ATE521610T1 - Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität - Google Patents
Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivitätInfo
- Publication number
- ATE521610T1 ATE521610T1 AT04761819T AT04761819T ATE521610T1 AT E521610 T1 ATE521610 T1 AT E521610T1 AT 04761819 T AT04761819 T AT 04761819T AT 04761819 T AT04761819 T AT 04761819T AT E521610 T1 ATE521610 T1 AT E521610T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- chemokine receptor
- receptor activity
- spir
- methods
- Prior art date
Links
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title 1
- 102000009410 Chemokine receptor Human genes 0.000 title 1
- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 abstract 1
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50140703P | 2003-09-10 | 2003-09-10 | |
| PCT/CA2004/001656 WO2005023809A1 (en) | 2003-09-10 | 2004-09-09 | Spiro compounds and methods for the modulation of chemokine receptor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE521610T1 true ATE521610T1 (de) | 2011-09-15 |
Family
ID=34273044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04761819T ATE521610T1 (de) | 2003-09-10 | 2004-09-09 | Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7288548B2 (de) |
| EP (1) | EP1786815B1 (de) |
| AT (1) | ATE521610T1 (de) |
| CA (1) | CA2579608A1 (de) |
| WO (1) | WO2005023809A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2676B1 (en) * | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| US7709642B2 (en) | 2004-06-25 | 2010-05-04 | Virochem Pharma, Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
| EP1824853A4 (de) | 2004-12-09 | 2010-06-09 | Virochem Pharma Inc | Neue spirotropanverbindungen und verfahren zur modulation der aktivität des chemokinrezeptors |
| BRPI0518859A2 (pt) | 2004-12-09 | 2008-12-09 | Virochem Pharma Inc | compostos de espirotropano e mÉtodos para a modulaÇço de atividade de receptor de quimiocina |
| BRPI0608847A2 (pt) * | 2005-03-08 | 2010-02-02 | Janssen Pharmaceutica Nv | derivados de diaza-espiro-[4,4]-nonano substituìdos e seu uso como antagonistas de neurocinina |
| JP2012526136A (ja) * | 2009-05-07 | 2012-10-25 | メルク・シャープ・エンド・ドーム・コーポレイション | 抗糖尿病化合物として有用な置換スピロ環式アミン |
| US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| CN108982465B (zh) * | 2018-06-06 | 2020-10-02 | 上海应用技术大学 | 酒中二氧化硫高通量sers在线检测方法 |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2021113362A1 (en) * | 2019-12-03 | 2021-06-10 | Kallyope, Inc. | Sstr5 antagonists |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8401907A (nl) * | 1983-06-27 | 1985-01-16 | Sandoz Ag | Spirosuccinimiden en werkwijzen voor het bereiden en toepassen van deze spirosuccinimiden. |
| JP2001526178A (ja) | 1997-08-28 | 2001-12-18 | メルク エンド カムパニー インコーポレーテッド | ピロリジン系およびピペリジン系ケモカイン受容体活性調節剤 |
| WO2000051607A1 (en) | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
| WO2000051609A1 (en) | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity |
| AU3386700A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
| AU3389300A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| US6248755B1 (en) | 1999-04-06 | 2001-06-19 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| WO2001030780A2 (en) | 1999-10-27 | 2001-05-03 | Cor Therapeutics, Inc. | Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation |
| JP2002095730A (ja) | 2000-07-21 | 2002-04-02 | Midori Anzen Co Ltd | 脱臭材及びその製造方法 |
| EP1326619A2 (de) | 2000-10-11 | 2003-07-16 | Merck & Co., Inc. | Pyrrolidin-modulatoren der ccr5-chemokin-rezeptor-aktivität |
| RU2315051C2 (ru) * | 2001-12-28 | 2008-01-20 | Акадиа Фармасьютикалз, Инк. | Спироазациклические соединения, способ ингибирования активности или активации серотонинового 5-нт2а рецептора, способ лечения болезненного состояния, связанного с серотониновым 5-нт2а рецептором, и их применение |
| WO2004058763A1 (en) | 2002-12-23 | 2004-07-15 | Merck & Co., Inc. | 4(spiropiperidinyl)methyl substituted pyrrolidines as modulators of chemokine receptor activity |
| WO2004058702A2 (en) | 2002-12-23 | 2004-07-15 | Merck & Co., Inc. | 4-[(4-(carboxyethyl) piperidinyl) methyl] pyrrolidines as modulators of chemokine receptor activity |
-
2004
- 2004-09-09 WO PCT/CA2004/001656 patent/WO2005023809A1/en active Application Filing
- 2004-09-09 EP EP04761819A patent/EP1786815B1/de not_active Expired - Lifetime
- 2004-09-09 AT AT04761819T patent/ATE521610T1/de not_active IP Right Cessation
- 2004-09-09 CA CA002579608A patent/CA2579608A1/en not_active Abandoned
- 2004-09-10 US US10/937,880 patent/US7288548B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2579608A1 (en) | 2005-03-17 |
| US20050070563A1 (en) | 2005-03-31 |
| EP1786815B1 (de) | 2011-08-24 |
| EP1786815A1 (de) | 2007-05-23 |
| US7288548B2 (en) | 2007-10-30 |
| EP1786815A4 (de) | 2009-03-18 |
| WO2005023809A1 (en) | 2005-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |