[go: up one dir, main page]

ATE500894T1 - Testvorrichtung und verfahren zum chemischen oder biologischen screening - Google Patents

Testvorrichtung und verfahren zum chemischen oder biologischen screening

Info

Publication number
ATE500894T1
ATE500894T1 AT03700978T AT03700978T ATE500894T1 AT E500894 T1 ATE500894 T1 AT E500894T1 AT 03700978 T AT03700978 T AT 03700978T AT 03700978 T AT03700978 T AT 03700978T AT E500894 T1 ATE500894 T1 AT E500894T1
Authority
AT
Austria
Prior art keywords
base
liquid
microwells
chemical
test device
Prior art date
Application number
AT03700978T
Other languages
English (en)
Inventor
Dmitri Papkovsky
John Alderman
Rosemary O'connor
Original Assignee
Univ College Cork Nat Univ Ie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ College Cork Nat Univ Ie filed Critical Univ College Cork Nat Univ Ie
Priority claimed from PCT/IE2003/000003 external-priority patent/WO2003059518A2/en
Application granted granted Critical
Publication of ATE500894T1 publication Critical patent/ATE500894T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/12Well or multiwell plates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/20Material Coatings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/22Transparent or translucent parts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/38Caps; Covers; Plugs; Pouring means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0689Sealing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/046Function or devices integrated in the closure
    • B01L2300/048Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/808Optical sensing apparatus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
AT03700978T 2002-01-17 2003-01-16 Testvorrichtung und verfahren zum chemischen oder biologischen screening ATE500894T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE20020025 2002-01-17
PCT/IE2003/000003 WO2003059518A2 (en) 2002-01-17 2003-01-16 An assay device and method for chemical or biological screening

Publications (1)

Publication Number Publication Date
ATE500894T1 true ATE500894T1 (de) 2011-03-15

Family

ID=33446347

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03700978T ATE500894T1 (de) 2002-01-17 2003-01-16 Testvorrichtung und verfahren zum chemischen oder biologischen screening

Country Status (5)

Country Link
US (1) US7138270B2 (de)
EP (1) EP1465730B1 (de)
AT (1) ATE500894T1 (de)
AU (1) AU2003202120A1 (de)
DE (1) DE60336296D1 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888110B2 (en) * 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
US8597597B2 (en) 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
EP1866075B1 (de) 2005-01-25 2010-09-08 Seng Enterprises Limited Mikrofluidische vorrichtung zur untersuchung zellen
WO2007052245A1 (en) 2005-11-03 2007-05-10 Seng Enterprises Ltd. Method and device for studying floating, living cells
US20070128668A1 (en) * 2005-12-01 2007-06-07 Larry Burg Quantitative use of tracer cells
US20080003696A1 (en) * 2006-06-30 2008-01-03 Andrew Rae Embossed reagent card
US20080051646A1 (en) * 2006-07-24 2008-02-28 Papkovsky Dmitri B Probe for cellular oxygen
US8252158B2 (en) 2006-11-01 2012-08-28 Honeywell International Inc. Oxygen sensors
US20080293157A1 (en) * 2007-05-24 2008-11-27 Gerald Frederickson Apparatus and method of performing high-throughput cell-culture studies on biomaterials
ATE534467T1 (de) * 2007-10-01 2011-12-15 Tecan Trading Ag Mikroküvetten-anordnung und deren verwendung
US20090098593A1 (en) * 2007-10-15 2009-04-16 Biocision, Inc. Laboratory plate thermal vault
WO2009055702A1 (en) * 2007-10-24 2009-04-30 Purdue Research Foundation Time of death biosensor
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
EP2237887A2 (de) 2007-12-26 2010-10-13 Seng Enterprises Ltd. Vorrichtung zur untersuchung von lebenden zellen
US9874520B1 (en) 2008-11-07 2018-01-23 Mocon, Inc. Epi-fluoresence confocal optical analyte sensor
US8241911B2 (en) * 2008-11-07 2012-08-14 Mocon, Inc. Calibration card for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
JP2012508378A (ja) * 2008-11-07 2012-04-05 モコン・インコーポレーテッド 光学式酸素センサ用キャリブレーションカード
US8323978B2 (en) * 2008-11-07 2012-12-04 Mocon, Inc. Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
CN102341491B (zh) * 2009-03-20 2014-08-20 国际商业机器公司 微生物培养装置及其操作方法
US9919311B2 (en) 2009-07-20 2018-03-20 Siloam Biosciences, Inc. Microfluidic assay platforms
US20110136247A1 (en) * 2009-12-07 2011-06-09 Dmitri Boris Papkovsky Photoluminescent oxygen probe with reduced cross-sensitivity to humidity
EP2529201A1 (de) 2010-01-27 2012-12-05 Luxcel Biosciences Ltd. Fotolumineszente drucksonde
TW201236760A (en) * 2010-11-01 2012-09-16 Nanoink Inc High-throughput assay methods and articles
US20120129268A1 (en) 2010-11-19 2012-05-24 Mayer Daniel W Photoluminescent oxygen probe with reduced cross-sensitivity to humidity
US9274060B1 (en) 2011-01-13 2016-03-01 Mocon, Inc. Methods for transmembrane measurement of oxygen concentration and monitoring changes in oxygen concentration within a space enclosed by a membrane employing a photoluminescent transmembrane oxygen probe
US9121827B2 (en) 2011-06-30 2015-09-01 Mocon, Inc. Method of contemporaneously monitoring changes in analyte concentration in a plurality of samples on individual schedules
AU2011373434B2 (en) * 2011-07-18 2016-05-26 Agilent Technologies, Inc. Method and device for detection and quantification of thermoduric microorganisms in a product
EP2745095B1 (de) * 2011-08-17 2021-12-08 Agilent Technologies, Inc. Apparat und verfahren zur bestätigung der funktionalität eines analytischen instruments basierend auf photolumineszenz
US9382510B2 (en) * 2011-08-25 2016-07-05 Jian Chen Methods and devices for electroporation
EP2786128A1 (de) 2011-09-06 2014-10-08 Luxcel Biosciences Limited Trockenbeschichtete photolumineszente sonde und verfahren zur herstellung und verwendung
EP2783202A1 (de) 2011-11-22 2014-10-01 Luxcel Biosciences Ltd. Vorrichtung und verfahren zum schnellen testen mehrerer biologischer proben auf sauerstoffverbrauch
GB201121959D0 (en) * 2011-12-21 2012-02-01 Univ Leeds Assay of functional cell viability
USD707845S1 (en) * 2012-01-13 2014-06-24 Nuhigh Biotechnologies Co. Ltd. Dividable microplate cover sheet
BR112014020083A8 (pt) * 2012-02-16 2017-07-11 3M Innovative Properties Company Dispositivos indicadores biológicos de esterilização e métodos de uso
US11293866B2 (en) 2012-03-22 2022-04-05 John EASTMAN Fiber optic analyte sensor
US9057687B2 (en) 2012-04-20 2015-06-16 Mocon, Inc. Calibration vial and technique for calibrating a fiber optic oxygen sensing needle
US8658429B1 (en) 2012-08-06 2014-02-25 Mocon, Inc. Photoluminescent oxygen probe tack
EP2929323B1 (de) 2012-12-05 2024-05-01 Agilent Technologies, Inc. Individuell und flexibel einsetzbare targetanalytempfindliche partikelsonden und verfahren zur herstellung und verwendung
CN105143436B (zh) * 2013-02-20 2018-01-23 陈剑 电穿孔方法与设备
CH708820A1 (de) 2013-11-07 2015-05-15 Tecan Trading Ag Inkubationskassette.
US10209166B2 (en) 2014-11-18 2019-02-19 Alfonso Heras System and method for processing biological specimens
US9316554B1 (en) 2014-12-23 2016-04-19 Mocon, Inc. Fiber optic analyte sensor with integrated in situ total pressure correction
FR3040895B1 (fr) * 2015-09-11 2020-01-10 Elvesys Substrat de support d'echantillon liquide, ensemble comportant un tel substrat et son utilisation
US20180155664A1 (en) * 2016-02-11 2018-06-07 Maribella Domenech Multi-microwell array for multi-cellular adjacent co-culture
EP3472351B1 (de) 2016-06-15 2020-10-28 Ludwig-Maximilians-Universität München Einzelmolekülnachweis bzw. -quantifizierung durch dna-nanotechnologie
US20200166529A1 (en) 2017-05-10 2020-05-28 Agilent Technologies, Inc. Real-Time Cellular or Pericellular Microenvironmental Oxygen Control
US12059683B2 (en) 2017-05-16 2024-08-13 Agilent Technologies, Inc. Headspace eliminating microtiter plate lid and method of optically measuring well oxygen concentration through the lid
DE102019003444A1 (de) * 2019-05-16 2020-11-19 Evorion Biotechnologies Gmbh Inkubationssystem
EP4103680A1 (de) * 2020-02-14 2022-12-21 3M Innovative Properties Company Kulturvorrichtung, das sauerstoffempfindliche luminophore enthält, und verfahren zum verwenden
WO2021165025A1 (en) * 2020-02-18 2021-08-26 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for cell-free protein synthesis or fluorescent assays in the context of cell-free protein synthesis and multi-well plate for use therewith
CA3176346A1 (en) * 2020-04-24 2021-10-28 Mark S. Evans Focal plane spacers for microscope slides and related systems and methods
CN117355640A (zh) * 2021-04-16 2024-01-05 普莱克斯姆公司 用于测定装置的盖
WO2023196546A1 (en) 2022-04-08 2023-10-12 Agilent Technologies, Inc. Headspace eliminating microtiter plate lid
EP4504409A1 (de) 2022-04-08 2025-02-12 Agilent Technologies, Inc. Mikrotiterplattendeckel und magnetadapter

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508637C3 (de) 1975-02-28 1979-11-22 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Anordnung zur optischen Messung von Blutgasen
US4294924A (en) 1980-02-25 1981-10-13 Data Packaging Corporation Method and container for growth of anaerobic microorganisms
US4387972A (en) * 1981-02-26 1983-06-14 Immuno Concepts, Inc. Microscope slide with confirming wells
US5155019A (en) 1982-08-31 1992-10-13 Becton, Dickinson And Company Detection of the presence of biological activity in a sealed container utilizing infrared analysis of carbon dioxide and apparatus therefor
CA1261717A (en) 1982-12-23 1989-09-26 John R. Bacon Method and apparatus for oxygen determination
US4599315A (en) 1983-09-13 1986-07-08 University Of California Regents Microdroplet test apparatus
US4657867A (en) 1984-11-01 1987-04-14 Becton, Dickinson And Company Multiwell tissue culture assembly with features for reduced media evaporation
US4810655A (en) 1985-07-03 1989-03-07 Abbott Laboratories Method for measuring oxygen concentration
US4722598A (en) * 1986-12-04 1988-02-02 Max M. Ford Diagnostic microscope slide having multiple sample wells and cover
US4947850A (en) 1988-03-11 1990-08-14 Trustees Of The University Of Pennsylvania Method and apparatus for imaging an internal body portion of a host animal
EP0388159A3 (de) 1989-03-15 1991-06-12 Seiko Instruments Inc. Gerät zur Versieglung einer Flüssigkeit in Hohlräumen
US5232839A (en) 1990-06-14 1993-08-03 Difco Laboratories Incorporated Detecting microbiological growth
US6395506B1 (en) * 1991-04-18 2002-05-28 Becton, Dickinson And Company Device for monitoring cells
US5371016A (en) 1993-04-26 1994-12-06 Becton, Dickinson And Company Detecting biological activities in culture vials
DE4405375C2 (de) 1994-02-19 1996-07-25 Fritz Nerbe Nachfolger Juergen Mikrotiterplatte
US5792426A (en) 1994-10-11 1998-08-11 Schweizerische Eidgenossenschaft Vertreten Durch Das Ac-Laboratorium Spiez Der Gruppe Rustung Multi-well titerplate for instrumental analysis
CA2179364C (en) 1995-06-27 1999-09-28 Klaus W. Berndt Method and apparatus for detecting microorganisms
EP0934428B1 (de) 1996-10-08 2004-01-02 Photonics Biosystems Mikrobiologisches schnellbestimmungsverfahren und vorrichtung, die die detektion des sauerstoffgradienten benutzt
DE19907011A1 (de) 1999-02-18 2000-08-31 Deutsches Krebsforsch Fluoreszenzkorrelationsspektroskopievorrichtung und -verfahren, insbesondere zur Mehrfarbenfluoreszenzkorrelationsspektroskopie
AU2001286262A1 (en) 2000-09-18 2002-04-02 Center For Advanced Science And Technology Incubation, Ltd. (Casti) Micro well array and method of sealing liquid using the micro well array

Also Published As

Publication number Publication date
EP1465730A2 (de) 2004-10-13
EP1465730B1 (de) 2011-03-09
WO2003059518A1 (en) 2003-07-24
US20040241783A1 (en) 2004-12-02
WO2003059518A3 (en) 2004-03-25
US7138270B2 (en) 2006-11-21
AU2003202120A1 (en) 2003-07-30
DE60336296D1 (de) 2011-04-21

Similar Documents

Publication Publication Date Title
ATE500894T1 (de) Testvorrichtung und verfahren zum chemischen oder biologischen screening
US4039247A (en) Device for use in testing of fluid samples on microscope slides
WO2004074818A3 (en) Assay apparatus and method using microfluidic arrays
SE0200860D0 (sv) Microfluidic cell and method for sample handling
DE69933588D1 (de) Mikrofabrizierte Vorrichtung zur Analyse von Zellen
ATE367449T1 (de) Nachweis biologischer moleküle mittels differentieller aufteilung von enzymsubstraten und -produkten
ATE426809T1 (de) Oberflache eines bei nichtspezifischer adsorption inhibierten basismaterials
WO2006076703A3 (en) Porous biosensing device
CA2047637A1 (en) Analysis element and process for its manufacture
US6767401B2 (en) Crystal forming apparatus and method for using same
ATE449865T1 (de) Teststreifen zum analytnachweis und verwendungsverfahren
ATE307670T1 (de) Reaktionsgefäss zur durchführung von array- verfahren
DE602004012293D1 (de) Vorrichtung zur bearbeitung einer flüssigkeitsprobe
NZ504112A (en) Continuous format high throughput screening for testing compound for biological activity
CA2031515A1 (en) Devices for Use in Chemical Test Procedures
WO2004053071A3 (en) Method for discovering neurogenic agents
US4204045A (en) Device for examining microorganisms
CN102680441A (zh) 分析芯片、分析系统及分析方法
WO2003096018A3 (de) Kit zur assay-entwicklung und für serien-analysen
DE60016779D1 (de) Assay-vorrichtung
WO2007047149A3 (en) Susceptibility-matched multi-well sample holders for high-throughput screening by magnetic analysis
DE602004022148D1 (de) Vorrichtung und verfahren zur prüfung von flüssigen proben
RU2002109000A (ru) Матричная пьезосорбционная ячейка детектирования
ATE333511T1 (de) Auf sporenauskeimung basierendes analytisches system
TW429312B (en) Method and apparatus for the rapid screening of analytes

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties