ATE490272T1 - Reportergenkonstrukt auf fluoreszenzbasis zur direkten erkennung der aktivierung von tgf-beta- rezeptoren sowie modulatoren dafür - Google Patents
Reportergenkonstrukt auf fluoreszenzbasis zur direkten erkennung der aktivierung von tgf-beta- rezeptoren sowie modulatoren dafürInfo
- Publication number
- ATE490272T1 ATE490272T1 AT08159781T AT08159781T ATE490272T1 AT E490272 T1 ATE490272 T1 AT E490272T1 AT 08159781 T AT08159781 T AT 08159781T AT 08159781 T AT08159781 T AT 08159781T AT E490272 T1 ATE490272 T1 AT E490272T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor
- tgf
- activation
- fluorescence
- modulators
- Prior art date
Links
- 230000004913 activation Effects 0.000 title abstract 5
- 108091005735 TGF-beta receptors Proteins 0.000 title abstract 3
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 title abstract 3
- 108700008625 Reporter Genes Proteins 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 6
- 108020003175 receptors Proteins 0.000 abstract 6
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 102000014172 Transforming Growth Factor-beta Type I Receptor Human genes 0.000 abstract 1
- 108010011702 Transforming Growth Factor-beta Type I Receptor Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 102000034287 fluorescent proteins Human genes 0.000 abstract 1
- 108091006047 fluorescent proteins Proteins 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08159781A EP2141179B1 (de) | 2008-07-04 | 2008-07-04 | Reportergenkonstrukt auf Fluoreszenzbasis zur direkten Erkennung der Aktivierung von TGF-Beta-Rezeptoren sowie Modulatoren dafür |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490272T1 true ATE490272T1 (de) | 2010-12-15 |
Family
ID=39661394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08159781T ATE490272T1 (de) | 2008-07-04 | 2008-07-04 | Reportergenkonstrukt auf fluoreszenzbasis zur direkten erkennung der aktivierung von tgf-beta- rezeptoren sowie modulatoren dafür |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100021931A1 (de) |
| EP (1) | EP2141179B1 (de) |
| AT (1) | ATE490272T1 (de) |
| DE (1) | DE602008003782D1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2498996C1 (ru) * | 2012-06-27 | 2013-11-20 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Химерный белок, являющийся флуоресцентным биосенсором для одновременной детекции пероксида водорода и фосфатидилинозитол-3,4,5-трифосфата, нуклеиновая кислота, кодирующая такой белок, кассета экспрессии и эукариотическая клетка-хозяин |
| WO2014153442A2 (en) * | 2013-03-21 | 2014-09-25 | The General Hospital Corporation | Methods and systems for treatment of ovarian cancer |
| CN104163868B (zh) * | 2013-05-17 | 2016-08-03 | 上海中医药大学 | 抗金葡菌药物筛选系统 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6469154B1 (en) | 1999-05-21 | 2002-10-22 | The Regents Of The University Of California | Fluorescent protein indicators |
| AU5275100A (en) | 1999-05-21 | 2000-12-12 | Regents Of The University Of California, The | Fluorescent protein indicators |
| US7060793B2 (en) | 1999-05-21 | 2006-06-13 | The Regents Of The University Of California | Circularly permuted fluorescent protein indicators |
| JP2002253261A (ja) | 2001-03-05 | 2002-09-10 | Inst Of Physical & Chemical Res | 蛍光タンパク質 |
| WO2005019447A1 (ja) | 2003-08-26 | 2005-03-03 | Japan Science And Technology Agency | 単色蛍光プローブ |
-
2008
- 2008-07-04 AT AT08159781T patent/ATE490272T1/de active
- 2008-07-04 EP EP08159781A patent/EP2141179B1/de not_active Not-in-force
- 2008-07-04 DE DE602008003782T patent/DE602008003782D1/de active Active
-
2009
- 2009-07-02 US US12/459,510 patent/US20100021931A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2141179A1 (de) | 2010-01-06 |
| DE602008003782D1 (de) | 2011-01-13 |
| EP2141179B1 (de) | 2010-12-01 |
| US20100021931A1 (en) | 2010-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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