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ATE543823T1 - Verfahren zur reduzierung von unreinheiten in oxycodonbase - Google Patents

Verfahren zur reduzierung von unreinheiten in oxycodonbase

Info

Publication number
ATE543823T1
ATE543823T1 AT07865161T AT07865161T ATE543823T1 AT E543823 T1 ATE543823 T1 AT E543823T1 AT 07865161 T AT07865161 T AT 07865161T AT 07865161 T AT07865161 T AT 07865161T AT E543823 T1 ATE543823 T1 AT E543823T1
Authority
AT
Austria
Prior art keywords
oxycodone base
reducing impurities
impurities
oxycodone
base
Prior art date
Application number
AT07865161T
Other languages
English (en)
Inventor
D Phillip Cox
Yong Zhang
Original Assignee
Noramco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noramco Inc filed Critical Noramco Inc
Application granted granted Critical
Publication of ATE543823T1 publication Critical patent/ATE543823T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT07865161T 2006-12-04 2007-12-04 Verfahren zur reduzierung von unreinheiten in oxycodonbase ATE543823T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87265506P 2006-12-04 2006-12-04
PCT/US2007/086372 WO2008070656A2 (en) 2006-12-04 2007-12-04 Process for reducing impurities in oxycodone base

Publications (1)

Publication Number Publication Date
ATE543823T1 true ATE543823T1 (de) 2012-02-15

Family

ID=39264513

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07865161T ATE543823T1 (de) 2006-12-04 2007-12-04 Verfahren zur reduzierung von unreinheiten in oxycodonbase

Country Status (9)

Country Link
US (1) US7875719B2 (de)
EP (1) EP2121698B1 (de)
JP (1) JP2010511725A (de)
CN (2) CN104761561A (de)
AT (1) ATE543823T1 (de)
AU (1) AU2007329451B2 (de)
CA (1) CA2671551C (de)
ES (1) ES2378710T3 (de)
WO (1) WO2008070656A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
ES2378710T3 (es) 2006-12-04 2012-04-17 Noramco, Inc. Procedimiento para reducir impurezas en la base de oxicodona
FR2923484B1 (fr) * 2007-11-09 2012-11-09 Sanofi Aventis Procede de preparation de composes morphiniques
AU2010206724A1 (en) * 2009-01-22 2011-07-28 Nanotherapeutics, Inc. Process for preparing particles of opioids and compositions produced thereby
GB2495062A (en) 2010-07-02 2013-03-27 Johnson Matthey Plc Process for the synthesis and purification of oxycodone
EA028092B1 (ru) 2012-07-16 2017-10-31 Родс Текнолоджис Способ усовершенствованного синтеза опиоидов
MX362186B (es) 2012-07-16 2019-01-08 Rhodes Tech Proceso de sintesis de opioides mejorado.
BR112015002024A2 (pt) 2012-08-03 2017-07-04 Johnson Matthey Plc processo para preparar um aduto de ácido-oxicodona, solução aquosa de aduto de ácido-oxicodona, aduto de ácido-oxicodona sólido, e, alcaloide oxicodona sólido
GB201313915D0 (en) * 2013-08-02 2013-09-18 Johnson Matthey Plc Process
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
KR101868723B1 (ko) 2014-01-15 2018-06-18 로드스 테크놀로지즈 개선된 옥시코돈 합성을 위한 방법
CA2937007C (en) 2014-01-15 2018-11-06 Rhodes Technologies Process for improved oxymorphone synthesis
US20160052932A1 (en) 2014-08-25 2016-02-25 Johnson Matthey Public Limited Company Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
ES2701855T3 (es) 2016-05-31 2019-02-26 Alcaliber Investig Desarrollo E Innovacion Slu Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina
EP3642207B1 (de) * 2017-06-20 2022-08-31 Johnson Matthey Public Limited Company Hydrierungsverfahren zur herstellung von oxycodon-hydrochlorid aus 14-hydroxycodeinon
CN115326937B (zh) * 2021-05-11 2024-06-18 山东省食品药品检验研究院 一种基因毒杂质捕捉用固相探针及其使用方法与应用
CN114634514B (zh) * 2022-04-14 2024-04-09 甘肃农垦药物碱厂有限公司 一种去甲羟吗啡酮中杂质的去除方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1485673A (en) * 1924-03-04 Ministrator
US1479293A (en) * 1924-01-01 Hiabtor fbettlid
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US6067749A (en) * 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6060943A (en) * 1998-04-14 2000-05-09 Nmb (Usa) Inc. Circuit simulating a diode
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US6864370B1 (en) * 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
SK286087B6 (sk) 2004-08-18 2008-03-05 Zentiva, A. S. Spôsob prípravy oxykodonu
GB0421149D0 (en) * 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
WO2006084389A1 (de) 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
PT2112153E (pt) * 2005-03-04 2010-12-17 Euro Celtique Sa Método de diminuír a quantidade de cetonas insaturadas em alfa-beta em composições de opiáceos
MX2008006710A (es) 2005-11-22 2008-12-16 Controlled Chemicals Inc Procedimientos para reducir niveles de aceptor de michael contaminantes en oxicodona y otras composiciones.
US8871779B2 (en) 2006-03-02 2014-10-28 Mallinckrodt Llc Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds
ES2378710T3 (es) 2006-12-04 2012-04-17 Noramco, Inc. Procedimiento para reducir impurezas en la base de oxicodona

Also Published As

Publication number Publication date
EP2121698A2 (de) 2009-11-25
EP2121698B1 (de) 2012-02-01
JP2010511725A (ja) 2010-04-15
AU2007329451B2 (en) 2012-08-30
US7875719B2 (en) 2011-01-25
CN101652369A (zh) 2010-02-17
CN104761561A (zh) 2015-07-08
WO2008070656A3 (en) 2008-07-24
CA2671551C (en) 2015-02-10
AU2007329451A1 (en) 2008-06-12
ES2378710T3 (es) 2012-04-17
US20080132703A1 (en) 2008-06-05
CA2671551A1 (en) 2008-06-12
WO2008070656A2 (en) 2008-06-12

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