ATE520028T1 - Test zum nachweis von proteinbindung - Google Patents
Test zum nachweis von proteinbindungInfo
- Publication number
- ATE520028T1 ATE520028T1 AT04776903T AT04776903T ATE520028T1 AT E520028 T1 ATE520028 T1 AT E520028T1 AT 04776903 T AT04776903 T AT 04776903T AT 04776903 T AT04776903 T AT 04776903T AT E520028 T1 ATE520028 T1 AT E520028T1
- Authority
- AT
- Austria
- Prior art keywords
- test
- phage
- protein binding
- detecting protein
- displayed
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48058703P | 2003-06-20 | 2003-06-20 | |
| PCT/US2004/019943 WO2004113556A2 (en) | 2003-06-20 | 2004-06-21 | Assay and kits for detecting protein binding |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520028T1 true ATE520028T1 (de) | 2011-08-15 |
Family
ID=33539315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04776903T ATE520028T1 (de) | 2003-06-20 | 2004-06-21 | Test zum nachweis von proteinbindung |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20050009099A1 (de) |
| EP (1) | EP1644513B1 (de) |
| JP (2) | JP4991291B2 (de) |
| AT (1) | ATE520028T1 (de) |
| AU (1) | AU2004250256B8 (de) |
| CA (1) | CA2526847C (de) |
| DK (1) | DK1644513T3 (de) |
| WO (1) | WO2004113556A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1891446T3 (pl) * | 2005-06-14 | 2013-08-30 | Cellzome Gmbh | Sposób identyfikacji nowych związków oddziałujących z enzymami |
| US20070128633A1 (en) * | 2005-10-11 | 2007-06-07 | Chembridge Research Laboratories, Inc. | Cell-free protein expression systems and methods of use thereof |
| JP5415264B2 (ja) | 2006-06-30 | 2014-02-12 | ドイスコベルク コーポレーション | 検出可能な核酸タグ |
| EP2045332B1 (de) | 2007-10-05 | 2010-07-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Proteomweite Quantifizierung kleiner an zelluläre Zielproteine gebundener Moleküle |
| KR101028875B1 (ko) | 2010-02-12 | 2011-04-12 | 메디스커브 주식회사 | 세포 내에서 세포내 물질의 생리활성 기능을 조절하는 조절물질을 검출하는 방법 |
| EP2766723A4 (de) * | 2011-10-12 | 2015-06-10 | Univ North Carolina | Multiplexierte kinasehemmerkügelchen und ihre verwendung |
| US9977015B2 (en) * | 2012-05-15 | 2018-05-22 | Massachusetts Institute Of Technology | Systems and methods for detecting molecular interactions using magnetic beads |
| EP3008083B1 (de) * | 2013-06-11 | 2021-06-30 | Paul Scherrer Institut | Verfahren zur bestimmung einer mutierbaren liganden-gpcr zur bindung an eine einzelne aminosäurelösung sowie paare von mutierten liganden und gpcr |
| EP3183580B1 (de) | 2014-08-21 | 2025-03-26 | Eurofins DiscoverX Corporation | Homogener thermal-shift-ligandenbindungstest |
| DE102015003503A1 (de) | 2015-03-20 | 2016-09-22 | Forschungszentrum Jülich GmbH | Spezifisch Amyloid-Beta bindende Peptide und deren Verwendung für die Therapie und Diagnose der Alzheimerschen Demenz |
| WO2024020328A1 (en) * | 2022-07-16 | 2024-01-25 | Eurofins Discoverx Corporation | Binding assays using phage display technology and kits thereof |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693489A (en) * | 1984-03-30 | 1997-12-02 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5198346A (en) * | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) * | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| US5437981A (en) * | 1990-02-26 | 1995-08-01 | Boehringer Mannheim Gmbh | Method for the immunological determination of ligands |
| US6172197B1 (en) * | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| DK1024191T3 (da) * | 1991-12-02 | 2008-12-08 | Medical Res Council | Fremstilling af autoantistoffer fremvist på fag-overflader ud fra antistofsegmentbiblioteker |
| WO1994013804A1 (en) * | 1992-12-04 | 1994-06-23 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| AT401526B (de) * | 1993-02-10 | 1996-09-25 | Scheirer Winfried | Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung |
| US5536814A (en) * | 1993-09-27 | 1996-07-16 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| WO1996002000A1 (en) * | 1994-07-08 | 1996-01-25 | New England Medical Center Hospitals, Inc. | E6 binding proteins |
| US6326155B1 (en) * | 1995-03-20 | 2001-12-04 | Dyax Corp. | Engineering affinity ligands for macromolecules |
| CA2219080A1 (en) | 1995-06-07 | 1996-12-27 | Ariad Gene Therapeutics, Inc. | Rapamycin-based regulation of biological events |
| WO1997034137A2 (en) * | 1996-03-12 | 1997-09-18 | Smithkline Beecham Corporation | Methods of the identification of pharmaceutically active compounds |
| US5766905A (en) * | 1996-06-14 | 1998-06-16 | Associated Universities Inc. | Cytoplasmic bacteriophage display system |
| IT1291913B1 (it) * | 1997-05-22 | 1999-01-21 | Angeletti P Ist Richerche Bio | Metodo che prevede l'uso di batteriofagi per la rivelazione della presenza di molecole di interesse in campioni biologici |
| US6245760B1 (en) * | 1997-05-28 | 2001-06-12 | Aventis Pharmaceuticals Products, Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| US6162613A (en) * | 1998-02-18 | 2000-12-19 | Vertex Pharmaceuticals, Inc. | Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases |
| US6897019B1 (en) * | 1998-04-17 | 2005-05-24 | Tufts College | Methods for treating and preventing insulin resistance and related disorders |
| US6602977B1 (en) * | 1999-04-19 | 2003-08-05 | Biovitrum Ab | Receptor structures |
| AU784501B2 (en) * | 1999-09-03 | 2006-04-13 | Yale University | Method to identify gene function using small molecule probes |
| WO2001053479A2 (en) * | 2000-01-24 | 2001-07-26 | Sangamo Biosciences, Inc. | Molecular switches ii |
| US7060506B2 (en) * | 2000-01-31 | 2006-06-13 | Cyclacel, Ltd. | Compositions and methods for monitoring the modification of modification dependent binding partner polypeptides |
| US20030166549A1 (en) * | 2000-02-02 | 2003-09-04 | Klaus Schughart | Targeting peptides |
| US6630335B1 (en) * | 2000-02-11 | 2003-10-07 | Millennium Pharmaceuticals, Inc. | 14171 protein kinase, a novel human protein kinase and uses thereof |
| WO2001098330A2 (en) * | 2000-06-20 | 2001-12-27 | Euroscreen S.A. | A RECOMBINANT CELL LINE EXPRESSING GPCRx11 AS A FUNCTIONAL RECEPTOR VALIDATED BY ANGIOPEPTIN AND USEFUL FOR SCREENING OF AGONISTS AND ANTAGONISTS |
| US20020123071A1 (en) * | 2000-12-04 | 2002-09-05 | Knudsen Sanne Moller | Method of identifying compounds capable of acting as agonists or antagonists of G-protein coupled receptors |
| US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
| CN100406891C (zh) * | 2001-06-27 | 2008-07-30 | 詹森药业有限公司 | 利用EPF受体鉴定结合或调节hDRR活性的化合物以及hDRR的分离 |
| US20080318204A1 (en) * | 2001-12-06 | 2008-12-25 | Linqi Zhang | Highly-Sensitive Genomic Assays Employing Chimeric Bacteriophage Standards |
| US20030194749A1 (en) * | 2002-02-15 | 2003-10-16 | Wandless Thomas J. | Wortmannin derivatives as probes of cellular proteins and processes |
-
2004
- 2004-06-21 EP EP04776903A patent/EP1644513B1/de not_active Expired - Lifetime
- 2004-06-21 US US10/873,835 patent/US20050009099A1/en not_active Abandoned
- 2004-06-21 DK DK04776903.9T patent/DK1644513T3/da active
- 2004-06-21 JP JP2006517526A patent/JP4991291B2/ja not_active Expired - Lifetime
- 2004-06-21 AU AU2004250256A patent/AU2004250256B8/en not_active Ceased
- 2004-06-21 WO PCT/US2004/019943 patent/WO2004113556A2/en active Application Filing
- 2004-06-21 CA CA2526847A patent/CA2526847C/en not_active Expired - Lifetime
- 2004-06-21 AT AT04776903T patent/ATE520028T1/de not_active IP Right Cessation
-
2007
- 2007-08-23 US US11/895,307 patent/US9267165B2/en active Active
-
2011
- 2011-10-14 JP JP2011226299A patent/JP5441978B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4991291B2 (ja) | 2012-08-01 |
| DK1644513T3 (da) | 2011-10-17 |
| JP5441978B2 (ja) | 2014-03-12 |
| US9267165B2 (en) | 2016-02-23 |
| JP2007524388A (ja) | 2007-08-30 |
| AU2004250256A1 (en) | 2004-12-29 |
| WO2004113556A2 (en) | 2004-12-29 |
| US20050009099A1 (en) | 2005-01-13 |
| AU2004250256B2 (en) | 2010-03-25 |
| EP1644513A2 (de) | 2006-04-12 |
| CA2526847C (en) | 2011-01-25 |
| EP1644513B1 (de) | 2011-08-10 |
| JP2012044996A (ja) | 2012-03-08 |
| EP1644513A4 (de) | 2007-10-17 |
| WO2004113556A3 (en) | 2005-11-03 |
| CA2526847A1 (en) | 2004-12-29 |
| US20080058219A1 (en) | 2008-03-06 |
| AU2004250256B8 (en) | 2010-04-08 |
| WO2004113556A8 (en) | 2005-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |