMERASE CHAIN REACTION-BASED GENOTYPING ASSAY FOR β2-ADRENERGIC RECEPTOR SINGLE NUCLEODITE POLYMORPHISM |
| US20050202075A1 (en) | 2004-03-12 | 2005-09-15 | Pardridge William M. | Delivery of genes encoding short hairpin RNA using receptor-specific nanocontainers |
| US20050260202A1 (en) * | 2004-03-19 | 2005-11-24 | The Regents Of The University Of California | Methods for producing proliferating muscle cells |
| CN101052717A (zh) | 2004-05-11 | 2007-10-10 | α基因株式会社 | 诱发rna干扰的多核苷酸以及使用该多核苷酸的基因表达抑制方法 |
| AU2005202624A1 (en) | 2004-06-28 | 2006-01-12 | Lifescan Scotland Limited | Resealable vial and dispensing mechanism for test sensor |
| WO2006022639A1 (en) | 2004-07-21 | 2006-03-02 | Applera Corporation | Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof |
| CA2584986A1 (en) | 2004-10-22 | 2006-05-04 | Neurologix, Inc. | Use of apoptosis inhibiting compounds in degenerative neurological disorders |
| NL1028134C2 (nl) | 2005-01-27 | 2006-07-31 | Sara Lee De Nv | Werkwijze voor het bereiden van een voor consumptie geschikte drank uit ten minste twee op te lossen en/of te extraheren ingredienten en een hoeveelheid vloeistof. |
| TW200635542A (en) | 2005-04-01 | 2006-10-16 | Dharma Drum Mountain | Method of establishing and using commemorative material |
| EP1885854B1 (de) | 2005-05-06 | 2012-10-17 | Medtronic, Inc. | Verfahren und sequenzen zur unterdrückung der expression des huntington-gens in primaten |
| US20080280843A1 (en) | 2006-05-24 | 2008-11-13 | Van Bilsen Paul | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
| GB0520235D0 (en) | 2005-10-05 | 2005-11-16 | Astrazeneca Ab | Method |
| EP1941059A4 (de) | 2005-10-28 | 2010-11-03 | Alnylam Pharmaceuticals Inc | Zusammensetzungen und verfahren zur hemmung der expression des huntingtin-gens |
| US20070259827A1 (en) | 2006-01-25 | 2007-11-08 | University Of Massachusetts | Compositions and methods for enhancing discriminatory RNA interference |
| ITRM20060289A1 (it) | 2006-05-31 | 2007-12-01 | Ranieri Cancedda | Bio membrana ingegnerizzata osteo angiogenica e suoi usi per la rigenerazione di tessuto osseo |
| US20080039415A1 (en) | 2006-08-11 | 2008-02-14 | Gregory Robert Stewart | Retrograde transport of sirna and therapeutic uses to treat neurologic disorders |
| CN200970210Y (zh) | 2006-10-12 | 2007-11-07 | 王会才 | 拖把清洗脱水机 |
| WO2008143774A2 (en) | 2007-05-01 | 2008-11-27 | University Of Massachusetts | Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy |
-
2003
- 2003-11-25 US US10/721,693 patent/US7605249B2/en not_active Expired - Fee Related
- 2003-11-26 AU AU2003293035A patent/AU2003293035A1/en not_active Abandoned
- 2003-11-26 EP EP07003775A patent/EP1829547A3/de not_active Withdrawn
- 2003-11-26 EP EP09013626A patent/EP2145628B1/de not_active Expired - Lifetime
- 2003-11-26 WO PCT/US2003/037650 patent/WO2004047872A2/en not_active Ceased
- 2003-11-26 AT AT09013626T patent/ATE550025T1/de active
- 2003-11-26 EP EP03790026A patent/EP1569662A2/de not_active Withdrawn
- 2003-11-26 EP EP07003774A patent/EP1832292A1/de not_active Withdrawn
- 2003-11-26 JP JP2005510322A patent/JP4868854B2/ja not_active Expired - Fee Related
- 2003-11-26 CA CA002507606A patent/CA2507606A1/en not_active Abandoned
-
2009
- 2009-08-27 US US12/549,110 patent/US8119611B2/en not_active Expired - Fee Related
-
2011
- 2011-07-25 JP JP2011162422A patent/JP2012006938A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1829547A3 (de) | 2007-09-12 |
| EP2145628B1 (de) | 2012-03-21 |
| US20040162255A1 (en) | 2004-08-19 |
| JP4868854B2 (ja) | 2012-02-01 |
| US8119611B2 (en) | 2012-02-21 |
| US20100063134A1 (en) | 2010-03-11 |
| JP2012006938A (ja) | 2012-01-12 |
| US7605249B2 (en) | 2009-10-20 |
| EP1569662A2 (de) | 2005-09-07 |
| WO2004047872A2 (en) | 2004-06-10 |
| EP1832292A1 (de) | 2007-09-12 |
| AU2003293035A1 (en) | 2004-06-18 |
| JP2006515864A (ja) | 2006-06-08 |
| AU2003293035A8 (en) | 2004-06-18 |
| CA2507606A1 (en) | 2004-06-10 |
| WO2004047872A3 (en) | 2005-02-03 |
| EP2145628A1 (de) | 2010-01-20 |
| EP1829547A2 (de) | 2007-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE550025T1 (de) | Behandlung neurodegenerativer erkrankungen mittels intrakranialer freisetzung von small- interfering-rna (sirna) | |
| WO2020198509A3 (en) | Modified oligonucleotides with increased stability | |
| WO2007109097A3 (en) | RNAi MODULATION OF TGF-BETA AND THERAPEUTIC USES THEREOF | |
| EP1325019A4 (de) | Antisense-modulation der clusterinexpression | |
| EP1569695A4 (de) | Antisense-modulationder apolipoprotein-b-expression | |
| ATE513843T1 (de) | Abstellen von genen in vivo durch chemischmodifizierte und stabile sirna | |
| EP1417351A4 (de) | Antisense-modulation der expression von apolipoprotein(a) | |
| EP1248794A4 (de) | Antisens-modulierung der smad7 expression | |
| EP1392867A4 (de) | Antisense-modulation der ptp18-expression | |
| EP1250157A4 (de) | Antisens-modulation der expression der induzierbaren stickstoffmonoxid-synthase | |
| TNSN08252A1 (en) | Sirna anti myosine va et depigmentation de la peau | |
| WO2003010284A3 (en) | Antisense modulation of c-reactive protein expression | |
| WO2003008543A3 (en) | Antisense modulation of bcl2-associated x protein expression | |
| WO2003046132A3 (en) | Antisense modulation of myd88 expression | |
| WO2004039957A3 (en) | Inhibition of gene expression using rna interfering agents | |
| EP1648910A4 (de) | Antisense-modulation der expression von stearoyl coa desaturase | |
| WO2003053341A3 (en) | Antisense modulation of ship-1 expression | |
| WO2005042719A3 (en) | Methods for treating and preventing ischemia-reperfusion injury using rna interfering agents | |
| WO2003104397A3 (en) | ANTISENSE MODULATION OF PROTEIN KINASE GR 6 EXPRESSION | |
| WO2003050244A3 (en) | Antisense modulation of g protein-coupled receptor etbr-lp-2 expression | |
| WO2003052062A3 (en) | Antisense modulation of cd36l1 expression | |
| EP1506216A4 (de) | Antisense-modulierung der kinesin-like-1-expression | |
| EP1390388A4 (de) | Antisense-modulation der expression des interferon-gamma-rezeptors 1 | |
| DE602005026834D1 (de) | Verwendung von gilz-protein zur modulation einer antigenspezifischen immunantwort | |
| ITMI20030860A1 (it) | Metodo per l'inibizione selettiva del gene n-myc |