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ATE527260T1 - (dihydro)pyrroloä2,1-aüisoquinoline - Google Patents

(dihydro)pyrroloä2,1-aüisoquinoline

Info

Publication number
ATE527260T1
ATE527260T1 AT09708584T AT09708584T ATE527260T1 AT E527260 T1 ATE527260 T1 AT E527260T1 AT 09708584 T AT09708584 T AT 09708584T AT 09708584 T AT09708584 T AT 09708584T AT E527260 T1 ATE527260 T1 AT E527260T1
Authority
AT
Austria
Prior art keywords
pyrroloä2
aüisoquinoline
dihydro
Prior art date
Application number
AT09708584T
Other languages
English (en)
Inventor
Rijn Rachel Deborah Van
Hubert Loozen
Cornelis Timmers
Der Veen Lars Van
Willem Karstens
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE527260T1 publication Critical patent/ATE527260T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT09708584T 2008-02-08 2009-02-06 (dihydro)pyrroloä2,1-aüisoquinoline ATE527260T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2706208P 2008-02-08 2008-02-08
EP08151199 2008-02-08
PCT/EP2009/051366 WO2009098283A1 (en) 2008-02-08 2009-02-06 (dihydro)pyrrolo[2,1-a]isoquinolines

Publications (1)

Publication Number Publication Date
ATE527260T1 true ATE527260T1 (de) 2011-10-15

Family

ID=39516937

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09708584T ATE527260T1 (de) 2008-02-08 2009-02-06 (dihydro)pyrroloä2,1-aüisoquinoline

Country Status (27)

Country Link
US (1) US8394789B2 (de)
EP (1) EP2252611B1 (de)
JP (1) JP5620823B2 (de)
KR (1) KR101586870B1 (de)
CN (1) CN102216297B (de)
AR (1) AR070345A1 (de)
AT (1) ATE527260T1 (de)
AU (1) AU2009211296B2 (de)
BR (1) BRPI0906937A2 (de)
CA (1) CA2713173C (de)
CL (1) CL2009000281A1 (de)
CO (1) CO6241120A2 (de)
DK (1) DK2252611T3 (de)
EC (1) ECSP10010303A (de)
ES (1) ES2373022T3 (de)
HK (1) HK1150597A1 (de)
HR (1) HRP20110942T1 (de)
IL (1) IL206378A0 (de)
MX (1) MX2010008717A (de)
NZ (1) NZ587164A (de)
PE (1) PE20091413A1 (de)
PL (1) PL2252611T3 (de)
PT (1) PT2252611E (de)
RU (1) RU2495037C2 (de)
SI (1) SI2252611T1 (de)
TW (1) TW200944523A (de)
WO (1) WO2009098283A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071587B2 (en) * 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
EP2504316A1 (de) 2009-11-23 2012-10-03 MSD Oss B.V. Heterocylische verbindungen als orexinrezeptorantagonisten
US20120174381A1 (en) 2011-01-10 2012-07-12 David Messick Apparatus and method for frame crimping
WO2012112958A2 (en) * 2011-02-19 2012-08-23 The Broad Institute, Inc High-throughput assays to probe leukemia within the stromal niche
EP2763986B1 (de) 2011-09-22 2017-06-07 Merck Sharp & Dohme B.V. Fsh-rezeptorantagonisten
US9527851B2 (en) * 2011-12-21 2016-12-27 Jiangsu Hengrui Medicine Co., Ltd. Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof
CN102718695B (zh) * 2012-06-25 2014-04-02 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
AU2013352304C1 (en) 2012-11-29 2018-03-22 Chemocentryx, Inc. CXCR7 antagonists
RU2550366C1 (ru) * 2014-05-22 2015-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 5,6-ДИГИДРОПИРРОЛО[2,1-a]ИЗОХИНОЛИНОВ
MX2021006915A (es) * 2018-12-12 2021-08-24 Chemocentryx Inc Inhibidores de cxcr7 para el tratamiento de cancer.
CN110540519B (zh) * 2019-09-05 2022-12-02 宁波大学 一种1,6-烯炔类化合物与酮类化合物的自由基环化反应方法
CN113999103A (zh) * 2021-11-26 2022-02-01 八叶草健康产业研究院(厦门)有限公司 一种α-羟基-环丁烷甲酸的制备方法
WO2024184461A2 (en) 2023-03-08 2024-09-12 Ferring B.V. Small molecule fsh receptor modulators

