[go: up one dir, main page]

ATE517622T1 - Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten - Google Patents

Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten

Info

Publication number
ATE517622T1
ATE517622T1 AT04796120T AT04796120T ATE517622T1 AT E517622 T1 ATE517622 T1 AT E517622T1 AT 04796120 T AT04796120 T AT 04796120T AT 04796120 T AT04796120 T AT 04796120T AT E517622 T1 ATE517622 T1 AT E517622T1
Authority
AT
Austria
Prior art keywords
salt
tetrahydropyranylcyclopentyltetrahydropyridopyr
diderivate
ccr
antagonist
Prior art date
Application number
AT04796120T
Other languages
English (en)
Inventor
Mark Jensen
Robert Larsen
Daniel Richard Sidler
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE517622T1 publication Critical patent/ATE517622T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
AT04796120T 2003-10-27 2004-10-25 Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten ATE517622T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51473503P 2003-10-27 2003-10-27
PCT/US2004/035069 WO2005044264A1 (en) 2003-10-27 2004-10-25 Ccr-2 antagonist salt

Publications (1)

Publication Number Publication Date
ATE517622T1 true ATE517622T1 (de) 2011-08-15

Family

ID=34572774

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04796120T ATE517622T1 (de) 2003-10-27 2004-10-25 Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten

Country Status (21)

Country Link
US (1) US7473696B2 (de)
EP (1) EP1682135B1 (de)
JP (1) JP4542550B2 (de)
KR (1) KR20060101476A (de)
CN (1) CN1870998B (de)
AT (1) ATE517622T1 (de)
AU (1) AU2004287416C1 (de)
BR (1) BRPI0415836A (de)
CA (1) CA2543201C (de)
CO (1) CO5690606A2 (de)
EC (1) ECSP066524A (de)
IL (1) IL175009A0 (de)
IS (1) IS8400A (de)
MA (1) MA28104A1 (de)
MX (1) MXPA06004647A (de)
NO (1) NO20062377L (de)
NZ (1) NZ546447A (de)
RU (1) RU2317295C1 (de)
UA (1) UA81365C2 (de)
WO (1) WO2005044264A1 (de)
ZA (1) ZA200602752B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
BRPI0316732B8 (pt) 2002-11-27 2021-05-25 Incyte Corp composto derivado de 3-aminopirrolidina e sua composição farmacêutica
EP1606280A4 (de) * 2003-03-18 2008-12-24 Merck & Co Inc Tetrahydropyranylcyclopentylheterocylamid­modulatoren der chemokinrezeptoraktivität
AR045875A1 (es) * 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2
DK1696919T3 (da) 2003-12-18 2013-12-09 Incyte Corp 3-cycloalkylaminopyrrolidin-derivater som modulatorer af chemokinreceptorer
KR100837019B1 (ko) 2004-05-11 2008-06-10 인사이트 코포레이션 케모카인 수용체 조절제로서3-(4-헤테로아릴사이클로헥실아미노)사이클로펜탄카복스아마이드
GB0413605D0 (en) * 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
WO2006004741A2 (en) 2004-06-28 2006-01-12 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
US7449467B2 (en) 2004-06-28 2008-11-11 Pfizer Inc. 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
WO2008060621A2 (en) 2006-11-17 2008-05-22 Abbott Laboratories Aminopyrrolidines as chemokine receptor antagonists
US20090076065A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched mk-0812
US7741327B2 (en) 2008-04-16 2010-06-22 Hoffmann-La Roche Inc. Pyrrolidinone glucokinase activators
US8178689B2 (en) 2010-06-17 2012-05-15 Hoffman-La Roche Inc. Tricyclic compounds
EP2685978A2 (de) * 2011-03-17 2014-01-22 Merck Sharp & Dohme Corp. Cyclohexan-substituierte amino-cyclopentan-derivate als nützliche ccr2-antagonisten
WO2013149376A1 (en) 2012-04-02 2013-10-10 Abbott Laboratories Chemokine receptor antagonists
EP2962691A4 (de) * 2013-02-28 2016-08-31 Santen Pharmaceutical Co Ltd Mittel zur prävention oder behandlung von erkrankungen der hinteren teile des auges mit einem tetrahydropyranyl-amino-cyclopentylcarbonyl-tetrahydropyridopyridin-derivat als wirkstoff
HUE060376T2 (hu) 2015-05-21 2023-02-28 Chemocentryx Inc Ccr2 modulátorok
MX2020003192A (es) 2017-09-25 2020-07-29 Chemocentryx Inc Terapia de combinacion usando un antagonista del receptor de quimiocina tipo 2 (ccr2) y un inhibidor de pd-1/pd-l1.
JP7442141B2 (ja) 2018-01-08 2024-03-04 ケモセントリックス，インコーポレイティド Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
CN112341350A (zh) * 2020-10-19 2021-02-09 江苏威奇达药业有限公司 酶法拆分γ-内酰胺后副产物的处理方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
GB9417249D0 (en) * 1994-08-26 1994-10-19 Wellcome Found A novel salt
JPH09291034A (ja) * 1996-02-27 1997-11-11 Yoshitomi Pharmaceut Ind Ltd 縮合ピリジン化合物およびその医薬としての用途
RU2174123C2 (ru) * 1996-10-28 2001-09-27 Новартис Аг Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
US6312689B1 (en) * 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
FR2787790A1 (fr) * 1998-12-23 2000-06-30 Sanofi Sa Procede de preparation du (r)-(+)-3-{1[2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl]-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates
WO2000076512A1 (en) 1999-06-11 2000-12-21 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
AU2001283345B2 (en) * 2000-08-17 2005-03-24 Merck Sharp & Dohme Corp. Cyclopentyl modulators of chemokine receptor activity
CA2430065C (en) * 2000-11-28 2008-05-20 Pfizer Products Inc. Salts of a isothiazole-4-carboxamide and their use as anti-hyperproliferation agents
KR20040066140A (ko) * 2001-11-29 2004-07-23 화이자 프로덕츠 인크. 5,8,14-트리아자테트라시클로[10.3.1.0(2,11).0(4,9)]헥사데카-2(11),3,5,7,9-펜타엔의 숙신산염 및 그의 제약 조성물
CN1608062A (zh) * 2001-12-12 2005-04-20 辉瑞产品公司 E－2－甲氧基－n－(3－{4－[3－甲基－4－(6－甲基－吡啶－3－基氧基) －苯氨基]－喹唑啉－6基}－烯丙基)－乙酰胺的盐，其制备和抗癌用途
JO2479B1 (en) * 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
JP3780291B2 (ja) * 2002-04-29 2006-05-31 メルク エンド カムパニー インコーポレーテッド テトラヒドロピラニルシクロペンチルテトラヒドロピリドピリジン系のケモカイン受容体活性調節剤
CA2483843A1 (en) * 2002-04-29 2003-11-13 Merck & Co. Inc. Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
AR045875A1 (es) * 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2

Also Published As

Publication number Publication date
JP4542550B2 (ja) 2010-09-15
KR20060101476A (ko) 2006-09-25
EP1682135A1 (de) 2006-07-26
CA2543201A1 (en) 2005-05-19
CN1870998B (zh) 2010-10-20
AU2004287416A1 (en) 2005-05-19
NO20062377L (no) 2006-05-24
UA81365C2 (en) 2007-12-25
IL175009A0 (en) 2006-08-20
ECSP066524A (es) 2006-10-10
NZ546447A (en) 2009-02-28
BRPI0415836A (pt) 2007-01-02
RU2317295C1 (ru) 2008-02-20
AU2004287416B2 (en) 2009-11-19
CA2543201C (en) 2010-12-21
EP1682135B1 (de) 2011-07-27
US7473696B2 (en) 2009-01-06
US20070135474A1 (en) 2007-06-14
CO5690606A2 (es) 2006-10-31
EP1682135A4 (de) 2009-11-25
JP2007509940A (ja) 2007-04-19
MXPA06004647A (es) 2006-06-27
ZA200602752B (en) 2007-08-29
CN1870998A (zh) 2006-11-29
IS8400A (is) 2006-04-06
MA28104A1 (fr) 2006-08-01
AU2004287416C1 (en) 2010-09-09
WO2005044264A1 (en) 2005-05-19

Similar Documents

Publication Publication Date Title
ATE517622T1 (de) Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten
WO2006034039A3 (en) Substituted morphinans and methods of their use
MXPA06000716A (es) Derivados de quinolina y quinazolina que tienen afinidad hacia receptores del tipo 5ht1.
GEP20074210B (en) Tropane derivatives as ccr5 modulators
BR0014352A (pt) Cetoenóis espirocìclicos substituìdos por trifluormetila
EP1600442A4 (de) Heteroarylcarbamoylbenzolderivate
DE60312701D1 (de) Darstellung von 1h-imidazoä4,5-cüchinolin-4-aminen über neue 1h-imidazoä4,5-cüchinolin-4-cyano- und 1h-imidazoä4,5-cüchinolin-4-carboxamid intermediate
EP1598349A4 (de) Neue 2-pyridincarbonsäureamidderivate
IL166235A (en) H-1-pyrolidine-4,2-deion spirocyclic annihilated conjugates in cisal alkoxies for use as pesticides, their preparation and intermediates
SI1910381T1 (sl) Substituirane spojine 1-oksa-3,8-diazaspiro(4,5)-dekan-2-on in njihova uporaba za pripravo zdravil
WO2007147771A3 (en) Tetralin and indane derivatives and uses thereof
MXPA05008183A (es) Proceso para preparar pirrolotriazina como inhibidores de cinasa.
NZ603792A (en) Modulators of 5-ht receptors and methods of use thereof
WO2003004497A1 (fr) Compose heterocyclique
AR045875A1 (es) Procedimiento para la preparacion del antagonista ccr-2
ATE409179T1 (de) Tetralin- und indanderivate und deren anwendungen als 5-ht-antagonisten
AU2003205964A1 (en) Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
ZA200900165B (en) 4-amino-3-arylamino-6-arylpyrazolo[3,4-D]pyrimidine derivatives, methods for their preparation and their use as antiviral agents
EP1786815A4 (de) Spiroverbindungen und -verfahren zur modulation von chemokin-rezeptor-aktivität
MX2009001141A (es) Derivados de acido tieno[3,2-c]piridin-2-carboxilico.
AU2003214520A1 (en) Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
MX2007004591A (es) Proceso para la preparacion de compuestos organicos.
EA200501829A1 (ru) Способ получения непептидных замещённых спиробензоазепиновых производных
IL173582A0 (en) A process for the preparation of phenyltetrazole derivatives
DK1501838T3 (da) Fremgangsmåde til fremstilling af clopidogrel

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties