[go: up one dir, main page]

ATE48140T1 - Modifizierte nukleotide und verfahren zu ihrer herstellung und anwendung. - Google Patents

Modifizierte nukleotide und verfahren zu ihrer herstellung und anwendung.

Info

Publication number
ATE48140T1
ATE48140T1 AT82301804T AT82301804T ATE48140T1 AT E48140 T1 ATE48140 T1 AT E48140T1 AT 82301804 T AT82301804 T AT 82301804T AT 82301804 T AT82301804 T AT 82301804T AT E48140 T1 ATE48140 T1 AT E48140T1
Authority
AT
Austria
Prior art keywords
processes
production
compounds
applications include
modified nucleotides
Prior art date
Application number
AT82301804T
Other languages
English (en)
Inventor
David C Ward
Alexander A Waldrop Iii
Pennina R Langer
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Priority claimed from EP82301804A external-priority patent/EP0063879B1/de
Application granted granted Critical
Publication of ATE48140T1 publication Critical patent/ATE48140T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT82301804T 1981-04-17 1982-04-06 Modifizierte nukleotide und verfahren zu ihrer herstellung und anwendung. ATE48140T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25522381A 1981-04-17 1981-04-17
EP82301804A EP0063879B1 (de) 1981-04-17 1982-04-06 Modifizierte Nukleotide und Verfahren zu ihrer Herstellung und Anwendung

Publications (1)

Publication Number Publication Date
ATE48140T1 true ATE48140T1 (de) 1989-12-15

Family

ID=26085237

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82301804T ATE48140T1 (de) 1981-04-17 1982-04-06 Modifizierte nukleotide und verfahren zu ihrer herstellung und anwendung.

Country Status (2)

Country Link
EP (1) EP0329198B1 (de)
AT (1) ATE48140T1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681726A (en) * 1988-09-19 1997-10-28 Stratagene Method of double stranded DNA synthesis
FR2780059B1 (fr) 1998-06-17 2002-10-11 Bio Merieux Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US7060441B2 (en) 2001-05-04 2006-06-13 Biomerieux Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
FR2868071B1 (fr) 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2886735B1 (fr) 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
FR2917090B1 (fr) 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2934595B1 (fr) 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
EP2390351A1 (de) 2010-05-27 2011-11-30 Centre National de la Recherche Scientifique (CNRS) Verfahren zur DNA-Sequenzierung durch Hybridisierung
EP2390350A1 (de) 2010-05-27 2011-11-30 Centre National de la Recherche Scientifique (CNRS) Verfahren zur DNA-Sequenzierung durch Polymerisation
FR2968302B1 (fr) 2010-12-06 2012-11-30 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
CN104254617B (zh) 2011-12-22 2017-04-26 国家科学研究中心 通过单分子杂交和操作进行的dna检测和定量的方法
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
BR112015017354A2 (pt) 2013-01-22 2017-11-21 Centre Nat Rech Scient método para detectar pelo menos uma base modificada
CN107771222B (zh) 2015-05-07 2019-06-04 巴黎科学与文学联大-拉丁区 使用力诱导的链侵入原位形成发夹
BR112020001503A2 (pt) * 2017-07-24 2020-07-21 Union Carbide Corporation polímeros catiônicos livres de cloreto usando ânions acetatos.
FR3075820B1 (fr) 2017-12-21 2022-12-30 Paris Sciences Lettres Quartier Latin Molecule d'adn double-brin pour la detection et la caracterisation des interactions moleculaires

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN142734B (de) * 1975-04-28 1977-08-20 Miles Lab
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede

Also Published As

Publication number Publication date
EP0329198A2 (de) 1989-08-23
EP0329198B1 (de) 1998-06-10
EP0329198A3 (de) 1991-03-27

Similar Documents

Publication Publication Date Title
ATE48140T1 (de) Modifizierte nukleotide und verfahren zu ihrer herstellung und anwendung.
DE3280478D1 (de) Basenmodifizierte Oligo- und Polynucleotide und Verfahren zu ihrer Herstellung und Verwendung
ATE106947T1 (de) Mittel und verfahren zur erhöhung der nukleinsäure-hybridisierung.
CY1108716T1 (el) Μεθοδος διαγνωσεως της νοσου του alzheimer με βαση μια μορφη μεταγραφης γονιδιου.
DE69333073D1 (de) Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
ATE190357T1 (de) Schnelles verfahren fur die dns sequenzierung und diagnostische anwendungen
DE69433626D1 (de) N-2 substituierte purine
DE69109100D1 (de) Oligonukleotid-analoge.
ATE252110T1 (de) Markierte oligonukleotide
AU6180190A (en) Fast process for detecting and/or identifying a single base on a nucleic acid sequence and its applications
ATE208813T1 (de) Modifizierte zellen mit resistenz gegen retroviralinfektionen
FI875082A (fi) Dna-sekvensser deriverade fraon genom av papillomavirus, deras anvaendning foer in vitro diagnostiska aendamaol; samt framstaellning av antigeniska kompositioner.
DE3583564D1 (de) Dna-sequenzen des ebv-genoms, rekombinante dna-molekuele, verfahren zur herstellung von ebv-verwandten antigenen sowie diagnostische zusammensetzungen und pharmazeutische zusammensetzungen, die die genannten antigene enthalten.
DE69026716D1 (de) Nukleinsäurefragmente von einem genom eines geeigneten mykobakteriums, ihre verwendung zur diagnose von mykobakterieninfektionen sowie diese fragmente enthaltende plasmide
EP0274482A4 (de) Zubereitungen und verfahren für klone, die assoziierte dna-sequenzen mit mehrfacharzneimittelresistenz in menschlichen zellen enthalten.
SE7806087L (sv) Forfarande for rening av nukleotidsekvenser lempliga som syntetiseringsmall i bakterier, mikroorganism innefattande dylik nukleotidsekvens samt rekombinant dna-overforingsvektor innefattande dylik nukleotid
ATE46518T1 (de) Sialosylcerebroside und verfahren zu ihrer herstellung.
DE3678702D1 (de) Antitumorprotein-gen von streptococcus pyogenes su, plasmide, die das gen enthalten, transformantenzellen, die die plasmide beherbergen, und verfahren zur herstellung des antitumorproteins.
ES2092568T3 (es) Identificacion de nuevos farmacos y reactivos.
DE3886234D1 (de) DNA-Sequenzen, Plasmide und Mikroorganismen sowie Verfahren zur Herstellung von Chinolinsäure.
DE3751114D1 (de) Dmd-sonden.
ATE11527T1 (de) Optisch aktive phenoxybenzoesaeure-derivate, verfahren zu ihrer herstellung und ihre verwendung als herbizide.
ATE108834T1 (de) Spezifische nukleinsäurefragmente des menschlichen villingens, ihre anwendung für diagnostische zwecke.
NO875058L (no) Oligonukleotidprober og fremgangsmÿte for detektering av nukleinsyrene i bakterier og andre levende organismer ved hybridisering.
ATE65543T1 (de) Dna-sequenzen des ebv-genoms, rekombinante dnamolek¨le, verfahren zur herstellung von ebvverwandten antigenen sowie diagnostische zusammensetzungen und pharmazeutische zusammensetzungen, die die genannten antigene enthalten.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time