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ATE535008T1 - MASS SPECTROMETRY WITH MULTIPOL ION GUIDE DEVICE - Google Patents

MASS SPECTROMETRY WITH MULTIPOL ION GUIDE DEVICE

Info

Publication number
ATE535008T1
ATE535008T1 AT99903281T AT99903281T ATE535008T1 AT E535008 T1 ATE535008 T1 AT E535008T1 AT 99903281 T AT99903281 T AT 99903281T AT 99903281 T AT99903281 T AT 99903281T AT E535008 T1 ATE535008 T1 AT E535008T1
Authority
AT
Austria
Prior art keywords
ion
ion guide
multipole
fragmentation
guide
Prior art date
Application number
AT99903281T
Other languages
German (de)
Inventor
Craig Whitehouse
Bruce Andrien
Erol Gulcicek
Original Assignee
Perkinelmer Health Sci Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkinelmer Health Sci Inc filed Critical Perkinelmer Health Sci Inc
Application granted granted Critical
Publication of ATE535008T1 publication Critical patent/ATE535008T1/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

Multipole ion guides (6) configured with one or more segments (1, 2, 3, 4) and positioned in a higher pressure vacuum region (72), are operated in mass to charge selection and ion fragmentation modes. Individual multipole ion guides are mounted in a linear assembly with no electrodes configured in between each multipole ion guide. At least a portion of each multipole ion guide mounted in a linear assembly resides in a vacuum region with higher background pressure. At least one ion guide (4) can be configured to extend continuously from one vaccum stage (72) into another (73). Individual sets of RF, +/- DC and secular frequency voltage supplies provide potentials to the rods of each multipole ion guide allowing the operation of ion transmission, ion trapping, mass to charge selection and ion fragmentation functions independently in each ion guide. The presence of higher background pressure along a portion of the multiple ion guide linear assembly allows the Collisional Induced Dissociation (CID) fragmentation of ions by axially accelerating ions from one multipole ion guide to an adjacent ion guide, analogous to a triple quadrupole function. Alternatively ions can be fragmented in one or more multipole ion guides using resonant frequency excitation CID, similar to ion fragmentation operation in three dimensional quadrupole ion traps.
AT99903281T 1998-01-23 1999-01-22 MASS SPECTROMETRY WITH MULTIPOL ION GUIDE DEVICE ATE535008T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7237498P 1998-01-23 1998-01-23
US8724698P 1998-05-29 1998-05-29
PCT/US1999/001335 WO1999038193A1 (en) 1998-01-23 1999-01-22 Mass spectrometry with multipole ion guide

Publications (1)

Publication Number Publication Date
ATE535008T1 true ATE535008T1 (en) 2011-12-15

Family

ID=26753301

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99903281T ATE535008T1 (en) 1998-01-23 1999-01-22 MASS SPECTROMETRY WITH MULTIPOL ION GUIDE DEVICE

Country Status (6)

Country Link
EP (1) EP1057209B1 (en)
JP (1) JP2002502085A (en)
AT (1) ATE535008T1 (en)
AU (1) AU2334199A (en)
CA (1) CA2318855C (en)
WO (1) WO1999038193A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2332534C (en) * 1998-05-29 2008-07-22 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guides
GB9820210D0 (en) 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
US6586727B2 (en) * 2000-06-09 2003-07-01 Micromass Limited Methods and apparatus for mass spectrometry
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
CA2431809C (en) * 2000-12-14 2013-07-02 Mds Inc., Doing Business As Mds Sciex Apparatus and method for msnth in a tandem mass spectrometer system
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6803565B2 (en) * 2001-05-18 2004-10-12 Battelle Memorial Institute Ionization source utilizing a multi-capillary inlet and method of operation
US6956205B2 (en) 2001-06-15 2005-10-18 Bruker Daltonics, Inc. Means and method for guiding ions in a mass spectrometer
JP3990889B2 (en) * 2001-10-10 2007-10-17 株式会社日立ハイテクノロジーズ Mass spectrometer and measurement system using the same
US7049580B2 (en) * 2002-04-05 2006-05-23 Mds Inc. Fragmentation of ions by resonant excitation in a high order multipole field, low pressure ion trap
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
GB2390478B (en) * 2002-05-17 2004-06-02 Micromass Ltd Mass spectrometer
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
CN101685755B (en) * 2003-01-24 2011-12-14 萨莫芬尼根有限责任公司 Controlling ion populations in a mass analyzer
ATE343221T1 (en) * 2003-04-09 2006-11-15 Mds Inc Dbt Mds Sciex Division DYNAMIC SIGNAL SELECTION IN A CHROMATOGRAPHY/MASS SPECTOMETRY/MASS SPEC ROMETRY SYSTEM
US20050242281A1 (en) * 2004-04-30 2005-11-03 Gangqiang Li Unevenly segmented multipole
JP4872088B2 (en) * 2004-05-05 2012-02-08 ディーエイチ テクノロジーズ ディベロップメント ピーティーイー リミテッド Ion guide for mass spectrometer
GB2427067B (en) * 2005-03-29 2010-02-24 Thermo Finnigan Llc Improvements relating to ion trapping
DE102005061425B4 (en) * 2005-12-22 2009-06-10 Bruker Daltonik Gmbh Restricted fragmentation in ion trap mass spectrometers
CA2636822C (en) 2006-01-11 2015-03-03 Mds Inc., Doing Business Through Its Mds Sciex Division Fragmenting ions in mass spectrometry
GB0624679D0 (en) * 2006-12-11 2007-01-17 Shimadzu Corp A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer
GB2497799B (en) * 2011-12-21 2016-06-22 Thermo Fisher Scient (Bremen) Gmbh Collision cell multipole
JP6044385B2 (en) * 2013-02-26 2016-12-14 株式会社島津製作所 Tandem mass spectrometer
GB2541346B (en) * 2014-06-25 2022-05-11 Hitachi High Tech Corp Mass spectrometer
GB2534569A (en) 2015-01-27 2016-08-03 Shimadzu Corp Method of controlling a DC power supply
JP2022513801A (en) * 2018-12-13 2022-02-09 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド Effective potential matching at the boundaries of segmented quadrupoles in a mass spectrometer
GB2631679A (en) 2023-05-26 2025-01-15 Thermo Fisher Scient Bremen Gmbh High-voltage RF generator for ion optics
GB2630625B (en) * 2023-06-01 2025-07-16 Edinburgh Instruments Ltd Apparatus and method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3410997A (en) * 1964-09-08 1968-11-12 Bell & Howell Co Multipole mass filter
US4328420A (en) * 1980-07-28 1982-05-04 French John B Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system
US4814613A (en) * 1987-03-06 1989-03-21 Extrel Corporation Collision cell for triple quadrupole tandem mass spectrometry
EP0748249B1 (en) * 1994-02-28 2009-07-08 Analytica Of Branford, Inc. Multipole ion guide for mass spectrometry
DE19517507C1 (en) * 1995-05-12 1996-08-08 Bruker Franzen Analytik Gmbh High frequency ion transfer guidance system for transfer of ions into vacuum of e.g. ion trap mass spectrometer
JPH11510946A (en) * 1995-08-11 1999-09-21 エムディーエス ヘルス グループ リミテッド Spectrometer with axial electric field
DE69715190T2 (en) * 1996-06-06 2003-04-30 Mds Inc., Etobicoke MULTIPOLE MASS SPECTROMETER WITH AXIAL OUTPUT

Also Published As

Publication number Publication date
CA2318855C (en) 2006-07-11
EP1057209B1 (en) 2011-11-23
EP1057209A4 (en) 2006-02-01
AU2334199A (en) 1999-08-09
CA2318855A1 (en) 1999-07-29
JP2002502085A (en) 2002-01-22
WO1999038193A1 (en) 1999-07-29
EP1057209A1 (en) 2000-12-06

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