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ATE461919T1 - Verfahren zur herstellung von montelukast und zwischenprodukte dafür - Google Patents

Verfahren zur herstellung von montelukast und zwischenprodukte dafür

Info

Publication number
ATE461919T1
ATE461919T1 AT05735077T AT05735077T ATE461919T1 AT E461919 T1 ATE461919 T1 AT E461919T1 AT 05735077 T AT05735077 T AT 05735077T AT 05735077 T AT05735077 T AT 05735077T AT E461919 T1 ATE461919 T1 AT E461919T1
Authority
AT
Austria
Prior art keywords
intermediate products
products therefor
producing montelukast
montelukast
producing
Prior art date
Application number
AT05735077T
Other languages
English (en)
Inventor
Arjanne Overeem
Reinerus Gieling
Jie Zhu
Thijs Lambertus
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Application granted granted Critical
Publication of ATE461919T1 publication Critical patent/ATE461919T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
AT05735077T 2004-04-30 2005-04-14 Verfahren zur herstellung von montelukast und zwischenprodukte dafür ATE461919T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56660304P 2004-04-30 2004-04-30
US58467504P 2004-07-02 2004-07-02
US11/081,689 US7829716B2 (en) 2004-04-30 2005-03-17 Process for making montelukast and intermediates therefor
PCT/EP2005/004014 WO2005105750A1 (en) 2004-04-30 2005-04-14 Process for making montelukast and intermediates therefor

Publications (1)

Publication Number Publication Date
ATE461919T1 true ATE461919T1 (de) 2010-04-15

Family

ID=34965297

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05735077T ATE461919T1 (de) 2004-04-30 2005-04-14 Verfahren zur herstellung von montelukast und zwischenprodukte dafür

Country Status (6)

Country Link
US (1) US7829716B2 (de)
EP (1) EP1740545B1 (de)
AR (1) AR048876A1 (de)
AT (1) ATE461919T1 (de)
DE (1) DE602005020125D1 (de)
WO (1) WO2005105750A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL174758A (en) * 2003-10-10 2012-09-24 Synthon Bv Crystalline form of montelukast, pharmaceutical composition comprising it, process for the preparation thereof and uses thereof as a medicament
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
ATE497492T1 (de) 2005-07-05 2011-02-15 Teva Pharma Reinigung von montelukast
AR057909A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
CN101365683A (zh) * 2005-11-18 2009-02-11 斯索恩有限公司 制备孟鲁司特及其中间体的方法
EP1996552A1 (de) * 2006-03-17 2008-12-03 Synthon B.V. Montelukast-amantadin-salz
EP1886998A1 (de) 2006-08-09 2008-02-13 Esteve Quimica, S.A. Verfahren zur Reinigung von Montelukast und dessen Aminesalzen
CN101889081B (zh) 2007-09-28 2014-06-18 科德克希思公司 酮还原酶多肽及其用途
EP2276739A1 (de) * 2008-04-25 2011-01-26 Synthon B.V. Verfahren zur herstellung von montelukast-zwischenprodukten
EP2552892A1 (de) 2010-03-31 2013-02-06 KRKA, D.D., Novo Mesto Effiziente synthese zur herstellung von montelukast und neue kristalline form von zwischenprodukten darin
US8471030B2 (en) 2010-12-06 2013-06-25 Orochem Technologies Inc. Purification of montelukast using simulated moving bed
EP2502910A1 (de) 2011-03-15 2012-09-26 Laboratorios Lesvi, S.L. Camphersulfonsalz eines Montelukastschlüssels Zwischenprodukt
WO2020049505A1 (en) 2018-09-06 2020-03-12 Innopharmascreen Inc. Methods and compositions for treatment of asthma or parkinson's disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266568A (en) * 1990-10-12 1993-11-30 Merck Frosst Canada, Inc. Hydroxyalkylquinoline ether acids as leukotriene antagonists
US5565473A (en) * 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5856322A (en) * 1990-10-12 1999-01-05 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
DE69129257T2 (de) 1990-10-12 1998-11-05 Merck Frosst Canada Inc., Kirkland, Quebec Ungesättigte Hydroxyalkylchinolinsäuren als Leukotrien-Antagonisten
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
TW448160B (en) * 1993-12-28 2001-08-01 Merck & Co Inc Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
GB9423511D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US5523477A (en) * 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5869673A (en) * 1997-02-28 1999-02-09 Merck & Co., Inc. Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde
US6585115B1 (en) * 2000-11-28 2003-07-01 Baker Hughes Incorporated Apparatus and method for transferring dry oil and gas well drill cuttings
CN1420113A (zh) * 2001-11-16 2003-05-28 北京上地新世纪生物医药研究所 孟鲁司特钠的制备方法及其制备中间体
CN1171873C (zh) * 2001-12-26 2004-10-20 北京上地新世纪生物医药研究所 一种孟鲁司特钠的制备方法及其制备中间体
US20040265375A1 (en) * 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets
IL174758A (en) * 2003-10-10 2012-09-24 Synthon Bv Crystalline form of montelukast, pharmaceutical composition comprising it, process for the preparation thereof and uses thereof as a medicament
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor

Also Published As

Publication number Publication date
DE602005020125D1 (de) 2010-05-06
US7829716B2 (en) 2010-11-09
WO2005105750A1 (en) 2005-11-10
EP1740545B1 (de) 2010-03-24
AR048876A1 (es) 2006-06-07
EP1740545A1 (de) 2007-01-10
US20050245568A1 (en) 2005-11-03

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties