ATE464309T1 - Indolizinderivate und deren verwendung als crth2- antagonisten - Google Patents
Indolizinderivate und deren verwendung als crth2- antagonistenInfo
- Publication number
- ATE464309T1 ATE464309T1 AT06755627T AT06755627T ATE464309T1 AT E464309 T1 ATE464309 T1 AT E464309T1 AT 06755627 T AT06755627 T AT 06755627T AT 06755627 T AT06755627 T AT 06755627T AT E464309 T1 ATE464309 T1 AT E464309T1
- Authority
- AT
- Austria
- Prior art keywords
- c1c6alkyl
- hydrogen
- fully
- partially fluorinated
- independently
- Prior art date
Links
- 102000009389 Prostaglandin D receptors Human genes 0.000 title abstract 2
- 108050000258 Prostaglandin D receptors Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 abstract 1
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 abstract 1
- -1 C1C6alkyl Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0512944.0A GB0512944D0 (en) | 2005-06-24 | 2005-06-24 | Indolizine compounds |
| PCT/GB2006/002341 WO2006136859A2 (en) | 2005-06-24 | 2006-06-26 | Indoli zine derivatives and their use as crth2 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE464309T1 true ATE464309T1 (de) | 2010-04-15 |
Family
ID=34856120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06755627T ATE464309T1 (de) | 2005-06-24 | 2006-06-26 | Indolizinderivate und deren verwendung als crth2- antagonisten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090163534A1 (de) |
| EP (1) | EP1910357B1 (de) |
| JP (1) | JP2008543921A (de) |
| CN (1) | CN101243086A (de) |
| AT (1) | ATE464309T1 (de) |
| DE (1) | DE602006013643D1 (de) |
| GB (1) | GB0512944D0 (de) |
| WO (1) | WO2006136859A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ574705A (en) | 2006-08-07 | 2011-12-22 | Actelion Pharmaceuticals Ltd | (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives |
| EA200970590A1 (ru) * | 2006-12-21 | 2009-12-30 | Арджента Дискавери Лимитед | Антагонисты crth2 |
| GB0625842D0 (en) * | 2006-12-22 | 2007-02-07 | Argenta Discovery Ltd | Indolizine derivatives |
| CA2681409A1 (en) * | 2007-03-21 | 2008-09-25 | Argenta Oral Therapeutics Limited | Indolizine acetic acid derivatives as crth2 antagonists |
| EP2129661B1 (de) * | 2007-03-29 | 2012-02-08 | Pulmagen Therapeutics (Asthma) Limited | Chinolinderivate als crth2-rezeptorliganden |
| RU2491279C2 (ru) * | 2007-09-25 | 2013-08-27 | Актимис Фармасьютикалз, Инк. | 2-s-бензилзамещенные пиримидины в качестве антагонистов crth2 |
| GB0719521D0 (en) * | 2007-10-05 | 2007-11-14 | Argenta Discovery Ltd | Compounds |
| CA2707785C (en) | 2007-12-14 | 2015-11-03 | Pulmagen Therapeutics (Asthma) Limited | Indoles and their therapeutic use |
| EP2268281A4 (de) * | 2008-02-15 | 2012-05-02 | Abbott Lab | Thienopyrrole und pyrrolothiazole als neue therapiemittel |
| EP2331541B1 (de) | 2008-09-04 | 2015-04-22 | Boehringer Ingelheim International GmbH | Indolizine als inhibitoren der leukotrienproduktion |
| BRPI0921038A2 (pt) * | 2008-11-17 | 2019-09-24 | Hoffmann La Roche | ácido naftilacéticos |
| AR077428A1 (es) | 2009-07-29 | 2011-08-24 | Sanofi Aventis | (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos |
| EP2558447B1 (de) | 2010-03-22 | 2014-09-17 | Actelion Pharmaceuticals Ltd. | 3-(heteroaryl-amino-)1,2,3,4-tetrahydro-9h-carbazol-derivate und ihre verwendung als prostaglandin-d2-rezeptormodulatoren |
| EP2457900A1 (de) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | Neue Pyrazolderivate mit CRTH2-antagonistischem Verhalten |
| MX338516B (es) | 2011-04-14 | 2016-04-20 | Actelion Pharmaceuticals Ltd | Derivados de acido 7- (heteroaril-amino) -6, 7, 8, 9- tetrahidropirido[1,2-a] indol acetico y sus usos como modulador del receptor de prostaglandina. |
| CN104114169A (zh) | 2011-12-16 | 2014-10-22 | 阿托佩斯治疗有限公司 | 用于治疗嗜酸细胞性食管炎的crth2拮抗剂和质子泵抑制剂的组合物 |
| KR101864060B1 (ko) | 2014-03-17 | 2018-06-01 | 이도르시아 파마슈티컬스 리미티드 | 아자인돌 아세트산 유도체 및 프로스타글란딘 ｄ2 수용체 조절제로서의 그의 용도 |
| AU2015233046A1 (en) | 2014-03-18 | 2016-11-03 | Idorsia Pharmaceuticals Ltd | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators |
| KR20180053345A (ko) | 2015-09-15 | 2018-05-21 | 이도르시아 파마슈티컬스 리미티드 | 결정질 형태 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1174124A (en) * | 1967-06-30 | 1969-12-10 | Beecham Group Ltd | Pharmacologically Active Indolizine Compounds |
| GB1268424A (en) * | 1969-10-04 | 1972-03-29 | Beecham Group Ltd | Indolizine derivatives |
| ES421284A1 (es) * | 1973-12-07 | 1976-04-16 | Farmasimes S A | Procedimiento para la preparacion de derivados de acidos pirrocolinaceticos. |
| US20070232681A1 (en) * | 2003-10-14 | 2007-10-04 | Oxagen Limited | Compounds Having Crth2 Antagonist Activity |
| WO2005040112A1 (en) * | 2003-10-14 | 2005-05-06 | Oxagen Limited | Compounds with pgd2 antagonist activity |
| GB2407318A (en) * | 2003-10-23 | 2005-04-27 | Oxagen Ltd | Substituted Indol-3-yl acetic acid derivatives |
| GB0324763D0 (en) * | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
-
2005
- 2005-06-24 GB GBGB0512944.0A patent/GB0512944D0/en not_active Ceased
-
2006
- 2006-06-26 DE DE602006013643T patent/DE602006013643D1/de not_active Expired - Fee Related
- 2006-06-26 WO PCT/GB2006/002341 patent/WO2006136859A2/en not_active Ceased
- 2006-06-26 EP EP06755627A patent/EP1910357B1/de not_active Not-in-force
- 2006-06-26 CN CNA2006800305874A patent/CN101243086A/zh active Pending
- 2006-06-26 US US11/993,412 patent/US20090163534A1/en not_active Abandoned
- 2006-06-26 AT AT06755627T patent/ATE464309T1/de not_active IP Right Cessation
- 2006-06-26 JP JP2008517604A patent/JP2008543921A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006013643D1 (de) | 2010-05-27 |
| JP2008543921A (ja) | 2008-12-04 |
| WO2006136859A2 (en) | 2006-12-28 |
| EP1910357B1 (de) | 2010-04-14 |
| EP1910357A2 (de) | 2008-04-16 |
| US20090163534A1 (en) | 2009-06-25 |
| WO2006136859A3 (en) | 2007-04-05 |
| GB0512944D0 (en) | 2005-08-03 |
| CN101243086A (zh) | 2008-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |