ATE538130T1 - Pyrimidinderivate und ihre verwendung als p2y12- rezeptorantagonisten - Google Patents
Pyrimidinderivate und ihre verwendung als p2y12- rezeptorantagonistenInfo
- Publication number
- ATE538130T1 ATE538130T1 AT06728064T AT06728064T ATE538130T1 AT E538130 T1 ATE538130 T1 AT E538130T1 AT 06728064 T AT06728064 T AT 06728064T AT 06728064 T AT06728064 T AT 06728064T AT E538130 T1 ATE538130 T1 AT E538130T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- pyrimidine derivatives
- pyrimidine
- derivatives
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2005004578 | 2005-04-28 | ||
| IB2005053711 | 2005-11-10 | ||
| PCT/IB2006/051318 WO2006114774A2 (en) | 2005-04-28 | 2006-04-27 | Pyrimidine derivatives and their use as p2y12 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538130T1 true ATE538130T1 (de) | 2012-01-15 |
Family
ID=37075078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06728064T ATE538130T1 (de) | 2005-04-28 | 2006-04-27 | Pyrimidinderivate und ihre verwendung als p2y12- rezeptorantagonisten |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8048881B2 (de) |
| EP (1) | EP1893634B1 (de) |
| JP (1) | JP4955658B2 (de) |
| KR (1) | KR101310016B1 (de) |
| CN (1) | CN101166756A (de) |
| AR (1) | AR056992A1 (de) |
| AT (1) | ATE538130T1 (de) |
| AU (1) | AU2006241260A1 (de) |
| BR (1) | BRPI0608089A2 (de) |
| CA (1) | CA2604967C (de) |
| ES (1) | ES2377337T3 (de) |
| IL (1) | IL186939A0 (de) |
| MX (1) | MX2007013436A (de) |
| NO (1) | NO20076094L (de) |
| NZ (1) | NZ563584A (de) |
| RU (1) | RU2410393C2 (de) |
| TW (1) | TW200640877A (de) |
| WO (1) | WO2006114774A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100210635A1 (en) * | 2006-03-29 | 2010-08-19 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
| AR063258A1 (es) * | 2006-10-13 | 2009-01-14 | Actelion Pharmaceuticals Ltd | Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos. |
| CL2007003038A1 (es) * | 2006-10-25 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos. |
| MY153427A (en) * | 2007-04-23 | 2015-02-13 | Sanofi Aventis | Quinoline-carboxamide derivatives as p2y12 antagonists |
| SI2225253T1 (sl) * | 2007-11-29 | 2012-09-28 | Actelion Pharmaceuticals Ltd | Derivati fosfonske kisline in njihova uporaba kot antagonisti receptorja P2Y12 |
| JP5504171B2 (ja) * | 2007-12-26 | 2014-05-28 | サノフイ | Ｐ２ｙ１２アンタゴニストとしてのヘテロサイクリックピラゾール−カルボキサミド |
| WO2009080227A2 (en) | 2007-12-26 | 2009-07-02 | Sanofi-Aventis | Pyrazole-carboxamide derivatives as p2y12 antagonists |
| MX2010009561A (es) | 2008-02-29 | 2010-09-24 | Renovis Inc | Compuestos amida, composiciones y usos de los mismos. |
| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| AR071652A1 (es) * | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| TW200948788A (en) * | 2008-04-22 | 2009-12-01 | Daiichi Sankyo Co Ltd | 5-hydroxypyrimidine-4-carboxamide compounds |
| US20110237578A1 (en) | 2008-09-18 | 2011-09-29 | Zhi-Liang Wei | Amide compounds, compositions and uses thereof |
| KR101114503B1 (ko) * | 2008-12-04 | 2012-02-15 | 지에스건설 주식회사 | 부유물 수거장치 |
| CA2756542C (en) * | 2009-04-08 | 2017-08-22 | Actelion Pharmaceuticals Ltd | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines |
| CN102405220B (zh) * | 2009-04-22 | 2015-05-27 | 埃科特莱茵药品有限公司 | 噻唑衍生物及其作为p2y12受体拮抗剂的用途 |
| ES2470329T3 (es) | 2009-08-28 | 2014-06-23 | Daiichi Sankyo Company, Limited | Derivado del ácido 3-(biariloxi) priopi�nico |
| WO2013033178A1 (en) | 2011-08-30 | 2013-03-07 | University Of Utah Research Foundation | Methods and compositions for treating nephrogenic diabetes insipidus |
| PL2753606T3 (pl) * | 2011-09-02 | 2018-02-28 | Purdue Pharma L.P. | Pirymidyny jako blokery kanałów sodowych |
| KR102552795B1 (ko) | 2016-09-22 | 2023-07-06 | 이도르시아 파마슈티컬스 리미티드 | 결정질 형태 |
| JP7580918B2 (ja) | 2017-03-15 | 2024-11-12 | イドルシア・ファーマシューティカルズ・リミテッド | Ｐ２ｙ１２受容体アンタゴニストの皮下投与 |
| CN112500354A (zh) * | 2020-12-08 | 2021-03-16 | 烟台凯博医药科技有限公司 | 一种4-氯-6-环丙基嘧啶-5-胺的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5373586A (en) | 1976-12-09 | 1978-06-30 | Mitsubishi Chem Ind Ltd | New penicillin derivatives |
| US6861424B2 (en) * | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| CA2507657C (en) * | 2002-12-11 | 2011-05-31 | Schering Aktiengesellschaft | 2-aminocarbonyl-quinoline compounds as platelet adenosine diphosphate receptor antagonists |
| AR063258A1 (es) | 2006-10-13 | 2009-01-14 | Actelion Pharmaceuticals Ltd | Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos. |
| CL2007003038A1 (es) | 2006-10-25 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos. |
| SI2225253T1 (sl) | 2007-11-29 | 2012-09-28 | Actelion Pharmaceuticals Ltd | Derivati fosfonske kisline in njihova uporaba kot antagonisti receptorja P2Y12 |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| CA2756542C (en) | 2009-04-08 | 2017-08-22 | Actelion Pharmaceuticals Ltd | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines |
| CN102405220B (zh) | 2009-04-22 | 2015-05-27 | 埃科特莱茵药品有限公司 | 噻唑衍生物及其作为p2y12受体拮抗剂的用途 |
-
2006
- 2006-04-25 TW TW095114722A patent/TW200640877A/zh unknown
- 2006-04-26 AR ARP060101670A patent/AR056992A1/es not_active Application Discontinuation
- 2006-04-27 BR BRPI0608089-8A patent/BRPI0608089A2/pt not_active IP Right Cessation
- 2006-04-27 EP EP06728064A patent/EP1893634B1/de active Active
- 2006-04-27 MX MX2007013436A patent/MX2007013436A/es active IP Right Grant
- 2006-04-27 KR KR1020077026652A patent/KR101310016B1/ko active IP Right Grant
- 2006-04-27 ES ES06728064T patent/ES2377337T3/es active Active
- 2006-04-27 AT AT06728064T patent/ATE538130T1/de active
- 2006-04-27 JP JP2008508400A patent/JP4955658B2/ja not_active Expired - Fee Related
- 2006-04-27 AU AU2006241260A patent/AU2006241260A1/en not_active Withdrawn
- 2006-04-27 CA CA2604967A patent/CA2604967C/en active Active
- 2006-04-27 US US11/912,545 patent/US8048881B2/en active Active
- 2006-04-27 CN CNA2006800143742A patent/CN101166756A/zh active Pending
- 2006-04-27 WO PCT/IB2006/051318 patent/WO2006114774A2/en active Application Filing
- 2006-04-27 NZ NZ563584A patent/NZ563584A/en unknown
- 2006-04-27 RU RU2007143880/04A patent/RU2410393C2/ru not_active IP Right Cessation
-
2007
- 2007-10-25 IL IL186939A patent/IL186939A0/en unknown
- 2007-11-27 NO NO20076094A patent/NO20076094L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008539224A (ja) | 2008-11-13 |
| EP1893634A2 (de) | 2008-03-05 |
| KR20080004608A (ko) | 2008-01-09 |
| RU2007143880A (ru) | 2009-06-10 |
| CA2604967A1 (en) | 2006-11-02 |
| IL186939A0 (en) | 2008-02-09 |
| NO20076094L (no) | 2008-01-25 |
| BRPI0608089A2 (pt) | 2009-11-10 |
| AU2006241260A1 (en) | 2006-11-02 |
| KR101310016B1 (ko) | 2013-09-30 |
| CN101166756A (zh) | 2008-04-23 |
| WO2006114774A3 (en) | 2007-02-08 |
| US8048881B2 (en) | 2011-11-01 |
| US20080194576A1 (en) | 2008-08-14 |
| AR056992A1 (es) | 2007-11-07 |
| TW200640877A (en) | 2006-12-01 |
| JP4955658B2 (ja) | 2012-06-20 |
| RU2410393C2 (ru) | 2011-01-27 |
| ES2377337T3 (es) | 2012-03-26 |
| MX2007013436A (es) | 2008-01-16 |
| WO2006114774A2 (en) | 2006-11-02 |
| EP1893634B1 (de) | 2011-12-21 |
| NZ563584A (en) | 2011-03-31 |
| CA2604967C (en) | 2014-04-01 |
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