ATE544748T1 - COMPOSITIONS AND METHODS FOR THE TREATMENT OF CELL PROLIFERATION DISEASES - Google Patents
COMPOSITIONS AND METHODS FOR THE TREATMENT OF CELL PROLIFERATION DISEASESInfo
- Publication number
- ATE544748T1 ATE544748T1 AT05855828T AT05855828T ATE544748T1 AT E544748 T1 ATE544748 T1 AT E544748T1 AT 05855828 T AT05855828 T AT 05855828T AT 05855828 T AT05855828 T AT 05855828T AT E544748 T1 ATE544748 T1 AT E544748T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- cell proliferation
- compositions
- treatment
- proliferation diseases
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Abstract
The invention relates to compounds and methods for treating cell proliferation disorders.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US63983404P | 2004-12-28 | 2004-12-28 | |
US70455105P | 2005-08-01 | 2005-08-01 | |
US72734105P | 2005-10-17 | 2005-10-17 | |
PCT/US2005/047333 WO2006071960A2 (en) | 2004-12-28 | 2005-12-28 | Compositions and methods of treating cell proliferation disorders |
Publications (1)
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ATE544748T1 true ATE544748T1 (en) | 2012-02-15 |
Family
ID=36615518
Family Applications (1)
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AT05855828T ATE544748T1 (en) | 2004-12-28 | 2005-12-28 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CELL PROLIFERATION DISEASES |
Country Status (20)
Country | Link |
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US (5) | US7300931B2 (en) |
EP (1) | EP1836169B9 (en) |
JP (2) | JP5124285B2 (en) |
KR (2) | KR101478933B1 (en) |
CN (2) | CN101184734B (en) |
AT (1) | ATE544748T1 (en) |
AU (1) | AU2005321966B2 (en) |
BE (1) | BE2021C001I2 (en) |
BR (1) | BRPI0519424B8 (en) |
CA (1) | CA2594345C (en) |
CY (1) | CY2022001I2 (en) |
DK (1) | DK1836169T5 (en) |
ES (1) | ES2382068T3 (en) |
FR (1) | FR21C1064I2 (en) |
HK (2) | HK1108695A1 (en) |
HU (1) | HUS2100051I1 (en) |
LU (1) | LUC00235I2 (en) |
NL (1) | NL301145I2 (en) |
PL (1) | PL1836169T3 (en) |
WO (1) | WO2006071960A2 (en) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
CA2594345C (en) | 2004-12-28 | 2013-11-05 | Kinex Pharmaceuticals, Llc | Compositions and methods of treating cell proliferation disorders |
KR20070097590A (en) | 2005-01-25 | 2007-10-04 | 에픽스 델라웨어, 인코포레이티드 | Substituted Arylamine Compounds and Their Uses as 5-HT6 Modulators |
DK2041071T3 (en) * | 2006-06-29 | 2014-09-01 | Kinex Pharmaceuticals Llc | BIARLYL COMPOSITIONS AND PROCEDURES FOR MODULATING A CHINA CASE |
CA2656564C (en) * | 2006-06-29 | 2015-06-16 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
US7939529B2 (en) | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
US20210198202A1 (en) * | 2006-12-28 | 2021-07-01 | Athenex, Inc. | Compositions for modulating a kinase cascade and methods of use thereof |
AU2014200559B2 (en) * | 2006-12-28 | 2016-05-26 | Atnx Spv, Llc | Composition and Methods for Modulating a Kinase Cascade |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
TWI457336B (en) * | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | Composition and methods for modulating a kinase cascade |
WO2008127727A1 (en) * | 2007-04-13 | 2008-10-23 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
CN101687798B (en) * | 2007-05-17 | 2012-08-15 | 金克斯医药品有限公司 | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
AU2014202221B2 (en) * | 2007-05-17 | 2016-06-23 | Atnx Spv, Llc | Process for the Preparation of Compositions for Modulating a Kinase Cascade and Methods of Use Thereof |
WO2009009041A2 (en) * | 2007-07-06 | 2009-01-15 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
CN105796568A (en) * | 2007-10-20 | 2016-07-27 | 阿西纳斯公司 | Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof |
US8598165B2 (en) * | 2007-11-26 | 2013-12-03 | University Of Kansas | Morpholines as selective inhibitors of cytochrome P450 2A13 |
ES2531396T3 (en) | 2008-01-23 | 2015-03-13 | Bristol Myers Squibb Co | Process to prepare pyridinone compounds |
TWI510241B (en) | 2010-02-18 | 2015-12-01 | Vtv Therapeutice Llc | Phenyl-heteroaryl derivatives and methods of use thereof |
US8748423B2 (en) | 2010-04-16 | 2014-06-10 | Kinex Pharmaceuticals, Llc | Compositions and methods for the prevention and treatment of cancer |
MX2012014537A (en) | 2010-07-05 | 2013-02-21 | Merck Patent Gmbh | Bipyridyl derivatives useful for the treatment of kinase - induced diseases. |
SG11201400989TA (en) | 2011-09-27 | 2014-04-28 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
KR101415742B1 (en) * | 2011-12-21 | 2014-07-04 | 영남대학교 산학협력단 | 6-aminopyridin-3-ol derivative or a pharmaceutically acceptable salt thereof and pharmaceutical composition for treating or preventing angiogenesis-related disease comprising the same |
UY34632A (en) | 2012-02-24 | 2013-05-31 | Novartis Ag | OXAZOLIDIN- 2- ONA COMPOUNDS AND USES OF THE SAME |
CN102746255A (en) * | 2012-07-24 | 2012-10-24 | 安徽中医学院 | Compound having anti-tumor activity, and preparation method and application thereof |
CN105263907B (en) | 2012-08-30 | 2018-11-20 | 阿西纳斯公司 | N- (3- luorobenzyl) -2- (5- (4- morphlinophenyl) pyridine -2- base) acetamide as protein tyrosine kinase regulator |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
US9278950B2 (en) | 2013-01-14 | 2016-03-08 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
TWI662030B (en) | 2013-01-15 | 2019-06-11 | 英塞特控股公司 | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors |
MX355945B (en) | 2013-03-14 | 2018-05-07 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh. |
CR20160135A (en) | 2013-08-23 | 2016-08-05 | Incyte Corp | FUR CARBOXAMIDE COMPOUNDS AND TIENOPIRIDINE USEFUL AS PIM KINASE INHIBITORS |
US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
SMT201900304T1 (en) * | 2014-09-10 | 2019-07-11 | Glaxosmithkline Ip Dev Ltd | Pyridone derivatives as rearranged during transfection (ret) kinase inhibitors |
US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
AR105967A1 (en) | 2015-09-09 | 2017-11-29 | Incyte Corp | SALTS OF A PIM QUINASA INHIBITOR |
TW201718546A (en) | 2015-10-02 | 2017-06-01 | 英塞特公司 | Heterocyclic compounds useful as PIM kinase inhibitors |
CN106902357B (en) * | 2015-12-21 | 2021-08-03 | 广州市香雪制药股份有限公司 | Pharmaceutical composition and application thereof, pharmaceutical clathrate, intravenous preparation and preparation method |
CN106902358B (en) * | 2015-12-21 | 2020-07-10 | 广州市香雪制药股份有限公司 | Oral preparation and preparation method thereof |
CN110023310B (en) | 2016-08-12 | 2024-05-10 | 阿西纳斯公司 | Biaryl compositions and methods for modulating kinase cascades |
CN106810490A (en) * | 2017-02-06 | 2017-06-09 | 重庆泰润制药有限公司 | A kind of crystal formation of biaryl compound and its preparation method and application |
KR20240090837A (en) | 2017-03-10 | 2024-06-21 | 에이티엔엑스 에스피브이, 엘엘씨 | Methods of treating and/or preventing actinic keratosis |
CA3058695A1 (en) | 2017-04-26 | 2018-11-01 | Basilea Pharmaceutica International AG | Processes for the preparation of furazanobenzimidazoles and crystalline forms thereof |
