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ATE548643T1 - System und verfahren zur verstärkung von fluoreszenzsignalen - Google Patents

System und verfahren zur verstärkung von fluoreszenzsignalen

Info

Publication number
ATE548643T1
ATE548643T1 AT08742395T AT08742395T ATE548643T1 AT E548643 T1 ATE548643 T1 AT E548643T1 AT 08742395 T AT08742395 T AT 08742395T AT 08742395 T AT08742395 T AT 08742395T AT E548643 T1 ATE548643 T1 AT E548643T1
Authority
AT
Austria
Prior art keywords
fluorescent signals
illumination light
metal particle
amplifying fluorescent
reflectance
Prior art date
Application number
AT08742395T
Other languages
English (en)
Inventor
Jonas Korlach
Kevan Samiee
Stephen Turner
Jake Freudenthal
Original Assignee
Pacific Biosciences California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biosciences California filed Critical Pacific Biosciences California
Application granted granted Critical
Publication of ATE548643T1 publication Critical patent/ATE548643T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Luminescent Compositions (AREA)
AT08742395T 2007-03-30 2008-03-27 System und verfahren zur verstärkung von fluoreszenzsignalen ATE548643T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92116707P 2007-03-30 2007-03-30
PCT/US2008/004148 WO2008121374A2 (en) 2007-03-30 2008-03-27 Systems and methods for enhancing fluorescent signals

Publications (1)

Publication Number Publication Date
ATE548643T1 true ATE548643T1 (de) 2012-03-15

Family

ID=39795079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08742395T ATE548643T1 (de) 2007-03-30 2008-03-27 System und verfahren zur verstärkung von fluoreszenzsignalen

Country Status (4)

Country Link
US (1) US20080241866A1 (de)
EP (1) EP2134871B1 (de)
AT (1) ATE548643T1 (de)
WO (1) WO2008121374A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9575087B2 (en) 2012-09-06 2017-02-21 Parker-Hannifin Corporation Risk-managed, single-use, pre-calibrated, pre-sterilized sensors for use in bio-processing applications
US9637380B2 (en) 2008-03-31 2017-05-02 Pacific Biosciences Of California, Inc. Nanoscale apertures having islands of functionality
CA2720247C (en) 2008-03-31 2020-07-14 Pacific Biosciences Of California, Inc. Single molecule loading methods and compositions
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
WO2011031313A2 (en) 2009-09-11 2011-03-17 Pacific Biosciences Of California, Inc. Zero-mode waveguides with non-reflecting walls
US8367159B2 (en) 2009-09-11 2013-02-05 Pacific Biosciences Of California, Inc. Methods for producing ZMWs with islands of functionality
WO2011103504A1 (en) 2010-02-19 2011-08-25 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US9331113B2 (en) 2010-05-03 2016-05-03 The Regents Of The University Of California Wide-field lensless fluorescent imaging on a chip
GB201008981D0 (en) * 2010-05-28 2010-07-14 Perkinelmer Ltd Methods and apparatus relating to surface-enhanced raman spectroscopy
US9422154B2 (en) 2010-11-02 2016-08-23 International Business Machines Corporation Feedback control of dimensions in nanopore and nanofluidic devices
CN102175649B (zh) * 2011-01-04 2012-11-28 长沙理工大学 用于检测致癌基因C-myc重组蛋白的LSPR传感芯片
US8735175B2 (en) * 2011-03-18 2014-05-27 Chris D. Geddes Multicolor microwave-accelerated metal-enhanced fluorescence (M-MAMEF)
US8817259B2 (en) 2011-03-25 2014-08-26 Parker-Hannifin Corporation Optical sensors for monitoring biopharmaceutical solutions in single-use containers
US10149922B1 (en) 2012-10-24 2018-12-11 The Board Of Trustees Of The Leland Stanford Junior University Engineered collagen matrices for myocardial therapy
KR101431958B1 (ko) * 2013-01-31 2014-08-21 연세대학교 산학협력단 초고해상도 광학 영상 장치 및 이를 이용한 광학 영상 방법
WO2014144883A1 (en) * 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
JP6573899B2 (ja) 2013-11-17 2019-09-11 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 分子をプローブし、検出し、及び分析するための、外部光源を備えた集積デバイス
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
CN111710687B (zh) 2014-08-08 2023-11-14 宽腾矽公司 基于入射光子到达时间的识别、成像、测序法及存储介质
CA2957546A1 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Integrated device with external light source for probing, detecting, and analyzing molecules
WO2016023010A1 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Optical system and assay chip for probing, detecting, and analyzing molecules
EP2997883A1 (de) * 2014-09-17 2016-03-23 Universität Stuttgart Verfahren und Anordnung zur optischen Absorptionsmessung
EP3292220B1 (de) 2015-05-07 2022-07-13 Pacific Biosciences of California, Inc. Multiprozessor-pipeline-architektur
CN105352922B (zh) * 2016-01-04 2017-12-19 广东省生态环境与土壤研究所 一种y形dna组装结合信号扩增用于汞离子的检测方法及检测试剂盒
KR20180111999A (ko) 2016-02-17 2018-10-11 테서렉트 헬스, 인코포레이티드 수명 촬상 및 검출 응용을 위한 센서 및 디바이스
US10876969B2 (en) * 2016-08-10 2020-12-29 Atila Biosystems Incorporated Apparatus for detecting fluorescent signals emitted by samples
EP4224530A1 (de) 2016-12-22 2023-08-09 Quantum-si Incorporated Integrierter photodetektor mit direktem pixel-binning
BR112020000826A2 (pt) 2017-07-24 2020-07-21 Quantum-Si Incorporated instrumento bio-optoeletrônico maciçamente paralelo portátil
JP7460555B2 (ja) 2018-06-22 2024-04-02 クアンタム－エスアイ インコーポレイテッド 様々な検出時間の電荷貯蔵ビンを有する集積光検出器
CN110066723A (zh) * 2019-05-05 2019-07-30 京东方科技集团股份有限公司 基因测序芯片、设备、制造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2332088C3 (de) * 1973-06-23 1982-04-22 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Perfluor-2-methyl-pentan
AT403961B (de) * 1995-03-17 1998-07-27 Avl Verbrennungskraft Messtech Optochemisches messsystem mit einem fluoreszenzsensor
US6136543A (en) * 1997-01-31 2000-10-24 Hitachi, Ltd. Method for determining nucleic acids base sequence and apparatus therefor
US5982534A (en) * 1997-06-18 1999-11-09 The Regents Of The University Of California Specimen illumination apparatus with optical cavity for dark field illumination
CA2318892A1 (en) * 1998-01-27 1999-07-29 Wisconsin Alumni Research Foundation Signal enhancement for fluorescence microscopy
FR2785052B1 (fr) * 1998-10-27 2000-12-01 Commissariat Energie Atomique Dispositif de determination de la concentration d'une substance melangee a un fluorophore et procede de mise en oeuvre de ce dispositif
EP1961826A3 (de) * 1999-03-10 2008-09-17 ASM Scientific, Inc. Verfahren zur direkten Sequenzierung von Nukleinsäuren
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US20010053521A1 (en) * 1999-09-27 2001-12-20 Kreimer David I. Amplification of analyte detection by substrates having particle structures with receptors
US6917726B2 (en) * 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
AU2001286759A1 (en) * 2000-08-25 2002-03-04 Genospectra, Inc. Three-dimensional probe carriers
US6818907B2 (en) * 2000-10-17 2004-11-16 The President And Fellows Of Harvard College Surface plasmon enhanced illumination system
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
WO2007016269A2 (en) * 2005-07-29 2007-02-08 Applera Corporation Detection of polyphosphate using fluorescently labeled polyphosphate acceptor substrates
WO2007137060A2 (en) * 2006-05-16 2007-11-29 Applied Biosystems Systems, methods, and apparatus for single molecule sequencing

Also Published As

Publication number Publication date
EP2134871A2 (de) 2009-12-23
WO2008121374A4 (en) 2009-01-15
US20080241866A1 (en) 2008-10-02
WO2008121374A3 (en) 2008-12-04
WO2008121374A2 (en) 2008-10-09
EP2134871A4 (de) 2010-05-26
EP2134871B1 (de) 2012-03-07

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