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8718980D0 (en) * 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
DE4343649A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Neue Pyridazino[4',5':3,4]pyrrolo-[2,1-a]isochinoline und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU772373B2 (en) * 1998-08-07 2004-04-22 Laboratoires Serono Sa FSH mimetics for the treatment of infertility
WO2000048144A1 (fr) 1999-02-15 2000-08-17 Medailles Souvenirs Dispositif de personnalisation et de distribution de medailles
JP2004505051A (ja) 2000-07-27 2004-02-19 スミスクライン　ビーチャム　コーポレーション 卵胞刺激ホルモン活性のアゴニスト
CA2431326A1 (en) * 2000-12-13 2002-06-20 Bayer Aktiengesellschaft Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
ATE319451T1 (de) 2001-07-02 2006-03-15 Akzo Nobel Nv Tetrahydrochinolin-derivate
WO2003014116A1 (en) 2001-08-06 2003-02-20 Bayer Corporation Pyrrolo[2.1-a]isoquinoline derivatives
WO2003014115A1 (en) 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
AU2002366362A1 (en) * 2001-12-18 2003-06-30 Bayer Aktiengesellschaft 2-substituted pyrrolo(2.1-a)isoquinolines against cancer
US7754722B2 (en) * 2002-09-20 2010-07-13 Merck Serono Sa Piperazine derivatives and methods of use
KR20060030483A (ko) 2003-06-30 2006-04-10 알타나 파마 아게 Ｐｄｅ10 억제제로서 피롤로디히드로이소퀴놀린
CA2530114A1 (en) 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
US20080004263A1 (en) 2004-03-04 2008-01-03 Santora Vincent J Ligands of Follicle Stimulating Hormone Receptor and Methods of Use Thereof
ATE430148T1 (de) 2005-01-12 2009-05-15 Nycomed Gmbh Neue pyrrolodihydroisochinoline als pde10- inhibitoren
CA2595075A1 (en) 2005-01-12 2006-07-20 Matthias Vennemann Pyrrolodihydroisoquinolines as antiproliferative agents
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
ES2361674T3 (es) 2005-05-04 2011-06-21 N.V. Organon Derivados de dihidropiridina.

Also Published As

Publication number Publication date
EP2252611B1 (de) 2011-10-05
HRP20110942T1 (hr) 2012-01-31
US20110039832A1 (en) 2011-02-17
RU2495037C2 (ru) 2013-10-10
CO6241120A2 (es) 2011-01-20
CL2009000281A1 (es) 2009-06-26
TW200944523A (en) 2009-11-01
ES2373022T3 (es) 2012-01-30
MX2010008717A (es) 2010-09-24
KR20100124279A (ko) 2010-11-26
ECSP10010303A (es) 2010-07-30
RU2010136057A (ru) 2012-03-20
HK1150597A1 (de) 2012-01-06
BRPI0906937A2 (pt) 2016-04-19
PT2252611E (pt) 2011-12-20
IL206378A0 (en) 2010-12-30
CN102216297B (zh) 2014-06-25
KR101586870B1 (ko) 2016-01-19
NZ587164A (en) 2011-06-30
AU2009211296B2 (en) 2014-01-30
CA2713173A1 (en) 2009-08-13
WO2009098283A1 (en) 2009-08-13
AR070345A1 (es) 2010-03-31
CN102216297A (zh) 2011-10-12
PE20091413A1 (es) 2009-09-23
AU2009211296A1 (en) 2009-08-13
DK2252611T3 (da) 2012-01-30
CA2713173C (en) 2016-04-19
JP5620823B2 (ja) 2014-11-05
SI2252611T1 (sl) 2012-02-29
JP2011511041A (ja) 2011-04-07
PL2252611T3 (pl) 2012-03-30
EP2252611A1 (de) 2010-11-24
US8394789B2 (en) 2013-03-12

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