ATE483804T1 - Verfahren zur zuordnung von nukleinsäuren und zur identifikation fein strukturierter variationen in nukleinsäuren sowie hilfsmittel dafür - Google Patents
Verfahren zur zuordnung von nukleinsäuren und zur identifikation fein strukturierter variationen in nukleinsäuren sowie hilfsmittel dafürInfo
- Publication number
- ATE483804T1 ATE483804T1 AT07701933T AT07701933T ATE483804T1 AT E483804 T1 ATE483804 T1 AT E483804T1 AT 07701933 T AT07701933 T AT 07701933T AT 07701933 T AT07701933 T AT 07701933T AT E483804 T1 ATE483804 T1 AT E483804T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acids
- nucleic acid
- assigning
- linked
- tools therefor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75641706P | 2006-01-04 | 2006-01-04 | |
| US79292606P | 2006-04-17 | 2006-04-17 | |
| US81437806P | 2006-06-15 | 2006-06-15 | |
| PCT/CN2007/000001 WO2007076726A1 (en) | 2006-01-04 | 2007-01-04 | Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE483804T1 true ATE483804T1 (de) | 2010-10-15 |
Family
ID=38227922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07701933T ATE483804T1 (de) | 2006-01-04 | 2007-01-04 | Verfahren zur zuordnung von nukleinsäuren und zur identifikation fein strukturierter variationen in nukleinsäuren sowie hilfsmittel dafür |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1969146B1 (de) |
| CN (1) | CN101395281B (de) |
| AT (1) | ATE483804T1 (de) |
| DE (1) | DE602007009634D1 (de) |
| WO (1) | WO2007076726A1 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0514910D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Method for sequencing a polynucleotide template |
| GB0514935D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Methods for sequencing a polynucleotide template |
| US7932029B1 (en) * | 2006-01-04 | 2011-04-26 | Si Lok | Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities |
| CA2641851A1 (en) | 2006-02-08 | 2007-08-16 | Eric Hans Vermaas | Method for sequencing a polynucleotide template |
| US7754429B2 (en) | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
| EP2191011B1 (de) * | 2007-08-29 | 2017-03-29 | Illumina Cambridge Limited | Verfahren zur sequenzierung einer polynukleotidmatrize |
| US12060554B2 (en) | 2008-03-10 | 2024-08-13 | Illumina, Inc. | Method for selecting and amplifying polynucleotides |
| CN105602937A (zh) * | 2008-07-10 | 2016-05-25 | 港大科桥有限公司 | 用于核酸作图和鉴定核酸中的精细结构变化的方法 |
| WO2010003316A1 (en) * | 2008-07-10 | 2010-01-14 | Si Lok | Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids |
| WO2010127186A1 (en) * | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US20120178635A1 (en) * | 2009-08-06 | 2012-07-12 | University Of Virginia Patent Foundation | Compositions and methods for identifying and detecting sites of translocation and dna fusion junctions |
| EP3133169B1 (de) | 2009-08-25 | 2019-10-16 | Illumina, Inc. | Verfahren zur auswahl und amplifikation von polynukleotiden |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| EP2556171B1 (de) | 2010-04-05 | 2015-09-02 | Prognosys Biosciences, Inc. | Räumlich kodierte biologische assays |
| EP3150750B1 (de) | 2011-04-08 | 2018-12-26 | Prognosys Biosciences, Inc. | Peptidkonstrukte und testsysteme dafür |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| USRE50065E1 (en) | 2012-10-17 | 2024-07-30 | 10X Genomics Sweden Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| CN111233978B (zh) | 2013-03-15 | 2024-08-16 | 普罗格诺西斯生物科学公司 | 用于检测肽/mhc/tcr结合的方法 |
| CN111662960B (zh) | 2013-06-25 | 2024-04-12 | 普罗格诺西斯生物科学公司 | 采用微流控装置的空间编码生物分析 |
| WO2015070037A2 (en) | 2013-11-08 | 2015-05-14 | Prognosys Biosciences, Inc. | Polynucleotide conjugates and methods for analyte detection |
| US10020300B2 (en) | 2014-12-18 | 2018-07-10 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US10006910B2 (en) | 2014-12-18 | 2018-06-26 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
| US9618474B2 (en) | 2014-12-18 | 2017-04-11 | Edico Genome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US9859394B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US10429342B2 (en) | 2014-12-18 | 2019-10-01 | Edico Genome Corporation | Chemically-sensitive field effect transistor |
| US9857328B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same |
| ES2955916T3 (es) | 2015-04-10 | 2023-12-11 | Spatial Transcriptomics Ab | Análisis múltiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos |
| US10811539B2 (en) | 2016-05-16 | 2020-10-20 | Nanomedical Diagnostics, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| GB2578727A (en) * | 2018-11-05 | 2020-05-27 | Earlham Inst | Genomic analysis |
| EP3894590A2 (de) | 2018-12-10 | 2021-10-20 | 10X Genomics, Inc. | Verfahren zur verwendung von master/kopie-anordnungen zur räumlichen detektion |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| US12157124B2 (en) | 2019-11-06 | 2024-12-03 | 10X Genomics, Inc. | Imaging system hardware |
| WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
| EP4078596A4 (de) * | 2019-12-19 | 2024-01-24 | The Regents Of The University Of California | Verfahren zur herstellung von zielerfassungsnukleinsäuren |
| US12241890B2 (en) | 2019-12-23 | 2025-03-04 | 10X Genomics, Inc. | Methods for generating barcoded nucleic acid molecules using fixed cells |
| EP4219754B1 (de) | 2019-12-23 | 2024-05-15 | 10X Genomics, Inc. | Verfahren zur räumlichen analyse unter verwendung von rna-template-ligation |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| US12129516B2 (en) | 2020-02-07 | 2024-10-29 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
| US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
| ES2965354T3 (es) | 2020-04-22 | 2024-04-12 | 10X Genomics Inc | Métodos para análisis espacial que usan eliminación de ARN elegido como diana |
| AU2021275906A1 (en) | 2020-05-22 | 2022-12-22 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| EP4414459A3 (de) | 2020-05-22 | 2024-09-18 | 10X Genomics, Inc. | Simultane räumlich-zeitliche messung der genexpression und der zellaktivität |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| WO2021247543A2 (en) | 2020-06-02 | 2021-12-09 | 10X Genomics, Inc. | Nucleic acid library methods |
| CN116249785A (zh) | 2020-06-02 | 2023-06-09 | 10X基因组学有限公司 | 用于抗原-受体的空间转录组学 |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| EP4162074B1 (de) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon |
| EP4165207B1 (de) | 2020-06-10 | 2024-09-25 | 10X Genomics, Inc. | Verfahren zur bestimmung der position eines analyten in einer biologischen probe |
| AU2021288090A1 (en) | 2020-06-10 | 2023-01-19 | 10X Genomics, Inc. | Fluid delivery methods |
| WO2021263111A1 (en) | 2020-06-25 | 2021-12-30 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| US20230351619A1 (en) | 2020-09-18 | 2023-11-02 | 10X Genomics, Inc. | Sample handling apparatus and image registration methods |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| WO2022140028A1 (en) | 2020-12-21 | 2022-06-30 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| WO2022178267A2 (en) | 2021-02-19 | 2022-08-25 | 10X Genomics, Inc. | Modular assay support devices |
| EP4301870B1 (de) | 2021-03-18 | 2025-01-15 | 10X Genomics, Inc. | Multiplex-erfassung von gen- und proteinexpression aus einer biologischen probe |
| WO2022221425A1 (en) | 2021-04-14 | 2022-10-20 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
| WO2022256503A1 (en) | 2021-06-03 | 2022-12-08 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| WO2023034489A1 (en) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
| WO2023102118A2 (en) | 2021-12-01 | 2023-06-08 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| WO2023122033A1 (en) | 2021-12-20 | 2023-06-29 | 10X Genomics, Inc. | Self-test for pathology/histology slide imaging device |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5721098A (en) | 1986-01-16 | 1998-02-24 | The Regents Of The University Of California | Comparative genomic hybridization |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5753462A (en) * | 1995-06-07 | 1998-05-19 | Zymogenetics, Inc. | Secretion leader trap cloning method |
| US5866330A (en) * | 1995-09-12 | 1999-02-02 | The Johns Hopkins University School Of Medicine | Method for serial analysis of gene expression |
| US5874259A (en) | 1997-11-21 | 1999-02-23 | Wisconsin Alumni Research Foundation | Conditionally amplifiable BAC vector |
| AU2001251582A1 (en) * | 2000-04-14 | 2001-10-30 | Lynx Therapeutics, Inc. | Method and compositions for ordering restriction fragments |
| US6730500B1 (en) * | 2000-08-30 | 2004-05-04 | Zymogenetics, Inc. | Methods for generating a continuous nucleotide sequence from noncontiguous nucleotide sequences |
| US6709861B2 (en) * | 2000-11-17 | 2004-03-23 | Lucigen Corp. | Cloning vectors and vector components |
| DE10145553B4 (de) * | 2001-09-16 | 2006-06-08 | Gene Architects Ag | Nukleinsäure für einen Klonierungsvektor |
| DK1314783T3 (da) * | 2001-11-22 | 2009-03-16 | Sloning Biotechnology Gmbh | Nukleinsyrelinkere og deres anvendelse i gensyntese |
| AU2002365811A1 (en) * | 2001-12-03 | 2003-06-17 | Zymogenetics, Inc. | Methods for the selection and cloning of nucleic acid molecules free of unwanted nucleotide sequence alterations |
| EP1483404A2 (de) * | 2002-03-05 | 2004-12-08 | Solexa Ltd. | Methoden zur detektion genom-überspannender sequenzvariationen, welche mit einem phenotyp assoziiert sind |
| US20030186251A1 (en) * | 2002-04-01 | 2003-10-02 | Brookhaven Science Associates, Llc | Genome sequence tags |
| US20030235827A1 (en) * | 2002-06-25 | 2003-12-25 | Orchid Biosciences, Inc. | Methods and compositions for monitoring primer extension and polymorphism detection reactions |
| GB0228289D0 (en) * | 2002-12-04 | 2003-01-08 | Genome Inst Of Singapore Nat U | Method |
| US8222005B2 (en) * | 2003-09-17 | 2012-07-17 | Agency For Science, Technology And Research | Method for gene identification signature (GIS) analysis |
| ATE510024T1 (de) * | 2003-10-31 | 2011-06-15 | Advanced Genetic Analysis Corp Ab | Verfahren zur herstellung eines gepaarten tag aus einer nukleinsäuresequenz sowie verfahren zur verwendung davon |
| CN1597986A (zh) * | 2004-07-22 | 2005-03-23 | 东南大学 | 一种发卡结构探针的脱氧核糖核酸芯片及其应用方法 |
| CA2641851A1 (en) * | 2006-02-08 | 2007-08-16 | Eric Hans Vermaas | Method for sequencing a polynucleotide template |
-
2007
- 2007-01-04 AT AT07701933T patent/ATE483804T1/de not_active IP Right Cessation
- 2007-01-04 DE DE602007009634T patent/DE602007009634D1/de active Active
- 2007-01-04 CN CN200780007408.XA patent/CN101395281B/zh active Active
- 2007-01-04 WO PCT/CN2007/000001 patent/WO2007076726A1/en active Application Filing
- 2007-01-04 EP EP07701933A patent/EP1969146B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DE602007009634D1 (de) | 2010-11-18 |
| EP1969146A1 (de) | 2008-09-17 |
| WO2007076726A1 (en) | 2007-07-12 |
| EP1969146A4 (de) | 2009-08-12 |
| CN101395281A (zh) | 2009-03-25 |
| CN101395281B (zh) | 2013-05-01 |
| EP1969146B1 (de) | 2010-10-06 |
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Legal Events
| Date | Code | Title | Description |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |