ATE513835T1 - Verfahren zur herstellung von cefotetan - Google Patents
Verfahren zur herstellung von cefotetanInfo
- Publication number
- ATE513835T1 ATE513835T1 AT06113916T AT06113916T ATE513835T1 AT E513835 T1 ATE513835 T1 AT E513835T1 AT 06113916 T AT06113916 T AT 06113916T AT 06113916 T AT06113916 T AT 06113916T AT E513835 T1 ATE513835 T1 AT E513835T1
- Authority
- AT
- Austria
- Prior art keywords
- cefotetan
- tautomer
- producing
- precipitate
- free
- Prior art date
Links
- SRZNHPXWXCNNDU-RHBCBLIFSA-N cefotetan Chemical compound N([C@]1(OC)C(N2C(=C(CSC=3N(N=NN=3)C)CS[C@@H]21)C(O)=O)=O)C(=O)C1SC(=C(C(N)=O)C(O)=O)S1 SRZNHPXWXCNNDU-RHBCBLIFSA-N 0.000 title abstract 4
- 229960005495 cefotetan Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000001914 filtration Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001115A ITMI20051115A1 (it) | 2005-06-14 | 2005-06-14 | Procedimento per l'ottenimento di cefotetan con resa elevata |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE513835T1 true ATE513835T1 (de) | 2011-07-15 |
Family
ID=36838686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06113916T ATE513835T1 (de) | 2005-06-14 | 2006-05-15 | Verfahren zur herstellung von cefotetan |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7560545B2 (de) |
| EP (1) | EP1734043B1 (de) |
| KR (1) | KR20060130491A (de) |
| CN (1) | CN1880318B (de) |
| AT (1) | ATE513835T1 (de) |
| ES (1) | ES2367367T3 (de) |
| IT (1) | ITMI20051115A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20051085A1 (it) * | 2005-06-10 | 2006-12-11 | Acs Dobfar Spa | Metodo di purificazione del cefotetan |
| CN103044458A (zh) * | 2012-12-25 | 2013-04-17 | 深圳华润九新药业有限公司 | 头孢替坦二钠纯化方法 |
| CN107141307B (zh) * | 2017-05-17 | 2019-09-17 | 华北制药河北华民药业有限责任公司 | 一种高纯度注射用头孢替坦二钠的制备方法 |
| CN112745336B (zh) * | 2020-12-27 | 2021-12-14 | 山东罗欣药业集团恒欣药业有限公司 | 一种抗感染类头孢药物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH648317A5 (de) * | 1977-06-10 | 1985-03-15 | Yamanouchi Pharma Co Ltd | 7alpha-methoxy-7betha-(1,3-dithietan-2- carboxamido)cephalosporansaeurederivate und verfahren zu ihrer herstellung. |
| EP0290136A3 (de) * | 1987-03-31 | 1990-03-14 | Yamanouchi Pharmaceutical Co. Ltd. | 7-Beta-substituierte-3-niedrig alkanoylacetoxymethyl-7-alpha-methoxy-3-cephem-4-carboxylsäure und Verfahren zu ihrer Herstellung |
| ITMI20010964A1 (it) * | 2001-05-10 | 2002-11-10 | Acs Dobfar Spa | Procedimento per l'ottenimento di composti utili per la produzione del cefotetan e nuovi composti cosi' ottenuti |
| ITMI20051085A1 (it) * | 2005-06-10 | 2006-12-11 | Acs Dobfar Spa | Metodo di purificazione del cefotetan |
| ITMI20051991A1 (it) * | 2005-10-20 | 2007-04-21 | Acs Dobfar Spa | Purificazione di prodotti beta-lattamici |
-
2005
- 2005-06-14 IT IT001115A patent/ITMI20051115A1/it unknown
-
2006
- 2006-05-12 US US11/383,075 patent/US7560545B2/en not_active Expired - Fee Related
- 2006-05-15 EP EP06113916A patent/EP1734043B1/de not_active Not-in-force
- 2006-05-15 ES ES06113916T patent/ES2367367T3/es active Active
- 2006-05-15 AT AT06113916T patent/ATE513835T1/de active
- 2006-05-24 KR KR1020060046640A patent/KR20060130491A/ko not_active Abandoned
- 2006-06-13 CN CN2006100926462A patent/CN1880318B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060130491A (ko) | 2006-12-19 |
| EP1734043B1 (de) | 2011-06-22 |
| CN1880318B (zh) | 2010-09-15 |
| ITMI20051115A1 (it) | 2006-12-15 |
| EP1734043A1 (de) | 2006-12-20 |
| ES2367367T3 (es) | 2011-11-02 |
| US20060281916A1 (en) | 2006-12-14 |
| CN1880318A (zh) | 2006-12-20 |
| US7560545B2 (en) | 2009-07-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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