|
US6143496A
(en)
*
|
1997-04-17 |
2000-11-07 |
Cytonix Corporation |
Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
|
|
JP2002233382A
(ja)
*
|
2001-02-09 |
2002-08-20 |
Sapporo Breweries Ltd |
ビール酵母の識別方法
|
|
TWI307277B
(en)
*
|
2002-07-30 |
2009-03-11 |
Wyeth Corp |
Parenteral formulations
|
|
AU2003902299A0
(en)
*
|
2003-05-13 |
2003-05-29 |
Flinders Medical Centre |
A method of analysing a marker nucleic acid molecule
|
|
JP2007521018A
(ja)
*
|
2003-10-29 |
2007-08-02 |
リボメド バイオテクノロジーズ,インコーポレイテッド |
反復的オリゴヌクレオチド合成のための組成物、方法、および検出技術
|
|
FR2863274B1
(fr)
*
|
2003-12-05 |
2012-11-16 |
Commissariat Energie Atomique |
Procede d'evaluation quantitative d'un rearrangement ou d'une recombinaison genetique ciblee d'un individu et ses applications.
|
|
WO2006046860A1
(en)
*
|
2004-10-25 |
2006-05-04 |
Erasmus Universiteit Rotterdam |
Determining the replicative history of lymphocytes
|
|
JP5133238B2
(ja)
*
|
2005-04-15 |
2013-01-30 |
エピゲノミックス アクチェンゲゼルシャフト |
遠隔サンプル由来のdna断片を提供する方法
|
|
CA2611671C
(en)
|
2005-06-15 |
2013-10-08 |
Callida Genomics, Inc. |
Single molecule arrays for genetic and chemical analysis
|
|
WO2007123392A1
(en)
*
|
2006-04-24 |
2007-11-01 |
Erasmus Universiteit Rotterdam |
Determining the replicative history of lymphocytes
|
|
US20080050724A1
(en)
*
|
2006-08-24 |
2008-02-28 |
Microfluidic Systems, Inc. |
Method of detecting one or more limited copy targets
|
|
WO2008026927A2
(en)
*
|
2006-08-30 |
2008-03-06 |
Academisch Medisch Centrum |
Process for displaying t- and b-cell receptor repertoires
|
|
US20080153094A1
(en)
*
|
2006-10-13 |
2008-06-26 |
Minor James M |
Reduction of nonspecific binding in nucleic acid assays and nucleic acid synthesis reactions
|
|
EP2150628B1
(de)
*
|
2007-06-01 |
2013-12-11 |
Monoquant PTY LTD |
Verfahren für dna-bruchstellenanalyse
|
|
US20160068905A1
(en)
|
2007-11-26 |
2016-03-10 |
Immunid |
Method for Studying V(D)J Combinatory Diversity
|
|
EP2062982A1
(de)
*
|
2007-11-26 |
2009-05-27 |
ImmunID |
Verfahren zur Untersuchung der kombinatorischen Diversität von V(D)J.
|
|
US8592150B2
(en)
|
2007-12-05 |
2013-11-26 |
Complete Genomics, Inc. |
Methods and compositions for long fragment read sequencing
|
|
EP2281065B1
(de)
*
|
2008-04-16 |
2015-09-09 |
HudsonAlpha Institute For Biotechnology |
Verfahren für die beurteilung und den vergleich von immunrepertoires
|
|
EP2479287B1
(de)
|
2008-05-13 |
2014-07-23 |
Gen-Probe Incorporated |
Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und Fangen von Zielnukleinsäuresequenzen
|
|
US9528160B2
(en)
|
2008-11-07 |
2016-12-27 |
Adaptive Biotechnolgies Corp. |
Rare clonotypes and uses thereof
|
|
US9365901B2
(en)
|
2008-11-07 |
2016-06-14 |
Adaptive Biotechnologies Corp. |
Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
|
|
US9506119B2
(en)
|
2008-11-07 |
2016-11-29 |
Adaptive Biotechnologies Corp. |
Method of sequence determination using sequence tags
|
|
US8628927B2
(en)
|
2008-11-07 |
2014-01-14 |
Sequenta, Inc. |
Monitoring health and disease status using clonotype profiles
|
|
US9394567B2
(en)
|
2008-11-07 |
2016-07-19 |
Adaptive Biotechnologies Corporation |
Detection and quantification of sample contamination in immune repertoire analysis
|
|
EP3699296A1
(de)
|
2008-11-07 |
2020-08-26 |
Adaptive Biotechnologies Corporation |
Verfahren zur überwachung von zuständen durch sequenzanalyse
|
|
US8748103B2
(en)
|
2008-11-07 |
2014-06-10 |
Sequenta, Inc. |
Monitoring health and disease status using clonotype profiles
|
|
US8691510B2
(en)
|
2008-11-07 |
2014-04-08 |
Sequenta, Inc. |
Sequence analysis of complex amplicons
|
|
US20100124741A1
(en)
*
|
2008-11-18 |
2010-05-20 |
Quest Disgnostics Investments Incorporated |
METHODS FOR DETECTING IgH/BCL-1 CHROMOSOMAL TRANSLOCATION
|
|
US8367330B2
(en)
*
|
2008-12-22 |
2013-02-05 |
Quest Diagnostics Investments Incorporated |
Methods for detecting TCR-gamma gene rearrangement
|
|
DK2387627T3
(en)
|
2009-01-15 |
2016-07-04 |
Adaptive Biotechnologies Corp |
Adaptive immunity profiling and methods for producing monoclonal antibodies
|
|
US9524369B2
(en)
|
2009-06-15 |
2016-12-20 |
Complete Genomics, Inc. |
Processing and analysis of complex nucleic acid sequence data
|
|
RU2539032C2
(ru)
*
|
2009-06-25 |
2015-01-10 |
Фред Хатчинсон Кансэр Рисёч Сентер |
Способ измерения искусственного иммунитета
|
|
US9043160B1
(en)
|
2009-11-09 |
2015-05-26 |
Sequenta, Inc. |
Method of determining clonotypes and clonotype profiles
|
|
EE201000013A
(et)
*
|
2010-01-29 |
2011-10-17 |
Selfdiagnostics O� |
Meetod ja kiirtesti seade sihtmrk-molekuli proovimaterjalist detekteerimiseks
|
|
JP2011223940A
(ja)
*
|
2010-04-21 |
2011-11-10 |
Asahi Breweries Ltd |
偽陰性を排除するpcr検査方法およびそれに使用するプライマー
|
|
CA2798431C
(en)
|
2010-05-06 |
2018-10-23 |
Sequenta, Inc. |
Monitoring health and disease status using clonotype profiles
|
|
US11022573B2
(en)
*
|
2010-08-31 |
2021-06-01 |
Canon U.S.A., Inc. |
Positive controls
|
|
JP6159252B2
(ja)
*
|
2010-08-31 |
2017-07-05 |
キヤノン ユー.エス. ライフ サイエンシズ, インコーポレイテッドCanon U.S. Life Sciences, Inc. |
熱較正
|
|
WO2012097374A1
(en)
|
2011-01-14 |
2012-07-19 |
Cb Biotechnologies, Inc. |
Immunodiversity assessment method and its use
|
|
CN106434871B
(zh)
*
|
2011-05-17 |
2020-08-18 |
德克斯特里蒂诊断公司 |
用于检测目标核酸的方法与组合物
|
|
EP2744916A4
(de)
|
2011-07-13 |
2015-06-17 |
Primeradx Inc |
Multimodale verfahren zur simultanen erkennung und quantifizierung mehrerer nukleinsäuren in einer probe
|
|
US10385475B2
(en)
|
2011-09-12 |
2019-08-20 |
Adaptive Biotechnologies Corp. |
Random array sequencing of low-complexity libraries
|
|
US9279159B2
(en)
|
2011-10-21 |
2016-03-08 |
Adaptive Biotechnologies Corporation |
Quantification of adaptive immune cell genomes in a complex mixture of cells
|
|
EP3492604B1
(de)
*
|
2011-11-04 |
2021-01-06 |
Gen-Probe Incorporated |
Molekulartestreagenzien und -verfahren
|
|
EP3388535B1
(de)
|
2011-12-09 |
2021-03-24 |
Adaptive Biotechnologies Corporation |
Diagnose von lymphoid-malignomen und nachweis von minimaler resterkrankung
|
|
US9499865B2
(en)
|
2011-12-13 |
2016-11-22 |
Adaptive Biotechnologies Corp. |
Detection and measurement of tissue-infiltrating lymphocytes
|
|
GB201203720D0
(en)
*
|
2012-03-02 |
2012-04-18 |
Babraham Inst |
Method of identifying VDJ recombination products
|
|
US10077478B2
(en)
|
2012-03-05 |
2018-09-18 |
Adaptive Biotechnologies Corp. |
Determining paired immune receptor chains from frequency matched subunits
|
|
CN102605070A
(zh)
*
|
2012-03-19 |
2012-07-25 |
中国人民解放军第二军医大学 |
淋巴细胞基因重排克隆性检测试剂盒及其检测方法
|
|
US9150905B2
(en)
|
2012-05-08 |
2015-10-06 |
Adaptive Biotechnologies Corporation |
Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions
|
|
EP3330384B1
(de)
|
2012-10-01 |
2019-09-25 |
Adaptive Biotechnologies Corporation |
Immunkompetenzbeurteilung durch adaptive immunrezeptordiversität und klonalitätscharakterisierung
|
|
CA2900240A1
(en)
|
2013-02-22 |
2014-08-28 |
Sequenta, Inc. |
Rare clonotypes and uses thereof
|
|
US10119134B2
(en)
|
2013-03-15 |
2018-11-06 |
Abvitro Llc |
Single cell bar-coding for antibody discovery
|
|
EP3004367A4
(de)
*
|
2013-06-07 |
2017-02-22 |
Athena Diagnostics Inc. |
Molekulare strichcodierung für multiplex-sequenzierung
|
|
US9708657B2
(en)
|
2013-07-01 |
2017-07-18 |
Adaptive Biotechnologies Corp. |
Method for generating clonotype profiles using sequence tags
|
|
US10227655B2
(en)
|
2013-10-29 |
2019-03-12 |
Region Syddanmark |
Method for analyzing body fluid samples
|
|
US20160326571A1
(en)
*
|
2013-10-31 |
2016-11-10 |
Atherotech, Inc. |
Methods for nucleic acid amplification
|
|
CN106103711A
(zh)
|
2013-11-21 |
2016-11-09 |
组库创世纪株式会社 |
T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用
|
|
CA2941612A1
(en)
|
2014-03-05 |
2015-09-11 |
Adaptive Biotechnologies Corporation |
Methods using randomer-containing synthetic molecules
|
|
US11390921B2
(en)
|
2014-04-01 |
2022-07-19 |
Adaptive Biotechnologies Corporation |
Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
|
|
US10066265B2
(en)
|
2014-04-01 |
2018-09-04 |
Adaptive Biotechnologies Corp. |
Determining antigen-specific t-cells
|
|
US20150284786A1
(en)
*
|
2014-04-04 |
2015-10-08 |
Affymetrix, Inc. |
Compositions and Methods for Molecular Inversion Probe Assays
|
|
ES2777529T3
(es)
|
2014-04-17 |
2020-08-05 |
Adaptive Biotechnologies Corp |
Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
|
|
US10202640B2
(en)
|
2014-05-07 |
2019-02-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
|
|
US10590483B2
(en)
|
2014-09-15 |
2020-03-17 |
Abvitro Llc |
High-throughput nucleotide library sequencing
|
|
ES2784343T3
(es)
|
2014-10-29 |
2020-09-24 |
Adaptive Biotechnologies Corp |
Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras
|
|
EP3018214B1
(de)
|
2014-11-05 |
2017-12-13 |
Fundacion de Investigacion Hospital 12 de Octubre |
Verfahren zur Quantifizierung des Niveaus minimaler Resterkrankung bei einer Person
|
|
US10246701B2
(en)
|
2014-11-14 |
2019-04-02 |
Adaptive Biotechnologies Corp. |
Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
|
|
AU2015353581A1
(en)
|
2014-11-25 |
2017-06-15 |
Adaptive Biotechnologies Corporation |
Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
|
|
EP3591074B1
(de)
|
2015-02-24 |
2024-10-23 |
Adaptive Biotechnologies Corp. |
Verfahren zur diagnose einer infektionskrankheit und bestimmung des hla-status mittels immunrepertoiresequenzierung
|
|
AU2016242967B2
(en)
|
2015-04-01 |
2021-07-01 |
Adaptive Biotechnologies Corp. |
Method of identifying human compatible T cell receptors specific for an antigenic target
|
|
US11124823B2
(en)
|
2015-06-01 |
2021-09-21 |
Becton, Dickinson And Company |
Methods for RNA quantification
|
|
CN108474026A
(zh)
*
|
2016-01-29 |
2018-08-31 |
豪夫迈·罗氏有限公司 |
用于核酸测序的新的衔接子和使用方法
|
|
US20170226593A1
(en)
*
|
2016-02-08 |
2017-08-10 |
The Johns Hopkins University |
Handheld nucleic acid-based assay for rapid identification
|
|
US11459619B2
(en)
|
2016-02-08 |
2022-10-04 |
The Johns Hopkins University |
Handheld nucleic acid-based assay for rapid identification
|
|
US12104206B2
(en)
|
2016-02-11 |
2024-10-01 |
Htg Molecular Diagnostics, Inc. |
Method of direct target sequencing using nuclease protection
|
|
US20200299761A1
(en)
*
|
2016-03-23 |
2020-09-24 |
The Methodist Hospital System |
Pre-transplant tcr clonality assessment to predict post-liver transplant survival
|
|
US20170275680A1
(en)
*
|
2016-03-24 |
2017-09-28 |
Paul Chi Hang Li |
Methods and Apparatus for Nanoparticle-assisted Nucleic Acid Amplification, Hybridization and Microarray Analysis
|
|
CA3019422A1
(en)
*
|
2016-03-29 |
2017-10-05 |
William Marsh Rice University |
Surface-based detection of nucleic acids in convection flow fluidic devices
|
|
EP3440222B1
(de)
*
|
2016-04-04 |
2025-02-19 |
F. Hoffmann-La Roche AG |
Verfahren für die zubereitung von nukleinsäureproben
|
|
JP7129343B2
(ja)
|
2016-05-02 |
2022-09-01 |
ベクトン・ディキンソン・アンド・カンパニー |
正確な分子バーコーディング
|
|
CN106191262A
(zh)
*
|
2016-07-18 |
2016-12-07 |
南开大学 |
一种分析Igκ基因二次重排中间产物的方法及试剂盒
|
|
US20180037942A1
(en)
*
|
2016-08-03 |
2018-02-08 |
Cellular Research, Inc. |
Enzyme-independent molecular indexing
|
|
US10428325B1
(en)
|
2016-09-21 |
2019-10-01 |
Adaptive Biotechnologies Corporation |
Identification of antigen-specific B cell receptors
|
|
CN106701954A
(zh)
*
|
2017-01-09 |
2017-05-24 |
浙江大学 |
一种用于检测肝癌的引物组及检测方法
|
|
US10822662B2
(en)
|
2017-03-06 |
2020-11-03 |
Karkinos Precision Oncology LLC |
Diagnostic methods for identifying T-cell lymphoma and leukemia by high-throughput TCR-β sequencing
|
|
CN108823306A
(zh)
*
|
2017-05-03 |
2018-11-16 |
杭州赫玛生物科技有限公司 |
检测白血病细胞的系统和方法
|
|
CN115927620A
(zh)
*
|
2017-05-23 |
2023-04-07 |
杭州赫玛生物科技有限公司 |
用于进行白血病诊疗的系统
|
|
EP4212631A1
(de)
|
2017-09-01 |
2023-07-19 |
Life Technologies Corporation |
Zusammensetzungen und verfahren zur sequenzierung des immunrepertoires
|
|
EP3695010A4
(de)
*
|
2017-10-10 |
2021-11-17 |
Memorial Sloan-Kettering Cancer Center |
System und verfahren zur primer-extraktion und klonalitätsdetektion
|
|
US11254980B1
(en)
|
2017-11-29 |
2022-02-22 |
Adaptive Biotechnologies Corporation |
Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
|
|
CH714402A1
(fr)
*
|
2017-12-04 |
2019-06-14 |
Fond Luc Montagnier |
Procédé de détection de la présence d'un élément biochimique.
|
|
WO2019126209A1
(en)
|
2017-12-19 |
2019-06-27 |
Cellular Research, Inc. |
Particles associated with oligonucleotides
|
|
WO2019237146A1
(en)
*
|
2018-06-11 |
2019-12-19 |
Monoquant Pty Ltd |
Amplification method and primers for use therein
|
|
CN110656161B
(zh)
*
|
2018-06-28 |
2022-12-13 |
苏州云泰生物医药科技有限公司 |
用于检测人免疫球蛋白基因重排的毛细管电泳试剂盒及其使用方法
|
|
EP3824103A1
(de)
|
2018-07-18 |
2021-05-26 |
Life Technologies Corporation |
Zusammensetzungen und verfahren zur sequenzierung des immunrepertoires
|
|
CA3125762A1
(en)
|
2019-01-10 |
2020-07-16 |
Iovance Biotherapeutics, Inc. |
System and methods for monitoring adoptive cell therapy clonality and persistence
|
|
WO2020150356A1
(en)
|
2019-01-16 |
2020-07-23 |
Becton, Dickinson And Company |
Polymerase chain reaction normalization through primer titration
|
|
EP4423664A4
(de)
|
2021-10-25 |
2025-08-27 |
Singular Genomics Systems Inc |
Manipulation und detektion biologischer proben
|
|
CN113957128A
(zh)
*
|
2021-12-21 |
2022-01-21 |
迈杰转化医学研究(苏州)有限公司 |
一种核酸完整性评估试剂盒及评估方法
|
|
CN115927631A
(zh)
*
|
2022-11-03 |
2023-04-07 |
北京泛生子基因科技有限公司 |
用于人白血病微小残留病监测的引物组合物、试剂盒及其应用
|
|
AU2024228388A1
(en)
|
2023-02-27 |
2025-10-02 |
Adaptive Biotechnologies Corp. |
Therapeutic t cell receptors targeting kras g12d
|
|
WO2025059162A1
(en)
|
2023-09-11 |
2025-03-20 |
Dana-Farber Cancer Institute, Inc. |
Car-engager containing il-2 variants to enhance the functionality of car t cells
|
|
CN117363722A
(zh)
*
|
2023-12-07 |
2024-01-09 |
北京旌准医疗科技有限公司 |
一种用于检测igk和igl基因的引物组合及其应用
|
|
CN118932067B
(zh)
*
|
2024-09-12 |
2025-10-03 |
上海信诺佰世医学检验有限公司 |
Igh基因克隆型检测多重pcr引物组、设计方法及应用
|
|
CN120330335A
(zh)
*
|
2025-04-28 |
2025-07-18 |
武汉希诺医学检验实验室有限公司 |
血液肿瘤诊疗引物组、试剂盒及应用
|