KR20240119192A (en) | 2017-09-07 | 2024-08-06 | 아테넥스 에이치케이 이노베이티브 리미티드 | Solid forms of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-n-benzylacetamide |
WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
CN113117376B (en) * | 2019-12-30 | 2022-08-19 | 中国科学院高能物理研究所 | Phenanthroline derivative extracting agent and preparation method and application thereof |
CN113461665B (en) * | 2020-03-31 | 2023-05-19 | 成都赜灵生物医药科技有限公司 | Diaryl derivative, preparation method and application thereof |
CN113354575B (en) * | 2021-06-07 | 2022-09-27 | 河南应用技术职业学院 | Synthesis method of terbinafine |
EP4186890A1 (en) | 2021-11-29 | 2023-05-31 | Moehs Ibérica, S.L. | Preparation of n-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide for the synthesis of tirbanibulin |
WO2023134751A1 (en) * | 2022-01-14 | 2023-07-20 | 武汉人福创新药物研发中心有限公司 | Tubulin-src dual-target inhibitor and use thereof |
CN116444425A (en) * | 2022-01-14 | 2023-07-18 | 武汉人福创新药物研发中心有限公司 | tubulin-SRC dual target inhibitors |
EP4302831A1 (en) | 2022-07-04 | 2024-01-10 | Trifarma S.p.A. | Process for synthesis of tirbanibulin |
CN115073362A (en) * | 2022-08-04 | 2022-09-20 | 重庆迈德凯医药有限公司 | Synthesis method of tinib bulin |
CN117624139A (en) * | 2022-08-25 | 2024-03-01 | 武汉人福创新药物研发中心有限公司 | Diaryl compound, preparation method and application thereof |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1185180B (en) * | 1963-10-19 | 1965-01-14 | Hoechst Ag | Process for the preparation of benzenesulfonylureas |
US3761477A (en) * | 1968-11-08 | 1973-09-25 | Mc Neil Labor Inc | Pyrazineacetic acids, lower alkyl esters, amides and salts |
IT1044222B (en) * | 1972-05-23 | 1980-03-20 | Zambeletti Spa L | BIPHYLYL ALCANOYLAMINOPYRIDINE FOR LONG-LASTING ANTI-INFLAMMATORY ACTIVITIES |
AT341512B (en) * | 1975-01-09 | 1978-02-10 | Thomae Gmbh Dr K | METHOD OF MANUFACTURING NEW BIPHENYLATHERS |
CA1261835A (en) | 1984-08-20 | 1989-09-26 | Masaaki Toda | (fused) benz(thio)amides |
JPS62252755A (en) * | 1986-04-11 | 1987-11-04 | Daikin Ind Ltd | Novel n-benzylbenzamide derivative and herbicide containing said derivative as active component |
US5232948A (en) | 1990-09-10 | 1993-08-03 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted monocyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity |
CH685875A5 (en) | 1991-04-26 | 1995-10-31 | Pierre Baudet | The protective N-phenyl-benzamide against the harmful effects of ultra-violet light |
EP0613879A4 (en) | 1991-05-20 | 1995-05-03 | Tsumura & Co | PHELLODENDRIN ANALOGS AND TYPE IV ALLERGY SUPPRESSOR CONTAINING THEM AS ACTIVE INGREDIENTS. |
DE4236103A1 (en) | 1992-10-26 | 1994-04-28 | Hoechst Ag | Process for the cross-coupling of aromatic boronic acids with aromatic halogen compounds or perfluoroalkyl sulfonates |
US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
FR2705671B1 (en) * | 1993-05-26 | 1995-07-07 | Inst Nat Sante Rech Med | New hydroxybiphenyl derivatives, their preparation and the pharmaceutical compositions containing them. |
CA2144669A1 (en) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Biphenyl derivatives |
FR2737721B1 (en) * | 1995-08-08 | 1997-09-05 | Roussel Uclaf | NOVEL BIPHENYL COMPOUNDS, THEIR PREPARATION METHOD AND INTERMEDIATES THEREOF, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
WO1998021185A1 (en) * | 1996-11-08 | 1998-05-22 | Sankyo Company, Limited | Arylureas or arylmethylcarbamoyl derivatives |
ZA985542B (en) | 1997-07-03 | 1999-04-07 | Smithkline Beecham Corp | Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents |
JP2001023259A (en) * | 1999-07-09 | 2001-01-26 | Sony Corp | Magneto-optical recording medium and its production |
WO2001019788A2 (en) | 1999-09-17 | 2001-03-22 | Cor Therapeutics, Inc. | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa |
US6844367B1 (en) * | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
US6372752B1 (en) * | 2000-02-07 | 2002-04-16 | Genzyme Corporation | Inha inhibitors and methods of use thereof |
US20040039048A1 (en) * | 2000-02-11 | 2004-02-26 | Manuel Guzman Pastor | Therapy with cannabinoid compounds for the treatment of brain tumors |
KR100423899B1 (en) | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | Indazoles substituted with 1,1-dioxoisothiazolidine useful as inhibitors of cell proliferation |
UY26780A1 (en) | 2000-06-15 | 2002-01-31 | Pharmacia Corp | CYCLALQUIL AVB3 ANTAGONISTS |
US6376524B1 (en) * | 2000-06-21 | 2002-04-23 | Sunesis Pharmaceuticals, Inc. | Triphenyl compounds as interleukin-4 antagonists |
JP2002020362A (en) * | 2000-07-06 | 2002-01-23 | Nippon Oruganon Kk | New biphenyl derivative |
JP2004517074A (en) * | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | Substituted polycyclic aryl and heteroaryl pyridines useful for selectively inhibiting the coagulation cascade |
JP4160401B2 (en) | 2001-03-29 | 2008-10-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Inhibitors of C-JUNN terminal kinase (JNK) and other protein kinases |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
DE10201764A1 (en) | 2002-01-18 | 2003-07-31 | Bayer Cropscience Ag | Substituted 4-aminopyridine derivatives |
JP2003231633A (en) * | 2002-02-06 | 2003-08-19 | Tanabe Seiyaku Co Ltd | Medicinal composition |
AU2003215112A1 (en) * | 2002-02-07 | 2003-09-02 | Axys Pharmaceuticals | Novel bicyclic hydroxamates as inhibitors of histone deacetylase |
WO2003066572A1 (en) | 2002-02-07 | 2003-08-14 | Wisconsin Alumni Research Foundation | Polyamine compounds and compositions for use in conjunction with cancer therapy |
FR2836917B1 (en) | 2002-03-11 | 2006-02-24 | Lipha | NITROSO DIPHENYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS MEDICAMENTS FOR THE TREATMENT OF DISEASES CHARACTERIZED BY OXIDATIVE STRESS SITUATION |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
TWI319387B (en) * | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
DE10219294A1 (en) | 2002-04-25 | 2003-11-13 | Schering Ag | New substituted N-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl) derivatives, useful as cyclin-dependent kinase inhibitors for treating e.g. cancer, autoimmune diseases, cardiovascular diseases and neurodegenerative diseases |
GB0209891D0 (en) | 2002-04-30 | 2002-06-05 | Glaxo Group Ltd | Novel compounds |
WO2003093297A2 (en) | 2002-05-03 | 2003-11-13 | Exelixis, Inc. | Protein kinase modulators and methods of use |
AR037647A1 (en) | 2002-05-29 | 2004-12-01 | Novartis Ag | USED DIARILUREA DERIVATIVES FOR THE TREATMENT OF DEPENDENT DISEASES OF THE PROTEIN KINase |
SE0201937D0 (en) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
ATE360015T1 (en) | 2002-07-31 | 2007-05-15 | Critical Outcome Technologies | PROTEIN TYROSINE KINASE INHIBITORS |
AU2003254177A1 (en) | 2002-07-31 | 2004-02-16 | Smithkline Beecham Corporation | Substituted benzanilides as modulators of the ccr5 receptor |
AU2002331472A1 (en) | 2002-08-07 | 2004-02-25 | Xavier, Mauro | Stretching lumbar-sacral floating (slsf) vest |
DE10238865A1 (en) | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | New carboxamides are melanin-concentrating hormone receptor antagonists, useful for treating e.g. metabolic diseases, diabetes, eating disorders, cardiovascular disease, emotional disorders, reproductive and memory disorders |
US20040242572A1 (en) * | 2002-08-24 | 2004-12-02 | Boehringer Ingelheim International Gmbh | New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture |
EP2172460A1 (en) | 2002-11-01 | 2010-04-07 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of JAK and other protein kinases |
CA2504941C (en) | 2002-11-08 | 2012-06-26 | Neurogen Corporation | 3-substituted-6-aryl pyridines |
SI1569907T1 (en) | 2002-12-13 | 2016-06-30 | Ym Biosciences Australia Pty Ltd | Nicotinamide-based kinase inhibitors |
AU2003299797A1 (en) | 2002-12-19 | 2004-07-14 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
UY28213A1 (en) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | NEW CYANOPIRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS. |
EP1656370B1 (en) * | 2003-06-03 | 2012-08-15 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic compounds and methods of making and using the same |
WO2005014532A1 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
US8202861B2 (en) | 2003-08-08 | 2012-06-19 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
US7338950B2 (en) * | 2003-10-07 | 2008-03-04 | Renovis, Inc. | Amide compounds as ion channel ligands and uses thereof |
CN1875002B (en) * | 2003-11-05 | 2011-08-03 | 霍夫曼-拉罗奇有限公司 | Phenyl derivatives as PPAR agonists |
PE20060285A1 (en) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | PYRIDONES SUBSTITUTE AS POL (ADP-RIBOSA) -POLYMERASE (PARP) INHIBITORS |
US20080269282A1 (en) | 2004-08-02 | 2008-10-30 | Genmedica Therapeutics Sl | Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof |
CA2594345C (en) | 2004-12-28 | 2013-11-05 | Kinex Pharmaceuticals, Llc | Compositions and methods of treating cell proliferation disorders |
US7968574B2 (en) * | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
KR20080040027A (en) | 2005-09-02 | 2008-05-07 | 아스테라스 세이야쿠 가부시키가이샤 | Amide Derivatives as ROCK Inhibitors |
WO2007095383A2 (en) | 2006-02-15 | 2007-08-23 | Myriad Genetics, Inc. | Prodrugs |
MX2008014450A (en) | 2006-05-18 | 2009-03-09 | Mannkind Corp | Intracellular kinase inhibitors. |
DK2041071T3 (en) | 2006-06-29 | 2014-09-01 | Kinex Pharmaceuticals Llc | BIARLYL COMPOSITIONS AND PROCEDURES FOR MODULATING A CHINA CASE |
CA2656564C (en) | 2006-06-29 | 2015-06-16 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
AU2007336781C1 (en) * | 2006-12-21 | 2014-10-09 | Sloan-Kettering Institute For Cancer Research | Pyridazinones and furan-containing compounds |
US7939529B2 (en) * | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
US7935697B2 (en) * | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
TWI457336B (en) * | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | Composition and methods for modulating a kinase cascade |
WO2008127727A1 (en) | 2007-04-13 | 2008-10-23 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
WO2009009041A2 (en) | 2007-07-06 | 2009-01-15 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
US8748423B2 (en) * | 2010-04-16 | 2014-06-10 | Kinex Pharmaceuticals, Llc | Compositions and methods for the prevention and treatment of cancer |
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