ATE492530T1 - Derivate einer arylsulfonamidosubstituierten hydroxamsäure als matrixmetalloproteinaseinhibitoren - Google Patents
Derivate einer arylsulfonamidosubstituierten hydroxamsäure als matrixmetalloproteinaseinhibitorenInfo
- Publication number
- ATE492530T1 ATE492530T1 AT05769876T AT05769876T ATE492530T1 AT E492530 T1 ATE492530 T1 AT E492530T1 AT 05769876 T AT05769876 T AT 05769876T AT 05769876 T AT05769876 T AT 05769876T AT E492530 T1 ATE492530 T1 AT E492530T1
- Authority
- AT
- Austria
- Prior art keywords
- arylsulfonamido
- derivatives
- hydroxamic acid
- matrix metalloproteinase
- substituted hydroxamic
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 title 1
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 230000003712 anti-aging effect Effects 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000174A ITFI20040174A1 (it) | 2004-08-03 | 2004-08-03 | Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi |
| PCT/EP2005/053722 WO2006013193A2 (en) | 2004-08-03 | 2005-07-29 | Derivatives of arylsulfonamido-substituted hydroxamic acid as matrix metalloproteinases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE492530T1 true ATE492530T1 (de) | 2011-01-15 |
Family
ID=35787488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05769876T ATE492530T1 (de) | 2004-08-03 | 2005-07-29 | Derivate einer arylsulfonamidosubstituierten hydroxamsäure als matrixmetalloproteinaseinhibitoren |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7772430B2 (de) |
| EP (2) | EP2308837A3 (de) |
| JP (1) | JP2008509108A (de) |
| CN (1) | CN101076514A (de) |
| AT (1) | ATE492530T1 (de) |
| AU (1) | AU2005268765B2 (de) |
| BR (1) | BRPI0514030A (de) |
| CA (1) | CA2580235A1 (de) |
| DE (1) | DE602005025495D1 (de) |
| IT (1) | ITFI20040174A1 (de) |
| MX (1) | MX2007001269A (de) |
| RU (2) | RU2406721C2 (de) |
| WO (1) | WO2006013193A2 (de) |
| ZA (1) | ZA200701798B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201100187A1 (ru) | 2008-07-14 | 2011-10-31 | Новартис Аг | Селективные ингибиторы ммр-12 и ммр-13 на основе гидроксамовой кислоты |
| DE102011088926A1 (de) * | 2011-12-19 | 2013-06-20 | Beiersdorf Ag | Haarstylingformulierung zur Erstellung eines flexiblen Haltes durch Einsatz von Octanohydroxamsäure |
| CA2861492C (en) * | 2011-12-28 | 2019-09-24 | Galectin Therapeutics, Inc. | Composition of novel carbohydrate drug for treatment of human diseases |
| EP2907512A1 (de) | 2014-02-14 | 2015-08-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Hemmer von MMP-12 als antivirale Wirkstoffe |
| CN105728047B (zh) * | 2016-03-24 | 2017-12-26 | 万华化学集团股份有限公司 | 一种氢甲酰化催化剂及其制备方法和应用 |
| JP2017210442A (ja) * | 2016-05-26 | 2017-11-30 | イノレックス インベストメント コーポレイション | マトリックスメタロプロテイナーゼを阻害して皮膚の老化を軽減する方法及び関連の相乗的組成物 |
| IT201600083975A1 (it) * | 2016-08-09 | 2018-02-09 | Consorzio Interuniversitario Naz Per La Scienza E Tecnologia Dei Materiali | Acido ialuronico funzionalizzato |
| JP6541118B1 (ja) * | 2018-04-27 | 2019-07-10 | 株式会社成和化成 | 化粧品基材および該化粧品基材を含有する毛髪用化粧品、美白剤 |
| LV15485B (lv) * | 2018-09-13 | 2020-06-20 | Latvijas Organiskās Sintēzes Institūts | Selenofēnhromenonu hidroksāmskābes, to izgatavošana un izmantošana angioģenēzes inhibīcijā |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU68901A1 (de) | 1973-11-30 | 1975-08-20 | ||
| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| CN100413859C (zh) * | 1996-01-23 | 2008-08-27 | 盐野义制药株式会社 | 磺化的氨基酸衍生物及含有它的金属蛋白酶抑制剂 |
| AU2792097A (en) * | 1996-05-24 | 1998-01-05 | Ono Pharmaceutical Co. Ltd. | Phenylsulfonamide derivatives |
| EP0939629A4 (de) * | 1996-07-22 | 2002-07-17 | Monsanto Co | Thiol-sulfonamide als metalloproteinaseinhibitoren |
| AU4812697A (en) * | 1996-10-22 | 1998-05-15 | Pharmacia & Upjohn Company | Alpha-amino sulfonyl hydroxamic acids as matrix metalloproteinase inhibitors |
| CN1113862C (zh) * | 1997-02-03 | 2003-07-09 | 辉瑞产品公司 | 芳基磺酰氨基异羟肟酸衍生物 |
| WO1998050348A1 (en) * | 1997-05-09 | 1998-11-12 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| AU746877B2 (en) * | 1997-07-31 | 2002-05-02 | Procter & Gamble Company, The | Acyclic metalloprotease inhibitors |
| JPH11199512A (ja) * | 1997-10-24 | 1999-07-27 | Pfizer Prod Inc | 変形性関節症および他のｍｍｐ媒介疾患の治療のためのｍｍｐ−１３選択的阻害剤の使用 |
| PA8469601A1 (es) * | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Procedimiento para alquilar sulfonamidas impedidas estericamente |
| JP2002533322A (ja) * | 1998-12-22 | 2002-10-08 | エフ．ホフマン−ラ ロシュ アーゲー | ヒドロキサム酸スルホンアミド |
| EP1139998B8 (de) | 1998-12-28 | 2006-01-11 | Südzucker AG Mannheim/Ochsenfurt | Verwendung von wasserunlöslichen linearen poly-alpha-glucan als uv-filter |
| FR2799964B1 (fr) | 1999-10-22 | 2002-07-26 | Oreal | Emulsions contenant au moins un filtre uv organique insoluble et un polymere associatif |
| EP1280506B1 (de) | 2000-05-10 | 2006-06-21 | Ciba SC Holding AG | Silylierte verbindungen als vorläufer für selbstbräunungs zusammensetzngen |
| GB0028161D0 (en) | 2000-11-17 | 2001-01-03 | Natural Environment Res | Personal care compositions |
| FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| DE10155200A1 (de) | 2001-11-12 | 2003-05-28 | Skinlab Gmbh | Verwendung von Cholesterin, cholesterinhaltigen Substanzen oder von den Cholesteringehalt erhöhenden Substanzen in kosmetischen und dermatologischen Zubereitungen zum Zwecke der UV-Protektion |
| DE10155769A1 (de) | 2001-11-14 | 2003-05-22 | Cognis Deutschland Gmbh | Kosmetische und/oder pharmazeutische Emulsionen |
| BR0311136A (pt) * | 2002-05-29 | 2007-04-27 | Merck & Co Inc | composto ou um sal, enanciÈmero, diaestereÈmero ou éster hidrolisável in vivo ou mistura dos mesmos farmaceuticamente aceitável, composição, e, método para inibir a atividade de fator letal (lf) liberado de bactérias em um mamìfero |
-
2004
- 2004-08-03 IT IT000174A patent/ITFI20040174A1/it unknown
-
2005
- 2005-07-29 CN CNA2005800336789A patent/CN101076514A/zh active Pending
- 2005-07-29 WO PCT/EP2005/053722 patent/WO2006013193A2/en active Search and Examination
- 2005-07-29 AT AT05769876T patent/ATE492530T1/de not_active IP Right Cessation
- 2005-07-29 AU AU2005268765A patent/AU2005268765B2/en not_active Ceased
- 2005-07-29 EP EP10188800A patent/EP2308837A3/de not_active Withdrawn
- 2005-07-29 EP EP05769876A patent/EP1781601B1/de not_active Expired - Lifetime
- 2005-07-29 MX MX2007001269A patent/MX2007001269A/es not_active Application Discontinuation
- 2005-07-29 US US11/659,431 patent/US7772430B2/en not_active Expired - Fee Related
- 2005-07-29 CA CA002580235A patent/CA2580235A1/en not_active Abandoned
- 2005-07-29 RU RU2007107872/04A patent/RU2406721C2/ru not_active IP Right Cessation
- 2005-07-29 DE DE602005025495T patent/DE602005025495D1/de not_active Expired - Lifetime
- 2005-07-29 BR BRPI0514030-7A patent/BRPI0514030A/pt not_active IP Right Cessation
- 2005-07-29 JP JP2007524333A patent/JP2008509108A/ja active Pending
-
2007
- 2007-02-28 ZA ZA200701798A patent/ZA200701798B/xx unknown
-
2010
- 2010-08-04 US US12/849,981 patent/US20100298439A1/en not_active Abandoned
- 2010-08-31 RU RU2010136061/04A patent/RU2010136061A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0514030A (pt) | 2008-05-27 |
| CN101076514A (zh) | 2007-11-21 |
| EP1781601A2 (de) | 2007-05-09 |
| WO2006013193A8 (en) | 2010-07-29 |
| CA2580235A1 (en) | 2006-02-09 |
| ZA200701798B (en) | 2008-08-27 |
| AU2005268765B2 (en) | 2011-08-04 |
| AU2005268765A1 (en) | 2006-02-09 |
| RU2010136061A (ru) | 2012-03-10 |
| EP2308837A2 (de) | 2011-04-13 |
| MX2007001269A (es) | 2007-07-16 |
| JP2008509108A (ja) | 2008-03-27 |
| US20100298439A1 (en) | 2010-11-25 |
| ITFI20040174A1 (it) | 2004-11-03 |
| RU2007107872A (ru) | 2008-09-10 |
| EP1781601B1 (de) | 2010-12-22 |
| WO2006013193A2 (en) | 2006-02-09 |
| DE602005025495D1 (de) | 2011-02-03 |
| US7772430B2 (en) | 2010-08-10 |
| WO2006013193A3 (en) | 2006-08-31 |
| US20080249032A1 (en) | 2008-10-09 |
| EP2308837A3 (de) | 2011-04-20 |
| RU2406721C2 (ru) | 2010-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200701798B (en) | Derivatives of arylsulfonamido-substituted hydroxamic acid as matrix metalioproteinases inhibitors | |
| ES2330291A1 (es) | Peptidos utiles en el tratamiento de la piel, mucosas y/o cuero cabelludo y su uso en composiciones cosmeticas o farmaceuticas. | |
| NO20071042L (no) | 5-substituerte 2-fenylaminobenzamider som MEK-inhibitorer | |
| DE602004017194D1 (de) | Pyridylpyrrol-derivate als wirksame kinase-hemmer | |
| BRPI0606817A2 (pt) | derivados de piridazina e seu uso como agentes terapêuticos | |
| BRPI0414867A (pt) | pirazolopiridinas e seus análogos | |
| ATE533795T1 (de) | Neutralisiertes kationisches polymer, zusammensetzung mit dem besagten polymer und kosmetisches behandlungsverfahren | |
| ITMI20041550A1 (it) | Uso di batteri probiotici per la preparazione di composizioni topiche per la protezione dell'epidermide | |
| ATE399012T1 (de) | Carbaminsäurederivate enthaltend eine piperazin verknüpfung als hdac-inhibitoren | |
| DOP2008000001A (es) | Oxazolidinonas substituidas y su uso | |
| DK1962815T3 (da) | Anvendelse af filmdannende hårplejepolymerer fra gruppen polyurethaner og farmaceutiske tilberedninger og plastre indeholdende nævnte polymerer | |
| EA200601212A1 (ru) | Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение | |
| NO20070067L (no) | Pyrrolopyridinderivater | |
| ATE517861T1 (de) | Benzylether und benzylaminoverbindungen als inhibitoren von beta-secretase zur behandlung von alzheimer-krankheit | |
| EA200970154A1 (ru) | Косметические или дерматологические препараты, содержащие n-ацетилцистеин | |
| TR200401603T4 (tr) | D vitamini benzerleri | |
| NO20064982L (no) | 1,3,4-oksadiazol-2-oner som PPAR delta modulatorer og anvendelse derav | |
| MX2022001031A (es) | Inhibidores derivados de difluorohaloalilamina-sulfona de lisil-oxidasas, metodos de preparacion y usos de los mismos. | |
| DK1635776T3 (da) | Lipidoverföringsproteinsystemer samt deres kosmetiske dermatologiske anvendelse | |
| WO2004100893A3 (en) | Methods for treatment of inflammatory diseases using ct-3 or analogs thereof | |
| PA8525801A1 (es) | Compuestos de pirazol, composiciones farmacéuticas, y métodos para modular y/o inhibir la actividad de erab/hadh2 | |
| BR0309195A (pt) | Derivados organossilicone de amino hidroxibenzofenonas e seu uso como filtros de uv-a em preparações comésticas | |
| MX2009012712A (es) | Nuevas 4-fenil-imidazol-2-tionas como inhibidores de la tirosinasa, su procedimiento de preparacion y su uso en medicina humana asi como en cosmetica. | |
| ATE280570T1 (de) | Coffein enthaltende zusammensetzung als hauptflegemittel | |
| MX2009012714A (es) | Nuevas 4-heteroail-imidazol-2-tionas como inhibidores de la tirosinasa, su procedimiento de preparacion y su uso en medicina humana asi como en cosmetica. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |